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ID 14206
Eprint ID
14206
フルテキストURL
Thumnail 104_863.pdf 431 KB
タイトル(別表記)
Studies on the mechanism of initial attack in intractable asthma Part 2. Lymphocyte subpopulations of asthmatics analyzed by two-color flow cytometry
著者
高田 穣 岡山大学医学部第二内科学教室
抄録
To elucidate the role of lymphocytes in asthmatics, lymphocyte subpopulations were analyzed using monoclonal antibodies (CD2, CD3, CD4, CD8, CD16, CD19, CD25, and HLA-DR, all from Leu series) and flow cytometry (FACScan, Beckton-Dickinson). Blood samples were obtained when there was no attack unless otherwise stated. Patients were defined as intractable when they had been taking more than 5 mg of prednisolone for at least one year. (1) Non-intractable asthmatics had greater % of CD16+NK cells as compared with agematched normal subjects. (2) No differences were observed between RAST or intradermal test-positive and negative patients, although the former had significantly higher serum IgE levels than the latter. (3) Intractable asthmatics showed an increased proportion of IL-2R+lymphocytes as compared with normal subjects. (4) Patients on attack also had a higher % of IL-2R+lymphocytes than patients without attack. These findings suggest that NK cells play an important role in bronchial asthma, and that activeted lymphocytes are involved in the pathogenesis of intractable asthma and asthmatic attack.
キーワード
intractable asthma
lymphocyte subpopulation
flow cytometry
備考
原著
発行日
1992-08
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
863
終了ページ
870
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/104/7-8/104_7-8_863/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma