検索結果 - 岡山大学学術成果リポジトリ

Human iPSC cardiomyocyte patch transplantation modifies extracellular matrix and fibroblast behavior after myocardial infarction

フルテキストURL	fulltext.pdf
著者	Torigata, Kosuke\| Matsuura, Ryohei\| Nagatomo, Fumiya\| Thiha, Moe\| Hikita, Takao\| Iseoka, Hiroko\| Takagi, Hiromitsu\| Koshimizu, Uichi\| Sakakima, Hiroki\| Izumi, Satoshi\| Hatano, Asuka\| Braun, Thomas\| Sawa, Yoshiki\| Miyagawa, Shigeru\| Nakayama, Masanori\|
キーワード	cell biology fibrosis stem cell research
発行日	2026-04
出版物タイトル	iScience
巻	29巻
号	4号
出版者	Elsevier BV
開始ページ	115341
ISSN	2589-0042
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 The Author(s).
論文のバージョン	publisher
PubMed ID	41953004
DOI	10.1016/j.isci.2026.115341
Web of Science KeyUT	001732109200001
関連URL	isVersionOf https://doi.org/10.1016/j.isci.2026.115341

Far-red-enriched ultra-long-day conditions induce constitutive FT expression and rapid flowering in radish rootstocks, promoting graft-mediated floral induction in Brassicaceae crops

フルテキストURL	fulltext.pdf
著者	Motoki, Ko\| Kakita, Nami\| Goto, Tanjuro\| Yasuba, Ken-ichiro\|
キーワード	FLOWERING LOCUS T (FT) Florigen Red/far-red ratio Graft-mediated floral induction Radish (Raphanus sativus) Cabbage (Brassica oleracea) Brassica rapa
発行日	2026-04
出版物タイトル	Scientia Horticulturae
巻	361巻
出版者	Elsevier BV
開始ページ	114818
ISSN	0304-4238
NCID	AA00836848
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 The Author(s).
論文のバージョン	publisher
DOI	10.1016/j.scienta.2026.114818
関連URL	isVersionOf https://doi.org/10.1016/j.scienta.2026.114818

Determination of picomolar to sub-nanomolar trace metals in seawater using an alternative chelating resin

フルテキストURL	fulltext.pdf
著者	Kanna, Naoya\| Obata, Hajime\| Kondo, Yoshiko\|
キーワード	Trace metals Solid-phase extraction Chelating resin InertSep ME-2
発行日	2026-05
出版物タイトル	Marine Chemistry
巻	276巻
出版者	Elsevier BV
開始ページ	104642
ISSN	0304-4203
NCID	AA0072137X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 The Authors.
論文のバージョン	publisher
DOI	10.1016/j.marchem.2026.104642
関連URL	isVersionOf https://doi.org/10.1016/j.marchem.2026.104642

Cation distribution and diffusion-path topologies of A-site-deficient perovskite LixLa(1−x)/3NbO3

フルテキストURL	fulltext.pdf
著者	Kitamura, Naoto\| Tang, Yizhong\| Kimura, Koji\| Obayashi, Ippei\| Onodera, Yohei\| Nakashima, Ken\| Ishibashi, Chiaki\| Idemoto, Yasushi\| Hayashi, Koichi\|
キーワード	A-site-deficient perovskite Li+ conduction Total scattering Local structure Persistent homology
発行日	2026-04-01
出版物タイトル	Journal of the Ceramic Society of Japan
巻	134巻
号	4号
出版者	Ceramic Society of Japan
開始ページ	225
終了ページ	231
ISSN	1348-6535
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2025 The Ceramic Society of Japan
論文のバージョン	publisher
DOI	10.2109/jcersj2.25074
Web of Science KeyUT	001722002900001
関連URL	isVersionOf https://doi.org/10.2109/jcersj2.25074

Mitochondrial inhibition enhances the sensitivity of pancreatic ductal adenocarcinoma cells to oncolytic adenovirus

フルテキストURL	fulltext.pdf
著者	Shoji, Ryohei\| Tazawa, Hiroshi\| Kuroda, Shinji\| Nishiyama, Takeyoshi\| Kajiwara, Yoshinori\| Yamada, Motohiko\| Nagai, Yasuo\| Inoue, Hiroaki\| Hashimoto, Naoyuki\| Kikuchi, Satoru\| Yoshida, Ryuichi\| Umeda, Yuzo\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
キーワード	MT: Regular Issue pancreatic cancer glycolysis oncolytic virotherapy CPI-613 PET/CT
発行日	2026-06
出版物タイトル	Molecular Therapy Oncology
巻	34巻
号	2号
出版者	Elsevier BV
開始ページ	201180
ISSN	2950-3299
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 The Author(s).
論文のバージョン	publisher
DOI	10.1016/j.omton.2026.201180
Web of Science KeyUT	001740821000001
関連URL	isVersionOf https://doi.org/10.1016/j.omton.2026.201180

Explainable analysis of the complex maze magnetic domain structure through extension of the Landau free energy model by adding an entropy feature

フルテキストURL	fulltext.pdf
著者	Masuzawa, K.\| Foggiatto, A. L.\| Kunii, S.\| Nagaoka, R.\| Taniwaki, M.\| Yamazaki, T.\| Mitsumata, C.\| Obayashi, I.\| Hiraoka, Y.\| Kotsugi, M.\|
発行日	2026-02-11
出版物タイトル	Scientific Reports
巻	16巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	12889
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2026
論文のバージョン	publisher
PubMed ID	41667607
DOI	10.1038/s41598-026-39617-x
関連URL	isVersionOf https://doi.org/10.1038/s41598-026-39617-x

Phenotypic and potential virulence features of Salmonella enterica serotypes from cancer patients in Kolkata, India

フルテキストURL	fulltext.pdf
著者	Chowdhury, Goutam\| Bhattacharya, Sanjay\| Goel, Gaurav\| Chatterji, Soumyadip\| Kitahara, Kei\| Ohno, Ayumu\| Lewis, Melissa Glenda\| Miyoshi, Shin-ichi\| Ramamurthy, Thandavarayan\| Mukhopadhyay, Asish K.\|
キーワード	Salmonella enterica Cancer Virulence Antimicrobial resistance PFGE
発行日	2025-10-09
出版物タイトル	BMC Infectious Diseases
巻	25巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	1263
ISSN	1471-2334
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025.
論文のバージョン	publisher
PubMed ID	41068693
DOI	10.1186/s12879-025-11679-8
Web of Science KeyUT	001591441800009
関連URL	isVersionOf https://doi.org/10.1186/s12879-025-11679-8

Sodium butyrate inhibits the expression of virulence factors in Vibrio cholerae by targeting ToxT protein

フルテキストURL	fulltext.pdf
著者	Kundu, Sushmita\| Das, Suman\| Maitra, Priyanka\| Halder, Prolay\| Koley, Hemanta\| Mukhopadhyay, Asish K.\| Miyoshi, Shin-ichi\| Dutta, Shanta\| Chatterjee, Nabendu Sekhar\| Bhattacharya, Sushmita\|
キーワード	sodium butyrate (SB) inhibitor pathogenesis Vibrio cholerae ctxAB antimicrobial resistance toxin-coregulated pilus (TcpA)
発行日	2025-05-27
出版物タイトル	mSphere
巻	10巻
号	5号
出版者	American Society for Microbiology
開始ページ	e00824-24
ISSN	2379-5042
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 Kundu et al.
論文のバージョン	publisher
PubMed ID	40261078
DOI	10.1128/msphere.00824-24
Web of Science KeyUT	001471908900001
関連URL	isVersionOf https://doi.org/10.1128/msphere.00824-24

Real-world evaluation of Armstrong's criteria in corticobasal degeneration: Phenotypic overlap and diagnostic challenges

