検索結果 - 岡山大学学術成果リポジトリ

Nuclear dynamics of topoisomerase II beta reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain

著者	Onoda, Akihisa\| Hosoya, Osamu\| Sano, Kuniaki\| Kiyama, Kazuko\| Kimura, Hiroshi\| Kawano, Shinji\| Furuta, Ryohei\| Miyaji, Mary\| Tsutsui, Ken\| Tsutsui, Kimiko M.\|
発行日	2014-07-17
出版物タイトル	Nucleic Acids Research
巻	42巻
号	14号
資料タイプ	学術雑誌論文

Comprehensive investigation of areae gastricae pattern in gastric corpus using magnifying narrow band imaging endoscopy in patients with chronic atrophic fundic gastritis.

著者	Kanzaki, Hiromitsu\| Uedo, Noriya\| Ishihara, Ryu\| Nagai, Kengo\| Matsui, Fumi\| Ohta, Takashi\| Hanafusa, Masao\| Hanaoka, Noboru\| Takeuchi, Yoji\| Higashino, Koji\| Iishi, Hiroyasu\| Tomita, Yasuhiko\| Tatsuta, Masaharu\| Yamamoto, Kazuhide\|
発行日	2012-06
出版物タイトル	Helicobacter
巻	17巻
号	3号
資料タイプ	学術雑誌論文

Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population

著者	Mizuki, Yutaka\| Takaki, Manabu\| Okahisa, Yuko\| Sakamoto, Shinji\| Kodama, Masafumi\| Ujike, Hiroshi\| Uchitomi, Yosuke\|
発行日	2014-11
出版物タイトル	Human Psychopharmacology: Clinical and Experimental
巻	29巻
号	6号
資料タイプ	学術雑誌論文

Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides

著者	Tada, Kotaro\| Hamada, Toshihisa\| Asagoe, Kenji\| Umemura, Hiroshi\| Mizuno-Ikeda, Kazuko\| Aoyama, Yumi\| Otsuka, Masaki\| Yamasaki, Osamu\| Iwatsuki, Keiji\|
発行日	2014-11
出版物タイトル	European Journal of Dermatology
巻	24巻
号	6号
資料タイプ	学術雑誌論文

Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease

フルテキストURL	O0004434_abstract_review.pdf O0004434_fulltext.pdf
著者	庄司凡\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	乙第4434号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Living Will Interest and Preferred End-of-life Care and Death Locations among Japanese Adults 50 and over: A Population-based Survey

フルテキストURL	O0004433_abstract_review.pdf O0004433_fulltext.pdf
著者	西江宏行\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	乙第4433号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

L-Carnitine Prevents Progression of Non-Alcoholic Steatohepatitis in a Mouse Model with Upregulation of Mitochondrial Pathway

フルテキストURL	K0005074_abstract_review.pdf K0005074_fulltext.pdf
著者	石川久\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	甲第5074号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Mean Lung Pressure during Adult High-Frequency Oscillatory Ventilation: An Experimental Study Using a Lung Model

フルテキストURL	K0005073_abstract_review.pdf K0005073_fulltext.pdf
著者	平山敬浩\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	甲第5073号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Synderome

フルテキストURL	K0005072_abstract_review.pdf K0005072_fulltext.pdf
著者	小林純子\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	甲第5072号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain

フルテキストURL	K0005071_abstract_review.pdf K0005071_fulltext.pdf
著者	小野田彰久\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	甲第5071号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Hepatitis C Virus-specific T-cell Response Correlates with Hepatitis Activity and Donor IL28B Genotype Early after Liver Transplantation

フルテキストURL	K0005070_abstract_review.pdf K0005070_fulltext.pdf
著者	津崎龍一郎\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	甲第5070号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

ONO-1301, a Sustained-Release Prostacyclin Analog, Ameliorates the Renal Alterations in a Mouse Type 2 Diabetes Model Possibly Through Its Protective Effects on Mesangial Cells

フルテキストURL	K0005069_abstract_review.pdf K0005069_fulltext.pdf
著者	綿谷博雪\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	甲第5069号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Comprehensive Investigation of Area Gastricae Pattern in Gastric Corpus using Magnifying Narrow Band Imaging Endoscopy in Patients with Chronic Atrophic Fundic Gastritis

フルテキストURL	K0005068_abstract_review.pdf K0005068_fulltext.pdf
著者	神崎洋光\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	甲第5068号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population

フルテキストURL	K0005067_abstract_review.pdf K0005067_fulltext.pdf
著者	水木寛\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	甲第5067号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語

Protective Effect of Eicosapentaenoic Acid on Insulin Resistance in Hyperlipidemic Patients and on the Postoperative Course of Cardiac Surgery Patients: The Possible Involvement of Adiponectin

フルテキストURL	K0005066_abstract_review.pdf K0005066_fulltext.pdf
著者	山本剛\|
発行日	2014-12-31
資料タイプ	学位論文
学位授与番号	甲第5066号
学位授与年月日	2014-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

A Rare Case of Inflammatory Myofibroblastic Tumor of the Diaphragmatic Parietal Pleura with Dissemination

JaLCDOI	10.18926/AMO/53124
フルテキストURL	69_1_65.pdf
著者	Ueno, Tsuyoshi\| Yamashita, Motohiro\| Sawada, Shigeki\| Suehisa, Hiroshi\| Kawamoto, Hiroaki\| Takahata, Hiroyuki\|
抄録	Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm that occurs at different sites in the body. Pleural IMT in particular is especially rare. IMTs infrequently tend to have malignancy. We report a rare case of advanced diaphragmatic parietal pleural IMT with dissemination. A 30-year-old woman complained of right upper abdominal pain. Computed tomography showed a large lobulated mass over the right diaphragm, but no disseminated nodules were noted. Intraoperatively, we found the primary tumor arising from the diaphragmatic parietal pleura and a dozen disseminated nodules, and we removed them completely. The histopathological and immunohistochemical diagnosis was IMT.
キーワード	inflammatory myofibroblastic tumor pleura dissemination
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2015-02
巻	69巻
号	1号
出版者	Okayama University Medical School
開始ページ	65
終了ページ	68
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25703173
Web of Science KeyUT	000349740300008

A Case of Incomplete Atypical Femoral Fracture with Histomorphometrical Evidence of Osteomalacia

JaLCDOI	10.18926/AMO/53123
フルテキストURL	69_1_59.pdf
著者	Tsuchie, Hiroyuki\| Miyakoshi, Naohisa\| Nishi, Tomio\| Abe, Hidekazu\| Segawa, Toyohito\| Shimada, Yoichi\|
抄録	Roughly half of the femoral fracture patients diagnosed with AFF according to the criteria suggested by a task force of the American Society for Bone and Mineral Research (ASBMR) have not undergone bisphosphonate (BP) therapy. One suspected cause of such fractures is severe bone loss due to osteomalacia, but the pathogenesis remains unknown. We report a case of an 84-year-old woman with AFF not treated by BP therapy, in whom underlying osteomalacia was histologically diagnosed. The involvement of femoral curvature and spino-pelvic malaligment in the fracture in the present case was considered.
キーワード	osteomalacia atypical fracture femur osteoporosis kyphosis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2015-02
巻	69巻
号	1号
出版者	Okayama University Medical School
開始ページ	59
終了ページ	63
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25703172
Web of Science KeyUT	000349740300007

Trend of Human Papillomavirus Genotypes in Cervical Neoplasia Observed in a Newly Developing Township in Yangon, Myanmar

JaLCDOI	10.18926/AMO/53122
フルテキストURL	69_1_51.pdf
著者	Mu Mu Shwe\| Kyi Kyi Nyunt\| Okada, Shigeru\| Harano, Teruo\| Hlaing Myat Thu\| Hla Myat Mo Mo\| Mo Mo Win\| Khin Khin Oo\| KhinThet Wai\| Khin Saw Aye\| Myo Khin\|
抄録	Persistent infection with oncogenic types of human papillomavirus (HPV) is the most important risk factor associated with cervical cancer. This study detected the oncogenic HPV genotypes in cervical neoplasia in relation to clinicopathological findings using a cross-sectional descriptive method in 2011 and 2012. Cervical swabs and colposcopy-directed cervical biopsy tissues were collected from 108 women (median age 45 years;range 20-78) showing cervical cytological changes at Sanpya General Hospital, Yangon, Myanmar. HPV DNA testing and genotyping were performed by polymerase chain reaction and restriction fragment length polymorphism. HPV was identified in women with cervical intraepithelial neoplasia (CIN) 1 (44.4%), CIN2 (63.2%), CIN3 (70.6%), and squamous cell carcinoma (SCC) (74.1%). The association between cervical neoplasia and HPV positivity was highly significant (p＝0.008). Most patients infected with HPV were between 40-49 years of age, and the youngest were in the 20- to 29-year-old age group. The most common genotype was HPV 16 (65.6%) with the following distribution:70% in CIN1, 41.7% in CIN2, 91.7% in CIN3, and 60% in SCC. HPV-31 was the second-most frequent (21.9%):30% in CIN1, 33.3% in CIN2, 8.3% in CIN3, and 15% in SCC. The third-most frequent-genotype was HPV-18 (7.8%):8.3% in CIN1, and 20% in SCC. Another genotype was HPV-58 (4.7%):16.7% in CIN1 and 5% in SCC. The majority of CIN/SCC cases were associated with HPV genotypes 16, 31, 18, and 58. If oncogenic HPV genotypes are positive, the possibility of cervical neoplasia can be predicted. Knowledge of the HPV genotypes distribution can predict the effectiveness of the currently used HPV vaccine.
キーワード	human papillomavirus genotyping Myanmar
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-02
巻	69巻
号	1号
出版者	Okayama University Medical School
開始ページ	51
終了ページ	58
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25703171
Web of Science KeyUT	000349740300006

