検索結果 - 岡山大学学術成果リポジトリ

Honeydew-associated microbes elicit defense responses against brown planthopper in rice

フルテキストURL	fulltext.pdf
著者	Wari, David\| Kabir, Md Alamgir\| Mujiono, Kadis\| Hojo, Yuko\| Shinya, Tomonori\| Tani, Akio\| Nakatani, Hiroko\| Galis, Ivan\|
キーワード	Honeydew-associated microorganisms phytoalexins plant defense rice (Oryza sativa) rice brown planthopper (Nilaparvata lugens) sucking insect
発行日	2019-05-02
出版物タイトル	Journal of Experimental Botany
巻	70巻
号	5号
出版者	Oxford University Press
開始ページ	1683
終了ページ	1696
ISSN	0022-0957
NCID	AA00697526
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s)
論文のバージョン	publisher
PubMed ID	30715410
DOI	10.1093/jxb/erz041
Web of Science KeyUT	000461145400021
関連URL	isVersionOf https://doi.org/10.1093/jxb/erz041

Comparative Gene Analysis Focused on Silica Cell Wall Formation: Identification of Diatom-Specific SET Domain Protein Methyltransferases

フルテキストURL	fulltext.pdf
著者	Nemoto, Michiko\| Iwaki, Sayako\| Moriya, Hisao\| Monden, Yuki\| Tamura, Takashi\| Inagaki, Kenji\| Mayama, Shigeki\| Obuse, Kiori\|
キーワード	Biomineralization Diatom Silica Transcriptome Proteome
備考	This is a post-peer-review, pre-copyedit version of an article published in Marine Biotechnology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10126-020-09976-1.\|
発行日	2020-06-03
出版物タイトル	Marine Biotechnology
出版者	Springer
ISSN	1436-2228
NCID	AA11357643
資料タイプ	学術雑誌論文
言語	フランス語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32488507
DOI	10.1007/s10126-020-09976-1
Web of Science KeyUT	000537432000001
関連URL	isVersionOf https://doi.org/10.1007/s10126-020-09976-1

Pressure dependence of Si diffusion in γ-Fe

タイトル（別表記）	Pressure dependence of Si diffusion in gamma-Fe
フルテキストURL	fulltext.pdf
著者	Tsujino, Noriyoshi\| Mârza, Andreea\| Yamazaki, Daisuke\|
キーワード	γ-Fe silicon diffusion high pressure planetary core
備考	This is an Accepted Manuscript of an article published by Mineralogical Society of America.\|
発行日	2020-05-01
出版物タイトル	American Mineralogist
巻	105巻
号	3号
出版者	Mineralogical Society of America
開始ページ	319
終了ページ	324
ISSN	0003-004X
NCID	AA00521712
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
DOI	10.2138/am-2020-7197
Web of Science KeyUT	000518370300003
関連URL	isVersionOf https://doi.org/10.2138/am-2020-7197

An accelerometer-based navigation system provides acetabular cup orientation accuracy comparable to that of computed tomography-based navigation during total hip arthroplasty in the supine position

フルテキストURL	fulltext.pdf
著者	Tetsunaga, Tomonori\| Yamada, Kazuki\| Tetsunaga, Tomoko\| Sanki, Tomoaki\| Kawamura, Yoshi\| Ozaki, Toshifumi\|
キーワード	Hip Navigation system Total hip replacement Retrospective study
発行日	2020-04-15
出版物タイトル	Journal of Orthopaedic Surgery and Research
巻	15巻
号	1号
出版者	BMC
開始ページ	147
ISSN	1749-799X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
PubMed ID	32295628
DOI	10.1186/s13018-020-01673-y
Web of Science KeyUT	000528950200002
関連URL	isVersionOf https://doi.org/10.1186/s13018-020-01673-y

Upregulated CCL20 and CCR6 in Cancer Stem Cells Converted from Mouse iPS Cells

フルテキストURL	fulltext.pdf
著者	Du, Juan\| Seno, Akimasa\| Sasada, Saki\| Xu, Yanning\| Oo, Aung Ko Ko\| Hassan, Ghmkin\| Ueno, Shunsuke\| Afify, Said M.\| Zahra, Maram H\| Okada, Nobuhiro\| Chen, Ling\| Fu, Xiaoying\| Tokutaka, Heizo\| Yan, Ting\| Seno, Masaharu\|
キーワード	miPSCs CSCs CCR6 CCL20
発行日	2020
出版物タイトル	Journal of Research in Medical and Dental Science
巻	8巻
号	1号
出版者	Amber Publication
開始ページ	200
終了ページ	207
ISSN	2347-2367
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher
Web of Science KeyUT	000518402400030
関連URL	isVersionOf https://www.jrmds.in/abstract/upregulated-ccl20-and-ccr6-in-cancer-stem-cells-converted-from-mouse-ips-cells-52887.html

