検索結果 14877 件
| 著者 | 岡山大学環境理工学部| |
|---|---|
| 発行日 | 2014-03 |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 巻 | 19巻 |
| 号 | 1号 |
| 資料タイプ | その他 |
| 著者 | 岡山大学環境理工学部| |
|---|---|
| 発行日 | 2014-03 |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 巻 | 19巻 |
| 号 | 1号 |
| 資料タイプ | その他 |
| 著者 | 岡山大学環境理工学部| |
|---|---|
| 発行日 | 2014-03 |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 巻 | 19巻 |
| 号 | 1号 |
| 資料タイプ | その他 |
| JaLCDOI | 10.18926/fest/52229 |
|---|---|
| タイトル（別表記） | Material design for the ceramics coating with high mold releasability by using molecular orbital calculations |
| フルテキストURL | fest_019_022_025.pdf |
| 著者 | 難波 徳郎| 藤原 二朗| 崎田 真一| 紅野 安彦| |
| 抄録 | To explore the ceramic materials appropriate for the coatings with high mold releasability, molecular orbital (MO) calculations have been applied to the ceramics with NaCl structure, such as TiN, TiC, CrN, etc. Chemical bonding characters were evaluated based on the MO calculations, which were correlated to the experimental surface free energy. The dispersion and polar components of surface free energy indicated high correlation with the bond overlap population of the surface bonds and the net charge of inside atoms of the cluster models, respectively. Among the ceramic materials investigated, MoN had the lowest surface free energy, being expected to be most suitable as the ceramic coating material with high releasability |
| キーワード | Material design Ceramic coating Releasability Molecular orbital calculation |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 発行日 | 2014-03 |
| 巻 | 19巻 |
| 号 | 1号 |
| 開始ページ | 22 |
| 終了ページ | 25 |
| ISSN | 2187-6940 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005394644 |
| JaLCDOI | 10.18926/fest/52228 |
|---|---|
| フルテキストURL | fest_019_008_021.pdf |
| 著者 | Ichiminami, Fumikazu| Dinçsoy, Meltem Okur| Dinçsoy, Enver Erdinç| |
| 抄録 | In this study, we examined the change of rice cultivation in consideration of the global warming. In Japan, rice which is suitable for subtropical zone is grown even in an environment of cool-temperate climate. Since the rice varieties that resist of cold weather have been developed, rice cultivation spread to north parts of the country gradually. Land productivity of rice has also improved markedly. As a result, northern Japan became the main producer of rice. Now, taking not only crop production but also the landscape formation and preservation of the natural environment into account, we should think about the rural society from different aspects. |
| キーワード | Global warming rice cultivation varieties acreage yield Japan |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 発行日 | 2014-03 |
| 巻 | 19巻 |
| 号 | 1号 |
| 開始ページ | 8 |
| 終了ページ | 21 |
| ISSN | 2187-6940 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120005394643 |
| JaLCDOI | 10.18926/fest/52227 |
|---|---|
| タイトル（別表記） | Numerical Evaluation of the Approximation by an Influence Function |
| フルテキストURL | fest_019_001_007.pdf |
| 著者 | 包 紅梅| 笛田 薫| |
| 抄録 | For evaluating statistical models one of the most effective criteria is cross-validation. But it requires a large amount of computation. Various alternative schemes are considered to reduce its computation. Modified generalized information criterion is one of those alternative schemes. In this criterion an influence function is used to estimate the parameters of the models. By the numerical simulation we studied the effect of an influence function. Surveying data of the lake depth are used as the sample data. We estimate the shape of lake bottom as spline surface. The estimated parameters and the estimated depths obtained by two criteria are compared and the effect of an information function is analysed. |
| キーワード | influence function information criteria CV mGIC B-spline |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 発行日 | 2014-03 |
| 巻 | 19巻 |
| 号 | 1号 |
| 開始ページ | 1 |
| 終了ページ | 7 |
| ISSN | 2187-6940 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120005394642 |
| 著者 | 岡山大学環境理工学部| |
|---|---|
| 発行日 | 2014-03 |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 巻 | 19巻 |
| 号 | 1号 |
| 資料タイプ | その他 |
| 著者 | 岡山大学環境理工学部| |
|---|---|
| 発行日 | 2014-03 |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 巻 | 19巻 |
| 号 | 1号 |
| 資料タイプ | その他 |
| 著者 | 野崎 貴博| 岩崎 志保| 鈴木 茂之| 山本 悦世| 南 健太郎| 田中 克典| 加藤 鎌司| |
|---|---|
