FullText URL KSSTA27_2_361.pdf Figs.pdf Table.pdf
Author Okazaki, Yoshiki| Furumatsu, Takayuki| Miyazawa, Shinichi| Kodama, Yuya| Kamatsuki, Yusuke| Hino, Tomohito| Masuda, Shin| Ozaki, Toshifumi|
Keywords Anterior cruciate ligament reconstruction Flexed-knee position Medial meniscus Meniscal repair Open magnetic resonance imaging Posterior shift
Published Date 2018-09-24
Publication Title Knee Surgery, Sports Traumatology, Arthroscopy
Volume volume27
Issue issue2
Publisher Springer
Start Page 361
End Page 368
ISSN 0942-2056
NCID AA10973641
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30251100
DOI 10.1007/s00167-018-5157-2
Web of Science KeyUT 000460315200005
Related Url isVersionOf https://doi.org/10.1007/s00167-018-5157-2
Author Okazaki, Yuki| Furumatsu, Takayuki| Okazaki, Yoshiki| Masuda, Shin| Hiranaka, Takaaki| Kodama, Yuya| Kamatsuki, Yusuke| Miyazawa, Shinichi| Tetsunaga, Tomonori| Ozaki, Toshifumi|
Keywords Magnetic resonance imaging Medial meniscus Meniscus extrusion Posterior root tear Three-dimensional assessment
Note This fulltext is available in Feb. 2021.|
Published Date 2020-01-01
Publication Title The Knee
Volume volume27
Issue issue1
Publisher Elsevier
Start Page 132
End Page 139
ISSN 09680160
NCID AA10996272
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31882388
DOI 10.1016/j.knee.2019.09.005
Web of Science KeyUT 000519666300017
Related Url isVersionOf https://doi.org/10.1016/j.knee.2019.09.005
Author Okazaki, Yoshiki| Furumatsu, Takayuki| Yamauchi, Takatsugu| Okazaki, Yuki| Kamatsuki, Yusuke| Hiranaka, Takaaki| Kajiki, Yuya| Zhang, Ximing| Ozaki, Toshifumi|
Keywords medial meniscus posterior root tear transtibial repair meniscal volume medial extrusion three-dimensional magnetic resonance imaging
Note This fulltext is available in Apr. 2021.|
Published Date 2020-04-06
Publication Title Knee Surgery, Sports Traumatology, Arthroscopy
Publisher Springer
ISSN 09422056
NCID AA10973641
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32253480
DOI 10.1007/s00167-020-05953-2
Web of Science KeyUT 000525297800001
Related Url isVersionOf https://doi.org/10.1007/s00167-020-05953-2
Author Tetsunaga, Tomonori| Furumatsu, Takayuki| Abe, Nobuhiro| Nishida, Keiichiro| Naruse, Keiji| Ozaki, Toshifumi|
Published Date 2009-09-18
Publication Title Journal of Biomechanics
Volume volume42
Issue issue13
Content Type Journal Article
Author Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu|
Published Date 2011-06-03
Publication Title Biochemical and Biophysical Research Communications
Volume volume409
Issue issue2
Content Type Journal Article
FullText URL OTSR105_1_107.pdf Fig.pdf
Author Furumatsu, Takayuki| Okazaki, Yuki| Okazaki, Yoshiki| Hino, Tomohito| Kamatsuki, Yusuke| Masuda, Shin| Miyazawa, Shinichi| Nakata, Eiji| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Keywords Descending knee motion Injury pattern Medial meniscus Posterior root tear Squatting
Published Date 2019-02-28
Publication Title Orthopaedics & Traumatology: Surgery & Research
Volume volume105
Issue issue1
Publisher Elsevier
Start Page 107
End Page 111
ISSN 18770568
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30442555
DOI 10.1016/j.otsr.2018.10.001
Web of Science KeyUT 000456541300018
Related Url isVersionOf https://doi.org/10.1016/j.otsr.2018.10.001
JaLCDOI 10.18926/AMO/57957
FullText URL 74_1_77.pdf
Author Endo, Hirosuke| Akazawa, Hirofumi| Yashiro, Masato| Yamada, Kazuki| Sanki, Tomoaki| Tetsunaga, Tomonori| Nishida, Keiichiro| Furumatsu, Takayuki| Ozaki, Toshifumi|
Abstract Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up.
