FullText URL K002286.pdf
Author 古松 毅之|
Published Date 2002-03-25
Content Type Thesis or Dissertation
Grant Number 甲第2286号
Granted Date 2002-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language 日本語
FullText URL fulltext.pdf
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Tanaka, Takaaki| Okazaki, Yuki| Kodama, Yuya| Kamatsuki, Yusuke| Masuda, Kenji| Seno, Noritaka| Ozaki, Toshifumi|
Keywords anterior cruciate ligament knee pullout suture screw fixation tibial eminence avulsion fracture
Published Date 2020-06-03
Publication Title Journal of Orthopaedic Surgery
Volume volume28
Issue issue2
Publisher SAGE Publications
Start Page 2309499020918681
ISSN 2309-4990
NCID AA11004541
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32489139
DOI 10.1177/2309499020918681
Web of Science KeyUT 000539749100001
Related Url isVersionOf https://doi.org/10.1177/2309499020918681
JaLCDOI 10.18926/AMO/32013
FullText URL fulltext.pdf
Author Ohzawa, Seiya| Takahara, Yasuhiro| Furumatsu, Takayuki| Inoue, Hajime|
Abstract <p>The authors analyzed the 5-year and 9-year survival in 134 of 165 patients who underwent total knee arthroplasties from 1989 to 1996 in our department. Patients were followed until December 31, 1998, or until the time of death. Diagnoses were rheumatoid arthritis in 81 patients (132 knees) and osteoarthritis in 53 patients (79 knees). The survival of the patients was compared to that of the age- and sex-adjusted general population. Kaplan-Meier survival curves were constructed. Twenty-two patients in the study died before the end of the follow-up. The cumulative 5-year patient survival was 88.7%, and 9-year patient survival was 64.4% for total knee arthroplasty patients. The standardized mortality ratio was 0.11 (95% confidence interval: 0.02-0.40) for the patients with osteoarthritis, and 0.81 (95% confidence interval: 0.52-1.25) for the patients with rheumatoid arthritis. The Cox proportional hazards model showed that the factors of male sex and rheumatoid arthritis were related to a higher mortality rate in the total knee arthroplasty group.</p>
Keywords total knee authroplasy patient survival rheumatoid arthritis
Amo Type Article
Published Date 2001-11
Publication Title Acta Medica Okayama
Volume volume55
Issue issue5
Publisher Okayama University Medical School
Start Page 295
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11688953
Web of Science KeyUT 000171635400006
Author Okazaki, Yuki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Okazaki, Yoshiki| Masuda, Shin| Hiranaka, Takaaki| Kodama, Yuya| Miyazawa, Shinichi| Ozaki, Toshifumi|
Keywords Anterior cruciate ligament Lateral meniscus Posterior root tear Transtibial pullout repair Meniscus extrusion
Note This fulltext is available in Apr. 2021.|
Published Date 2020-04-08
Publication Title Orthopaedics & Traumatology: Surgery & Research
Volume volume106
Issue issue3
Publisher Elsevier
Start Page 469
End Page 473
ISSN 1877-0568
Content Type Journal Article
language 英語
File Version Author
PubMed ID 32278734
DOI 10.1016/j.otsr.2019.10.022
Web of Science KeyUT 000539660200014
Related Url isVersionOf https://doi.org/10.1016/j.otsr.2019.10.022
Author Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu|
Published Date 2011-06-03
Publication Title Biochemical and Biophysical Research Communications
Volume volume409
Issue issue2
Content Type Journal Article
Author Okazaki, Yoshiki| Furumatsu, Takayuki| Yamauchi, Takatsugu| Okazaki, Yuki| Kamatsuki, Yusuke| Hiranaka, Takaaki| Kajiki, Yuya| Zhang, Ximing| Ozaki, Toshifumi|
Keywords medial meniscus posterior root tear transtibial repair meniscal volume medial extrusion three-dimensional magnetic resonance imaging
Note This fulltext is available in Apr. 2021.|
Published Date 2020-04-06
Publication Title Knee Surgery, Sports Traumatology, Arthroscopy
Publisher Springer
ISSN 09422056
NCID AA10973641
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32253480
DOI 10.1007/s00167-020-05953-2
Web of Science KeyUT 000525297800001
Related Url isVersionOf https://doi.org/10.1007/s00167-020-05953-2
Author Okazaki, Yuki| Furumatsu, Takayuki| Okazaki, Yoshiki| Masuda, Shin| Hiranaka, Takaaki| Kodama, Yuya| Kamatsuki, Yusuke| Miyazawa, Shinichi| Tetsunaga, Tomonori| Ozaki, Toshifumi|
Keywords Magnetic resonance imaging Medial meniscus Meniscus extrusion Posterior root tear Three-dimensional assessment
Note This fulltext is available in Feb. 2021.|
Published Date 2020-01-01
Publication Title The Knee
Volume volume27
Issue issue1
Publisher Elsevier
Start Page 132
End Page 139
ISSN 09680160
NCID AA10996272
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31882388
DOI 10.1016/j.knee.2019.09.005
Web of Science KeyUT 000519666300017
Related Url isVersionOf https://doi.org/10.1016/j.knee.2019.09.005
FullText URL J_Orthop_Sci_21_4_524.pdf fig.pdf
Author Furumatsu, Takayuki| Maehara, Ami| Ozaki, Toshifumi|
Note This is an Accepted Manuscript of an article published by Elsevier|
Published Date 2016-07
Publication Title Journal of Orthopaedic Science
Volume volume21
Issue issue4
Publisher Elsevier
Start Page 524
End Page 529
ISSN 0949-2658
NCID AA11052566
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 27113646
DOI 10.1016/j.jos.2016.02.013
Web of Science KeyUT 000381142800020
Related Url isVersionOf https://doi.org/10.1016/j.jos.2016.02.013
FullText URL J_Orthop_Sci_22_4_715.pdf fig.pdf
Author Lu, Zhichao| Furumatsu, Takayuki| Fujii, Masataka| Maehara, Ami| Ozaki, Toshifumi|
Keywords vascular endothelial growth factor (VEGF) meniscus meniscal injury hypoxia-inducible factor-1α (HIF-1α)
Note This is an Accepted Manuscript of an article published by Elsevier|
Published Date 2017-07
Publication Title Journal of Orthopaedic Science
Volume volume22
Issue issue4
Publisher Elsevier
Start Page 715
End Page 721
ISSN 0949-2658
NCID AA11052566
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28318650
DOI 10.1016/j.jos.2017.02.006
Web of Sience KeyUT 000407394700022
Related Url isVersionOf https://doi.org/10.1016/j.jos.2017.02.006
FullText URL J_Orthop_Sci_22_4_731.pdf fig.pdf tbl.pdf
Author Furumatsu, Takayuki| Fujii, Masataka| Kodama, Yuya| Ozaki, Toshifumi|
Note This is an Accepted Manuscript of an article published by Elsevier|
Published Date 2017-07
Publication Title Journal of Orthopaedic Science
Volume volume22
Issue issue4
Publisher Elsevier
Start Page 731
End Page 736
ISSN 0949-2658
NCID AA11052566
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28416188
DOI 10.1016/j.jos.2017.03.013
Web of Science KeyUT 000407394700025
Related Url isVersionOf https://doi.org/10.1016/j.jos.2017.03.013
FullText URL IntOrthop_43_5_1239.pdf Tables.pdf Fig.pdf
Author Furumatsu, Takayuki| Miyazawa, Shinichi| Fujii, Masataka| Tanaka, Takaaki| Kodama, Yuya| Ozaki, Toshifumi|
Keywords Arthroscopic scoring Medial meniscus Meniscal healing Posterior root tear Transtibial pullout repair
Published Date 2018-08-01
Publication Title International Orthopaedics
Volume volume43
Issue issue5
Publisher Springer
Start Page 1239
End Page 1245
ISSN 03412695
NCID AA0068148X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30069591
DOI 10.1007/s00264-018-4071-z
Web of Science KeyUT 000466730800024
Related Url isVersionOf https://doi.org/10.1007/s00264-018-4071-z
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Sugiu, Kazuhisa| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Takihira, Shota| Miyazawa, Shinichi| Nakata, Eiji| Ozaki, Toshifumi|
Note This fulltext will be available in Nov 2020 |
Published Date 2019-08-20
Publication Title Journal of Orthopaedic Science
Volume volume24
Issue issue6
Publisher Elsevier
Start Page 1058
End Page 1063
ISSN 09492658
NCID AA11052566
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.
