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ID 17700
Eprint ID
17700
フルテキストURL
Thumnail 88_1121.pdf 1.04 MB
タイトル(別表記)
Studies on chrysotherapy in rheumatoid arthritis Part Ⅱ Influence of gold salt on hypothalamo-hypophyseo-adrenocortical function
著者
大原 敦 岡山大学医学部大藤内科教室
抄録
The influence of gold salt on the hypothalamo-hypophyseo-adrenocortical (PHA) function was studied experimentally and clinically. The following results were obtained.1) The food intake of mature female CBA mice injected with gold thioglucose (GTG) increased significantly before a body weight increase and the level of plasma comp. B increased temporarily compared to control subjects. 2) The plasma comp. B level in mature female rabbit reached a peak at 2 or 3 days after an injection of gold sodium thiomalate (GTM). 3) Urinary 17 KGS of RA patients injected GTG or GTM increased temporarily at accumulation dose of about 140mg of total gold salt. 4) By PHA function test in RA patients, endocrine system abnormalities may originate at a more anatomical cranial site than hypophysis. 5) The response of the ACTH-Z, metopirone, LVP and insulin test were more higher than in RA patients before chrysotherapy than in the same patients after chrysotherapy. 6) These results suggest that the PHA system was stimulated by gold salt. This response was one of the pharmacological actions of gold salt but it was not anti-rheumatic action in RA.
発行日
1976-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
88巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1121
終了ページ
1133
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/88/11-12/88_11-12_1121/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma