ID 56681
FullText URL
Author
Elgaml, Abdelaziz Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Miyoshi, Shin-ichi Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Abstract
Vibrio vulnificus is a halophilic estuarine bacterium, but this species causes fatal septicemia in humans. V. vulnificus may encounter many kinds of stresses either in the natural environment or in the human body. One of the striking stresses is the exposure to the reactive oxygen species including nitric oxide (NO). The present study revealed that NO could participate in the regulation of the V. vulnificus community behavior. When the bacterium was cultivated in the presence of sub-lethal doses of an NO donor, the expression of the genes encoding NO-detoxifying enzymes was significantly increased. The NO donor was also found to cause significant increase in production of a metalloprotease, a putative virulence factor, by the bacterium.
Keywords
Vibrio vulnificus
Nitric oxide
Oxidative stress
Detoxification
Note
Note
Published Date
2015
Publication Title
Biocontrol Science
Volume
volume20
Issue
issue3
Publisher
The Society for Antibacterial and Antifungal Agents
Start Page
199
End Page
203
ISSN
13424815
NCID
AA11169621
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
Publisher
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.4265/bio.20.199
Project
Collaborative Research of Okayama University for Infectious Diseases in India