ID 40008
JaLCDOI
フルテキストURL
著者
Hirai, Kazuyuki Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Arimitsu, Hideyuki Department of Microbiology, Fujita Health University, School of Medicine
Umeda, Koji Immunology Research Institute, GHEN Corporation
Yokota, Kenji Graduate School of Health Sciences, Okayama University
Shen, Lianhua Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ayada, Kiyoshi Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kodama, Yoshikatsu Immunology Research Institute, GHEN Corporation
Tsuji, Takao Department of Microbiology, Fujita Health University, School of Medicine
Hirai, Yoshikazu Division of Infection and Immunuity, Jichi Medical School
Oguma, Keiji Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録
In an attempt to prepare egg yolk immunoglobulin (IgY) to treat and prevent cholera, hens were immunized by a mixture of heat- or formalin-killed Vibrio cholerae O1 and O139 organisms, or by the recombinant cholera toxin B subunit (CTB). The IgYs were partially purified from egg yolk and orally administered to suckling mice before or after challenge with live O1 or O139 cells. The anti-O1 and O139 IgYs and the mixture of either IgY with anti-CTB IgY significantly protected the occurrence of cholera caused by both O1 and O139 infection. Since large amounts of IgY can be prepared very easily and at low cost, this seems to be a useful procedure for preventing and treating cholera.
キーワード
Vibrio cholerae
O1
O139
IgY
Amo Type
Original Article
発行日
2010-06
出版物タイトル
Acta Medica Okayama
64巻
3号
出版者
Okayama University Medical School
開始ページ
163
終了ページ
170
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
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