The influences of additional dead space, tidal volume or muscular work upon the respiratory dead space were studied and the respiratory dead space in various pulmonary diseases was examined by the same Haldane method as in Part 1. The respiratory dead space increases in hyperpnae at will or at work, but the ratio of dead space to tidal volume i. e. VD/VT remains relatively constant. The respiratory dead space and VD/VT in pulmonal diseases are greater than in healthy state.