| 発行日 | 2013-12-27 |
| 出版物タイトル | 岡山大学埋蔵文化財調査研究センター紀要 |
| 巻 | 2012巻 |
| 資料タイプ | 紀要論文 |
| JaLCDOI | 10.18926/52197 |
|---|---|
| タイトル（別表記） | Interpretation for the " 神道（Shinto）" of Banzan Kumazawa |
| フルテキストURL | bhe_009_135_146.pdf |
| 著者 | 孫 路易| |
| 抄録 | 熊沢蕃山の思想を、朱子学または陽明学と比較しつつできるだけ深く掘り下げて解明することを試みる。本稿では、その本体論と生成論について考察する。 太虚と太極の両概念を用いるところにその本体論の特徴が見られる。気だけを本体とする本体論、或いは理だけを本体とする本体論では、思索が厳密になればなるほどその理論の行き詰まりが露呈する、ということに気付いた蕃山は、理と気の両方を本体とする必要があると考えた、と推察される。蕃山のいう太虚と太極は、両方とも理と気であるが、太虚は気に重きを置き、太極は理に重きを置く、という思想的な操作を通してその本体論に 用いたと思われる。 蕃山にあっては、「五行説」と「四象四化説」の二種類の生成論が見られる。「五行説」とは、陰陽の二気と木火土金水の五行が天地万物を生成する生成論であるが、陰陽の気はどのように生じたのかが常に問題となっていた当時、蕃山は、太虚の理が感じるものだとし、理が感じることによって陰陽を生じたとして、理は神だと認識した。そして、太虚は永遠に存続する万物の根源として神道だと解釈された。 「四象四化説」とは、日月星辰の四象と水火土石の四化が天地万物を生成する生成論である。日月星辰は天であり、水火土石は地である。万物も人間もすべて天地の気を受けて生成される存在であるが故に、天地は父母だとする。この考え方が、蕃山の独特の「孝」思想を導き出したのである。 孝の字は、老と子で構成され、老は理で、子は気であり、これは太虚を象っている、と蕃山はいう。太虚は神道であれば、孝は神道を象った字ともなるのである。 |
| キーワード | 太虚 太極 陰陽 五行 四象 四化 神道 孝 |
| 出版物タイトル | 大学教育研究紀要 |
| 発行日 | 2013-12-30 |
| 巻 | 9巻 |
| 開始ページ | 135 |
| 終了ページ | 146 |
| ISSN | 1881-5952 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005394619 |
| JaLCDOI | 10.18926/bgeou/52177 |
|---|---|
| タイトル（別表記） | The Discourse of Darwinism in Felix Holt, the Radical |
| フルテキストURL | bgeou_155_057_066.pdf |
| 著者 | 福永 信哲| |
| 抄録 | The present paper focuses attention on an influence of Darwinism as seen in the discourse of Felix Holt, the Radical. True George Eliot’s early and middle-period novels show signs of a vision of Natural History with its emphasis on scientific observation of the natural world. But as the impact of The Origin of Species (1859) sent a shock wave among the intellectual circle across Europe, she became growingly aware of its farreaching implications. Inevitably Eliot’s novelistic discourse has become permeated with the evolutionary outlook and terminology. Felix Holt marks a turning point in the sense that it is structurally conceived by the method of experimental science, and is clothed in its phraseology. We see how the writer’s moral and religious vision finds itself subtly reconciled with scientific world view. |
| キーワード | 進化 有機的生命 ネメシス 罪 仮説・検証 |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2014-02-25 |
| 巻 | 155巻 |
| 開始ページ | 57 |
| 終了ページ | 66 |
| ISSN | 1883-2423 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005394602 |
| JaLCDOI | 10.18926/ESR/52167 |
|---|---|
| タイトル（別表記） | Preliminary analyses on the climatological features of precipitation characteristics and large-scale atmospheric fields on the heavy rainfall days in the eastern part of Japan during the mature stage of the Baiu season |
| フルテキストURL | esr_020_1_025_034.pdf |
| 著者 | 松本 健吾| 加藤 内藏進| 大谷 和男| |
| 抄録 | Rainfall characteristics and large-scale atmospheric fields on the “heavy rainfall days” (with more than 50 mm/day) in the mature stage of the Baiu season (16 June ~ 15 July) at Tokyo in the eastern part of the Japan Islands were examined, based on the daily and the hourly precipitation data from 1971 to 2010. Appearance frequency of the “heavy rainfall days” at Tokyo attained only about 1/3 of that at Nagasaki in the western Japan. Furthermore, it is noted that about half of the “heavy rainfall days” at Tokyo were related to the typhoon. In detail, about half of the typhoon cases were associated with the direct approach of a typhoon (referred to as Pattern A, hereafter), the other half corresponded to the situation when the Baiu front also stagnated around Kanto District with a typhoon to the southwest of Kanto (Pattern B). Although the contribution of the intense rainfall with more than 10 mm/h to the total precipitation was large in Pattern A, that with less than 10 mm/h was dominant in Patterns B and C (Pattern C: meso-α-scale cyclone on the Baiu front approaching to the Kanto District). It is noted that about half of the “heavy rainfall days” corresponded to these pattern. In other words, unlike the localized torrential rain in western Japan, the “heavy rainfall days” due to the duration of “not-so-intense-rain” appeared rather frequently in the eastern part of Japan even in the Baiu season. In both Patterns B and C, relatively strong low-level southerly wind associated with the disturbance (a typhoon or a meso-α-scale cyclone) invades into the baroclinic zone in the basic field sustained as the sowthwestern edge of the cool Okhotsk air mass. It is interesting that the “heavy rainfall days” there due to the contribution of the persistent “not-so-intense-rain” occur just in such situation. |
| キーワード | rainfall characteristics in eastern Japan heavy rainfall in eastern Japan in Baiu season rainfall climatology |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2013-12-27 |
| 巻 | 20巻 |
| 号 | 1号 |
| 開始ページ | 25 |
| 終了ページ | 34 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2013 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| NAID | 120005394595 |
| JaLCDOI | 10.18926/ESR/52166 |
|---|---|
| タイトル（別表記） | A case study on the rainfall distribution over the Japan Islands associated with the approach of Ty0423 in late October (Comparison with that for Ty0418) |
| フルテキストURL | esr_020_1_013_024_rev.pdf |
| 著者 | 佐竹 愛| 加藤 内藏進| 盛 宣誠| 合田 泰弘| 池田 祥一郎| 塚本 修| |
| 抄録 | Rainfall distribution in the Japan Islands associated with the approach of Typhoon No.23 around 20 October 2004 (referred to Ty0423, hereafter) showed considerably different features from those in late summer of this year. The present study examined the detailed rainfall features around the Japan Islands brought by Ty0423 and the atmospheric processes based on the operational observation data by the Japan Meteorological Agency (JMA), comparing with those in association with Ty0418 around 7 September 2004. During the stage when Ty0423 was approaching or landing on the western part of the Japan Islands, the areal mean precipitation from Kyushu to Kanto District attained much larger than that for Ty0418, with wider extension of the area with the large amount of precipitation. It is interesting that, although the intense rainfall was observed only at the upstream side of the mountain range from Kyushu to Honshu District for Ty0418 except for the area near its center, strong rainfall with 10~30 mm/h persisted in wider regions from the western to the eastern part of the Japan Islands, resulting in the considerably large total rainfall for Ty0423. As for the case for Ty0423, the surface front with stable frontal surface was located just to the east of the Ty0423 center just before its landing at the Japan Islands. Thus, the huge moisture inflow mainly in the eastern region from the typhoon center seems to be redistributed widely over the Japan Islands area associated with the large-scale convergence around the stable frontal surface. In late October, the colder air associated with the high pressure system in the eastern Siberia can cover the northern part of the Japan Sea area as the seasonal march. Such basic field might be favorable for sustaining the synoptic-scale front just around the southern coast of the Japan Islands, even when the strong southerly wind invades associated with the typhoon approach there. |
| キーワード | Ty0423 Ty0418 rainfall in Japan associated with a typhoon in mid-autumn effects of a typhoon on the synoptic climatology in Japan in October |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2013-12-27 |
| 巻 | 20巻 |
| 号 | 1号 |
| 開始ページ | 13 |
| 終了ページ | 24 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2013 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| NAID | 120005394594 |
| JaLCDOI | 10.18926/ESR/52165 |
|---|---|
| タイトル（別表記） | On Periploma mitsuganoense Araki (Bivalvia: Mollusca) from the Miocene Bihoku Group in Niimi City, Okayama Prefecture, southwest Japan ―with special reference to it’s paleogeographic significance― |
| フルテキストURL | esr_020_1_007_011.pdf |
| 著者 | 田口 栄次| 岸本 眞五| 鈴木 茂之| |
| 抄録 | In this paper, we deal with re-description of Periploma mitsuganoense Araki and it’s morphological variation and significance of the molluscan fauna of it from the Miocene Bihoku Group in Niimi City, Okayama Prefecture, Southwest Japan. Moreover, the paleogeographic significance of this species is analyzed. The obtained results are summarized as follows: 1. The morphological variation of Periploma mitsuganoense Araki has a wide range on the basis of the analysis of the morphological outline. 2. The occurrence of P. mitsuganoense Araki from the Pectinid fauna is the first record in the West Setouchi Geological Province. 3. It is presumable that P. mitsuganoense Araki is an endemic species in the First Setouchi Geological Province from a view point of it’s spatial distribution. |