著者	Morihara, Ryuta\| Nomura, Emi\| Osakada, Yosuke\| Yunoki, Taijun\| Takemoto, Mami\| Yamashita, Toru\| Ishiura, Hiroyuki\|
キーワード	Corticobasal degeneration CBD Corticobasal syndrome CBS Armstrong's criteria
備考	© 2026 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Feb. 2027.\|
発行日	2026-04
出版物タイトル	Parkinsonism & Related Disorders
巻	145巻
出版者	Elsevier BV
開始ページ	108229
ISSN	1353-8020
NCID	AA11054368
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 Published by Elsevier Ltd.
論文のバージョン	author
PubMed ID	41671870
DOI	10.1016/j.parkreldis.2026.108229
Web of Science KeyUT	001689377900001
関連URL	isVersionOf https://doi.org/10.1016/j.parkreldis.2026.108229

The utility of Gold Coast criteria for amyotrophic lateral sclerosis

著者	Nomura, Emi\| Morihara, Ryuta\| Osakada, Yosuke\| Yunoki, Taijun\| Takemoto, Mami\| Yamashita, Toru\| Ishiura, Hiroyuki\|
キーワード	Amyotrophic lateral sclerosis ALS Gold Coast criteria Revised El Escorial criteria Awaji criteria
備考	© 2026 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Jan. 2027.\|
発行日	2026-02
出版物タイトル	Journal of the Neurological Sciences
巻	481巻
出版者	Elsevier BV
開始ページ	125733
ISSN	0022-510X
NCID	AA00703265
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 Elsevier B.V.
論文のバージョン	author
PubMed ID	41534442
DOI	10.1016/j.jns.2026.125733
Web of Science KeyUT	001668514200001
関連URL	isVersionOf https://doi.org/10.1016/j.jns.2026.125733

Lease or sale: When a durable goods monopolist can choose supply chain openness

フルテキストURL	fulltext.pdf
著者	Kitamura, Hiroshi\| Matsushima, Noriaki\| Sato, Misato\|
キーワード	Durable goods Exclusive supply chain Vertical relation Selling versus leasing
発行日	2026-07
出版物タイトル	Transportation Research Part E: Logistics and Transportation Review
巻	211巻
出版者	Elsevier BV
開始ページ	104882
ISSN	1366-5545
NCID	AA11125309
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 The Author(s).
論文のバージョン	publisher
DOI	10.1016/j.tre.2026.104882
関連URL	isVersionOf https://doi.org/10.1016/j.tre.2026.104882

Revisiting Adrenal Crisis Triggered by Influenza Infection: Lessons from Two Fatal Cases

JaLCDOI	10.18926/AMO/70458
フルテキストURL	80_2_153.pdf
著者	Ueda, Yoshiyuki\| Yumoto, Tetsuya\| Hongo, Takashi\| Obara, Takafumi\| Nojima, Tsuyoshi\| Tsukahara, Kohei\| Hasegawa, Kosei\| Futagawa, Natsuko\| Naito, Hiromichi\| Nakao, Atsunori\|
抄録	Adrenal crisis is a life-threatening endocrine emergency that can progress within hours despite a prior diagnosis and maintenance therapy. We describe a fatal influenza-triggered adrenal crisis in two patients: a child with panhypopituitarism and an adult with prior pituitary surgery, both presenting in cardiac arrest. Despite resuscitation and intravenous hydrocortisone, a fatal hypoxic-ischemic injury or multiorgan failure occurred. These cases highlight the fulminant course of an adrenal crisis and underscore the importance of early recognition, clinician awareness, prompt parenteral hydrocortisone administration, and reinforcement of education for patients, caregivers, and healthcare providers to improve preparedness and prevent avoidable deaths.
キーワード	adrenal insufficiency cardiac arrest hydrocortisone influenza shock
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2026-04
巻	80巻
号	2号
出版者	Okayama University Medical School
開始ページ	153
終了ページ	157
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42025437
Web of Science KeyUT	001761342100009

Complete Transection of the Common Bile Duct Caused by Blunt Abdominal Trauma: A Rare Case Report