File Version author
PubMed ID 31444009
DOI 10.1016/j.jos.2019.08.001
Web of Science KeyUT 000496202800019
Related Url isVersionOf https://doi.org/10.1016/j.jos.2019.08.001
FullText URL KSSTA27_2_361.pdf Figs.pdf Table.pdf
Author Okazaki, Yoshiki| Furumatsu, Takayuki| Miyazawa, Shinichi| Kodama, Yuya| Kamatsuki, Yusuke| Hino, Tomohito| Masuda, Shin| Ozaki, Toshifumi|
Keywords Anterior cruciate ligament reconstruction Flexed-knee position Medial meniscus Meniscal repair Open magnetic resonance imaging Posterior shift
Published Date 2018-09-24
Publication Title Knee Surgery, Sports Traumatology, Arthroscopy
Volume volume27
Issue issue2
Publisher Springer
Start Page 361
End Page 368
ISSN 0942-2056
NCID AA10973641
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30251100
DOI 10.1007/s00167-018-5157-2
Web of Science KeyUT 000460315200005
Related Url isVersionOf https://doi.org/10.1007/s00167-018-5157-2
JaLCDOI 10.18926/AMO/30974
FullText URL fulltext.pdf
Author Ikuma, Hisanori| Abe, Nobuhiro| Uchida, Youichiro| Furumatsu, Takayuki| Fujiwara, Kazuo| Nishida, Keiichiro| Ozaki, Toshifumi|
Abstract <p>Instability of the knee after the medial collateral ligament (MCL) injury is usually assessed with the manual valgus stress test, even though, in recent years, it has become possible to apply magnetic resonance imaging (MRI) to the assessment of the damage of the ligament. The valgus instability of 24 patients (12 isolated injuries and 12 multiple ligament injuries) who suffered MCL injury between 1993 and 1998 was evaluated with the Hughston and Eilers classification, which involves radiographic assessment under manual valgus stress to the injured knees. We developed a novel system for classifying the degree of injury to the MCL by calculating the percentage of injured area based on MRI and investigated the relationship between this novel MRI classification and the magnitude of valgus instability by the Hughston and Eilers classification. There was a significant correlation between the 2 classifications (p=0.0006). On the other hand, the results using other MRI based classification systems, such as the Mink and Deutsch classificaiton and the Petermann classification, were not correlated with the findings by the Hughston and Eilers classification in these cases (p0.05). Since MRI is capable of assessing the injured ligament in clinical practice, this novel classification system would be useful for evaluating the stability of the knee and choosing an appropriate treatment following MCL injury.</p>
Keywords medial collateral ligament magnetic resonance imaging knee instability novel method
Amo Type Original Article
Published Date 2008-06
Publication Title Acta Medica Okayama
Volume volume62
Issue issue3
Publisher Okayama University Medical School
Start Page 185
End Page 191
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18596835
Web of Science KeyUT 000257130300006
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Okazaki, Yuki| Yamawaki, Tadashi| Okazaki, Yoshiki| Kodama, Yuya| Kamatsuki, Yusuke| Ozaki, Toshifumi|
Keywords Medial meniscus Posterior root tear Bilateral injury Predictor Medial tibial slope Sensitivity and specificity
Note This is a post-peer-review, pre-copyedit version of an article published in Knee Surgery, Sports Traumatology, Arthroscopy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00167-020-06079-1. </br>This fulltext is available in June 2021.|
Published Date 2020-06-01
Publication Title Knee Surgery, Sports Traumatology, Arthroscopy
Publisher Springer
ISSN 0942-2056
NCID AA10973641
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version Author
PubMed ID 32488369
DOI 10.1007/s00167-020-06079-1
Web of Science KeyUT 000538465000003
Related Url isVersionOf https://doi.org/10.1007/s00167-020-06079-1
FullText URL Knee26_3_653.pdf tables.pdf Fig.pdf
Author Furumatsu, Takayuki| Okazaki, Yuki| Kodama, Yuya| Okazaki, Yoshiki| Masuda, Shin| Kamatsuki, Yusuke| Takihira, Shota| Hiranaka, Takaaki| Yamawaki, Tadashi| Ozaki, Toshifumi|
Keywords Clinical outcome Medial meniscus Meniscal healing Posterior root tear Transtibial pullout repair
Published Date 2019-06-30
Publication Title The Knee
Volume volume26
Issue issue3
Publisher Elsevier
Start Page 653
End Page 659
ISSN 09680160
NCID AA10996272
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 Elsevier B.V. All rights reserved.
File Version author
PubMed ID 30902517
DOI 10.1016/j.knee.2019.02.007
Web of Science KeyUT 000474504500017
Related Url isVersionOf https://doi.org/10.1016/j.knee.2019.02.007
JaLCDOI 10.18926/AMO/40007
FullText URL fulltext.pdf
Author Furumatsu, Takayuki| Ozaki, Toshifumi|
Abstract Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis.
