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ID 50973
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Author
Hayashi, Atsushi
Fumon, Takumi
Miki, Yukari
Sato, Hiaki
Yoshino, Tadashi
Abstract
Thymic carcinoma (TC) is often very difficult to distinguish from type B3 thymoma and lung squamous cell carcinoma (L-SCC) involving the anterior mediastinum. The present study evaluated the usefulness of immunohistochemical markers including c-Kit, CD5, glucose transporter-1 (GLUT-1), claudin-1 (CLDN-1), thymoproteasome β5t, p53 and Ki-67 (MIB-1) and thymic cortical environmental marker cells, cortical thymocytes (c-Thy) and thymic cortical dendritic macrophages (TCDMs) in distinguishing thymic carcinoma (TC) from type B3 thymoma or lung squamous cell carcinoma (L-SCC) using 17 cases of type B3 thymoma, 18 cases of TC and 12 cases of L-SCC. The results indicated that c-Kit and CD5 are very useful markers for TC, while GLUT-1, CLDN-1, p53 and Ki-67 are not. Thymic cortical microenvironmental marker cells, especially TCDMs, and thymic cortical epithelial cell-marker β5t are also useful for distinguishing TC from type B3 thymoma. Although none of these markers are adequate for making a distinction when used alone, the plural use of c-Kit, CD5, β5t thymic cortical environmental marker cells, c-Thys and TCDMs may therefore lead to a correct distinction between TC and type B3 thymoma or L-SCC. [J Clin Exp Hematop 53(1) : 9-19, 2013]
Keywords
thymic carcinoma
type B3 thymoma
lung squamous cell carcinoma
immunohistochemical distinction
Published Date
2013-06
Publication Title
Journal of Clinical and Experimental Hematopathology
Volume
volume53
Issue
issue1
Start Page
9
End Page
19
ISSN
1346-4280
Content Type
Journal Article
Official Url
http://dx.doi.org/10.3960/jslrt.53.9
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/50872
language
英語
Copyright Holders
© 2013 by The Japanese Society for Lymphoreticular Tissue Research
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Refereed
True
DOI
PubMed ID