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ID 17700
Eprint ID
17700
FullText URL
Thumnail 88_1121.pdf 1.04 MB
Title Alternative
Studies on chrysotherapy in rheumatoid arthritis Part Ⅱ Influence of gold salt on hypothalamo-hypophyseo-adrenocortical function
Author
Oohara, Atushi
Abstract
The influence of gold salt on the hypothalamo-hypophyseo-adrenocortical (PHA) function was studied experimentally and clinically. The following results were obtained.1) The food intake of mature female CBA mice injected with gold thioglucose (GTG) increased significantly before a body weight increase and the level of plasma comp. B increased temporarily compared to control subjects. 2) The plasma comp. B level in mature female rabbit reached a peak at 2 or 3 days after an injection of gold sodium thiomalate (GTM). 3) Urinary 17 KGS of RA patients injected GTG or GTM increased temporarily at accumulation dose of about 140mg of total gold salt. 4) By PHA function test in RA patients, endocrine system abnormalities may originate at a more anatomical cranial site than hypophysis. 5) The response of the ACTH-Z, metopirone, LVP and insulin test were more higher than in RA patients before chrysotherapy than in the same patients after chrysotherapy. 6) These results suggest that the PHA system was stimulated by gold salt. This response was one of the pharmacological actions of gold salt but it was not anti-rheumatic action in RA.
Published Date
1976-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume88
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1121
End Page
1133
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/88/11-12/88_11-12_1121/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma