検索結果 - 岡山大学学術成果リポジトリ

Optimising the oral midazolam dose for premedication in people with intellectual disabilities and/or autism spectrum disorder

フルテキストURL	fulltext.pdf
著者	Higuchi, Hitoshi\| Miyake, Kota\| Miyake, Saki\| Fujimoto, Maki\| Nishioka, Yukiko\| Maeda, Shigeru\| Miyawaki, Takuya\|
キーワード	autism spectrum disorder intellectual disabilities oral midazolam premedication sedation
発行日	2024-06-11
出版物タイトル	Journal of Applied Research in Intellectual Disabilities
巻	37巻
号	4号
出版者	Wiley
開始ページ	e13265
ISSN	1360-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Author(s).
論文のバージョン	publisher
PubMed ID	38859732
DOI	10.1111/jar.13265
Web of Science KeyUT	001242656000001
関連URL	isVersionOf https://doi.org/10.1111/jar.13265

Postnatal longitudinal analysis of serum nitric oxide and eosinophil counts in extremely preterm infants

フルテキストURL	fulltext.pdf
著者	Watanabe, Hirokazu\| Washio, Yosuke\| Tamai, Kei\| Morimoto, Daisaku\| Okamura, Tomoka\| Yoshimoto, Junko\| Nakanishi, Hidehiko\| Kageyama, Misao\| Uchiyama, Atsushi\| Tsukahara, Hirokazu\| Kusuda, Satoshi\|
キーワード	eosinophils extremely preterm infant nitric oxide relative adrenal insufficiency
発行日	2024-05
出版物タイトル	Pediatrics & Neonatology
巻	65巻
号	3号
出版者	Elsevier Taiwan
開始ページ	276
終了ページ	281
ISSN	1875-9572
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Taiwan Pediatric Association.
論文のバージョン	publisher
PubMed ID	37989707
DOI	10.1016/j.pedneo.2023.08.006
Web of Science KeyUT	001248036200001
関連URL	isVersionOf https://doi.org/10.1016/j.pedneo.2023.08.006

Bacterial DNA and serum IgG antibody titer assays for assessing infection of human-pathogenic and dog-pathogenic Porphyromonas species in dogs

フルテキストURL	fulltext.pdf
著者	Tai-Tokuzen, Masako\| Ito, Takashi\| Tamura, Kazuya\| Hirayama, Haruko\| Ogawa, Hirohito\| Nakamura, Shin\| Okubo, Keisuke\| Omori, Kazuhiro\| Yamamoto, Tadashi\| Mominoki, Katsumi\| Takashiba, Shogo\|
キーワード	Cross infection Human and dog Periodontal disease Porphyromonas gingivalis Porphyromonas gulae Detection assay
発行日	2024-06-15
出版物タイトル	Heliyon
巻	10巻
号	11号
出版者	Elsevier
開始ページ	e31872
ISSN	2405-8440
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Authors
論文のバージョン	publisher
DOI	10.1016/j.heliyon.2024.e31872
Web of Science KeyUT	001247098300003
関連URL	isVersionOf https://doi.org/10.1016/j.heliyon.2024.e31872

In Vitro Study of Tumor-Homing Peptide-Modified Magnetic Nanoparticles for Magnetic Hyperthermia

フルテキストURL	fulltext.pdf
著者	Zhou, Shengli\| Tsutsumiuchi, Kaname\| Imai, Ritsuko\| Miki, Yukiko\| Kondo, Anna\| Nakagawa, Hiroshi\| Watanabe, Kazunori\| Ohtsuki, Takashi\|
キーワード	tumor-homing peptide magnetic hyperthermia magnetic nanoparticles ferroptosis tumor-specific delivery
発行日	2024-06-03
出版物タイトル	Molecules
巻	29巻
号	11号
出版者	MDPI
開始ページ	2632
ISSN	1420-3049
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by the authors.
論文のバージョン	publisher
PubMed ID	38893510
DOI	10.3390/molecules29112632
Web of Science KeyUT	001245732000001
関連URL	isVersionOf https://doi.org/10.3390/molecules29112632

Anti-HMGB1 mAb Therapy Reduces Epidural Hematoma Injury

フルテキストURL	fulltext.pdf
著者	Gao, Shangze\| Wang, Dengli\| Liu, Keyue\| Tomono, Yasuko\| Fu, Li\| Gao, Yuan\| Takahashi, Yohei\| Yata, Mariko\| Nishibori, Masahiro\|
キーワード	epidural hematoma HMGB1 inflammatory response
発行日	2024-05-28
出版物タイトル	International Journal of Molecular Sciences
巻	25巻
号	11号
出版者	MDPI
開始ページ	5889
ISSN	1661-6596
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by the authors.
論文のバージョン	publisher
PubMed ID	38892076
DOI	10.3390/ijms25115889
Web of Science KeyUT	001245280300001
関連URL	isVersionOf https://doi.org/10.3390/ijms25115889

Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus

フルテキストURL	fulltext.pdf
著者	Uchida-Fukuhara, Yoko\| Shimamura, Shigeru\| Sawafuji, Rikai\| Nishiuchi, Takumi\| Yoneda, Minoru\| Ishida, Hajime\| Matsumura, Hirofumi\| Tsutaya, Takumi\|
備考	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-55779-y\|
発行日	2024-03-11
出版物タイトル	Scientific Reports
巻	14巻
号	1号
出版者	Nature Portfolio
開始ページ	5938
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38467689
DOI	10.1038/s41598-024-55779-y
Web of Science KeyUT	001182621300059
関連URL	isVersionOf https://doi.org/10.1038/s41598-024-55779-y

PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer

フルテキストURL	fulltext.pdf
著者	Thu, Yin Min\| Suzawa, Ken\| Tomida, Shuta\| Ochi, Kosuke\| Tsudaka, Shimpei\| Takatsu, Fumiaki\| Date, Keiichi\| Matsuda, Naoki\| Iwata, Kazuma\| Nakata, Kentaro\| Shien, Kazuhiko\| Yamamoto, Hiromasa\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Toyooka, Shinichi\|
発行日	2024-05-17
出版物タイトル	PLoS ONE
巻	19巻
号	5号
出版者	Public Library of Science
開始ページ	e0300644
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Thu et al.
論文のバージョン	publisher
PubMed ID	38758826
DOI	10.1371/journal.pone.0300644
Web of Science KeyUT	001227109100078
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0300644

Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis

フルテキストURL	fulltext.pdf
著者	Jiang, Fan\| Chen, Youyi\| Tomonobu, Nahoko\| Kinoshita, Rie\| Komalasari, Ni Luh Gede Yoni\| Kasano-Camones, Carlos Ichiro\| Ninomiya, Kazumi\| Murata, Hitoshi\| Yamamoto, Ken-Ichi\| Gohara, Yuma\| Ochi, Toshiki\| Ruma, I. Made Winarsa\| Sumardika, I. Wayan\| Zhou, Jin\| Honjo, Tomoko\| Sakaguchi, Yoshihiko\| Yamauchi, Akira\| Kuribayashi, Futoshi\| Futami, Junichiro\| Kondo, Eisaku\| Inoue, Yusuke\| Toyooka, Shinichi\| Sakaguchi, Masakiyo\|
キーワード	breast cancer invasion lysyl oxidase NF-κB MMP9
発行日	2024-05-28
出版物タイトル	Frontiers in Oncology
巻	14巻
出版者	Frontiers Media
開始ページ	1371307
ISSN	2234-943X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Jiang, Chen, Tomonobu, Kinoshita, Komalasari, Kasano-Camones, Ninomiya, Murata, Yamamoto, Gohara, Ochi, Ruma, Sumardika, Zhou, Honjo, Sakaguchi, Yamauchi, Kuribayashi, Futami, Kondo, Inoue, Toyooka and Sakaguchi.
論文のバージョン	publisher
PubMed ID	38863623
DOI	10.3389/fonc.2024.1371307
Web of Science KeyUT	001242409800001
関連URL	isVersionOf https://doi.org/10.3389/fonc.2024.1371307

Circadian Rhythms Fluctuate the Treatment Effects of Intravesical Treatments on Rat Urinary Frequency Models

フルテキストURL	fulltext.pdf
著者	Watanabe, Tomofumi\| Sadahira, Takuya\| Tominaga, Yusuke\| Maruyama, Yuki\| Nagasaki, Naoya\| Sekito, Takanori\| Edamura, Kohei\| Watanabe, Toyohiko\| Araki, Motoo\| Watanabe, Masami\|
発行日	2024-05-28
出版物タイトル	Veterinary Medicine International
巻	2024巻
出版者	Hindawi
開始ページ	6505595
ISSN	2090-8113
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2024 Tomofumi Watanabe et al.
論文のバージョン	publisher
PubMed ID	38836165
DOI	10.1155/2024/6505595
Web of Science KeyUT	001242506200002
関連URL	isVersionOf https://doi.org/10.1155/2024/6505595

SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes

フルテキストURL	fulltext.pdf
著者	Wang, Tianyi\| Gao, Tong\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
キーワード	autophagy mitophagy SPRED proteins MAPK/ERK mTOR hepatocellular carcinoma
発行日	2024-06-06
出版物タイトル	International Journal of Molecular Sciences
巻	25巻
号	11号
出版者	MDPI
開始ページ	6269
ISSN	1661-6596
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2024 by the authors.
論文のバージョン	publisher
DOI	10.3390/ijms25116269
Web of Science KeyUT	001245555700001
関連URL	isVersionOf https://doi.org/10.3390/ijms25116269

Realization of nodal-ring semimetal in pressurized black phosphorus

フルテキストURL	fulltext.pdf
著者	Akiba, Kazuto\| Akahama, Yuichi\| Tokunaga, Masashi\| Kobayashi, Tatsuo C.\|
発行日	2024-05-03
出版物タイトル	Physical Review B
巻	109巻
号	20号
出版者	American Physical Society (APS)
開始ページ	L201103
ISSN	2469-9950
NCID	AA11187113
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2024 American Physical Society
論文のバージョン	publisher
DOI	10.1103/physrevb.109.l201103
Web of Science KeyUT	001238896400003
関連URL	isVersionOf https://doi.org/10.1103/physrevb.109.l201103

Switchable synthesis of 3-aminoindolines and 2′-aminoarylacetic acids using Grignard reagents and 3-azido-2-hydroxyindolines

フルテキストURL	fulltext20240618-01.pdf
著者	Yamashiro, Toshiki\| Abe, Takumi\|
備考	This is an accepted manuscript published by The Royal Society of Chemistry.\| This fulltext file will be available in May 2025.\|
発行日	2024
出版物タイトル	Chemical Communications
巻	60巻
号	52号
出版者	Royal Society of Chemistry (RSC)
開始ページ	6615
終了ページ	6618
ISSN	1359-7345
NCID	AA11071130
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Royal Society of Chemistry 2024
論文のバージョン	author
PubMed ID	38847113
DOI	10.1039/d4cc01448k
Web of Science KeyUT	001240225400001
関連URL	isVersionOf https://doi.org/10.1039/d4cc01448k

An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function

フルテキストURL	fulltext.pdf
著者	Li, Yuying\| Wang, Qiong\| Jia, Huimin\| Ishikawa, Kazuya\| Kosami, Ken-Ichi\| Ueba, Takahiro\| Tsujimoto, Atsumi\| Yamanaka, Miki\| Yabumoto, Yasuyuki\| Miki, Daisuke\| Sasaki, Eriko\| Fukao, Yoichiro\| Fujiwara, Masayuki\| Kaneko-Kawano, Takako\| Tan, Li\| Kojima, Chojiro\| Wing, Rod A.\| Sebastian, Alfino\| Nishimura, Hideki\| Fukada, Fumi\| Niu, Qingfeng\| Shimizu, Motoki\| Yoshida, Kentaro\| Terauchi, Ryohei\| Shimamoto, Ko\| Kawano, Yoji\|
備考	The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48943-5\|
発行日	2024-05-30
出版物タイトル	Nature Communications
巻	15巻
号	1号
出版者	Nature Portfolio
開始ページ	4610
ISSN	2041-1723
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38816417
DOI	10.1038/s41467-024-48943-5
Web of Science KeyUT	001236316700012
関連URL	isVersionOf https://doi.org/10.1038/s41467-024-48943-5

