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JaLCDOI 10.18926/AMO/57951
フルテキストURL 74_1_41.pdf
著者 Amano, Hoichi| Fujimoto, Kenichi| Fujimori, Makoto| Saka, Natsumi| Nomura, Kyoko| Tanihara, Shinichi|
抄録 We aimed to clarify the prevalence of polypharmacy among elderly individuals in Japan. We used the data obtained from a large-scale population-based representative database of health insurance claims in a single prefecture in Japan. We examined all of the outpatient and pharmaceutical health insurance claims for National Health Insurance and those for Late-stage Elderly Health Insurance in Nagasaki Prefecture, Japan between April and June 2016. When two or more claim forms were issued for a patient in a single month, we combined the data and identified the number of prescribed drugs for each person. The definition of polypharmacy is a the prescription of six or more drugs per month. We investigated the prevalence of polypharmacy among the beneficiaries of the two insurance systems. Of the 605,406 beneficiaries of the 2 insurance systems, 121,033 (20.0%) patients with polypharmacy were identified. The prevalence of polypharmacy increased with age, especially among the beneficiaries aged > 85 years, with about half of the beneficiaries having polypharmacy status. About half of the people aged > 85 years in the database had polypharmacy status. When a drug is prescribed to an elderly individual, it is necessary to consider the possibility of polypharmacy-related problems.
キーワード health insurance claims late-stage elderly health insurance national health insurance Japan polypharmacy
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-02
74巻
1号
出版者 Okayama University Medical School
開始ページ 41
終了ページ 48
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099247
Web of Science KeyUT 000516606200006
NAID 120006795618
JaLCDOI 10.18926/AMO/57950
フルテキストURL 74_1_33.pdf
著者 Honda, Hiroyuki| Hanayama, Yoshihisa| Obika, Mikako| Hasegawa, Kou| Hamahara, Jun| Kishida, Masayuki| Hagiya, Hideharu| Ogawa, Hiroko| Kataoka, Hitomi| Otsuka, Fumio|
抄録 A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients’ gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups’ characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients’ SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients’ PPG levels were correlated with GERD-related symptoms, diabetic patients’ blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful
キーワード blood glucose type 2 diabetes mellitus gastroesophageal reflux depressive status postprandial plasma glucose
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-02
74巻
1号
出版者 Okayama University Medical School
開始ページ 33
終了ページ 40
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099246
Web of Science KeyUT 000516606200005
NAID 120006795617
JaLCDOI 10.18926/AMO/57949
フルテキストURL 74_1_27.pdf
著者 Toda, Kazukiyo| Yagata, Yukihisa| Kikuchi, Takeshi| Takigawa, Tomoyuki| Ito, Yasuo|
抄録 Pelvic fractures occur with high-energy trauma, and the patient’s clinical status is unstable. Although a number of surgical methods for unstable pelvic fractures are available, none can achieve strong fixation with minimal invasiveness. We describe a surgical transiliac rod and screw fixation (TIF) procedure that provides minimally invasive fixation using a spinal implant for unstable pelvic ring fractures, and we retrospectively analyzed the procedure’s outcomes in 27 patients with type B or C1 fractures (based on the AO/ATO classification system). Small skin incisions are made above the posterior superior iliac spines on both sides. The ilium is partially resected, and two iliac screws are inserted on each side. The spinous process of the sacral spine is then shaved, and the iliac screws are connected to 2 rods, one placed caudal to the other. Corrective manipulation is performed at the fracture site, and the rods are connected with connectors. Favorable fracture reduction, defined as a rating of ‘excellent’ or ‘good,’ was achieved in 77.8% of the patients. Transiliac rod and screw fixation (TIF) will be a useful therapeutic option for unstable pelvic ring fractures.
