| JaLCDOI | 10.18926/AMO/62395 |
|---|---|
| FullText URL | 75_4_439.pdf |
| Author | Mitsui, Takashi| Mishima, Sakurako| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi| |
| Abstract | Early diagnosis and therapy are important in a cesarean scar pregnancy (CSP), which can cause uterine rupture with resultant massive bleeding. However, there are some reports of CSPs continued to term. The optimal management of CSPs remains unclear; therefore, we investigated the clinical courses of CSPs diagnosed and treated at perinatal institutions in the Chugoku and Shikoku regions of Japan. We enrolled 60 women diag-nosed with CSP at 21 institutions from January 2006 to December 2015. Of the 60 women diagnosed with CSP, 57 were treated. Pregnancy was terminated in 48 women and continued in 9. Thirteen women underwent transabdominal hysterectomy; they experienced no postoperative complications or allogeneic blood transfu-sion. Nine women received therapies such as dilation and curettage, and 26 received non-surgical therapies such as methotrexate and topical administration of potassium chloride. Among 9 women who chose to con-tinue with their CSP, 7 successfully delivered newborns, 2 had uterine ruptures in the second trimester, and all women required transabdominal hysterectomy. Diagnosis and therapy in the first trimester of pregnancy are important in the management strategy of a CSP. When continuing a CSP, the risk of uterine rupture and trans-abdominal hysterectomy must be considered. |
| Keywords | cesarean scar pregnancy uterine rupture hysterectomy methotrexate potassium chloride |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-08 |
| Volume | volume75 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 439 |
| End Page | 445 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34511610 |
| Web of Science KeyUT | 000697944600005 |
| NAID | 120007146038 |
| JaLCDOI | 10.18926/AMO/62806 |
|---|---|
| FullText URL | 75_6_677.pdf |
| Author | Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi| |
| Abstract | Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy. |
| Keywords | endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 677 |
| End Page | 684 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955534 |
| Web of Science KeyUT | 000735297900002 |
| NAID | 120007180286 |
| JaLCDOI | 10.18926/AMO/62816 |
|---|---|
| FullText URL | 75_6_745.pdf |
| Author | Hayata, Kei| Mishima, Sakurako| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Ogawa, Chikako| Masuyama, Hisashi| |
| Abstract | NIPT is non-definitive testing to estimate the possibility that fetuses have trisomy 21, trisomy 18, or trisomy 13. However, in NIPT-positive and indeterminate cases, rare chromosomal disease may become apparent, requiring advanced genetic considerations and counseling skills. We experienced two such cases, a trisomy 21 mosaicism case triggered by NIPT-positive status and 18q deletion syndrome triggered by NIPT-indeterminate status. These cases have two clinical implications for NIPT. First, it was revealed that trisomy mosaicism might be found in NIPT-positive cases that have lower Z-Scores than those inferred from the fraction of fetal cfDNA in the case of standard trisomy. Second, it is possible that microdeletion syndrome could be the reason for an indeterminate NIPT result. Today’s genetic counseling requires more expertise in ethics and communication as well as genetic science because NIPT can lead to totally unexpected results. |
| Keywords | NIPT massively parallel sequencing trisomy 21 mosaicism 18q-deletion syndrome genetic counseling |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 745 |
| End Page | 750 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955544 |
| Web of Science KeyUT | 000735319800002 |
| NAID | 120007180276 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Eto, Eriko| Maki, Jota| Akagi, Teiji| Ito, Hiroshi| Masuyama, Hisashi| |
| Keywords | Anticoagulant Fontan circulation Labor analgesia Obstetrical complications Pregnancy |
| Published Date | 2019-12-30 |
| Publication Title | Journal of Cardiology Cases |
| Volume | volume21 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | 161 |
| End Page | 163 |
| ISSN | 18785409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 Published by Elsevier Ltd on behalf of Japanese College of Cardiology. |
| File Version | publisher |
| PubMed ID | 32256867 |
| DOI | 10.1016/j.jccase.2019.12.005 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jccase.2019.12.005 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Eto, Eriko| Mitsui, Takashi| Tamada, Shoko| Maki, Jota| Hayata, Kei| Masuyama, Hisashi| |
| Keywords | adrenal incidental tumor pregnancy subclinical Cushing's syndrome superimposed preeclampsia |
| Published Date | 2020-02-03 |
| Publication Title | Clinical Case Reports |
| Volume | volume8 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 481 |
| End Page | 483 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32185040 |
| DOI | 10.1002/ccr3.2592 |
| Web of Science KeyUT | 000519370400016 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.2592 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi| |
| Keywords | Cesarean scar pregnancy Gestational sac Human chorionic gonadotropin Systemic methotrexate |
| Published Date | 2021-05 |
| Publication Title | Taiwanese Journal of Obstetrics & Gynecology |
| Volume | volume60 |
| Issue | issue3 |
| Publisher | ELSEVIER TAIWAN |
| Start Page | 454 |
| End Page | 457 |
| ISSN | 1028-4559 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Taiwan Association of Obstetrics & Gynecology. |
| File Version | publisher |
| PubMed ID | 33966727 |
| DOI | 10.1016/j.tjog.2021.03.011 |
| NAID | 120007045005 |
| Web of Science KeyUT | 000651121800011 |