| キーワード | Periploma mitsuganoense Araki Mollusca Miocene Bihoku Group morphological variation paleogeographic significance |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2013-12-27 |
| 巻 | 20巻 |
| 号 | 1号 |
| 開始ページ | 7 |
| 終了ページ | 11 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2013 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| NAID | 120005394593 |
| JaLCDOI | 10.18926/ESR/52164 |
|---|---|
| タイトル（別表記） | Debris avalanche occurred in Kitamura area, Kurashiki City, Okayama Prefecture |
| フルテキストURL | esr_020_1_001_006.pdf |
| 著者 | 木村 裕貴| 鈴木 茂之| |
| 抄録 | The debris avalanche occurred in Kitamura area, Kurashiki City, Okayama Prefecture caused by the hard rain of Typhoon 12 of September, 2011. Furthermore, 11 small landslides occurred in the study area. In this area, the altitude of mountainous are not so high (150m to 250m) and the amount of precipitation which producted the debris avalanche was not very serious quantity with 230mm. However the debris avalanche occurred. One private house collapsed, and the first floor part of the Kitamura Elementary School was buried due to the debris flow. The purpose of this study is to examine causes of the debris avalanche disaster occurred in Kitamura area using applied geological technique. The length of the debris avalanche scar is about 250m, and alluvial fan is formed as a debris slope. The ground is composed of weathered granite and the bottom of the valley was filled by soils derived from disintegrated granite. There are three small landslides as head scarps with steep slopes at approximately 30°-35°. The debris avalanche was inferred to have started as a shallow soil slip at the head by rainfall. 3 major causes are inferred which originated the debris avalanche in the study area; steep slope, ground composed of weathered granite, existence of sandy soil which occupied at the bottom of valley. |
| キーワード | debris avalanche steep slope weathered granite |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2013-12-27 |
| 巻 | 20巻 |
| 号 | 1号 |
| 開始ページ | 1 |
| 終了ページ | 6 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2013 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| NAID | 120005394592 |
| JaLCDOI | 10.18926/AMO/52145 |
|---|---|
| フルテキストURL | 68_1_53.pdf |
| 著者 | Terasaka, Tomohiro| Ueta, Eijiro| Ebara, Hirotaka| Waseda, Koichi| Hanayama, Yoshihisa| Takaki, Akinobu| Kawabata, Tomoko| Sugiyama, Hitoshi| Hidan, Ko| Otsuka, Fumio| |
| 抄録 | A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patientʼs serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconiʼs syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis. |
| キーワード | adefovir dipivoxil (ADV) eldecalcitol Fanconi's syndrome hypophosphatemia osteomalacia |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-02 |
| 巻 | 68巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 53 |
| 終了ページ | 56 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24553490 |
| JaLCDOI | 10.18926/AMO/52144 |
|---|---|
| フルテキストURL | 68_1_47.pdf |
| 著者 | Ishikawa, Tsutomu| Araki, Motoo| Hirata, Takeshi| Watanabe, Masami| Ebara, Shin| Watanabe, Toyohiko| Nasu, Yasutomo| Kumon, Hiromi| |
| 抄録 | We report 3 patients with the rare complication of an indwelling urethral catheter misdirected into the ureter. This is the largest series to date. Patients were referred to us for a variety of reasons following exchange of their chronic indwelling urinary catheters. CT in all cases demonstrated the urinary catheters residing in the left ureter. The ages of the patients were 37, 67 and 81 years old. All patients suffered from neurogenic bladder. Two patients were female, one was male, and 2 of the 3 had a sensory disorder inhibiting their pain response. The catheters were replaced with open-end Foley catheters. Extensive follow-up CT scans were obtained in one case, demonstrating improvement of hydronephrosis and no evidence of ureteral stenosis. Cystoscopy in this patient demonstrated normally positioned and functioning ureteral orifices. Although the placement of an indwelling urethral catheter is a comparatively safe procedure, one must keep in mind that this complication can occur, particularly in female patients with neurogenic bladder. CT without contrast is a noninvasive, definitive diagnostic tool. |