JaLCDOI	10.18926/AMO/70457
フルテキストURL	80_2_147.pdf
著者	Sakamoto, Shinya\| Tabuchi, Motoyasu\| Hamada, Akira\| Yoshimatsu, Rika\| Saisaka, Yuichi\| Matsumoto, Manabu\| Iwata, Jun\| Okabayashi, Takehiro\|
抄録	Common bile duct (CBD) injury after blunt abdominal trauma is rare and difficult to diagnose. Delayed recognition leads to severe morbidity. A 70-year-old Japanese man was admitted after sustaining blunt abdominal trauma. Ultrasonography revealed intra-abdominal fluid, suggesting bleeding. Contrast-enhanced computed tomography revealed pancreatic head injury, intra-abdominal bleeding, and pseudoaneurysm of the anterior superior pancreatoduodenal artery (ASPDA). Bile duct injury was not evident. The application of transarterial embolization (TAE) controlled the bleeding. Canulation into the pancreatic or biliary duct was not possible during endoscopic retrograde cholangiopancreatography. An emergency laparotomy revealed severe pancreatic head and extrahepatic bile duct injuries. Pancreaticoduodenectomy/Child reconstruction was performed. Complete CBD transection was confirmed. The patient was ultimately discharged without complications. Early recognition, timely surgical management, and intensive care are essential for favorable outcomes in patients who have sustained abdominal trauma.
キーワード	blunt abdominal trauma intensive care emergency laparotomy pancreatoduodenectomy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2026-04
巻	80巻
号	2号
出版者	Okayama University Medical School
開始ページ	147
終了ページ	152
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42025436
Web of Science KeyUT	001761342100008

Necrotizing Fasciitis Caused by ESBL-Producing Raoultella ornithinolytica in an Immunocompromised Patient with VEXAS Syndrome

JaLCDOI	10.18926/AMO/70456
フルテキストURL	80_2_141.pdf
著者	Sakamoto-Tokunaga, Moe\| Katsuyama, Takayuki\| Matoba, Masaki\| Tamura, Tomokazu\| Kubota, Natsuki\| Terajima, Yuya\| Shidahara, Kenta\| Hirose, Kei\| Matsumoto, Kazuya\| Nawachi, Shoichi\| Nakadoi, Takato\| Katayama, Yu\| Hayashi, Keigo\| Miyawaki, Yoshia\| Katsuyama, Eri\| Watanabe, Haruki\| Takano-Narazaki, Mariko\| Matsumoto, Yoshinori\| Sada, Ken-Ei\| Tsuji, Shuma\| Gotoh, Kazuyoshi\| Fukushima, Shinnosuke\| Hagiya, Hideharu\| Wada, Jun\|
抄録	VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory somatic) syndrome has a poor prognosis, with infections being a major cause of death. Raoultella ornithinolytica is an environmental bacterium found predominantly in soil and water. Although R. ornithinolytica can cause various infections, necrotizing fasciitis due to this bacterium has not been reported. We describe the case of an 84-year-old Japanese male with VEXAS syndrome who developed septic shock and necrotizing fasciitis while he was under immunosuppressive therapy. The pathogen was initially misidentified as R. planticola by mass spectrometry but later confirmed by whole-genome sequencing as extended spectrum β-lactamase (ESBL) produced by R. ornithinolytica. Although a life-saving leg amputation was required, the patient recovered with appropriate antibiotic therapy. R. ornithinolytica is thus able to cause severe skin infections in immunocompromised individuals.
キーワード	necrotizing fasciitis Raoultella ornithinolytica VEXAS syndrome whole-genome sequence
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2026-04
巻	80巻
号	2号
出版者	Okayama University Medical School
開始ページ	141
終了ページ	145
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42025435
Web of Science KeyUT	001761342100007

Impact of Proteinuria on Postoperative Complications Following Colorectal Cancer Surgery