| Related Url | isVersionOf https://doi.org/10.1016/j.tjog.2021.03.011 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mitoma, Tomohiro| Hayata, Kei| Yokohata, Satomi| Ohira, Akiko| Kashino, Chiaki| Kirino, Satoe| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Masuyama, Hisashi| |
| Keywords | Lupus Myometrium Placenta accreta spectrum Estrogen Uterine atony |
| Published Date | 2022-07-02 |
| Publication Title | BMC Pregnancy And Childbirth |
| Volume | volume22 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 535 |
| ISSN | 1471-2393 |
| NCID | AA12035416 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35780086 |
| DOI | 10.1186/s12884-022-04864-z |
| Web of Science KeyUT | 000820223600001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12884-022-04864-z |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mitoma, Tomohiro| Maki, Jota| Ooba, Hikaru| Eto, Eriko| Takahashi, Kasumi| Kondo, Tsunemasa| Ikeda, Tomohiro| Sakamoto, Yoko| Mitsuhashi, Toshiharu| Masuyama, Hisashi| |
| Keywords | Oestrogen replacement therapy Knee osteoarthritis Muscle resistance exercise Sarcopenia Physical performance |
| Published Date | 2023-02-18 |
| Publication Title | BMC Geriatrics |
| Volume | volume23 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 104 |
| ISSN | 1471-2318 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 36800940 |
| DOI | 10.1186/s12877-023-03828-y |
| Web of Science KeyUT | 000936860000001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12877-023-03828-y |
| FullText URL | fulltext20230424-01.pdf |
|---|---|
| Author | Mishima, Sakurako| Mitsui, Takashi| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Hayata, Kei| Washio, Yosuke| Yoshimoto, Junko| Tsukahara, Hirokazu| Masuyama, Hisashi| |
| Keywords | Short stature catch-up growth small-for-gestational age premature birth hypertensive disorders of pregnancy |
| Published Date | 2023-03-08 |
| Publication Title | Hypertension in Pregnancy |
| Volume | volume42 |
| Issue | issue1 |
| Publisher | Taylor and Francis |
| Start Page | 2187623 |
| ISSN | 1064-1955 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 36891613 |
| DOI | 10.1080/10641955.2023.2187623 |
| Web of Science KeyUT | 000953321900001 |
| Related Url | isVersionOf https://doi.org/10.1080/10641955.2023.2187623 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohira, Akiko| Maki, Jota| Ageta, Kohei| Nakato, Hikari| Oba, Hikaru| Mitoma, Tomohiro| Mishima, Sakurako| Tani, Kazumasa| Kirino, Satoe| Eto, Eriko| Nakao, Atsunori| Masuyama, Hisashi| |
| Keywords | Simulation-based education Ultrasound Paramedics FAST |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-54779-2| |
| Published Date | 2024-02-20 |
| Publication Title | Scientific Reports |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4190 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38378769 |
| DOI | 10.1038/s41598-024-54779-2 |
| Web of Science KeyUT | 001173675500048 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-024-54779-2 |
| JaLCDOI | 10.18926/AMO/67547 |
|---|---|
| FullText URL | 78_4_313.pdf |
| Author | Eto, Eriko| Maki, Jota| Yamashita, Noriyuki| Hasegawa, Toru| Suemori, Ayano| Nakato, Hikari| Oba, Hikaru| Mitoma, Tomohiro| Mishima, Sakurako| Kirino, Satoe| Ohira, Akiko| Masuyama, Hisashi| |
| Abstract | During the coronavirus pandemic, face-to-face simulation education became impossible. Therefore, we aimed to develop remote-access simulation education with a sense of realism through Information and Communication Technology (ICT) using a perinatal whole-body management and delivery simulator. In September 2021, we administered a multi-center simultaneous remote simulation based on our developed model. Ten universities in the Chugoku–Shikoku region were connected via a web-conferencing system to a live broadcast of a virtual vaginal birth in which a fictional hospitalized pregnant woman experienced accelerated labor and gave birth through vacuum delivery for fetal distress. A Video on Demand (VOD) was made beforehand using a new simulator that allowed for a visual understanding of the process of the inter-vaginal examination. We provided a participatory program that enhanced the sense of realism by combining VOD and real-time lectures on each scenario, with two-way communication between participants and trainee doctors using a chat function. Most participants answered “satisfied” or “very satisfied” with the content, level of difficulty, and level of understanding. From November 2021, we have used the videos of all processes in face-to-face classes. Our construction of a high-flexibility education system using remote simulation in the field of obstetrics and gynecology, especially in the vaginal delivery module, is unique, creative, and sustainable. |
| Keywords | remote simulator education perinatal simulator information and communication technology high-flexibility education |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-08 |
| Volume | volume78 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 313 |
| End Page | 322 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39198985 |
| Web of Science KeyUT | 001310576400002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Albuayjan, Haya Hamed Hassan| Watanabe, Mayu| Sugawara, Ryosuke| Katsuyama, Eri| Mise, Koki| Oi, Yukiko| Kanno, Ayaka| Yang, BoXuan| Tahara, Toshihisa| Nojima, Ichiro| Nakatsuka, Atsuko| Eguchi, Jun| Maki, Jota| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi| Wada, Jun| |
| Published Date | 2025-05-30 |
| Publication Title | Scientific Reports |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 18981 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 40447728 |
| DOI | 10.1038/s41598-025-03879-8 |
| Web of Science KeyUT | 001499629300002 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-025-03879-8 |