Genetic variation and phenotypic plasticity in circadian rhythms in an armed beetle, Gnatocerus cornutus (Tenebrionidae)

フルテキストURL	BJLS_fulltext.pdf
著者	Matsumura, Kentarou\| Abe, Masato S\| Sharma, Manmohan D\| Hosken, David J\| Yoshii, Taishi\| Miyatake, Takahisa\|
キーワード	circadian rhythm Gnatocerus cornutus isofemale line power of circadian rhythm
備考	This is a pre-copyedited, author-produced version of an article accepted for publication in Biological Journal of the Linnean Society following peer review. The version of record Kentarou Matsumura et. al. Genetic variation and phenotypic plasticity in circadian rhythms in an armed beetle, Gnatocerus cornutus (Tenebrionidae). Biological Journal of the Linnean Society, 130(1), 34–40 (2020) is available online at: https://doi.org/10.1093/biolinnean/blaa016.\|
発行日	2020-05-07
出版物タイトル	Biological Journal of the Linnean Society
巻	130巻
号	1号
出版者	Oxford University Press
開始ページ	34
終了ページ	40
ISSN	0024-4066
NCID	AA00565321
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Linnean Society of London
論文のバージョン	author
DOI	10.1093/biolinnean/blaa016
Web of Science KeyUT	000537358400003
関連URL	isVersionOf https://doi.org/10.1093/biolinnean/blaa016

A proposal of calligraphy learning assistant system with letter portion practice function using projection mapping

フルテキストURL	fulltext.pdf
著者	Huda, Samsul\| Funabiki, Nobuo\| Kuribayashi, Minoru\| Kao, Wen-Chung \|
キーワード	Raspberry Pi Calligraphy Learning assistant system Projection mapping
発行日	2019-10-23
出版物タイトル	International Journal of Web Information Systems
巻	16巻
号	2号
出版者	Emerald
開始ページ	137
終了ページ	149
ISSN	1744-0084
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Emerald Publishing Limited
論文のバージョン	author
DOI	10.1108/IJWIS-07-2019-0032
Web of Science KeyUT	000537471300001
関連URL	isVersionOf https://doi.org/10.1108/IJWIS-07-2019-0032

A Randomized Phase 2 Trial of Antibiotic Prophylaxis Versus No Intervention for Muscle Biopsy in A Neurology Department

JaLCDOI	10.18926/AMO/59961
フルテキストURL	74_3_261.pdf
著者	Nakahara, Keiichi\| Ikeda, Tokunori\| Takamatsu, Koutaro\| Tawara, Nozomu\| Hara, Kentaro\| Enokida, Yuki\| Tanoue, Naomi\| Narita, Sawana\| Fujii, Akiko\| Yamanouchi, Yoshinori\| Morinaga, Jun\| Yamashita, Satoshi\|
抄録	Muscle biopsy can be used to confirm the diagnosis of neuromuscular diseases. However, it is unclear whether antibiotic prophylaxis prior to muscle biopsy is needed to prevent surgical site infection (SSI). We are conducting a phase 2, single-center, open-labeled, prospective randomized trial to clarify the need for antibiotic prophylaxis in patients at low risk for SSI undergoing muscle biopsy. Patients will be randomized to an antibiotic prophylaxis group or a control group, and the incidence of SSI will be compared between the groups. Our findings will clarify the need for antibiotic prophylaxis in this patient population.
キーワード	muscle biopsy antibiotic prophylaxis
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	261
終了ページ	264
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577026
Web of Science KeyUT	000543363400011
NAID	120006862802

Intravenous Vitamin C as Ancillary Treatment for Cranial Polyneuritis and Meningitis due to Varicella Zoster Virus Reactivation