Keywords epigenetics DNA methylation histone acetylation and HAT histone deacetylation and HDAC chondrogenesis
Amo Type Review
Published Date 2010-06
Publication Title Acta Medica Okayama
Volume volume64
Issue issue3
Publisher Okayama University Medical School
Start Page 155
End Page 161
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20596126
Web of Science KeyUT 000279094300001
JaLCDOI 10.18926/AMO/41320
FullText URL 64_6_351.pdf
Author Furumatsu, Takayuki| Asahara, Hiroshi|
Abstract Chondrocyte differentiation is the fundamental process in skeletal development. From the mesenchymal condensation of chondroprogenitors to the hypertrophic maturation of chondrocytes, chondrogenesis is sequentially regulated by cross-talk among transcription factors, growth factors, and chromatin structure. The master transcription factor Sry-type HMG box (Sox) 9 has an essential role in the expression of chondrogenic genes through the association with Sox9-binding sites on its target genes. Several transcription factors and coactivators, such as Scleraxis/E47 and p300, cooperatively modulate the Sox9-dependent transcription by interacting with Sox9. The Sox9-related transcriptional apparatus activates its target gene expression through p300-mediated histone acetylation on chromatin. The transforming growth factor (TGF)-β superfamily also plays a key role in chondrocyte differentiation. The TGF-β-regulated Smad3/4 complex activates Sox9-dependent transcription on chromatin by associating with Sox9 itself, and by recruiting p300 onto Sox9. These findings suggest that the epigenetic status including histone modification and chromatin structure, directly influences Sox9-regulated chondrocyte differentiation. In this article, we review the regulators of Sox9 expression itself, modulators of posttranslational Sox9 function, and Sox9-associating factors in the Sox9-dependent epigenetic regulation during chondrogenesis.
Keywords Sox9 TGF-β-Smad3 coactivator p300 scleraxis/E47 chondrogenesis
Amo Type Review
Published Date 2010-12
Publication Title Acta Medica Okayama
Volume volume64
Issue issue6
Publisher Okayama University Medical School
Start Page 351
End Page 357
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21173804
Web of Science KeyUT 000285664200001
JaLCDOI 10.18926/AMO/49259
FullText URL 67_1_65.pdf
Author Sakata, Kenichiro| Furumatsu, Takayuki| Abe, Nobuhiro| Miyazawa, Shinichi| Sakoma, Yoshimasa| Ozaki, Toshifumi|
Abstract Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human osteoarthritis. We retrospectively investigated cartilage repairs after marrow stimulation for the treatment of large cartilage defects in osteoarthritic knees. Tissues were obtained from patients who underwent total knee arthroplasty (TKA) after arthroscopic marrow stimulation in medial compartmental osteoarthritis. Clinical findings and cartilage repair were assessed. Sections of medial femoral condyles were histologically investigated by safranin O staining and anti-type II collagen antibody. Marrow stimulation decreased the knee pain in the short term. However, varus leg alignment gradually progressed, and TKA conversions were required. The grade of cartilage repair was not improved. Marrow stimulations resulted in insufficient cartilage regeneration on medial femoral condyles. Safranin O-stained proteoglycans and type II collagen were observed in the deep zone of marrow-stimulated holes. This study demonstrated that marrow stimulation resulted in failed cartilage repair for the treatment of large cartilage defects in osteoarthritic knees. Our results suggest that arthroscopic marrow stimulation might not improve clinical symptoms for the long term in patients suffering large osteoarthritic cartilage defects.
Keywords bone marrow stimulation microfracture subchondral drilling osteoarthritis of the knee cartilage repair
Amo Type Case Report
Published Date 2013-02
Publication Title Acta Medica Okayama
Volume volume67
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 74
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23439511
Web of Science KeyUT 000316829900009
Author Kamatsuki, Yusuke| Furumatsu, Takayuki| Hiranaka, Takaaki| Okazaki, Yoshiki| Okazaki, Yuki| Kodama, Yuya| Hino, Tomohito| Masuda, Shin| Miyazawa, Shinichi| Ozaki, Toshifumi|
Keywords Medial meniscus Posterior root tear Pullout repair Tibial tunnel Meniscus extrusion Three-dimensional CT
Note This fulltext is available in May 2021.|
Published Date 2020-05-25
Publication Title Knee Surgery, Sports Traumatology, Arthroscopy
Publisher Springer
ISSN 09422056
NCID AA10973641
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32451621
DOI 10.1007/s00167-020-06070-w
Web of Science KeyUT 000535430500004
Related Url isVersionOf https://doi.org/10.1007/s00167-020-06070-w