Photoinduced dynamics during electronic transfer from narrow to wide bandgap layers in one-dimensional heterostructured materials

フルテキストURL	fulltext.pdf
著者	Saida, Yuri\| Gauthier, Thomas\| Suzuki, Hiroo\| Ohmura, Satoshi\| Shikata, Ryo\| Iwasaki, Yui\| Noyama, Godai\| Kishibuchi, Misaki\| Tanaka, Yuichiro\| Yajima, Wataru\| Godin, Nicolas\| Privault, Gael\| Tokunaga, Tomoharu\| Ono, Shota\| Koshihara, Shin-Ya\| Tsuruta, Kenji\| Hayashi, Yasuhiko\| Bertoni, Roman\| Hada, Masaki\|
備考	The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48880-3\|
発行日	2024-05-30
出版物タイトル	Nature Communications
巻	15巻
号	1号
出版者	Nature Portfolio
開始ページ	4600
ISSN	2041-1723
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38816382
DOI	10.1038/s41467-024-48880-3
Web of Science KeyUT	001236316700036
関連URL	isVersionOf https://doi.org/10.1038/s41467-024-48880-3

Calcification of a Hydrophilic Acrylic Intraocular Lens after Glaucoma Surgery

JaLCDOI	10.18926/AMO/67206
フルテキストURL	78_3_295.pdf
著者	Okamoto, Sara\| Shiode, Yusuke\| Kimura, Shuhei\| Hosokawa, Mio\| Matoba, Ryo\| Kanzaki, Yuki\| Kindo, Hiroya\| Morita, Tetsuro\| Tsuji, Akihiro\| Takahashi, Kosuke\| Morizane, Yuki\|
抄録	A Japanese woman in her 70s was referred to our hospital for the evaluation and treatment of high intraocular pressure (IOP) in her right eye. She had undergone bilateral cataract surgeries and the insertion of hydrophilic acrylic intraocular lenses (IOLs). We performed trabeculotomy and trabeculectomy to lower her right IOP; thereafter, a circular opacity was observed on the right eye’s IOL surface. We removed the right IOL because that eye’s vision had decreased due to IOL opacification. The analysis of the removed IOL revealed that the main opacity component was calcium phosphate. This is the first post-glaucoma-surgery IOL calcification case report.
キーワード	intraocular lens IOL IOL calcification hydrophilic acrylic IOL glaucoma surgery
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	295
終了ページ	300
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902219
Web of Science KeyUT	001267339400001

Organized Chronic Subdural Hematoma (OCSDH) Mimicking Meningioma

JaLCDOI	10.18926/AMO/67204
フルテキストURL	78_3_285.pdf
著者	Hirano, Shuichiro\| Otani, Yoshihiro\| Fujii, Kentaro\| Date, Isao\|
抄録	Organized chronic subdural hematoma (OCSDH) is a relatively rare condition that forms over a longer period of time compared to chronic subdural hematoma and is sometimes difficult to diagnose with preoperative imaging. We resected an intracranial lesion in a 37-year-old Japanese man; the lesion had been increasing in size for >17 years. The preoperative diagnosis based on imaging findings was meningioma; however, pathological findings revealed OCSDH. Clinicians should be aware that OCSDH mimics other tumors and consider surgical strategies for this disease.
キーワード	meningioma organized chronic subdural hematoma
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	285
終了ページ	290
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902217
Web of Science KeyUT	001267351900002

The Role of the Lipid Profile and Oxidative Stress in Fatigue, Sleep Disorders and Cognitive Impairment in Patients with Multiple Sclerosis

JaLCDOI	10.18926/AMO/67201
フルテキストURL	78_3_259.pdf
著者	Vural, Gonul\| Demir, Esra\| Gumusyayla, Sadiye\| Eren, Funda\| Barakli, Serdar\| Neselioglu, Salim\| Erel, Ozcan\|
抄録	The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured. We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients.
キーワード	multiple sclerosis dysfunctional HDL thiol–disulfide homeostasis cognitive decline
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	259
終了ページ	270
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902214
Web of Science KeyUT	001267351000007

Comparative Analysis of Thoracic Rotation Exercises: Range of Motion Improvement in Standing and Quadruped Variants

JaLCDOI	10.18926/AMO/67200
フルテキストURL	78_3_251.pdf
著者	Murofushi, Koji\| Mitomo, Sho\| Hirohata, Kenji\| Furuya, Hidetaka\| Katagiri, Hiroki\| Kaneoka, Koji\| Yagishita, Kazuyoshi\|
抄録	There have been few investigations into the effectiveness of thoracic spine exercises for improving thoracic range of motion (ROM) in any plane. This study assessed the effectiveness of two thoracic spine exercises: one in the quadruped position and one in the thoracic standing position. We determined how these exercises affect thoracic spine mobility ROM over a 2-week intervention period. Thirty-nine healthy participants were enrolled and assigned to a Quadruped Thoracic Rotation group (n=17 participants: 9 females and 8 males) or Flamenco Thoracic Spine Rotation group (n=22: 14 females and 8 males). All participants were administered a KOJI AWARENESSTM screening test, and the initial thoracic spine ROM before intervention exercise was measured in a laboratory setting. Quadruped Thoracic Rotation was performed as the quadruped exercise and Flamenco Thoracic Spine Rotation as the standing exercise. The KOJI AWARENESSTM thoracic spine test and ROM were evaluated on the day after the first exercise session and again after the program. Despite their different approaches to thoracic mobility, the quadruped exercise and standing exercise achieved equivalent improvement in thoracic ROM after 2 weeks. Practitioners have a range of exercise options for enhancing thoracic mobility based on their environmental or task-specific needs.
キーワード	thoracic spine thoracic rotation range of motion exercise intervention
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	251
終了ページ	258
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902213
Web of Science KeyUT	001267351000006

A Multidisciplinary Approach to Hip Fractures: Evaluating Outcomes on Mortality and Secondary Hip Fractures

JaLCDOI	10.18926/AMO/67198
フルテキストURL	78_3_237.pdf
著者	Muraoka, Osamu\| Imai, Norio\| Kuraishi, Tatsuya\| Imai, Makoto\| Fukuhara, Takashi\| Yoshimine, Toshifumi\|
抄録	Fracture liaison services (FLS) have been introduced in Japan and several other countries to reduce medical complications and secondary fractures. We aimed to evaluate the effects of the implementation of an FLS approach on patient outcomes during hospitalization at our hospital and over a 2-year follow-up post-injury. This retrospective cohort study included patients ≥ 60 years admitted to our hospital for hip fragility fractures between October 1, 2016, and July 31, 2020. Patient groups were defined as those treated before (control group, n=238) and after (FLS group, n=196) establishment of the FLS protocol at our institution. The two groups were compared in terms of time to surgery, length of hospital stay, and the incidence of complications after admission, including secondary hip fracture and mortality rates. The follow-up period was 24 months. FLS focuses on early surgery within 48 h of injury and assessing osteoporosis treatment before injury to guide post-discharge anti-osteoporosis medication. FLS reduced the length of hospital stay (p<0.001) and the prevalence of complications after admission (p<0.001), particularly cardiovascular disease, and it increased adherence to anti-osteoporosis medication. These FLS effects resulted in lower secondary hip fracture and mortality rates at 12 and 24 months post-injury. FLS for fragility hip fractures can improve patient outcomes during hospitalization and over a 2-year follow-up period.
キーワード	fracture liaison services complications after admission secondary hip fracture mortality
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	237
終了ページ	243
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902211
Web of Science KeyUT	001267351000004

Effect of Lipopolysaccharide on the Duration of Zolpidem-Induced Loss of Righting Reflex in Mice

JaLCDOI	10.18926/AMO/67197
フルテキストURL	78_3_227.pdf
著者	Wada, Yudai\| Ushio, Soichiro\| Kitamura, Yoshihisa\| Zamami, Yoshito\| Sendo, Toshiaki\|
抄録	Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression.
キーワード	lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	227
終了ページ	235
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902210
Web of Science KeyUT	001267351000003