検索結果 50155 件
| JaLCDOI | 10.18926/AMO/54417 |
|---|---|
| フルテキストURL | 70_3_183.pdf |
| 著者 | Sawada, Shigeki| Hiroshi, Suehisa| Ueno, Tsuyoshi| Yamashita, Motohiro| |
| 抄録 | We reviewed post-operative complication and mortality rates from 1995 through 2014 and evaluated the changes in those rates across that 20-year period. Two thousand and three hundred sixteen patients with lung cancer underwent resection at our institution between 1995 and 2014. This timespan was divided into four 5-year periods. Each patientʼs age, Charlson comorbidity index score, and extent of surgery in each 5-year period were summarized, and the changes in these factors over the 20-year span were evaluated. The complication and mortality rates were calculated for each 5-year period, and the changes in those rates over the 20-years were evaluated. The number of patients with higher Charlson comorbidity index scores increased during the 20-year period. Of the 455 patients who developed complications, 97 developed life-threating complications. There were 16 post-operative deaths and 23 in-hospital deaths. There were no significant changes in the complication rate or mortality rate during the 20-year period. Both rates were significantly correlated with the extent of resection. Although the number of patients with comorbidities increased in the 20-year period, the post-operative complication and mortality rates, as well as in-hospital mortality, did not change significantly. |
| キーワード | post-operative complication post-operative mortality lung cancer surgery outcomes |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-06 |
| 巻 | 70巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 183 |
| 終了ページ | 188 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27339207 |
| Web of Science KeyUT | 000379406100005 |
| JaLCDOI | 10.18926/AMO/54416 |
|---|---|
| フルテキストURL | 70_3_175.pdf |
| 著者 | Setiawan, Heri| Nagaoka, Kenjiro| Kubo, Masayuki| Fujikura, Yoshihisa| Ogino, Keiki| |
| 抄録 | Oxidative stress is widely known to play a role in asthma. However, the contribution of xanthine oxidoreductase (XOR) as a source of the superoxide anion radical (O2－) in oxidative stress associated with asthma has not yet been examined in detail. Here we investigated pathophysiological changes in XOR in an experimental model of asthma induced by the house dust mite Dermatophagoides farinae (Df). In the lungs of Df-treated mice, the production of O2－ from XOR increased and the nitrite concentrations decreased, whereas the protein expression of XOR remained unchanged. Moreover, the protein expression levels of XOR and the hydrogen peroxide (H2O2) concentrations in bronchoalveolar lavage fluid (BALF) were higher in the Df-treated mice than in saline-treated mice. Immunohistochemically, although XOR was highly localized in the bronchial epithelial cells of the saline-treated mice, immunostaining for XOR was absent in the bronchial epithelium of Df-treated mice. These results suggest that oxidative stress is up-regulated by increases in the conversion of the dehydrogenase form (xanthine dehydrogenase; XDH) of XOR to the oxidase form (xanthine oxidase; XOD). |
| キーワード | xanthine oxidase oxidative stress asthma |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-06 |
| 巻 | 70巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 175 |
| 終了ページ | 182 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27339206 |
| Web of Science KeyUT | 000379406100004 |
| JaLCDOI | 10.18926/AMO/54415 |
|---|---|
| フルテキストURL | 70_3_167.pdf |
| 著者 | Sugihara, Satoshi| Doi, Hiroyuki| Kato, Masahiko| Mitoh, Yoshihiro| Tsuda, Toshihide| Ikeda, Satoru| |
| 抄録 | Aflatoxin (AFT) contamination is frequent in foods grown in tropical regions, including rice. Although AFTs are generally not found in temperate-region foods, global warming has affected typical temperate-region climates, potentially permitting the contamination of foods with AFT-producing Aspergillus flavus (A. flavus). Here we investigated the AFT production in rice during storage under natural climate conditions in Japan. We examined AFTs in brown rice and rough rice artificially contaminated with A. flavus for 1 year in Japan, and we subjected AFTs in white rice to the same treatment in airtight containers and examined the samples in warm and cold seasons, simulating the storage of white rice in general households. In the brown rice, AFTs increased after 2 months (March) and peaked after 9 months (October). The AFT contamination in the rough rice was minimal. After the polishing and cooking of the brown rice, AFTs were undetectable. In the white rice stored in airtight containers, AFTs increased after 1 month (August) and peaked after 2 months (September). Minimal AFTs were detected in the cold season. Thus, AFT contamination in rice may occur in temperate regions following A. flavus contamination. The storage of rice as rough rice could provide be useful for avoiding AFT contamination. |
| キーワード | Aspergillus flavus aflatoxin rice temperate region storage |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-06 |
| 巻 | 70巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 167 |
| 終了ページ | 173 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27339205 |
| Web of Science KeyUT | 000379406100003 |
| JaLCDOI | 10.18926/AMO/54414 |
|---|---|
| フルテキストURL | 70_3_159.pdf |
| 著者 | Yoshioka, Takashi| Otsuki, Hideo| Uehara, Shinya| Shimizu, Toshihiro| Murao, Wataru| Fujio, Koji| Fujio, Kei| Wada, Koichiro| Araki, Motoo| Nasu, Yasutomo| |
| 抄録 | Upper urinary tract calculi are common; however, there is no recommended treatment selection for elderly patients. Ureteroscopic holmium laser lithotripsy (URS lithotripsy) is minimally invasive, and it provides a high stone-free rate (SFR) treatment for upper urinary tract calculi. Here, we retrospectively evaluated the surgical outcomes of URS lithotripsy after dividing the 189 cases into 3 groups by patient age: the ʻ＜65 groupʼ (＜65 years old, n＝108), the ʻ65-74 groupʼ (65-74 years old, n＝42), and the ʻ 75 groupʼ ( 75 years old, n＝39). The patientsʼ characteristics, stone status, and perioperative outcomes were assessed. The 65-74 group and the 75 group had a significantly higher prevalence of hypertension compared to the＜65 group. Compared to the＜65 group, the 65-74 group had a significantly higher prevalence of hyperlipidemia, and the 75 group had significantly higher the American Society of Anesthesiologists (ASA) scores. Despite these preoperative risk factors, SFR and postoperative pyelonephritis in the 65-74 group and the 75 group were similar to those of the＜65 group. In conclusion, URS lithotripsy is the preferred treatment for upper urinary tract calculi, even for elderly patients who have multiple preoperative risk factors. |
| キーワード | upper urinary tract calculi ureteroscopy (URS) holmium laser lithotripsy elderly patients stone-free rate (SFR) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-06 |
| 巻 | 70巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 159 |
| 終了ページ | 166 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27339204 |
| Web of Science KeyUT | 000379406100002 |
| JaLCDOI | 10.18926/AMO/54413 |
|---|---|
| フルテキストURL | 70_3_151.pdf |
| 著者 | Wada, Jun| Nakatsuka, Atsuko| |
| 抄録 | The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In obesity and type 2 diabetes, impaired oxidation, reduced mitochondrial contents, lowered rates of oxidative phosphorylation and excessive reactive oxygen species (ROS) production have been reported. Mitochondrial biogenesis is regulated by various transcription factors such as peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), peroxisome proliferator-activated receptors (PPARs), estrogen-related receptors (ERRs), and nuclear respiratory factors (NRFs). Mitochondrial fusion is promoted by mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1), while fission is governed by the recruitment of dynamin-related protein 1 (DRP1) by adaptor proteins such as mitochondrial fission factor (MFF), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51), and fission 1 (FIS1). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARKIN promote DRP1-dependent mitochondrial fission, and the outer mitochondrial adaptor MiD51 is required in DRP1 recruitment and PARKIN-dependent mitophagy. This review describes the molecular mechanism of mitochondrial dynamics, its abnormality in diabetes and obesity, and pharmaceuticals targeting mitochondrial biogenesis, fission, fusion and mitophagy. |
| キーワード | fusion fission oxidative stress mitochondria diabetes |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-06 |
| 巻 | 70巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 151 |
| 終了ページ | 158 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27339203 |
| Web of Science KeyUT | 000379406100001 |
| 著者 | 岡山実験動物研究会| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |
| 著者 | 岡山実験動物研究会| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |
| 著者 | 岡山実験動物研究会| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |
| 著者 | 岡山実験動物研究会| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |
| 著者 | 岡山実験動物研究会| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |
| 著者 | 岡山実験動物研究会| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |
| 著者 | 木村 透| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |
| 著者 | 矢田 範夫| 上藤 千佳| 平山 晴子| 樅木 勝巳| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 工藤 季之| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 目加田 和之| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 釘本 綾子| 相澤 清香| 御輿 真穂| 高橋 純夫| 竹内 栄| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 城ヶ原 貴通| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 若井 拓哉| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |
| 著者 | 樅木 勝巳| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |
| 著者 | 勝股 靖貴| |
|---|---|
| 発行日 | 2016-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 32巻 |
| 資料タイプ | その他 |