このエントリーをはてなブックマークに追加
ID 50973
フルテキストURL
著者
Hayashi, Atsushi Department of Medical Technology, Graduate School of Health Science, Okayama University
Fumon, Takumi Department of Medical Technology, Graduate School of Health Science, Okayama University
Miki, Yukari Department of Medical Technology, Graduate School of Health Science, Okayama University
Sato, Hiaki Department of Medical Technology, Graduate School of Health Science, Okayama University
Yoshino, Tadashi Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Takahashi, Kiyoshi Department of Medical Technology, Graduate School of Health Science, Okayama University
抄録
Thymic carcinoma (TC) is often very difficult to distinguish from type B3 thymoma and lung squamous cell carcinoma (L-SCC) involving the anterior mediastinum. The present study evaluated the usefulness of immunohistochemical markers including c-Kit, CD5, glucose transporter-1 (GLUT-1), claudin-1 (CLDN-1), thymoproteasome β5t, p53 and Ki-67 (MIB-1) and thymic cortical environmental marker cells, cortical thymocytes (c-Thy) and thymic cortical dendritic macrophages (TCDMs) in distinguishing thymic carcinoma (TC) from type B3 thymoma or lung squamous cell carcinoma (L-SCC) using 17 cases of type B3 thymoma, 18 cases of TC and 12 cases of L-SCC. The results indicated that c-Kit and CD5 are very useful markers for TC, while GLUT-1, CLDN-1, p53 and Ki-67 are not. Thymic cortical microenvironmental marker cells, especially TCDMs, and thymic cortical epithelial cell-marker β5t are also useful for distinguishing TC from type B3 thymoma. Although none of these markers are adequate for making a distinction when used alone, the plural use of c-Kit, CD5, β5t thymic cortical environmental marker cells, c-Thys and TCDMs may therefore lead to a correct distinction between TC and type B3 thymoma or L-SCC. [J Clin Exp Hematop 53(1) : 9-19, 2013]
キーワード
thymic carcinoma
type B3 thymoma
lung squamous cell carcinoma
immunohistochemical distinction
発行日
2013-06
出版物タイトル
Journal of Clinical and Experimental Hematopathology
53巻
1号
開始ページ
9
終了ページ
19
ISSN
1346-4280
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.3960/jslrt.53.9
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/50872
言語
English
著作権者
© 2013 by The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン
publisher
査読
有り
DOI
PubMed ID