キーワード pelvic ring fractures sacral fracture transiliac rod and screw fixation spinal fixation system minimally invasive surgery
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-02
74巻
1号
出版者 Okayama University Medical School
開始ページ 27
終了ページ 32
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099245
Web of Science KeyUT 000516606200004
NAID 120006795616
JaLCDOI 10.18926/AMO/57948
フルテキストURL 74_1_17.pdf
著者 Ishii, Kenzo| Morimatsu, Hiroshi| Ono, Kazumi| Miyasho, Koji|
抄録 We performed a retrospective cohort study of 911 high-energy trauma patients who underwent chest CT scans at least twice after admission. We hypothesized that in high-energy trauma patients, a high-inspired oxygen concentration delivered after admission results in dorsal atelectasis. The study’s primary outcome was dorsal atelectasis formation diagnosed based on CT images. We defined dorsal atelectasis as the presence of atelectasis at ≥ 10 mm thick on CT images. We defined high-inspired oxygen concentration as >60% oxygen delivered between two CT scans. Four hundred sixty-five patients (51.0%) developed atelectasis according to the second CT scan, and 338 (37.1%) received a high-inspired oxygen concentration. A univariate analysis showed that the rate of the high-inspired oxygen concentration in the atelectasis group was significantly higher than that in the non-atelectasis group (43.4% vs. 30.1%, p<0.001). However, a logistic regression analysis showed that there was no significant relationship between the oxygen concentration and the formation of dorsal atelectasis (OR: 1.197, 95%CI: 0.852-1.683, p=0.30). Age, the Injury Severity Score, BMI, and smoking were found to be risk factors of dorsal atelectasis formation in high-energy trauma patients. There was no relationship between the oxygen concentration and atelectasis formation in our series of high-energy trauma patients.
キーワード trauma patient dorsal atelectasis oxygen concentration
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-02
74巻
1号
出版者 Okayama University Medical School
開始ページ 17
終了ページ 26
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099244
Web of Science KeyUT 000516606200003
NAID 120006795615
JaLCDOI 10.18926/AMO/57947
フルテキストURL 74_1_7.pdf
著者 Sanki, Tomoaki| Endo, Hirosuke| Tetsunaga, Tomonori| Furumatsu, Takayuki| Yamada, Kazuki| Ozaki, Toshifumi|
抄録 We investigated the relationship between the initial contact status and stress shielding in total hip arthroplasty (THA) using fit-and-fill type straight-stem implants. In addition we evaluated the clinical and radiographic outcomes. Subjects were 100 hips of 94 patients who underwent THA and were followed-up for ≥10 years. Contact areas with the femoral cortical bone were investigated according to the zonal distribution of Gruen using postoperative CT images. Depending on the number of contact areas, the patients were classified into high contact [HC], medium contact [MC], and low contact [LC] groups. Radiographic and clinical outcomes were evaluated. In the HC group (20 hips), severe stress shielding was observed in 12 hips, which was statistically significant (p=0.008). In the LC group (29 hips), mild stress shielding was observed in 27 hips which was statistically significant (p<0.001). No significant differences were observed among the 3 groups in clinical outcomes, Harris hip score (p=0.719) or Japanese Orthopedic Association (JOA) score (p=0.301). In insertion of cementless collared fit-and-fill type straight-stem implants, severe late stress shielding of the femoral bone may occur if high contact of the femoral component is achieved. However, the degree of stress shielding does not result in adverse clinical outcomes.
キーワード fit-and-fill stress shielding cementless straight stem total hip arthroplasty
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-02
74巻
1号
出版者 Okayama University Medical School
開始ページ 7
終了ページ 15
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099243
Web of Science KeyUT 000516606200002
NAID 120006795614
JaLCDOI 10.18926/AMO/57946
フルテキストURL 74_1_1.pdf
著者 Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro|
抄録 Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.
キーワード cancer stem cell stemness iron chelation chemotherapy
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2020-02
74巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 6
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099242
Web of Science KeyUT 000516606200001
NAID 120006795613
フルテキストURL CORR477_8_1892.pdf
著者 Kunisada, Toshiyuki| Fujiwara, Tomohiro| Hasei, Joe| Nakata, Eiji| Senda, Masuo| Ozaki, Toshifumi|
発行日 2019-08
出版物タイトル Clinical Orthopaedics and Related Research
477巻
8号
出版者 Lippincott, Williams & Wilkins
開始ページ 1892
終了ページ 1901
ISSN 0009-921X
NCID AA00607942
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 30985613
DOI 10.1097/CORR.0000000000000764
Web of Science KeyUT 000509664400024
関連URL isVersionOf https://doi.org/10.1097/CORR.0000000000000764
フルテキストURL PJAB95_4_165.pdf