Keywords idiopathic chondrolysis hip joint medication bump arthroscopy
Amo Type Case Report
Published Date 2020-02
Publication Title Acta Medica Okayama
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 77
End Page 81
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099253
reference Waldenstrom H : On necrosis of the joint cartilage by epiphyseolysis capitis femoralis. Acta Chir Scand (1930) 67: 936-946.| Jones BS: Adolescent chondrolysis of the hip joint. South African Med J (1971) 45: 196-202.| Duncan JW, Nasca R and Schrantz J: The bizarre stiff hip. Possible Idiopathic Chondrolysis. J Am Med Assoc (1975) 231: 382-385.| Segaren N, Abdul-Jabar, Segaren N and Hashemi-Nejad A: Idiopathic chodrolysis of the hip: presentation, natural history and treatment options. J Pediatr Orthop B (2014) 23: 112-116.| Hoven H, Keessen W and Kuis W: Idiopathic chondrolysis of the hip; a distinct clinical entity ? Acta Orthop Scand (1989) 60: 661-663.| Dechosilpa C, Mulpruek P, Woratanarat P and Thiabratana P: Idiopathic chondrolysis of hip. Idiopathic Chondrolysis of Hip (ICH): report of three cases. Malaysian Orthopaedic J (2014) 8: 30-32.| Sureka J, Jakkani RK, Inbaraji A and Panwar S: Idiopathic chondrolysis of hip. Jpn J Radiol (2011) 29: 283-285.| Daluga DJ and Millar EA: Idipathic chondrolysis of the hip. J Pediatr Orthop (1989) 9: 405-411.| Johnson K, Haigh SF, Ehtisham S, Ryder C and Gardner-Medwin J: Childhood idiopathic chondrolysis of the hip; MRI features. Pediatr Radiol (2003) 33: 194-199.| Laor T and Crawford AH: Idiopathic chondrolysis of the hip in children; early MRI findings. AJR (2009) 192: 526-531.| Khoshhal KI, Awaad Y and Abbak AA: Botulinum neurotoxin-A in idiopathic chondrolysis; a case report of two cases. J Pediatr Orthop B (2014) 23: 441-446.| Picazo DR, Perez FD, Ortega PJ and Aparicio NG: An usual case of chondrolysis of the hip; a possible etiology for a rare condition - a case report. J Pediatr Orthop B (2016) 25: 533-538.| Appleyard DV, Schiller JR, Eberson CP and Ehrlich MG: Idiopathic chondrolysis treated with eternercept. Orthopedics (2009) 32: 214‒217.| Roy DR and Crawford AH: Idiopathic chondrolysis of the hip; management by subtotal capsulectomy and aggressive rehabilitation. J Pediatr Orthop (1988) 8: 203-207.| Garcia ADC, Fernandez PL, Gonzalez MPC, Garcia AC, Gonzalez LR and Jimenez JP: Idiopathic chondrolysis of the hip; long term evolution. J Pediatr Orthop (1999) 19: 449-454.|
JaLCDOI 10.18926/AMO/41320
FullText URL 64_6_351.pdf
Author Furumatsu, Takayuki| Asahara, Hiroshi|
Abstract Chondrocyte differentiation is the fundamental process in skeletal development. From the mesenchymal condensation of chondroprogenitors to the hypertrophic maturation of chondrocytes, chondrogenesis is sequentially regulated by cross-talk among transcription factors, growth factors, and chromatin structure. The master transcription factor Sry-type HMG box (Sox) 9 has an essential role in the expression of chondrogenic genes through the association with Sox9-binding sites on its target genes. Several transcription factors and coactivators, such as Scleraxis/E47 and p300, cooperatively modulate the Sox9-dependent transcription by interacting with Sox9. The Sox9-related transcriptional apparatus activates its target gene expression through p300-mediated histone acetylation on chromatin. The transforming growth factor (TGF)-β superfamily also plays a key role in chondrocyte differentiation. The TGF-β-regulated Smad3/4 complex activates Sox9-dependent transcription on chromatin by associating with Sox9 itself, and by recruiting p300 onto Sox9. These findings suggest that the epigenetic status including histone modification and chromatin structure, directly influences Sox9-regulated chondrocyte differentiation. In this article, we review the regulators of Sox9 expression itself, modulators of posttranslational Sox9 function, and Sox9-associating factors in the Sox9-dependent epigenetic regulation during chondrogenesis.