JaLCDOI	10.18926/AMO/70455
フルテキストURL	80_2_131.pdf
著者	Nakata, Shunsuke\| Takatsu, Fumiaki\| Mikuriya, Yoshihiro\| Kakishita, Tomokazu\| Hato, Shinji\| Ohta, Koji\| Kobatake, Takaya\|
抄録	Colorectal surgery is associated with a high incidence of postoperative complications regardless of the advances in surgical techniques and multidisciplinary treatment. Proteinuria is common in patients with malignancies, but few studies have investigated the association between preoperative proteinuria and patient prognoses, especially postoperative complications. We investigated the impact of proteinuria on patients undergoing colorectal surgery in a single-center, retrospective cohort study of 767 patients who underwent surgical resection for colorectal cancer between January 2016 and December 2022 at the National Hospital Organization Shikoku Cancer Center. Among them, 81 patients with preoperative proteinuria were compared with the control group of 686 patients without proteinuria. Our analyses revealed that the patients with proteinuria had malnutrition with a significantly lower prognostic nutritional index compared to the no-proteinuria control group (p<0.001). The proteinuria group had a significantly advanced tumor stage (p=0.005), experienced more bleeding during the surgery (p=0.002), and required more transfusions (p<0.001). Postoperative complications were significantly more frequent in the proteinuria group (p=0.03), thus demonstrating that proteinuria was independently associated with postoperative complications (p=0.045). Proteinuria in patients undergoing colorectal cancer surgery can therefore be considered a risk factor for postoperative complications.
キーワード	colorectal cancer surgery proteinuria complication malnutrition
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2026-04
巻	80巻
号	2号
出版者	Okayama University Medical School
開始ページ	131
終了ページ	139
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42025434
Web of Science KeyUT	001761342100006

Mini-open Corpectomy and Posterior Spinal Fixation with Single-Position Surgery in Lateral Decubitus Position for Osteoporotic Thoracolumbar Vertebral Collapse in Elderly Patients

JaLCDOI	10.18926/AMO/70454
フルテキストURL	80_2_119.pdf
著者	Ikuma, Hisanori\| Hirose, Tomohiko\| Kawasaki, Keisuke\| Otsuka, Kazutoshi\|
抄録	We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in the lateral decubitus position in patients aged > 75 years with thoracolumbar vertebral collapse. The cases of 30 consecutive patients who underwent this procedure and had ≥ 1-year follow-up were retrospectively analyzed. The mean operative time was 78.8 min and the estimated blood loss was 115.7 ml per level. The complications included adjacent junctional failure (n=9, 30%), deep venous thrombosis (n=3, 10%), delirium (n=3, 10%), pleural injury (n=2, 6%), screw backout (n=1, 3%) kidney injury (n=1, 3%), chylothorax (n=1, 3%), and wound dehiscence (n=1, 3%). Seven cases (23.3%) required reoperation. Local kyphosis showed significant improvement (p<0.05) that was maintained at the final follow-up. The Japanese Orthopaedic Association Back Pain Evaluation Questionnaire and a visual analogue scale indicated significant improvement in all categories at the final follow-up (p<0.05). The use of mini-open corpectomy and posterior fixation with SPAPS can thus provide reliable radiological correction and good postoperative clinical outcomes even in patients aged > 75 years. However, a limitation of this procedure is the rate of reoperation (23.3%) for osteoporosis-related adjacent segment fracture and screw backout.
キーワード	single postion surgery osteoporotic vertebral collapse anterior and posterior combined surgery minimum invasive surgery
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2026-04
巻	80巻
号	2号
出版者	Okayama University Medical School
開始ページ	119
終了ページ	129
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42025433
Web of Science KeyUT	001761342100005

A Mixed-Methods Study on Changes in Interprofessional Education Attitudes and Fundamental Competencies: A Pre–Post Analysis of Clinical Training in Dietetic Students