JaLCDOI	10.18926/AMO/59960
フルテキストURL	74_3_257.pdf
著者	Hongo, Takashi\| Ikeda, Fusao\| Fujioka, Shinichi\| Akatsuka, Riku\| Fujiwara, Tosifumi\| Yamamoto, Kazuhide\|
抄録	A 65-year-old Japanese woman developed vesicular eruptions on her right ear due to varicella zoster virus (VZV) reactivation, followed by cranial polyneuritis and meningitis affecting her right cranial nerves V, VII, VIII, IX, and X. After acyclovir administration, her facial paralysis worsened. Intravenous methylprednisolone and vitamin C were administered on Day 4 post-admission. Her symptoms steadily improved, and by Day 45 she had fully recovered. Cranial polyneuritis is a rare complication of VZV reactivation, and there is no established method of treatment. This is the first report of full recovery from cranial polyneuritis using intravenous vitamin C as ancillary treatment.
キーワード	varicella zoster virus polyneuritis vitamin C meningitis facial nerve palsy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	257
終了ページ	260
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577025
Web of Science KeyUT	000543363400010
NAID	120006862801

Successful Treatment of Staphylococcus schleiferi Infection after Aortic Arch Repair: In Situ Aortic Arch Replacement and Domino Reconstruction of the Debranching Graft using Autologous Iliac Artery

JaLCDOI	10.18926/AMO/59959
フルテキストURL	74_3_251.pdf
著者	Murakami, Takashi\| Tokuda, Takanori\| Nishimura, Shinsuke\| Fujii, Hiromichi\| Takahashi, Yosuke\| Yamane, Kokoro\| Inoue, Kazushige\| Yamada, Koichi\| Kakeya, Hiroshi\| Shibata, Toshihiko\|
抄録	A 62-year-old Japanese male presented with graft infection by Staphylococcus schleiferi 50 days after debranching of the left subclavian artery and frozen elephant trunk repair for the entry closure of a Stanford type B aortic dissection. The graft was removed, and the patient was successfully treated using in situ reconstruction of the arch with omental flap coverage, removal of the debranching graft, autologous iliac artery grafting, and longterm antibiotics. Domino reconstruction of the infected debranching graft using autologous external iliac artery and a Dacron graft can thus be a good option in similar cases.
キーワード	autologous iliac artery graft Staphylococcus schleiferi graft infection domino reconstruction Dacron graft
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	251
終了ページ	255
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577024
Web of Science KeyUT	000543363400009
NAID	120006862800

Effect of Vonoprazan on Delayed Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasia among Antithrombotic Drug Users: A Single-Center, Single-Arm Prospective Observational Case Control Study

JaLCDOI	10.18926/AMO/59958
フルテキストURL	74_3_245.pdf
著者	Yamamoto, Shumpei\| Takayama, Hiroshi\| Shimodate, Yuichi\| Takezawa, Rio\| Nishimura, Naoyuki\| Doi, Akira\| Mouri, Hirokazu\| Matsueda, Kazuhiro\| Mizuno, Motowo\| Okada, Hiroyuki\|
抄録	Antithrombotic therapy is a major risk factor for delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasia. A potassium-competitive acid blocker, vonoprazan, is expected to prevent delayed bleeding better than conventional proton pomp inhibitors (PPIs), but the evidence is controversial. We sought to clarify the efficacy of vonoprazan for prevention of delayed bleeding after gastric ESD in patients under antithrombotic therapy. We prospectively registered 50 patients who underwent gastric ESD while receiving antithrombotic therapy and vonoprazan in our institution between October 2017 and September 2018. The incidence of delayed bleeding was compared with that in a historical control group of 116 patients treated with conventional PPI. We also evaluated risk factors associated with delayed bleeding. Delayed bleeding was observed in 8 of 50 patients (16.0%), which was not dissimilar from the incidence in the historical control group (12.1%) (p=0.49). In the univariate analysis, age (> 70 years) (p=0.034), multiple antithrombotic drug use (p<0.01), procedure time (> 200 min) (p=0.038) and tumor size (> 40 mm) (p<0.01) were associated with delayed bleeding after gastric ESD, but vonoprazan was not (p=0.49). Vonoprazan may not be more effective than conventional PPIs in preventing delayed bleeding after gastric ESD in patients receiving antithrombotic therapy.
キーワード	vonoprazan endoscopic submucosal dissection antithrombotic drug gastric cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	245
終了ページ	250
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577023
Web of Science KeyUT	000543363400008
NAID	120006862799

Serum REIC/Dickkopf-3 Protein Level Predicts Disease-Free Survival in Patients with Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/59957
フルテキストURL	74_3_237.pdf
著者	Oyama, Atsushi\| Uchida, Daisuke\| Shiraha, Hidenori\| Sawahara, Hiroaki\| Kato, Ryo\| Iwamuro, Masaya\| Horiguchi, Shigeru\| Okada, Hiroyuki\|
抄録	The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC.
キーワード	enzyme-linked immunosorbent assay liver resection primary radiofrequency ablation Huh7 Hep3B
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	237
終了ページ	243
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577022
Web of Science KeyUT	000543363400007
NAID	120006862798

Formulas to Estimate Appropriate Surgical Amounts of Unilateral Recession-Resection in Intermittent Exotropia with Distance-Near Disparity

JaLCDOI	10.18926/AMO/59956
フルテキストURL	74_3_229.pdf
著者	Shibata, Kiyo\| Hamasaki, Ichiro\| Toshima, Shinji\| Shimizu, Takehiro\| Kono, Reika\| Miyata, Manabu\| Morisawa, Shin\| Furuse, Takashi\| Hasebe, Satoshi\| Ohtsuki, Hiroshi\| Morizane, Yuki\| Shiraga, Fumio\|
抄録	The purpose of this study was to derive new formulas to provide an optimal surgical procedure and optimal amount of recession-resection (RR) surgery in intermittent exotropia (IXT) with a disparity in angle of deviation depending on the fixation distance. The records of 117 consecutive patients with IXT who underwent RR surgery between March 2008 and December 2011 at Okayama University Hospital were retrospectively examined. Multivariable linear regression analysis was performed using the observed corrective angle of deviation at distance or near fixation as the dependent variable, and amounts of lateral rectus muscle (LR) recession (mm) and medial rectus muscle (MR) resection, and age at surgery (years) as independent variables. Two simultaneous formulas were derived: corrective angle of deviation at distance fixation (°)=1.8×recession (mm)+1.6× resection (mm)+0.15×age (years)–6.6, and corrective angle at near fixation (°)=1.5×recession (mm)+1.7× resection (mm)+0.18×age (years)–3.8. Comparisons of coefficient values of the formulas between distance and near fixation revealed that LR recession was more affected by the corrective angle in distance than near fixation. MR resection was more affected at near than distance fixation. We found that our new formulas estimated the appropriate amount of unilateral RR surgery.
キーワード	surgical amount intermittent exotropia recession and resection procedure strabismus surgery recurrent exotropia
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	229
終了ページ	236
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577021

Association of explanatory histological findings and urinary protein and serum creatinine levels at renal biopsy in lupus nephritis: a cross-sectional study

フルテキストURL	fulltext.pdf
著者	Katsuyama, Eri\| Miyawaki, Yoshia\| Sada, Ken-Ei\| Asano, Yosuke\| Hayashi, Keigo\| Yamamura, Yuriko\| Hiramatsu-Asano, Sumie\| Morishita, Michiko\| Ohashi, Keiji\| Watanabe, Haruki\| Katsuyama, Takayuki\| Narazaki, Mariko\| Matsumoto, Yoshinori\| Wada, Jun\|
キーワード	Lupus nephritis Active lesions Chronic lesions Urinary protein Serum creatinine
発行日	2020-06-01
出版物タイトル	BMC Nephrology
巻	21巻
号	1号
出版者	BMC
開始ページ	208
ISSN	1471-2369
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	32487161
DOI	10.1186/s12882-020-01868-9
Web of Science KeyUT	000538054600002
関連URL	isVersionOf https://doi.org/10.1186/s12882-020-01868-9

A Possible Protective Effect of the 'Cam Deformity' on Femoral Neck Fracture: The Relationship between Hip Morphology and the Types of Hip Fracture

JaLCDOI	10.18926/AMO/59954
フルテキストURL	74_3_221.pdf
著者	Yagura, Takuma\| Oe, Kenichi\| Paku, Masaaki\| Tajima, Takeshi\| Nakamura, Masaya\| Iida, Hirokazu\| Saito, Takanori\|
抄録	We retrospectively evaluated the cases of 169 hip fracture patients, their previous fractures, and the contralateral hip joint’s morphology. A history of contralateral hip fracture was present in 23 patients (Contra group). The other patients had a unilateral hip fracture: a trochanteric fracture (Troch group, n=73) or a femoral neck fracture (Neck group, n=73). In the Troch and Neck groups, we used anteroposterior and cross-table axialview radiographs of the contralateral hip to evaluate the proximal femur’s anatomy. In the Contra group, the concordance rate between the first and second types of hip fracture was 65.2%, and the second hip fracture’s morphology indicated that the trochanteric fracture had a cam deformity in terms of the femoral head-neck ratio. The average alpha angle and femoral head-neck offset in the Troch group were significantly larger than those in the Neck group. In the Neck group, pistol-grip deformities of Arbeitsgemeinschaft für Osteosynthesefragen types B1 (subcapital), B2 (transcervical), and B3 (displaced) were observed in 42.1%, 75%, and 6% of cases, respectively. There was a smaller alpha angle and a larger femoral head-neck offset in the contralateral hip of femoral neck fractures; thus, the “cam deformity” may protect against femoral neck fractures.
キーワード	cam deformity femoral neck fracture trochanteric fracture bilateral hip fractures
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	221
終了ページ	227
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577020
Web of Science KeyUT	000543363400006
NAID	120006862796

Combining pullout suture and retrograde screw fixation for anterior cruciate ligament tibial eminence avulsion fractures: A case report

フルテキストURL	fulltext.pdf
著者	Hiranaka, Takaaki\| Furumatsu, Takayuki\| Tanaka, Takaaki\| Okazaki, Yuki\| Kodama, Yuya\| Kamatsuki, Yusuke\| Masuda, Kenji\| Seno, Noritaka\| Ozaki, Toshifumi\|
キーワード	anterior cruciate ligament knee pullout suture screw fixation tibial eminence avulsion fracture
発行日	2020-06-03
出版物タイトル	Journal of Orthopaedic Surgery
巻	28巻
号	2号
出版者	SAGE Publications
開始ページ	2309499020918681
ISSN	2309-4990
NCID	AA11004541
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2020
論文のバージョン	publisher
PubMed ID	32489139
DOI	10.1177/2309499020918681
Web of Science KeyUT	000539749100001
関連URL	isVersionOf https://doi.org/10.1177/2309499020918681

Exploring the Issues of Advance Directives in Patients with Mild Dementia in Taiwan

JaLCDOI	10.18926/AMO/59952
フルテキストURL	74_3_215.pdf
著者	Chou, Hsi-Hsien\|
抄録	Due to cultural traditions, most Taiwanese do not have an advance directive or healthcare proxy. We explored how patients with mild dementia in Taiwan may still make self-determined decisions concerning advance directives for their healthcare and end-of-life care choices as the disease progresses. We examined 260 respondents with mild dementia at a Taiwan medical center: 199 patients who agreed (and 61 patients who disagreed) with the concept of advance directives completed a structured questionnaire. Multiple logistic regression models to determine the between-group differences revealed that the following were positively associated with approval of end-of-life directives: maintaining one’s quality of life (adjusted odds ratio [AOR], 2.44; 95% CI: 1.07-5.53), discussion with family members (AOR, 3.50; 95% CI: 1.49-8.26), and friend support networks (AOR, 3.36; 95% CI: 1.34-8.43). Cardiopulmonary resuscitation (AOR, 0.27; 95% CI: 0.09-0.79) was negatively associated with approval. There was also a positive association between the support of the legal validity of end-of-life directives (OR, 1.93; 95% CI: 1.07-3.48), without other confounding factors. In Taiwanese society, we remain mindful of cultural influences that may impact patients, including maintaining one’s quality of life, discussion with family members, and friend/support networks. These influences may help dementia patients complete their advance directives.
キーワード	advance directive dementia patient autonomy quality of life culture
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	215
終了ページ	220
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577019
Web of Science KeyUT	000543363400005
NAID	120006862794

A Clinical Study Evaluating an Aspiration-type Semi-Automatic Cutting Biopsy Needle (SCIRO-1702)

JaLCDOI	10.18926/AMO/59951
フルテキストURL	74_3_209.pdf
著者	Matsui, Yusuke\| Hiraki, Takao\| Iguchi, Toshihiro\| Sakurai, Jun\| Uka, Mayu\| Masaoka, Yoshihisa\| Gobara, Hideo\| Kanazawa, Susumu\|
抄録	An aspiration-type semi-automatic cutting biopsy needle enables tissue cutting during application of negative pressure, which is expected to contribute to a larger amount of specimen. The aim of the present study was to evaluate this novel needle in a clinical setting. Patients who underwent image-guided percutaneous biopsy for lung or renal masses were enrolled. Cutting biopsy was performed with and without aspiration during each procedure. The specimens were weighed using an electronic scale. The weights were compared between specimens obtained with and without aspiration using a paired t-test. The data from 45 lung and 30 renal biopsy procedures were analyzed. In lung biopsy, the mean±standard deviation weights of specimens obtained with and without aspiration were 2.20±1.05 mg and 2.24±1.08 mg, respectively. In renal biopsy, the mean weights were 6.52±2.18 mg and 6.42±1.62 mg, respectively. The weights were not significantly different between specimens obtained with and without aspiration either in lung (p=0.799) or renal (p=0.789) biopsies. The application of negative pressure with the aspiration-type semi-automatic cutting biopsy needle did not contribute to an increase in the amount of the specimen obtained in lung and renal biopsies.
キーワード	biopsy cutting needle aspiration clinical study
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	209
終了ページ	214
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577018
Web of Science KeyUT	000543363400004
NAID	120006862793

Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland

JaLCDOI	10.18926/AMO/59950
フルテキストURL	74_3_199.pdf
著者	Fujita, Hirofumi\| Bando, Tetsuya\| Oyadomari, Seiichi\| Ochiai, Kazuhiko\| Watanabe, Masami\| Kumon, Hiromi\| Ohuchi, Hideyo\|
抄録	Dickkopf 3 (Dkk3) is a secreted protein belonging to the Dkk family and encoded by the orthologous gene of REIC. Dkk3/REIC is expressed by mouse and human adrenal glands, but the understanding of its roles in this organ is still limited. To determine the functions of Dkk3 in the mouse adrenal gland, we first identified that the mouse Dkk3 protein is N-glycosylated in the adrenal gland as well as in the brain. We performed proteome analysis on adrenal glands from Dkk3-null mice, in which exons 5 and 6 of the Dkk3 gene are deleted. Twodimensional polyacrylamide gel electrophoresis of adrenal proteins from wild-type and Dkk3-null mice revealed 5 protein spots whose intensities were altered between the 2 genotypes. Mass spectrometry analysis of these spots identified binding immunoglobulin protein (BiP), an endoplasmic reticulum (ER) chaperone. To determine whether mouse Dkk3 is involved in the unfolded protein response (UPR), we carried out a reporter assay using ER-stress responsive elements. Forced expression of Dkk3 resulted in the induction of distinct levels of reporter expression, showing the UPR initiated by the ER membrane proteins of activating transcription factor 6 (ATF6) and inositol-requring enzyme 1 (IRE1). Thus, it is possible that Dkk3 is a physiological ER stressor in the mouse adrenal gland.
キーワード	Dkk3 knockout mouse adrenal gland glucose-regulated protein 78 proteome endoplasmic reticulum stress
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	199
終了ページ	208
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577017
Web of Science KeyUT	000543363400003
NAID	120006862792

Risk Factors for Chronic Damage Accumulation Across Different Onset Eras in Systemic Lupus Erythematosus: A Cross-sectional Analysis of a Lupus Registry of Nationwide Institutions (LUNA)

JaLCDOI	10.18926/AMO/59949
フルテキストURL	74_3_191.pdf
著者	Ohashi, Keiji\| Sada, Ken-Ei\| Asano, Yosuke\| Hayashi, Keigo\| Yamamura, Yuriko\| Asano, Sumie Hiramatsu\| Miyawaki, Yoshia\| Morishita, Michiko\| Katsuyama, Eri\| Watanabe, Haruki\| Tatebe, Noriko\| Narazaki, Mariko\| Matsumoto, Yoshinori\| Sunahori-Watanabe, Katsue\| Kawabata, Tomoko\| Yajima, Nobuyuki\| Wada, Jun\|
抄録	Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
キーワード	systemic lupus erythematosus chronic damage glucocorticoids, disease activity disease duration
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	191
終了ページ	198
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577016
Web of Science KeyUT	000543363400002
NAID	120006862791