検索結果 - 岡山大学学術成果リポジトリ

Effects of Dexmedetomidine on Serum Interleukin-6, Hemodynamic Stability, and Postoperative Pain Relief in Elderly Patients under Spinal Anesthesia

JaLCDOI	10.18926/AMO/54002
フルテキストURL	70_1_37.pdf
著者	Yun, So Hui\| Park, Jong Cook\| Kim, Sang Rim\| Choi, Yun Suk\|
抄録	The beneficial effects of dexmedetomidine (DEX) have not been extensively investigated in elderly patients receiving spinal anesthesia. This study evaluated the effects of intravenous DEX infusion on stress and hemodynamic response, as well as on postoperative analgesia in elderly patients undergoing total knee arthroplasty (TKA). We randomly allocated 45 adult patients to 3 patient groups (n=15 each): uni-saline group patients underwent unilateral TKA with saline administration, uni-DEX group patients underwent unilateral TKA with DEX administration, and bilateral-DEX group patients underwent bilateral TKA with DEX administration. Serum interleukin-6 (IL-6) levels were significantly lower in the bilateral-DEX group than in the uni-saline group 6 and 24h postoperatively, and were negatively correlated with total DEX dosage 24h postoperatively. Bradycardia occurred more frequently in the uni-DEX and bilateral-DEX groups than in the uni-saline group. The total dose of required supplementary analgesics was significantly higher in the uni-saline group than in the uni-DEX and bilateral-DEX groups 6h postoperatively. The results indicate that perioperative intravenous DEX administration decreases postoperative serum IL-6 levels in patients undergoing bilateral TKA, and has a postoperative analgesic effect in patients undergoing unilateral or bilateral TKA.
キーワード	analgesic effect dexmedetomidine hemodynamic response stress response
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-02
巻	70巻
号	1号
出版者	Okayama University Medical School
開始ページ	37
終了ページ	43
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26899608
Web of Science KeyUT	000371288700005

A Long-term Survivor after Congenital Acute Myeloid Leukemia with t(8 ; 16)(p11 ; p13)

JaLCDOI	10.18926/AMO/54001
フルテキストURL	70_1_31.pdf
著者	Hanada, Takae\| Kanamitsu, Kiichiro\| Chayama, Kosuke\| Miyamura, Takako\| Kanazawa, Yui\| Muraoka, Michiko\| Washio, Kana\| Imada, Masahide\| Kageyama, Misao\| Takeuchi, Akihito\| Tamai, Kei\| Oda, Megumi\| Shimada, Akira\|
抄録	The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8 ; 16) (p11 ; p13) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ-CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ-CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ-CBP in the pediatric population might show better prognoses.
キーワード	congenital leukemia AML t(8 ; 16)(p11 ; p13) MOZ-CBP
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-02
巻	70巻
号	1号
出版者	Okayama University Medical School
開始ページ	31
終了ページ	35
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26899607
Web of Science KeyUT	000371288700004

Calcium Phosphate Composition Affects Ureteroscopic Laser Lithotripsy

JaLCDOI	10.18926/AMO/54000
フルテキストURL	70_1_25.pdf
著者	Otsuki, Hideo\| Yoshioka, Takashi\| Shimizu, Toshihiro\| Nakanishi, Yusuke\| Fujio, Kei\| Murao, Wataru\| Uehara, Shinya\| Kikuchi, Hirosato\| Fujio, Koji\|
抄録	The effects of stone composition on transurethral lithotripsy (TUL) have not been sufficiently elucidated. The purpose of this study was to identify how calcium phosphate stone composition impacts TUL. Two hundred eighty-nine cases of semi-rigid and/or flexible TUL for upper urinary tract calculi were reviewed retrospectively. Inclusion criteria were a preoperative assessment by noncontrast computed tomography (NCCT) and a stone composition analysis. Small stones and those without calcium composition were excluded. Stone core radiodensity (SCR) was measured by taking the average of the upper 3 of 5 points in the proximity of the center of the stone on NCCT. Fifty-three patients with calcium phosphate composition (CaP) and 118 patients with calcium oxalate and without phosphate composition were eligible for analysis. SCR was significantly higher in the CaP group (p<0.01). The CaP patient group needed a significantly longer operation time (p=0.014) and more laser energy (p=0.085), and tended to have a lower rate of complete lithotripsy (p=0.096) and higher incidence of postoperative pyelonephritis (p=0.181). Stones containing calcium phosphate are harder, demand more laser energy, and require a longer operating time. NCCT evaluation can estimate stone composition preoperatively, and may be a useful tool for predicting operative outcomes.
キーワード	ureteroscopic lithotripsy stone composition calcium phosphate radiodensity complication
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-02
巻	70巻
号	1号
出版者	Okayama University Medical School
開始ページ	25
終了ページ	29
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26899606
Web of Science KeyUT	000371288700003

The Function of β2-glycoprotein I in Angiogenesis and Its in Vivo Distribution in Tumor Xenografts

JaLCDOI	10.18926/AMO/53999
フルテキストURL	70_1_13.pdf
著者	Arum Tri Wahyuningsih\| Shen, Lianhua\| Kobayashi, Kazuko\| Sasaki, Takanori\| Takenaka, Fumiaki\| Hanada, Takahisa\| Akehi, Masaru\| Akahoshi, Akiya\| Ozeki, Eiichi\| Ando, Eiji\| Matsuura, Eiji\|
抄録	Intact β2-glycoprotein I (iβ2GPI) is a glycoprotein that regulates coagulation and fibrinolysis. Nicked β2GPI (nβ2GPI) possesses an angiogenic property at a relatively low concentration, and an antiangiogenic property at a high concentration. Here we investigated the functions of βi 2GPI and nβ2GPI in vascular endothelial growth factor (VEGF)-A-induced endothelial cell proliferation and tube formation. We used noninvasive PET imaging to analyze the in vivo distribution of intravenously injected β2GPI variants in tumor lesions in mice. iβ2GPI was incubated with plasmin to obtain nβ2GPI, and its N-terminal sequence was analyzed. nβ2GPI had at least one other cleavage site upstream of the β2GPIʼs domain V, whereas the former plasmin-cleavage site locates between K317 and T318. Both of intact and nicked β2GPI significantly inhibited the VEGF-A-induced cell proliferation and the tube formation of human umbilical vein endothelial cells (HUVECs). PET imaging visualized considerably distributed intensities of all tested β2GPI variants in tumor lesions of pancreatic tumor cell-xenografts. These results indicate that β2GPI may be physiologically and pathophysiologically important in the regulation of not only coagulation and fibrinolysis, but also angiogenesis.
キーワード	β2-glycoprotein I (β2GPI) angiogenesis vascular endothelial growth factor-A (VEGF-A) positron emission tomography (PET) imaging
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-02
巻	70巻
号	1号
出版者	Okayama University Medical School
開始ページ	13
終了ページ	24
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26899605
Web of Science KeyUT	000371288700002

Nuclear Hormone Receptor Expression in Mouse Kidney and Renal Cell Lines

著者	Ogawa, Daisuke\| Eguchi, Jun\| Wada, Jun\| Terami, Naoto\| Hatanaka, Takashi\| Tachibana, Hiromi\| Nakatsuka, Atsuko\| Sato Horiguchi, Chikage\| Nishii, Naoko\| Makino, Hirofumi\|
発行日	2014-01-22
出版物タイトル	PLOS ONE
巻	9巻
号	1号
資料タイプ	学術雑誌論文

