FullText URL J_Pharm_Sci_130_1_24.pdf
Author Tangsucharit, Panot| Takatori, Shingo| Zamami, Yoshito| Goda, Mitsuhiro| Pakdeechote, Poungrat| Kawasaki, Hiromu| Takayama, Fusako|
Keywords Acetylcholine-induced vasodilatation CGRPergic nerves Muscarinic receptor subtypes Rat mesenteric arteries
Published Date 2016-01
Publication Title Journal of Pharmacological Sciences
Volume volume130
Issue issue1
Publisher Japanese Pharmacological Society
Start Page 24
End Page 32
ISSN 1347-8613
NCID AA11806667
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 26825997
DOI 10.1016/j.jphs.2015.12.005
Web of Science KeyUT 000369700500004
Related Url https://doi.org/10.1016/j.jphs.2015.12.005
Author Zamami, Yoshito| Takatori, Shingo| Iwatani, Yukiko| Yamawaki, Kosuke| Miyashita, Satoko| Yabumae, Nana| Takayama, Fusako| Mio, Mitsunobu| Kawasaki, Hiromu|
Published Date 2008-03-01
Publication Title 藥學雜誌
Volume volume128
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/31835
FullText URL fulltext.pdf
Author Takayama, Fusako| Nakamoto, Kazuo| Kawasaki, Hiromu| Mankura, Mitsumasa| Egashira, Toru| Ueki, Keiji| Hasegawa, Azusa| Okada, Shigeru| Mori, Akitane|
Abstract <p>Vitis coignetiae Pulliat (Yamabudo) is used as a health juice and wine based on the abundant polyphenols and anthocyanins in its fruit. However, it is not known whether the leaves of this plant confer similar benefits. This study investigated the hepatoprotective effects of aqueous extracts from Vitis coignetiae Pulliat leaves (VCPL) in an animal model of nonalcoholic steatohepatitis (NASH). Rats were fed a choline-deficient high-fat diet for four weeks to generate fatty livers. NASH was induced by oxidative stress loading. Ten weeks later, blood and liver samples were collected from anesthetized animals and assessed biochemically, histologically, and histochemically to determine the extent of oxidative stress injury and the overall effects of VCPL. Six-week VCPL extract supplementation reduced serum levels of liver enzymes, decreased CYP2E1 induction, increased plasma antioxidant activities and delayed the progression of liver fibrosis. The findings suggested that VCPL has strong radical-scavenging activity and may be beneficial in preventing NASH progression.</p>
Keywords Yamabudo nonalcoholic steatohepatitis antioxidant hepatoprotection
Amo Type Original Article
Published Date 2009-04
Publication Title Acta Medica Okayama
Volume volume63
Issue issue2
Publisher Okayama University Medical School
Start Page 105
End Page 111
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 19404342
Web of Science KeyUT 000265457600005