検索結果 416 件
著者 | Nishino, Hiroshi| Sakai, Masaki| |
---|---|
発行日 | 1997-10 |
出版物タイトル | The Journal of Experimental Biology |
巻 | 200巻 |
号 | 20号 |
資料タイプ | 学術雑誌論文 |
著者 | Fleischmajer, Raul| Utani, Atsushi| Douglas MacDonald II, E.| Perlish, Jerome S| Pan, Te-Cheng| Chu, Mon-Li| Nomizu, Motoyoshi| Ninomiya, Yoshifumi| Yamada, Yoshihiko| |
---|---|
発行日 | 1998-7 |
出版物タイトル | Journal of Cell Science |
巻 | 111巻 |
号 | 14号 |
資料タイプ | 学術雑誌論文 |
著者 | Kumashiro, Mikihiko| Sakai, Masaki| |
---|---|
発行日 | 2001-03 |
出版物タイトル | The Journal of Experimental Biology |
巻 | 204巻 |
号 | 6号 |
資料タイプ | 学術雑誌論文 |
著者 | Kamioka, Hiroshi| Ishihara, Yoshihito| Ris, Hans| Murshid, Sakhr A.| Sugawara, Yasuyo| Yamamoto, Teruko Takano| Lim, Soo-Siang| |
---|---|
発行日 | 2008-09-21 |
出版物タイトル | Microscopy and Microanalysis |
巻 | 13巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | Kikuchi, Kazuhiro| Ekwall, Hans| Tienthai, Paisan| Kawai, Yasuhiro| Noguchi, Junko| Kaneko, Hiroyuki| Rpdriguez-Martinez, Heriberto| |
---|---|
発行日 | 2002-07-25 |
出版物タイトル | Zygote |
巻 | 10巻 |
号 | 4号 |
資料タイプ | 学術雑誌論文 |
著者 | Sumimoto, Tetsuhiro| Maruyama, Toshinori| Azuma, Yoshiharu| Goto, Sachiko| Mondou, Munehiro| Furukawa, Noboru| Okada, Saburo| |
---|---|
発行日 | 2003-5 |
出版物タイトル | Instrumentation and Measurement Technology Conference |
巻 | 2巻 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/32899 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Hosogi, Mizuho| Okada, Ayumi| Yamanaka, Eriko| Ootyou, Keiko| Tsukamoto, Chiaki| Morishima, Tsuneo| |
抄録 | Self-esteem is the evaluative feelings one holds for oneself and the sense that one has essential worth. It is evaluated as the difference between the actual self and the ideal self. Healthy self-esteem supports psychological stability and positive social activity and is an essential element in the psychological development of children. The purpose of this study was to evaluate self-esteem in children with psychosomatic symptoms and elucidate a strategy for using such evaluations in therapy. We evaluated self-esteem in 56 patients at the Department of Pediatrics of Okayama University Hospital who were undergoing outpatient therapy for psychosomatic symptoms, using Pope's 5-scale test of self-esteem for children. We examined patient attributes, course of therapy, and social adjustment. Patients with low self-esteem on multiple scales at the first visit were all female, and these patients had a significantly higher frequency of family function problems, such as a family member with a psychiatric disorder, economic hardship, or experience of child abuse. Moreover, the prognosis for these patients was poor regardless of their social adjustment at the first visit. |
キーワード | self-esteem psychosomatic symptom family function child abuse 5-scale test of self-esteem |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-10 |
巻 | 61巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 271 |
終了ページ | 281 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 17971844 |
Web of Science KeyUT | 000250431700005 |
JaLCDOI | 10.18926/AMO/32897 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Matsukawa, Akihiro| |
抄録 | The innate immune system provides immediate defense against infection and serves as the first line of host defense during infection. In innate immunity, leukocytes such as neutrophils and macrophages recognize and respond to pathogens in a non-specific manner. Therefore, the recruitment and activation of leukocytes are essential in innate immunity, and are governed by a variety of chemical mediators including cytokines. Cytokines are generally divided into 2 types, termed type-1 and type-2 cytokines. Type-1 cytokines are important in local host defense, while type-2 cytokines play a protective role when inflammatory response spreads to the body. These cytokines exert their biological functions through the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1/3/4/6 are transcription factors that mediate IFNgamma/IL-10/IL-12/IL-13 cytokine signaling, respectively. Evidence indicates that STAT proteins have a significant impact on innate immunity during sepsis. This review focuses on recent understandings in the regulation of innate immunity by STAT proteins during sepsis and septic shock. The suppressor of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing cytoplasmic proteins that complete a negative feedback loop to attenuate signal transduction from cytokines that act through the JAK/STAT pathway. The participation of SOCS proteins in sepsis is also discussed. |
キーワード | cytokines innate immunity sepsis SOCS STAT |
Amo Type | Review |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-10 |
巻 | 61巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 239 |
終了ページ | 245 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 17971840 |
Web of Science KeyUT | 000250431700001 |
JaLCDOI | 10.18926/AMO/32896 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Okada, Ayumi| Tsukamoto, Chiaki| Hosogi, Mizuho| Yamanaka, Eriko| Watanabe, Kumi| Ootyou, Keiko| Morishima, Tsuneo| |
抄録 | Phagophobia is a disorder characterized by a conditioned excessive fear of eating and is initiated by an event such as vomiting or choking. During childhood, vomiting often occurs as a result of infection or overeating, and painful experiences bring about maladaptive eating behavior like food refusal. There have been few reports of phagophobia, and patients have sometimes been misdiagnosed with anorexia nervosa (AN). The objective of this study was to elucidate the psycho-pathology and current treatment of patients with phagophobia by analyzing case studies. We describe 6 cases with phagophobia. Patients with strong obsessions were refractory to treatment, indicating that evaluation of premorbid personality is crucial to the prognosis. It is important to classify this disorder according to psycho-pathology into "post-traumatic type" and "gain-from-illness type" to make a treatment plan. A solution focused approach is also effective for patients and their family. Paying close attention to these conditions and to the diagnostic concept referred as "hagophobia" is useful in achieving these aims. |
キーワード | phagophobia functional dysphagia eating disorder premorbid character solution focused approach |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-10 |
巻 | 61巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 261 |
終了ページ | 269 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 17971843 |
Web of Science KeyUT | 000250431700004 |
JaLCDOI | 10.18926/AMO/32868 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Arata, Ryoji| Saika, Takashi| Tsushima, Tomoyasu| Abarzua, Fernando| Nasu, Yasutomo| Kumon, Hiromi| |
抄録 | To compare the quality of life (QOL) in patients with ileal neobladder and sigmoidal neobladder, a retrospective survey was conducted using a formulated questionnaire. Between January and March 1999, a QOL survey was conducted using self-administered questionnaires (EORTC QLQ-C30, IPSS, supplemented with detailed questionnaires about continence, sexual function, and patient’s satisfaction with the selected urinary diversion method) for 78 patients with orthotopic urinary reservoir (OUR) who were followed-up for more than 3 months after cystectomy. Among 78 patients, 63 had OUR using an ileal segment (male/female=59/4, median age: 70.8 years old, median follow-up: 1.7 years). Fifteen patients had OUR using a sigmoidal segment (male/female=13/2, median age: 71.9, median follow-up: 3.9). The QLQ-C30 functional evaluation and the items in relation to sexual function showed no diff erences between the 2 groups. Concerning the voiding condition, bladder emptying, frequency, and urgency, scores in the sigmoidal OUR group were signifi cantly higher. The QOL score concerning voiding conditions, daytime, and nighttime continence and quantity of pad showed a better score in the ileal OUR group. Concerning the satisfaction with methods of urinary diversion, patients in the sigmoidal OUR group expressed less satisfaction than their preoperative expectations. Considering several postoperative voiding conditions, ileal OUR seems superior to sigmoidal OUR. |
キーワード | urinary diversion orthotopic urinary reservoirs bladder cancer quality of life |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-08 |
巻 | 61巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 229 |
終了ページ | 234 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 17726512 |
Web of Science KeyUT | 000248957100007 |
JaLCDOI | 10.18926/AMO/32851 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Shintani, Mai| Senda, Masuo| Takayanagi, Tomoko| Katayama, Yoshimi| Furusawa, Kazunari| Okutani, Tamami| Kataoka, Masaki| Ozaki, Toshifumi| |
抄録 | To assess the effects of service dogs on health-related quality of life (HRQOL), we conducted a survey of 10 service dog owners using SF-36v2 (Medical Outcomes Study 36 Item Short-Form Health Survey Version 2.0) and compared it with a matched control group of people with physical disabilities who did not have service dogs but were eligible for one. The scores for mental health and role emotional of service dog owners were relatively high, and their mental component summary was higher than the general population norm. These results indicate that service dogs affect the mentality of their owners. The comparison with the control group indicated that service dogs alleviate the mental burden of daily activities, and subjectively improved the physical functioning of their owners. This study showed that service dogs have positive functional and mental effects on their disabled owners. |
キーワード | service dog HRQOL SF-36v2 people with physical disability |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2010-04 |
巻 | 64巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 109 |
終了ページ | 113 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 20424665 |
Web of Science KeyUT | 000276996900004 |
JaLCDOI | 10.18926/AMO/32814 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Okamoto, Akira| Yamamura, Masahiro| Iwahashi, Mitsuhiro| Aita, Tetsushi| Ueno, Akiko| Kawashima, Masanori| Yamana, Jiro| Kagawa, Hidetoshi| Makino, Hirofumi| |
抄録 | High levels of soluble CD30 (sCD30) were detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA), indicating the involvement of CD30+ T cells in the pathogenesis. We investigated the induction of CD30 and its functions in CD4+T cells from patients with established RA (disease duration >_2 years). CD4+ T cells from both the peripheral blood (PB) and synovial tissue (ST) of RA patients expressed surface CD30 when stimulated with anti-CD3 antibody (Ab) and anti-CD28 Ab, but their CD30 induction was slower and weaker compared with PB CD4+ T cells of healthy controls (HC). Immunohistochemical analysis showed that only a small proportion of lymphocytes expressed CD30 in the ST (-1%). RA PB CD4+ T cells, after recovery from 6-day stimulation with anti-CD3 Ab and anti-CD28 Ab, showed in intracellular cytokine staining that CD30+ T cells could produce more interleukin-4 (IL-4) but less interferon-gamma. In the culture of RA PB CD4+ T Cells with anti-CD3 Ab and anti-CD28 Ab, blocking anti-CD30 Ab similarly inhibited the cell proliferation and activation of nuclear factor-kappaB on day 4 in RA and HC, but inhibited the apoptotic cell death on day 6 only in RA. These results indicate that despite high-level expression of sCD30, the anti-inflammatory activity of IL-4-producing CD30+ CD4+ T cells may be limited in the ST due to a poor induction of surface CD30 and a susceptibility to CD30-mediated cell death. |
キーワード | apoptosis CD4 Tcells CD30 interleukin-4(IL=4) rheumatoid arthritis(RA) |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2003-12 |
巻 | 57巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 267 |
終了ページ | 277 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 14726963 |
Web of Science KeyUT | 000187556500001 |
JaLCDOI | 10.18926/AMO/32689 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Orita, Kunzo| Miwa, Hiroaki| Kaneda, Shoken| |
抄録 | By dividing at random 14 normal persons into 7 pairs of two individuals each, lymphocytes were isolated from their peripheral blood and taking one of the pairs as stimulating cells or antigens and the others as responding cells, mixed lymphocyte culture (MLC) was carried out. As for the method of MLC we used our MLC method of unidirectional mixed culture with a small amount of lymphocytes in additition of 1% (v /v) PHA.M and cultured for three days, and a widely used conventional method in which 3H.thymidine uptake was the parameter of the blastformation rate and cultured for seven days. In comparing the results of these two groups of MLC the data in six experiments out of the seven coincided. Namely, with 5x 104 cells each of stimulating cell group and responding cell group, it is possible to achieve satisfactory MLC, the culture can be done only for three days without requiring any special technique and the results can be readily evaluated. Therefore, MLC by our simple method would yield satisfactory results in clinics. |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1974-08 |
巻 | 28巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 253 |
終了ページ | 257 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4280235 |
NAID | 120002311525 |
JaLCDOI | 10.18926/AMO/32622 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuharu| Ochi, Koji| Harada, Hideo| Soda, Ryo| Takahashi, Kiyoshi| Kimura, Ikuro| |
抄録 | Twenty-one patients with atopic asthma were classified into three types according to their symptoms (clinical diagnosis): Ia, simple bronchoconstriction; Ib, bronchoconstriction + hypersecretion; and II, bronchiolar obstruction, and this classification was compared with a classification made according to clinical findings and examinations (score diagnosis). Type Ib asthma was characterized by the increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF), while type II was characterized by ventilatory dysfunction in small airways and the increased incidence of neutrophils in BALF. Four patients, whose expectoration was between 50 and 99ml/day, of the 12 with type Ia assessed by clinical diagnosis were evaluated as type Ib by score diagnosis. One patient with type II by clinical diagnosis was assessed as questionable type II by score diagnosis. In the other 16 patients, the clinical and score diagnoses were the same. |
キーワード | bronchial asthma classification ventilatory function cellular composition of BALF sore diagnosis |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1992-08 |
巻 | 46巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 295 |
終了ページ | 301 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 1442153 |
Web of Science KeyUT | A1992JL44200010 |
JaLCDOI | 10.18926/AMO/32582 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ohbuchi, Shinji| |
抄録 | The rats which received the repeated intra peritoneal or intravenous injections of methyl palmitate showed a marked depressed phagocytic activity of the RES as shown by the clearance test with radioactive iron as well as by histological observations and a significantly suppressed antibody formation against the challenge by BSA. Differing from the cases of the blockade of the RES made by PVP or radiogold, the injection of methyl palmitate did not result in any injurious effect on the lymph follicles of lymph nodes and spleen and the plasma cells proliferation as revealed by the histological observation. Histochemical observations of iron phagocytosis of the RES done by Perls stain revealed that methyl palmitate suppressed the phagocytic activity of the Kupffer cells of the liver dramatically and also suppressed the phagocytic activity of the sinus-lining cells in spleen to a lesser degree. The result indicates that the injection of methyl palmitate attacks the phagocytic function of the RES selectively and induces the reduced immune response of the organism without giving any damages to the proliferation of immunologically com petent cells. The fact suggests that the RES lowered in their phagocytic activity fails to produce the informational substance for immune response, showing a lower level in the antibody formation even in the presence of antigen and proliferating immunologically competent cells. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1968-06 |
巻 | 22巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 137 |
終了ページ | 146 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4239072 |
NAID | 120002312296 |
JaLCDOI | 10.18926/AMO/32565 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Namba, Masayoshi| Hirose, Masaharu| Kishimoto, Ritsu| |
抄録 | When cultured cells are used in experiments, It is very important to know from what kinds of cells the cultured cells are originated, and what characteristics the cultured cells maintain continuously in vitro Some properties of rat liver cells in long-term cultivation were examined for the purpose of identifying the cultured cells with parenchymal liver cells by investigating their functions. The production of rat serum albumin and α-globulin which is regarded as specific functions of liver parenchymal cells was detected in these cultured rat liver cells with the method of immunoelectrophoresis. Histochemically, acid phosphatase, glucose-6-phosphate dehydrogenase, succinic dehydrogenase, lactic dehydrogenase, and adenosine triphosphatase were demonstrated in the cultured rat liver cells which were morphologically epithelial. Alkaline phosphatase showed little activity in these cells. Glycogen was recognized by the periodic acid-Schiff technique, when bovine serum concentration in the culture fluid was reduced to 5 per cent. These histochemical findings of cultured rat liver cells were identical with those of parenchymal liver cells in vivo. These facts suggest that there is a possibility of the continuous cultivation of liver cells by the present methods and of the identification of the cultured cells with the parenchymal liver cells from their functions. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1968-08 |
