ID 40008
JaLCDOI
FullText URL
Author
Hirai, Kazuyuki
Arimitsu, Hideyuki
Umeda, Koji
Shen, Lianhua
Ayada, Kiyoshi
Kodama, Yoshikatsu
Tsuji, Takao
Hirai, Yoshikazu
Abstract
In an attempt to prepare egg yolk immunoglobulin (IgY) to treat and prevent cholera, hens were immunized by a mixture of heat- or formalin-killed Vibrio cholerae O1 and O139 organisms, or by the recombinant cholera toxin B subunit (CTB). The IgYs were partially purified from egg yolk and orally administered to suckling mice before or after challenge with live O1 or O139 cells. The anti-O1 and O139 IgYs and the mixture of either IgY with anti-CTB IgY significantly protected the occurrence of cholera caused by both O1 and O139 infection. Since large amounts of IgY can be prepared very easily and at low cost, this seems to be a useful procedure for preventing and treating cholera.
Keywords
Vibrio cholerae
O1
O139
IgY
Amo Type
Original Article
Published Date
2010-06
Publication Title
Acta Medica Okayama
Volume
volume64
Issue
issue3
Publisher
Okayama University Medical School
Start Page
163
End Page
170
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT