マンガンの生体影響に関する研究 第2編 マンガンヒュームの性状と吸入動物による運命及び血清酵素の変動

The present study was designed to examine the physicochemical properties and effect of generated with an manganese fumes atomic absorption buner. Mice were exposed to approximately 9.5mg/m for 1, 3, 5, and 8 hours. Manganese levels in the lung, liver, kidney and brain were measured 1, 3, 5, 10 and 15 days after the inhalation. The chemical from of Mn in the fumes was wore matallic than oxide. Observation though the electron microscope showed the presence of fine particles (0.02-0.1μm) in the Mn fumes. Manganese fumes rapidly accumulated in the lungs and subsequently moved into various organs through the blood. The biological half life (BHL) of manganese in the lungs was calculated to be 0.82 days and 75.26 days and in the brain 12.76 days and 58.59 days. Manganese content in the brain was significant, but only half that of the other organs.