JaLCDOI	10.18926/AMO/70453
フルテキストURL	80_2_109.pdf
著者	Sonoi, Mika\| Sonoi, Norihiro\| Koyama, Yoko\|
抄録	This study examined the effects of interprofessional education (IPE) on dietetics students during clinical training, focusing on changes in their attitudes toward IPE and their fundamental competencies. Eighty third-year female students (mean age, 21.0 years) at a Japanese women’s university participated. Self-administered surveys were conducted before and after clinical training to assess attitudes toward IPE using the Readiness for Interprofessional Learning Scale (RIPLS) and the Shakaijin Kisoryoku (SKL; Fundamental Competencies for Working Persons) scale. Quantitative data were analyzed using paired t-tests, chi-squared tests, and cluster analyses. Qualitative data from open-ended responses were analyzed thematically. RIPLS and SKL scores increased significantly, from 65.3 to 68.9, and from 28. 4 to 33. 2, respectively (p<0.001). All 12 SKL items showed significant improvement. In free responses, “initiative” (66 mentions), “communication” (10), and “execution” (8) were the most frequently cited as improved competencies. Cluster analysis identified three groups: increasing scores (n=25), high baseline (n=30), and minimal change (n=25). No significant correlation was found between changes in RIPLS and SKL scores (r=−0.108, p=0.355). IPE integrated into clinical training may enhance dietetics students’ attitudes toward interprofessional collaboration and contribute to the development of professional identity. Individualized, phased IPE implementation is recommended to accommodate differences in learner readiness.
キーワード	interprofessional education dietetics students clinical training professional competencies transformative learning
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2026-04
巻	80巻
号	2号
出版者	Okayama University Medical School
開始ページ	109
終了ページ	117
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42025432
Web of Science KeyUT	001761342100004

Consistent Clinical Outcomes of Anteroinferior Minimally Invasive Plate Osteosynthesis for Midshaft Clavicle Fractures Across AO/OTA Fracture Types

JaLCDOI	10.18926/AMO/70452
フルテキストURL	80_2_099.pdf
著者	Nguyen Trung Thanh\| Nakamichi, Ryo\| Shimamura, Yasunori\| Saito, Taichi\| Ishihara, Takeshi\| Furutani, Tomoki\| Shitozawa, Hisakazu\| Noda, Tomoyuki\| Ozaki, Toshifumi\|
抄録	Although the performance of minimally invasive plate osteosynthesis (MIPO) via the anteroinferior approach is increasingly adopted for midshaft clavicle fractures, the influence of fracture morphology on clinical outcomes under a standardized protocol is unclear. We retrospectively analyzed the cases of 54 patients who underwent anteroinferior MIPO for an acute midshaft clavicle fracture (AO/OTA types B1, B2, B3) performed by a single surgeon across three affiliated institutions (2009-2022). We evaluated the clinical outcomes, i.e., the surgical time, incision length, radiographic union, reduction accuracy, range of motion, pain (visual analog scale [VAS]), and complications and compared them among the three AO/OTA subtypes. The mean incision length (3.4 cm) and surgical time (71-79 min) were similar among the groups (both p>0.2). All fractures achieved radiographic union at a mean of 3.5 months. Postoperative alignment and clavicular length were maintained (length reduction −1.0±2.2 mm [B1], −0.5±2.0 mm [B2], −0.6±1.8 mm [B3]; p=0.825; angulation −0.8±3.4°, −1.1±3.1°, −0.3±3.3°; p=0.888). At 3 months, shoulder elevation and abduction were 169°-175° (p=0.079) and 164°-175° (p=0.324). Pain was minimal (100-mm VAS: ≤1 mm; p=0.782). One plate-fatigue failure occurred; no supraclavicular-nerve symptoms were recorded. Anteroinferior MIPO yielded consistent outcomes across AO/OTA types, with excellent union rates, functional recovery, and few complications, indicating that this technique is safe and reproducible for the surgical management of midshaft clavicle fractures.
キーワード	clavicle fracture minimally invasive plate osteosynthesis anteroinferior plating AO/OTA classification
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2026-04
巻	80巻
号	2号
出版者	Okayama University Medical School
開始ページ	99
終了ページ	107
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42025431
Web of Science KeyUT	001761342100003

