Bulletin of Faculty of Health Sciences Okayama University Medical School
Published by Faculty of Health Sciences Okayama University Medical School

<Formerly known as>
岡山大学医療技術短期大学部紀要 (1巻-9巻)

Correlation between IgG class of rheumatoid factors, immune complexes and C-reactive protein in human sera containing RF.

唐下 博子 岡山大学医療技術短期大学部衛生技術学科
一村 光子 岡山大学医療技術短期大学部衛生技術学科
﨑山 順子 岡山大学医療技術短期大学部衛生技術学科
森 秀治 岡山大学医療技術短期大学部衛生技術学科
中田 安成 岡山大学医療技術短期大学部衛生技術学科
遠藤 浩 岡山大学医療技術短期大学部衛生技術学科
抄録
We measured the concentration of three immunoglobulin classes of rheumatoid factors (Ig-RFs), C3d binding IgG immune complex (C3d-IC), C1q binding IgG immune complex (C1q-IC) and C-reactive protein (CRP) in 74 samples of human sera with high levels of RF (24.0~2350.0IU/ml). In sera with high levels of C3d-IC (>15.0μg/ml), there was a positive correlation between the levels of CRP and the IgG-RF, but there was no correlation between the levels of CRP and the immune complexes (C3d-IC and C1q-IC). And then, there was a positive correlation between the levels of CRP and IgG-RF or C3d-IC and IgG-RF when the levels of C1q-IC in patients sera were higher than 80.0μg/ml. However, there was no correlation between the levels of CRP and C1q-IC in these patients sera containing high levels of both C3d-IC and C1q-IC. These results indicated that the determination of C3d-IC, C1q-IC, IgG-RF and CRP in human sera containing RF denote different implications as inflammatory indexes on progression of rheumatoid arthritis and other autoimmune diseases.
キーワード
self-associating IgG rheumatoid factor (自己IgG結合性リウマチ因子)
C1q binding IgG immune complex (C1q結合IgG免疫複合体)
C3d binding IgG immune complex (C3d結合IgG免疫複合体)
C-reactive protein (C反応性タンパク質(CRP))
ISSN
0917-4494
NCID
AN10355371