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ID 60244
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Watanabe, Takaichi Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technolog ORCID Kaken ID researchmap
Kimura, Yukitaka Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University Kaken ID publons
Ono, Tsutomu Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology ORCID Kaken ID publons researchmap
Abstract
We describe a versatile and facile route to the continuous production of monodisperse polylactide (PLA) microcapsules with controllable structures. With the combination of microfluidic emulsification, solvent diffusion, and internal phase separation, uniform PLA microcapsules with a perfluorooctyl bromide (PFOB) core were successfully obtained by simply diluting monodisperse ethyl acetate (EA)-in-water emulsion with pure water. Rapid extraction of EA from the droplets into the aqueous phase enabled the solidification of the polymer droplets in a nonequilibrium state during internal phase separation between a concentrated PLA/EA phase and a PFOB phase. Higher-molecular-weight PLA generated structural complexity of the microcapsules, yielding core–shell microcapsules with covered with small PFOB droplets. Removal of the PFOB via freeze drying gave hollow microcapsules with dimpled surfaces. The core–shell ratios and the diameter of these microcapsules could be finely tuned by just adjusting the concentration of PFOB and flow rates on emulsification, respectively. These biocompatible microcapsules with controllable size and structures are potentially applicable in biomedical fields such as drug delivery carriers of many functional molecules.
Note
“This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/la403883a.”
Published Date
2013-10-29
Publication Title
Langmuir
Volume
volume29
Issue
issue46
Publisher
American Chemical Society
Start Page
14082
End Page
14088
ISSN
0743-7463
NCID
AA10461730
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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isVersionOf https://doi.org/10.1021/la403883a