Effects of Nonsurgical Periodontal Treatment on Bacterial and Clinical Parameters in Down Syndrome Patients Based on 16S rRNA Gene Amplicon Sequencing

JaLCDOI	10.18926/AMO/70451
フルテキストURL	80_2_085.pdf
著者	Shiba, Takahiko\| Takamori, Mitsuhito\| Katagiri, Sayaka\| Kobayashi, Ryota\| Kawauchi, Aki\| Ohsugi, Yujin\| Lin, Peiya\| Ekuni, Daisuke\| Egusa, Masahiko\| Iwata, Takanori\| Maeda, Shigeru\|
抄録	Individuals with Down syndrome (DS) are more susceptible to periodontal disease; however, microbial changes following treatment remain insufficiently understood. This study evaluated the effects of nonsurgical periodontal therapy on clinical outcomes and oral microbiome dynamics in 6 patients with DS using 16S rRNA gene amplicon sequencing. Bacterial diversity, composition, network structure, and predicted functional pathways were analyzed using dental plaque samples. Bleeding on probing decreased significantly (p=0.047) after treatment, with a trend toward reduction in periodontal inflamed surface area (p=0.05). The abundance of Fusobacteria at the class level decreased significantly after treatment. The abundance of Mogibacterium timidum was higher in the pretreatment group than in the posttreatment group. M. timidum was positively correlated with Treponema denticola and associated with multiple bacterial taxa in the network during pretreatment. Predicted functional pathways related to aromatic compound degradation were more abundant in posttreatment samples than in pretreatment samples. An increase in the abundance of Fusobacterium and the positive correlation between T. denticola and M. timidum, together with their associations with other periodontal pathogens before treatment, may contribute to the development of periodontitis in individuals with DS. Nonsurgical periodontal therapy produces measurable clinical improvement and promotes microbial shifts in patients with DS.
キーワード	Down Syndrome 16S rRNA Gene Amplicon Sequencing periodontitis nonsurgical periodontal treatment oral microbiome
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2026-04
巻	80巻
号	2号
出版者	Okayama University Medical School
開始ページ	85
終了ページ	97
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42025430
Web of Science KeyUT	001761342100002

Involvement of ADAM12 in TGF-β1-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts

JaLCDOI	10.18926/AMO/70450
フルテキストURL	80_2_075.pdf
著者	Lin, Deting\| Horita, Masahiro\| Watanabe, Masahito\| Hasei, Joe\| Ohtsuki, Takashi\| Otsuka, Noriaki\| Ichikawa, Chinatsu\| Shimizu, Noriyuki\| Naniwa, Shuichi\| Ozaki, Toshifumi\| Nishida, Keiichiro\|
抄録	A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared with OA and healthy control (HC) synovial tissues. The effect of inflammatory cytokines (TNF-α, TGF-β1, and PDGF-BB) on ADAM12 expression in RASFs from RA patients was examined by real-time RT-PCR. The effect of ADAM12 knock-down by ADAM12 siRNA and ADAM12 overexpression on cell proliferation of RASFs were examined by WST-1 assay. ADAM12 was identified predominantly in RA synovial tissue rather than OA and HC synovial tissues. Stimulation with TGF-β1 upregulated the expression of ADAM12 and cell proliferation of RASFs. ADAM12 siRNA suppressed TGF-β1-induced cell proliferation of RASFs, while ADAM12 overexpression promoted the cell proliferation of RASFs. These findings demonstrate that ADAM12 may have a key role in TGF-β1-induced cell proliferation of synovial fibroblasts in patients with RA.
キーワード	rheumatoid arthritis synovial tissue TGF-β1 ADAM12 cell proliferation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2026-04
巻	80巻
号	2号
出版者	Okayama University Medical School
開始ページ	75
終了ページ	83
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42025429
Web of Science KeyUT	001761342100001