| キーワード | complication indwelling urethral catheter imaging computed tomography ureter |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-02 |
| 巻 | 68巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 47 |
| 終了ページ | 51 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24553489 |
| Web of Science KeyUT | 000331592800008 |
| JaLCDOI | 10.18926/AMO/52143 |
|---|---|
| フルテキストURL | 68_1_43.pdf |
| 著者 | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
| 抄録 | The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p＝0.7709, women:p＝0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese. |
| キーワード | proteinuria estimated glomerular filtration rate (eGFR) lifestyle modification |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-02 |
| 巻 | 68巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 43 |
| 終了ページ | 46 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24553488 |
| Web of Science KeyUT | 000331592800007 |
| JaLCDOI | 10.18926/AMO/52142 |
|---|---|
| フルテキストURL | 68_1_35.pdf |
| 著者 | Araki, Motoo| Jeong, Wooju| Park, Sung Yul| Lee, Young Hoon| Nasu, Yasutomo| Kumon, Hiromi| Hong, Sung Joon| Rha, Koon Ho| |
| 抄録 | The purpose of this study was to compare the positive surgical margin (PSM) rates of 2 techniques of robot-assisted radical prostatectomy (RARP) for pT2 (localized) prostate cancer. A retrospective analysis was conducted of 361 RARP cases, performed from May 2005 to September 2008 by a single surgeon (KHR) at our institution (Yonsei University College of Medicine). In the conventional technique, the bladder neck was transected first. In the modified ultradissection, the lateral border of the bladder neck was dissected and then the bladder neck was transected while the detrusor muscle of the bladder was well visualized. Perioperative characteristics and outcomes and PSM rates were analyzed retrospectively for pT2 patients (n＝217), focusing on a comparison of those undergoing conventional (n＝113) and modified ultradissection (n＝104) techniques. There was no difference between the conventional and modified ultradissection group in mean age, BMI, PSA, prostate volume, biopsy Gleason score, and DʼAmico prognostic criteria distributions. The mean operative time was shorter (p＜0.001) and the estimated blood loss was less (p＜0.01) in the modified ultradissection group. The PSM rate for the bladder neck was significantly reduced by modified ultradissection, from 6.2% to 0% (p＜0.05). In conclusion, modified ultradissection reduces the PSM rate for the bladder neck. |
| キーワード | robot-assisted radical prostatectomy prostate cancer surgery surgical margin technique |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-02 |
| 巻 | 68巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 35 |
| 終了ページ | 41 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24553487 |
| Web of Science KeyUT | 000331592800006 |
| JaLCDOI | 10.18926/AMO/52140 |
|---|---|
| フルテキストURL | 68_1_23.pdf |
| 著者 | Ueno, Tsuyoshi| Toyooka, Shinichi| Fukazawa, Takuya| Kubo, Takafumi| Soh, Junichi| Asano, Hiroaki| Muraoka, Takayuki| Tanaka, Norimitsu| Maki, Yuho| Shien, Kazuhiko| Furukawa, Masashi| Sakaguchi, Masakiyo| Yamamoto, Hiromasa| Tsukuda, Kazunori| Miyoshi, Shinichiro| |
| 抄録 | The microRNA-34s (miR-34s) have p53 response elements in their 5ʼ-flanking regions and demonstrate tumor-suppressive functions. In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. We subcutaneously transplanted NCI-H290, a human MPM cell line, into BALB/C mice and injected adenovirus vector expressing miR-34b/c, luciferase driven by the cytomegalovirus promoter (Ad-miR-34b/c or Ad-Luc), or PBS control into tumors over 5mm in diameter. A statistically significant growth inhibition of the tumor volume was observed in the Ad-miR-34b/c group from day 6 onward compared to the Ad-Luc group. The inhibition rate of Ad-miR-34b/c, compared to the tumor volume treated with Ad-Luc, was 58.6% on day 10 and 54.7% on day13. Our results indicate that adenovirus-mediated miR-34b/c gene therapy could be useful for the clinical treatment of MPM. |
| キーワード | mesothelioma microRNA microRNA-34b/c p53 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-02 |
| 巻 | 68巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 23 |
| 終了ページ | 26 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24553485 |
| Web of Science KeyUT | 000331592800004 |