著者 Nakamura, Eizo| Kunihiro, Tak| Ota, Tsutomu| Sakaguchi, Chie| Tanaka, Ryoji| Kitagawa, Hiroshi| Kobayashi, Katsura| Yamanaka, Masahiro| Shimaki, Yuri| Bebout, Gray E.| Miura, Hitoshi| Yamamoto, Tetsuo| Malkovets, Vladimir| Grokhovsky, Victor| Koroleva, Olga| Litasov, Konstantin|
キーワード ordinary chondrite chronology geochemistry impact melting asteroid comet
発行日 2019-04-11
出版物タイトル Proceedings of the Japan Academy, Ser. B Physical and Biological Sciences
95巻
4号
開始ページ 165
終了ページ 177
ISSN 0386-2208
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Japan Academy
論文のバージョン publisher
PubMed ID 30971619
DOI 10.2183/pjab.95.013
Web of Science KeyUT 000470804000002
関連URL isVersionOf https://doi.org/10.2183/pjab.95.013
フルテキストURL BS69_4_633.pdf
著者 Kuya, Noriyuki| Sun, Jian| Iijima, Ken| Venuprasad, Ramaiah| Yamamoto, Toshio|
キーワード QTL anaerobic germination anoxic water direct seeding genetic resources phenotyping method rice
出版物タイトル Breeding Science
69巻
4号
出版者 Japanese Society of Breeding
開始ページ 633
終了ページ 639
ISSN 1344-7610
NCID AA11353132
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 by JAPANESE SOCIETY OF BREEDING
論文のバージョン publisher
PubMed ID 31988627
DOI 10.1270/jsbbs.19003
Web of Science KeyUT 000504401200009
関連URL isVersionOf https://doi.org/10.1270/jsbbs.19003
フルテキストURL IM58_2_311.pdf
著者 Nishimura, Yoshito| Yasuda, Miho| Hasegawa, Kou| Otsuka, Fumio|
キーワード adrenal medullary hyperplasia stroke hypertension and catecholamines
発行日 2019-01-15
出版物タイトル Internal Medicine
58巻
2号
開始ページ 311
終了ページ 311
ISSN 0918-2918
NCID AA10827774
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 2019 (c) The Japanese Society of Internal Medicine
論文のバージョン author
PubMed ID 30146579
DOI 10.2169/internalmedicine.1182-18
Web of Science KeyUT 000455930700027
関連URL isVersionOf https://doi.org/10.2169/internalmedicine.1182-18
フルテキストURL JCEH59_2_46.pdf
著者 Sato, Yasuharu|
キーワード EBV-positive mucocutaneous ulcer Immunodeficiency-associated LPD MTX immunosuppressive drugs spontaneous regression
発行日 2019-06-28
出版物タイトル Journal of Clinical and Experimental Hematopathology
59巻
2号
出版者 Japanese Society for Lymphoratic Tissue Research
開始ページ 46
終了ページ 47
ISSN 1346-4280
NCID AA11556796
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 Copyright © 2019 The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン publisher
PubMed ID 31257344
DOI 10.3960/jslrt.19020
Web of Science KeyUT 000473169400001
関連URL isVersionOf https://doi.org/10.3960/jslrt.19020
フルテキストURL JCEH59_2_64.pdf
著者 Ikeda, Tomoka| Gion, Yuka| Yoshino, Tadashi| Sato, Yasuharu|
キーワード EBV-positive mucocutaneous ulcer clinical features immunosuppression pathological features
発行日 2019-06-28
出版物タイトル Journal of Clinical and Experimental Hematopathology
59巻
2号
出版者 Japanese Society for Lymphoratic Tissue Research
開始ページ 64
終了ページ 6471
ISSN 1346-4280
NCID AA11556796
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 Copyright © 2019 The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン publisher
PubMed ID 31257347
DOI 10.3960/jslrt.18039
Web of Science KeyUT 000473169400004
関連URL isVersionOf https://doi.org/10.3960/jslrt.18039
フルテキストURL NC11_235.pdf
著者 Kawai, T.| Wang, C. G.| Kandori, Y.| Honoki, Y.| Matano, K.| Kambe, T.| Zheng, Guo-qing|
発行日 2020-01-13
出版物タイトル Nature Communications
11巻
出版者 Springer Nature
開始ページ 235
ISSN 2041-1723
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2020
論文のバージョン publisher
PubMed ID 31932585
DOI 10.1038/s41467-019-14126-w
関連URL isVersionOf https://doi.org/10.1038/s41467-019-14126-w
フルテキストURL DMJ38_5_798.pdf
著者 Kominami, Nao| Shimada, Yasushi| Hosaka, Keiichi| Minh Nguyet Luong| Yoshiyama, Masahiro| Sadr, Alireza| Sumi, Yasunori| Tagami, Junji|
キーワード Dentin Internal fracture Microtensile bond strength test SS-OCT
発行日 2019-09-27
出版物タイトル Dental Materials Journal
38巻
385号
出版者 Japanese Society for Dental Materials and Devices
開始ページ 798
終了ページ 805
ISSN 0287-4547
NCID AA10443149
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Japanese Society for Dental Materials and Devices
論文のバージョン publisher
PubMed ID 31341147
DOI 10.4012/dmj.2018-232
Web of Science KeyUT 000500359500015
関連URL isVersionOf https://doi.org/10.4012/dmj.2018-232
フルテキストURL DMJ38_5_779.pdf
著者 Rima Zakzuk Alshahni| Shimada, Yasushi| Zhou, Yuan| Yoshiyama, Masahiro| Sadr, Alireza| Sumi, Yasunori| Tagami, Junji|
キーワード Bottom Dentin-enamel junction Gap SS-OCT Self-etch adhesive
発行日 2019-09-27
出版物タイトル Dental Materials Journal
38巻
5号
出版者 Japanese Society for Dental Materials and Devices
開始ページ 779
終了ページ 789
ISSN 0287-4547
NCID AA10443149
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Japanese Society for Dental Materials and Devices
論文のバージョン publisher
PubMed ID 31341148
DOI 10.4012/dmj.2018-265
Web of Science KeyUT 000500359500013
関連URL isVersionOf https://doi.org/10.4012/dmj.2018-265
フルテキストURL JCBN64_2_143.pdf
著者 Sueishi, Yoshimi| Masamoto, Hiroaki| Kotake, Yashige|
キーワード ESR spin trapping MULTIS antioxidant capacity ginger multiple free-radical scavenging method.