巻 | 22巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 209 |
終了ページ | 217 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4239564 |
NAID | 120002311791 |
JaLCDOI | 10.18926/AMO/32513 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Hayashi, Hideo| |
抄録 | 1) In order to study the molecular structure and electron transfer activities of mitochondrial inner membrane, dissolution and reconstitution of membranous structure and function of the inner membrane of beef heart mitochondria were carried out. 2) The inner membrane of mitochondria could be dissolved into some unit of particles 70-140 Å in diameter by the treatment with bile salts at the concentration 0.5 mg of deoxycholate per mg of protein, 0.5 mg of cholate per mg of protein and 74.5 mg of crystalline potassium chloride per ml of the suspension. 3) The dissolved unit particles readily reaggregated into a vesicular membrane simultaneously restoring over-all electron transfer activities by the removal of bile salts with dilution of the suspension.4) Isolated electron transfer unit particle fraction contammg all components of the electron transfer chain but no structural protein were soluble in aqueous solution due to some residual bile salts used in the preparation. The removal of bile salts by dilution led the dispersed particles to aggregate into membrane and restore their over-all enzymatic activities. 5) From these results and the results of the reconstitution of membrane from purified complexes as described in the previous paper, it may be concluded as follows: The mitochondrial inner membrane may consist of several kinds of repeating unit particles conjugating each other with adjacent particles. It is necessary for over·all enzymatic activities that some unit components aggregate into a single vesicular membrane. Structural proteins may play an important role in the constitution of the membranous structure and in the over-all enzymatic activities. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1969-08 |
巻 | 23巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 303 |
終了ページ | 322 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4243563 |
NAID | 120002312207 |
JaLCDOI | 10.18926/AMO/32507 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Namba, Masayoshi| |
抄録 | The liver cells obtained from a calf have been cultured continuously for 257 days in total at present (May 31, 1967). The primary culture was maintained in rotatory culture for about 2 months with gradual and continuous cell proliferation. The two original strains, LD-BS20 and LD-CS20, have been maintained in static culture since 4th subcultivation. Three substrains, LD-BS10, YLE-BS20 and LD-CS10, were derived from the original strains. Two kinds of appropriate media, in which the cells could be subcultured with trypsin without severe damages and maintained with some characteristic functions of liver cells, were reported. The one consisted of 20 per cent bovine serum, 0.4 per cent lactalbumin hydrolysate and saline D, and the other was added with 0.08 per cent yeast extract to the above mentioned medium. Calf serum examined was not so effective as bovine serum for cell proliferation. Morphologically, the cultured cells resembled parenchymal liver cells quite well. The cells spread wide with abundant pale staining cytoplasm and their large nuclei, oval or round, generally contained one to several nucleoli. The cells as well as the nuclei varied considerably in size, some being two to four times larger than others. Binuclear, trinuclear or polynuclear cells were also observed. No silver impregnated fiber was detected among the epithelial cells. Two attempts to characterize cell types in culture were made. First, the presence of glycogen was tested with PAS reaction and saliva digestion procedure. Secondly, the albumin formation in cultured liver cells was examined with the fluorescent antibody technique. The fact that both albumin and glycogen were observed in the cells suggests strongly that there is a possibility of the continuous cultivation of liver cells by the present method, and by these procedures it seems possible to identify functionally the cultured cells with the parenchymal liver cells. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1967-06 |
