Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

免疫反応下における好塩基球の形態学的研究 第2編 抗ヒト免疫グロブリンによる好塩基球の形態学的変化の走査型電子顕微鏡観察

Kobayashi, Makoto
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Abstract
Morphological change of blood basophils were investigated in 3 healthy controls, 4 atopic and 4 intractable asthmatics by scanning electron microscopy after they had been exposed to anti-human IgE or anti-human IgG. Most of the basophils from healthy controls, atopic and intractable asthmatics challenged with physiological saline solution (P. S. S.) were sphericalshaped. Basophils from atopic asthmatics, or basophils from healthy controls and intractable asthmatics after passively sensitized with IgE rich serum, were pear-shaped or 'swollen' when challenged with anti-IgE. In such conditions some basophils showed surface structural changes such as hemispheric projections, pore formation or ruptured cell membrane. Basophils from intractable asthmatics tended to be pear-shaped or 'swollen' and also showed surface structural changes as mentioned above when anti-IgG was added. The results show that not only IgE but also IgG may participate in the pathogenesis of bronchial asthma, especially of intractable asthma.
Keywords
好塩基球
走査電顕
抗ヒト免疫グロプリン
アトピー型喘息
重症難治性喘息
ISSN
0030-1558
NCID
AN00032489