発行日 2019-03-01
出版物タイトル Journal of Clinical Biochemistry and Nutrition
64巻
2号
出版者 The Society for Free Radical Research Japan
開始ページ 143
終了ページ 147
ISSN 0912-0009
NCID AA10710201
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 30936626
DOI 10.3164/jcbn.18-41
Web of Science KeyUT 000464890300006
関連URL isVersionOf https://doi.org/10.3164/jcbn.18-41
フルテキストURL HJ88_1_1.pdf
著者 Yoshida, Yuichi|
発行日 2019-01-31
出版物タイトル The Horticulture Journal
88巻
1号
出版者 Japanese Society for Horticultural Science
開始ページ 1
ISSN 21890102
NCID AA12708073
資料タイプ その他
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
DOI 10.2503/hortj.88.1
Web of Science KeyUT 000457292200001
関連URL isVersionOf https://doi.org/10.2503/hortj.88.1
フルテキストURL JP60_8_1681.pdf
著者 Feyissa, Dejene Hailemariam| Kitagawa, Hiroshi| Bizuneh, Tesfaye Demissie| Tanaka, Ryoji| Kabeto, Kurkura| Nakamura, Eizo|
キーワード Ethiopian Plateau Ethiopian rift Afar depression mantle source mantle melting
発行日 2019-09-12
出版物タイトル Journal of Petrology
60巻
8号
出版者 Oxford University Press
開始ページ 1681
終了ページ 1715
ISSN 0022-3530
NCID AA0070444X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
DOI 10.1093/petrology/egz043
Web of Science KeyUT 000509550500007
関連URL isVersionOf https://doi.org/10.1093/petrology/egz043
フルテキストURL OL18_3_2756.pdf
著者 Seno, Akimasa| Murakami, Chikae| El‑Aarag, Bishoy| Iwasaki, Yoshiaki| Ohara, Toshiaki| Seno, Masaharu|
キーワード cancer stem cell conditioned medium mouse embryonic stem cells
発行日 2019-09
出版物タイトル Oncology Letters
18巻
3号
出版者 Spandidos Publications
開始ページ 2756
終了ページ 2762
ISSN 1792-1074
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Seno et al.
論文のバージョン publisher
PubMed ID 31452753
DOI 10.3892/ol.2019.10614
Web of Science KeyUT 000487675500075
関連URL isVersionOf https://doi.org/10.3892/ol.2019.10614
フルテキストURL IJMS20_5_1042.pdf
著者 Apriliana Cahya Khayrani| Mahmud, Hafizah| Zahra, Maram H.| Aung Ko Ko Oo| Oze, Miharu| Du, Juan| Alam, Md Jahangir| Afify, Said M.| Hagar A. Abu Quora| Shigehiro, Tsukasa| Anna Sanchez Calle| Okada, Nobuhiro| Seno, Akimasa| Fujita, Koki| Hamada, Hiroki| Seno, Yuhki| Mandai, Tadakatsu| Seno, Masaharu|
キーワード CD44 glycosylated paclitaxel liposome modified paclitaxel ovarian cancer specific targeting
発行日 2019-02-27
出版物タイトル International Journal of Molecular Sciences
20巻
5号
出版者 MDPI
開始ページ 1042
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 by the authors.
論文のバージョン publisher
PubMed ID 30818864
DOI 10.3390/ijms20051042
Web of Science KeyUT 000462542300041
関連URL isVersionOf https://doi.org/10.3390/ijms20051042