Keywords Sox9 TGF-β-Smad3 coactivator p300 scleraxis/E47 chondrogenesis
Amo Type Review
Published Date 2010-12
Publication Title Acta Medica Okayama
Volume volume64
Issue issue6
Publisher Okayama University Medical School
Start Page 351
End Page 357
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21173804
Web of Science KeyUT 000285664200001
JaLCDOI 10.18926/AMO/49259
FullText URL 67_1_65.pdf
Author Sakata, Kenichiro| Furumatsu, Takayuki| Abe, Nobuhiro| Miyazawa, Shinichi| Sakoma, Yoshimasa| Ozaki, Toshifumi|
Abstract Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human osteoarthritis. We retrospectively investigated cartilage repairs after marrow stimulation for the treatment of large cartilage defects in osteoarthritic knees. Tissues were obtained from patients who underwent total knee arthroplasty (TKA) after arthroscopic marrow stimulation in medial compartmental osteoarthritis. Clinical findings and cartilage repair were assessed. Sections of medial femoral condyles were histologically investigated by safranin O staining and anti-type II collagen antibody. Marrow stimulation decreased the knee pain in the short term. However, varus leg alignment gradually progressed, and TKA conversions were required. The grade of cartilage repair was not improved. Marrow stimulations resulted in insufficient cartilage regeneration on medial femoral condyles. Safranin O-stained proteoglycans and type II collagen were observed in the deep zone of marrow-stimulated holes. This study demonstrated that marrow stimulation resulted in failed cartilage repair for the treatment of large cartilage defects in osteoarthritic knees. Our results suggest that arthroscopic marrow stimulation might not improve clinical symptoms for the long term in patients suffering large osteoarthritic cartilage defects.
Keywords bone marrow stimulation microfracture subchondral drilling osteoarthritis of the knee cartilage repair
Amo Type Case Report
Published Date 2013-02
Publication Title Acta Medica Okayama
Volume volume67
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 74
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23439511
Web of Science KeyUT 000316829900009
FullText URL K002286.pdf
Author 古松 毅之|
Published Date 2002-03-25
Content Type Thesis or Dissertation
Grant Number 甲第2286号
Granted Date 2002-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language 日本語
JaLCDOI 10.18926/AMO/40007
FullText URL fulltext.pdf
Author Furumatsu, Takayuki| Ozaki, Toshifumi|
Abstract Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis.
