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ID 31835
JaLCDOI
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Author
Takayama, Fusako
Nakamoto, Kazuo
Kawasaki, Hiromu Kaken ID publons
Mankura, Mitsumasa
Egashira, Toru
Ueki, Keiji
Hasegawa, Azusa
Okada, Shigeru
Mori, Akitane
Abstract

Vitis coignetiae Pulliat (Yamabudo) is used as a health juice and wine based on the abundant polyphenols and anthocyanins in its fruit. However, it is not known whether the leaves of this plant confer similar benefits. This study investigated the hepatoprotective effects of aqueous extracts from Vitis coignetiae Pulliat leaves (VCPL) in an animal model of nonalcoholic steatohepatitis (NASH). Rats were fed a choline-deficient high-fat diet for four weeks to generate fatty livers. NASH was induced by oxidative stress loading. Ten weeks later, blood and liver samples were collected from anesthetized animals and assessed biochemically, histologically, and histochemically to determine the extent of oxidative stress injury and the overall effects of VCPL. Six-week VCPL extract supplementation reduced serum levels of liver enzymes, decreased CYP2E1 induction, increased plasma antioxidant activities and delayed the progression of liver fibrosis. The findings suggested that VCPL has strong radical-scavenging activity and may be beneficial in preventing NASH progression.

Keywords
Yamabudo
nonalcoholic steatohepatitis
antioxidant
hepatoprotection
Amo Type
Original Article
Published Date
2009-04
Publication Title
Acta Medica Okayama
Volume
volume63
Issue
issue2
Publisher
Okayama University Medical School
Start Page
105
End Page
111
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT