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ID 14206
Eprint ID
14206
FullText URL
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Title Alternative
Studies on the mechanism of initial attack in intractable asthma Part 2. Lymphocyte subpopulations of asthmatics analyzed by two-color flow cytometry
Author
Takata, Minoru
Abstract
To elucidate the role of lymphocytes in asthmatics, lymphocyte subpopulations were analyzed using monoclonal antibodies (CD2, CD3, CD4, CD8, CD16, CD19, CD25, and HLA-DR, all from Leu series) and flow cytometry (FACScan, Beckton-Dickinson). Blood samples were obtained when there was no attack unless otherwise stated. Patients were defined as intractable when they had been taking more than 5 mg of prednisolone for at least one year. (1) Non-intractable asthmatics had greater % of CD16+NK cells as compared with agematched normal subjects. (2) No differences were observed between RAST or intradermal test-positive and negative patients, although the former had significantly higher serum IgE levels than the latter. (3) Intractable asthmatics showed an increased proportion of IL-2R+lymphocytes as compared with normal subjects. (4) Patients on attack also had a higher % of IL-2R+lymphocytes than patients without attack. These findings suggest that NK cells play an important role in bronchial asthma, and that activeted lymphocytes are involved in the pathogenesis of intractable asthma and asthmatic attack.
Keywords
intractable asthma
lymphocyte subpopulation
flow cytometry
Note
原著
Published Date
1992-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume104
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
863
End Page
870
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/104/7-8/104_7-8_863/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
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language
日本語
Copyright Holders
岡山医学会
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Refereed
True
Eprints Journal Name
joma