Comparison of Urinary Levels of 8-Hydroxy-2’-deoxyguanosine between Young Females with and without Depressive Symptoms during Different Menstrual Phases

JaLCDOI	10.18926/AMO/53121
フルテキストURL	69_1_45.pdf
著者	Iida, Tadayuki\| Inoue, Ken\| Ito, Yasuhiro\| Ishikawa, Hiroaki\| Kagiono, Miwa\| Teradaira, Ryoji\| Chikamura, Chiho\| Harada, Toshihide\| Ezoe, Satoko\| Yatsuya, Hiroshi\|
抄録	This study aimed to clarify the association between depressive symptoms and a marker of oxidative stress-induced DNA damage in young females. Since the menstrual cycle may confound or modify this association, depressive symptoms and urinary levels of 8-hydroxy-2ʼ deoxyguanosine (8-OHdG) were evaluated during each menstrual phase. A total of 57 female fourth-year students (aged 21.6±0.8) from a Japanese health science university were studied. The menstrual cycle was divided into 3 phases:menstrual (days 1 to 3 after the onset of menses);proliferative (days 13 to 15);and secretory (days 24 to 26). Depressive symptoms were assessed by the self-rating depression scale (SDS). Positive depressive symptoms were defined as a score of 53 or more during 2 different menstrual phases. The association between the presence of depressive symptoms and 8-OHdG levels adjusting for the menstrual cycle was examined by two-way analysis of variance with the menstrual cycle (menstrual, proliferative, and secretory phases) as the within-individual factor. The menstrual cycle did not show a significant correlation with urinary 8-OHdG levels. On the other hand, the menstrual cycle-adjusted 8-OHdG level was significantly higher in those with depressive symptoms (7.01ng/mL) than in those without them (3.98ng/mL). The ROC curve analysis showed that urinary 8-OHdG levels had reasonably high discriminative performance throughout all the menstrual cycles (0.73-0.81;all p＜0.05). These results indicated the presence of oxidative stress in subjects with depressive symptoms independent of the menstrual cycle.
キーワード	depression 8-OHdG menstrual cycle
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-02
巻	69巻
号	1号
出版者	Okayama University Medical School
開始ページ	45
終了ページ	50
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25703170
Web of Science KeyUT	000349740300005

Magnified Endoscopic Features of Duodenal Follicular Lymphoma and Other Whitish Lesions

JaLCDOI	10.18926/AMO/53120
フルテキストURL	69_1_37.pdf
著者	Iwamuro, Masaya\| Okada, Hiroyuki\| Takata, Katsuyoshi\| Kawai, Yoshinari\| Kawano, Seiji\| Nasu, Junichiro\| Kawahara, Yoshiro\| Tanaka, Takehiro\| Yoshino, Tadashi\| Yamamoto, Kazuhide\|
抄録	The sensitivity and specificity of magnified endoscopic features for differentiating follicular lymphoma from other diseases with duodenal whitish lesions have never been investigated. Here we compared the magnified endoscopic features of duodenal follicular lymphoma with those of other whitish lesions. We retrospectively reviewed the cases of patients with follicular lymphoma (n＝9), lymphangiectasia (n＝7), adenoma (n＝10), duodenitis (n＝4), erosion (n＝1), lymphangioma (n＝1), and hyperplastic polyp (n＝1). The magnified features of the nine follicular lymphomas included enlarged villi (n＝8), dilated microvessels (n＝5), and opaque white spots of various sizes (n＝9). The lymphangiectasias showed enlarged villi, dilated microvessels, and white spots, but the sizes of the white spots were relatively homogeneous and their margin was clear. Observation of the adenoma and duodenitis revealed only whitish villi. Although the lymphangioma was indistinguishable from the follicular lymphomas by magnified features, it was easily diagnosed based on the macroscopic morphology. In conclusion, magnified endoscopic features, in combination with macroscopic features, are useful for differentiating follicular lymphomas from other duodenal diseases presenting whitish lesions.
キーワード	duodenal neoplasm follicular lymphoma gastrointestinal lymphoma magnifying endoscopy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-02
巻	69巻
号	1号
出版者	Okayama University Medical School
開始ページ	37
終了ページ	44
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25703169
Web of Science KeyUT	000349740300004