Entecavir Reduces Hepatocarcinogenesis in Chronic Hepatitis B Patients

JaLCDOI	10.18926/AMO/53996
フルテキストURL	70_1_1.pdf
著者	Yasunaka, Tetsuya\| Ikeda, Fusao\| Wada, Nozomu\| Morimoto, Yuki\| Fujioka, Shin-ichi\| Toshimori, Junichi\| Kobashi, Haruhiko\| Kariyama, Kazuya\| Morimoto, Yoichi\| Takayama, Hiroki\| Seno, Tomonori\| Takaguchi, Koichi\| Moriya, Akio\| Miyatake, Hirokazu\| Okamoto, Ryoichi\| Yabushita, Kazuhisa\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
抄録	Chronic hepatitis B (CHB) leads to cirrhosis and hepatocellular carcinoma (HCC). With a cohort of 1,206 CHB patients who visited Okayama University Hospital and related hospitals in 2011 and 2012, we compared the incidence rates of HCC among the patients grouped by age, hepatitis B virus (HBV) DNA, hepatitis B e antigen (HBeAg), and treatment. HCCs were observed in 115 patients with the median observation period of 1,687 days. Among the HCC patients aged ≥ 35 years, HBV DNA ≥ 4 log copies/mL and positive HBeAg at diagnosis (n=184), the HCC incidence rate was 8.4% at 5 years in the entecavir (ETV)-treated patients, 21.8% in the lamivudine (LVD)-treated patients, and 26.4% among the patients not treated with drugs. The cumulative HCC incidence was significantly reduced in the ETV-treated patients compared to those treated with LVD or not treated (p=0.013). Among the patients aged ≥ 35 years with HBV DNA ≥ 4 log copies/mL and negative HBeAg (n=237), the cumulative HCC incidence was 14.6% in 5 years in ETV group and 13.9% among those not treated with a drug (p>0.05). Only small numbers of HCCs occurred in other patients. In CHB patients aged≥35 years with HBV DNA ≥4 log copies/mL and positive HBeAg, ETV treatment is recommended for the suppression of HCC development.
キーワード	entecavir hepatitis B virus lamivudine hepatocellular carcinoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-02
巻	70巻
号	1号
出版者	Okayama University Medical School
開始ページ	1
終了ページ	12
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26899604
Web of Science KeyUT	000371288700001

Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis

著者	Nakatsuka, Atsuko\| Matsuyama, Makoto\| Yamaguchi, Satoshi\| Katayama, Akihiro\| Eguchi, Jun\| Murakami, Kazutoshi\| Teshigawara, Sanae\| Ogawa, Daisuke\| Wada, Nozomu\| Yasunaka, Tetsuya\| Ikeda, Fusao\| Takaki, Akinobu\| Watanabe, Eijiro\| Wada, Jun\|
発行日	2016-02-17
出版物タイトル	Scientific Reports
巻	6巻
資料タイプ	学術雑誌論文

Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells

著者	Yoshimura, Teizo\| Howard, O. M. Zack\| Ito, Toshihiro\| Kuwabara, Masaki\| Matsukawa, Akihiro\| Chen, Keqiang\| Liu, Ying\| Liu, Mingyong\| Oppenheim, Joost J.\| Wang, Ji Ming\|
発行日	2013-03-18
出版物タイトル	PLOS ONE
巻	8巻
号	3号
資料タイプ	学術雑誌論文

Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice

著者	Subramanian, Venkateswaran\| Moorleghen, Jessica　J.\| Balakrishnan, Anju\| Howatt, Deborah　A.\| Chishti, Athar H.\| Uchida, Haruhito A.\|
発行日	2013-08-19
出版物タイトル	PLOS ONE
巻	8巻
号	8号
資料タイプ	学術雑誌論文

Practical Application of Methanol-Mediated Mutualistic Symbiosis between Methylobacterium Species and a Roof Greening Moss, Racomitrium japonicum

著者	Tani, Akio\| Takai, Yuichiro\| Suzukawa, Ikko\| Akita, Motomu\| Murase, Haruhiko\| Kimbara, Kazuhide\|
発行日	2012-03-29
出版物タイトル	PLOS ONE
巻	7巻
号	3号
資料タイプ	学術雑誌論文

奥付

著者	岡山大学農学部附属山陽圏フィールド科学センター\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	その他

センター報告投稿要領

著者	岡山大学農学部附属山陽圏フィールド科学センター\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	その他

資料

著者	岡山大学農学部附属山陽圏フィールド科学センター\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	その他

運営

著者	岡山大学農学部附属山陽圏フィールド科学センター\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	その他

地域連携

著者	岡山大学農学部附属山陽圏フィールド科学センター\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	その他

間欠冷蔵処理回数がイチゴ‘女峰’の開花に及ぼす影響

著者	吉田裕一\| 後藤丹十郎\| 安場健一郎\| 田中義行\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	紀要論文

挿し苗時期，苗の大きさとクラウンの深さがイチゴ‘さちのか’ の花芽分化と開花に及ぼす影響

著者	吉田裕一\| 宮地大介\| 後藤丹十郎\| 田中義行\| 安場健一郎\| 本村翔\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	紀要論文

試験研究

著者	岡山大学農学部附属山陽圏フィールド科学センター\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	その他

教育

著者	岡山大学農学部附属山陽圏フィールド科学センター\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	その他

著者	岡山大学農学部附属山陽圏フィールド科学センター\|
発行日	2015-04-01
出版物タイトル	岡山大学農学部センター報告
巻	37巻
資料タイプ	その他