Keywords epigenetics DNA methylation histone acetylation and HAT histone deacetylation and HDAC chondrogenesis
Amo Type Review
Published Date 2010-06
Publication Title Acta Medica Okayama
Volume volume64
Issue issue3
Publisher Okayama University Medical School
Start Page 155
End Page 161
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20596126
Web of Science KeyUT 000279094300001
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Kamatsuki, Kamatsuki| Sugiu, Kazuhisa| iyazawa, Shinichi| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Kodama, Yuya| Ozaki, Toshifumi|
Keywords Anterior cruciate ligament reconstruction Chondral damage Meniscal repair
Note This fulltext is available in Feb. 2022.|
Published Date 2020-04
Publication Title Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
Volume volume20
Publisher Elsevier
Start Page 1
End Page 5
ISSN 22146873
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32042596
DOI 10.1016/j.asmart.2020.01.001
Web of Science KeyUT 000526087700001
Related Url isVersionOf https://doi.org/10.1016/j.asmart.2020.01.001
Author Okazaki, Yuki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Saito, Taichi| Ozaki, Toshifumi|
Note This fulltext is available in March. 2021.|
Published Date 2020-03-26
Publication Title Journal of Orthopaedic Science
Publisher Elsevier
ISSN 09492658
NCID AA11052566
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Japanese Orthopaedic Association.
File Version author
PubMed ID 32223991
DOI 10.1016/j.jos.2020.02.015
Related Url isVersionOf https://doi.org/10.1016/j.jos.2020.02.015
JaLCDOI 10.18926/AMO/53910
FullText URL 69_6_355.pdf
Author Okada, Yukimasa| Furumatsu, Takayuki| Miyazawa, Shinichi| Tanaka, Takaaki| Fujii, Masataka| Ozaki, Toshifumi| Abe, Nobuhiro|
Abstract Venous thromboembolism (VTE) is a potential complication occurring after total knee arthroplasty (TKA). We investigated the incidence of VTE after TKA using contrast-enhanced computed tomography (CT), and assessed the efficacy of VTE prophylaxis (fondaparinux and enoxaparin). At our hospital, 189 patients (225 knees) underwent TKA between April 2007 and October 2011. The 225 knees were divided into a control group with no VTE prophylaxis (31 cases), a fondaparinux group (107 cases), and an enoxaparin group (87 cases). Contrast-enhanced CT screening for VTE was performed in all cases on day 5 or 6 after TKA. D-dimer levels were measured on day 5 after TKA, and were significantly lower in the fondaparinux (9.8±3.8) and enoxaparin groups (9.4±4.9) than in the control group (15.6±9.8) (p<0.001). However, no statistically significant difference in the incidence of VTE was observed among the groups (control, 61.3%;fondaparinux, 49.5%;enoxaparin, 50.6%). Prophylaxis was not effective for the prevention of VTE as detected by contrast-enhanced CT after TKA. CT should be performed after TKA, even when VTE prophylaxis is used.
Keywords venous thromboembolism contrast-enhanced computed tomography total knee arthroplasty fondaparinux enoxaparin
Amo Type Original Article
Published Date 2015-12
Publication Title Acta Medica Okayama
Volume volume69
Issue issue6
Publisher Okayama University Medical School
Start Page 355
End Page 359
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26690246
Web of Sience KeyUT 000368434500005
JaLCDOI 10.18926/AMO/54806
FullText URL 70_6_441.pdf
Author Kashihara, Naoko| Furumatsu, Takayuki| Kodama, Yuya| Tanaka, Takaaki| Ozaki, Toshifumi|
Abstract Concurrent meniscal repair with anterior cruciate ligament (ACL) reconstruction has shown good clinical outcomes, but it has a considerable risk of progressing to post-traumatic osteoarthritis of the knee. Here we investigated postoperative changes in the position of the lateral meniscus (LM) and assessed the short-term clinical results after concurrent LM repair with ACL reconstruction. Twentyseven patients underwent LM repair of a peripheral longitudinal tear concomitant with ACL reconstruction. We evaluated the preoperative and postoperative values of the Lysholm score and anteroposterior instability. The length and width of the lateral tibial plateau were determined by radiographic images. The length, width, body width, extrusion, and height of the LM were measured in magnetic resonance images and compared between the preoperative and postoperative measurements. Our analysis revealed that concurrent LM repair with ACL reconstruction improved the shortterm clinical outcomes. Although the body width and height of the LM did not change, the postoperative LM extrusion and LM width were significantly increased after the surgery. The post-traumatic transposition of the LM may not be completely prevented by LM repair concomitant with ACL reconstruction.