巻 | 21巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 133 |
終了ページ | 145 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4229241 |
NAID | 120002311776 |
JaLCDOI | 10.18926/AMO/32472 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Yamamoto, Goki| |
抄録 | Effects of sodium oleate and bovine serum albumin (BSA) on rat liver mitochondrial function and structure were studied by measuring oxygen uptake, 90° light-scattering, adenosine triphosphatase activity and pyridine nucleotides fluorescence. 1. The low concentration of oleate induced the uncoupling of oxidative phosphorylation and the scattering change of mitochondria. This action of oleate differed from that of oleate at a high concentration which induces the high amplitude swelling with respect to its physiological and biochemical properties. The degrees of reversal swelling (shrinkage) and of oxygen uptake induced by oleate in the presence of Pi and succinate were altered proportionately to the concentration of oleate, and the concentration of oleate to the shrinkage coincided with that of the maximal respiratory release. 2. Antimycin A or 2, 4- dinitrophenol prevented the oleate-induced mitochondrial shrinkage, but the treatment of these agents after prior incubation with Pi and succinate allowed the shrinkage, though the degree was small in its extent compared with that in the absence of inhibitors. On the other hand, oligomycin did not affect the shrinkage with oleate. 3. BSA protected the mitochondrial phosphorylation from the uncoupling action of oleate without showing any effect of its own. A complete reversal could readily be demonstrated by a sufficient amount of BSA from the uncoupling, structural changes, and oxidation of intramitochondrial pyridine nucleotides induced by oleate in a low concentration. 4. The oleate-stimulated latent ATPase activity was proportional to the oleate-induced shrinkage of mitochondria with respect to the concentration of oleate. The latent ATPase was abolished also by the addition of a sufficient amount of BSA. 5. The action of oleate on the phosphorylation sequence of mitochondria was discussed on the basis of the present findings. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1964-10 |
巻 | 18巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 247 |
終了ページ | 259 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 14311536 |
NAID | 120002312036 |
JaLCDOI | 10.18926/AMO/32295 |
---|---|
フルテキストURL | fulltext.pdf 55_4_259.pdf |
著者 | Hinev, Alexander| |
抄録 | Fracture of the penis is an unusual blunt traumatic injury of the erect penis. Twenty-five such cases, treated at the 2 main urological departments in the town of Varna between 1984 and 1999, were analyzed retrospectively. The average annual incidence in this series was 0.33 per 100,000 inhabitants. Most of the injuries occurred during vigorous sexual intercourse. Clinical diagnosis was mainly based on the patient's history and the physical findings. The diagnosis was verified by ultrasonography. In a few cases retrograde urethrography and cavernosography were used as additional diagnostic tools. Cavernosography was complicated by postprocedural priapism in 1 case. Unilateral tear of the corpora cavernosa was found in 24 cases. In 3 cases, partial (in 2) or complete (in 1) disruption of the corpus spongiosum and the urethra was found as well. The trauma was bilateral in 1 case in which 2/3 of the entire circumference of the penis was ruptured, including both corpora cavernosa and the urethra. Seventeen patients received immediate surgical repair. Most of them experienced an uneventful postoperative period with no serious consequences affecting their sexual function. Surgery was delayed in 6 and rejected in 2 cases. In all cases in which conservative (nonsurgical) management was the first treatment option, late complications (penile aneurysm, induration, penile curvature, erectile dysfunction) were observed and the final results were assessed as satisfactory or poor. We recommend immediate surgical treatment of all cases of penile fracture. Emergency surgical repair offers a chance for complete recovery and is the best method for providing a good functional prognosis. |
キーワード | penis penile fracture treatment compilcations |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2000-10 |
巻 | 54巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 211 |
終了ページ | 216 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 11061570 |
Web of Science KeyUT | 000090098600004 |