Keywords lateral meniscus meniscal extrusion meniscal repair anterior cruciate ligament reconstruction
Amo Type Original Article
Published Date 2016-12
Publication Title Acta Medica Okayama
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 441
End Page 448
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003668
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Miyazawa, Shinichi| Okazaki, Yoshiki| Okazaki, Yuki| Takihira, Shota| Kodama, Yuya| Kamatsuki, Yusuke| Masuda, Shin| Saito, Taichi| Ozaki, Toshifumi|
Keywords Medial meniscus posterior root tear Transtibial pullout repair Modified Mason-Allen suture Two simple stitches Clinical outcomes
Note This fulltext is available in May 2021.|
Published Date 2020-05-11
Publication Title The Knee
Volume volume27
Issue issue3
Publisher Elsevier
Start Page 701
End Page 708
ISSN 0968-0160
NCID AA10996272
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Elsevier B.V.
File Version author
PubMed ID 32563426
DOI 10.1016/j.knee.2020.04.023
Web of Science KeyUT 000542165100013
Related Url isVersionOf https://doi.org/10.1016/j.knee.2020.04.023
Author Sakata, Kenichiro| Furumatsu, Takayuki| Miyazawa, Shinichi| Okada, Yukimasa| Fujii, Masataka| Ozaki, Toshifumi|
Published Date 2013-01
Publication Title International Orthopaedics
Volume volume37
Issue issue1
Content Type Journal Article
FullText URL fulltext.pdf
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Tanaka, Takaaki| Okazaki, Yuki| Kodama, Yuya| Kamatsuki, Yusuke| Masuda, Kenji| Seno, Noritaka| Ozaki, Toshifumi|
Keywords anterior cruciate ligament knee pullout suture screw fixation tibial eminence avulsion fracture
Published Date 2020-06-03
Publication Title Journal of Orthopaedic Surgery
Volume volume28
Issue issue2
Publisher SAGE Publications
Start Page 2309499020918681
ISSN 2309-4990
NCID AA11004541
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32489139
DOI 10.1177/2309499020918681
Web of Science KeyUT 000539749100001
Related Url isVersionOf https://doi.org/10.1177/2309499020918681
Author Saiga, Kenta| Furumatsu, Takayuki| Yoshida, Aki| Masuda, Shin| Takihira, Shota| Abe, Nobuhiro| Ozaki, Toshifumi|
Published Date 2010-11-12
Publication Title Biochemical and Biophysical Research Communications
Volume volume402
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/57717
FullText URL 73_6_523.pdf
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Okazaki, Yoshiki| Kamatsuki, Yusuke| Masuda, Shin| Okazaki, Yuki| Takihira, Shota| Miyazawa, Shinichi| Nakata, Eiji| Ozaki, Toshifumi|
Abstract The case of an individual with a bilateral anterior cruciate ligament (ACL) tear combined with a medial meniscus (MM) posterior root tear is described. A 34-year-old Japanese man with bilateral ACL rupture that occurred > 10 years earlier was diagnosed with bilateral ACL tear combined with MM posterior root tear (MMPRT). We performed a transtibial pullout repair of the MMPRT with ACL reconstruction. The tibial tunnels for the MM posterior root repair and ACL reconstruction were created separately. Postoperatively, a good clinical outcome and meniscal healing were obtained. Our surgical technique may thus contribute to anatomical MM posterior root repair and ACL reconstruction.
Keywords bilateral anterior cruciate ligament tear medial meniscus posterior root tear pullout repair case report
Amo Type Case Report
Published Date 2019-12
Publication Title Acta Medica Okayama
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 523
End Page 528
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871335
Web of Science KeyUT 000503431400008