検索結果 13651 件
| フルテキストURL | K0005538_abstract_review.pdf K0005538_summary.pdf |
|---|---|
| 著者 | 上杉 英里| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5538号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（理学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005510 abstract_review.pdf K0005510_summary.pdf K0005510_fulltext.pdf |
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| 著者 | 竹内 真由| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5510号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（歯学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005509 abstract_review.pdf K0005509_summary.pdf K0005509_fulltext.pdf |
|---|---|
| 著者 | 川端 勇也| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5509号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（歯学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005508 abstract_review.pdf K0005508_summary.pdf K0005508_fulltext.pdf |
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| 著者 | 片岡 広太| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5508号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（歯学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005498 abstract_review.pdf K0005498_summary.pdf K0005498_fulltext.pdf K0005498_other.pdf |
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| 著者 | 田村 庄平| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5498号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（歯学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| フルテキストURL | K0005475_abstract_review.pdf K0005475_summary.pdf K0005475_fulltext.pdf |
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| 著者 | 鍛治園 誠| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5475号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005470_abstract_review.pdf K0005470_summary.pdf K0005470_fulltext.pdf |
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| 著者 | 原 暁生| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5470号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005468_abstract_review.pdf K0005468_summary.pdf K0005468_fulltext.pdf K0005468_others.pdf |
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| 著者 | 垣尾 勇樹| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5468号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005463_abstract_review.pdf K0005463_summary.pdf K0005463_fulltext.pdf |
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| 著者 | 樋口 裕二| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5463号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | http://creativecommons.org/licenses/by/4.0 |
| フルテキストURL | K0005454_abstract_review.pdf K0005454_summary.pdf K0005454_fulltext.pdf |
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| 著者 | 山根 健太郎| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5454号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005450_abstract_review.pdf K0005450_summary.pdf K0005450_fulltext.pdf |
|---|---|
| 著者 | 花岡 義行| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5450号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005449_abstract_review.pdf K0005449_summary.pdf K0005449_fulltext.pdf |
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| 著者 | 柴田 敬| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5449号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| フルテキストURL | K0005447_abstract_review.pdf K0005447_summary.pdf K0005447_fulltext.pdf |
|---|---|
| 著者 | 𦚰 隆博| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5447号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005440_abstract_review.pdf K0005440_summary.pdf K0005440_fulltext.pdf |
|---|---|
| 著者 | 加持 達弥| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5440号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| JaLCDOI | 10.18926/AMO/54987 |
|---|---|
| フルテキストURL | 71_2_179.pdf |
| 著者 | Nosaka, Nobuyuki| Tsukahara, Kohei| Knaup, Emily| Yabuuchi, Toshihiko| Kikkawa, Tomonobu| Fujii, Yosuke| Yashiro, Masato| Yasuhara, Takao| Okada, Ayumi| Ugawa, Toyomu| Nakao, Atsunori| Tsukahara, Hirokazu| Date, Isao| |
| 抄録 | Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management. |
| キーワード | cerebral perfusion encephalopathy child intracranial pressure neurological intensive care |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 179 |
| 終了ページ | 180 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420900 |
| JaLCDOI | 10.18926/AMO/54983 |
|---|---|
| フルテキストURL | 71_2_143.pdf |
| 著者 | Kataoka, Hiroaki| Miyatake, Nobuyuki| Kitayama, Naomi| Murao, Satoshi| Tanaka, Satoshi| |
| 抄録 | We compared the toe pinch force in men with and without type 2 diabetes mellitus (T2DM). Sixty-eight male T2DM patients and 35 apparently healthy men matched for age, sex, and body mass index (BMI) were enrolled in this cross-sectional study. We compared the toe pinch force between the subjects with and without T2DM, and we evaluated the effect of diabetic polyneuropathy on toe pinch force in the patients. The toe pinch force of the T2DM patients was significantly lower than that of the subjects without diabetes (3.12±1.22 kg vs. 4.40±1.19 kg, p<0.001). Multiple regression analysis showed that T2DM was a determinant of reduced toe pinch force. In addition, the toe pinch force of patients with diabetic polyneuropathy was significantly lower than that of patients without diabetic polyneuropathy (2.31±0.93 kg vs. 3.70±1.07 kg, p<0.001). Multiple regression analysis showed that diabetic polyneuropathy was a determinant of the toe pinch force in men with T2DM, even after adjusting for age, BMI, HbA1c, and duration of diabetes. Reduced toe pinch force is a fundamental feature of motor dysfunction in men with T2DM, and diabetic polyneuropathy might be associated with toe pinch force in these patients. |
| キーワード | type 2 diabetes mellitus toe pinch force diabetic polyneuropathy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 143 |
| 終了ページ | 149 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420896 |
| JaLCDOI | 10.18926/AMO/54982 |
|---|---|
| フルテキストURL | 71_2_135.pdf |
| 著者 | Mori, Akihiro| Watanabe, Masami| Sadahira, Takuya| Kobayashi, Yasuyuki| Ariyoshi, Yuichi| Ueki, Hideo| Wada, Koichiro| Ochiai, Kazuhiko| Li, Shun-Ai| Nasu, Yasutomo| |
| 抄録 | The cluster of differentiation 147 (CD147), also known as EMMPRIN, is a key molecule that promotes cancer progression. We previously developed an adenoviral vector encoding a tumor suppressor REIC/Dkk-3 gene (Ad-REIC) for cancer gene therapy. The therapeutic effects are based on suppressing the growth of cancer cells, but, the underlying molecular mechanism has not been fully clarified. To elucidate this mechanism, we investigated the effects of Ad-REIC on the expression of CD147 in LNCaP prostate cancer cells. Western blotting revealed that the expression of CD147 was significantly suppressed by Ad-REIC. Ad-REIC also suppressed the cell growth of LNCaP cells. Since other researchers have demonstrated that phosphorylated mitogen-activated protein kinases (MAPKs) and c-Myc protein positively regulate the expression of CD147, we investigated the correlation between the CD147 level and the activation of MAPK and c-Myc expression. Unexpectedly, no positive correlation was observed between CD147 and its possible regulators, suggesting that another signaling pathway was involved in the downregulation of CD147. This is the first study to show the downregulation of CD147 by Ad-REIC in prostate cancer cells. At least some of the therapeutic effects of Ad-REIC may be due to the downregulation of the cancer-progression factor, CD147. |
| キーワード | prostate cancer REIC/Dkk-3 CD147 cell growth p38 MAP kinase |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 135 |
| 終了ページ | 142 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420895 |
| JaLCDOI | 10.18926/AMO/54980 |
|---|---|
| フルテキストURL | 71_2_119.pdf |
| 著者 | Oda, Yoshiaki| Takigawa, Tomoyuki| Sugimoto, Yoshihisa| Tanaka, Masato| Akazawa, Hirofumi| Ozaki, Toshifumi| |
| 抄録 | Patients with cerebral palsy (CP) frequently present with scoliosis; however, the pattern of curve progression is difficult to predict. We aimed to clarify the natural course of the progression of scoliosis and to identify scoliosis predictors. This was a retrospective, single-center, observational study. Total of 92 CP patients from Asahikawasou Ryouiku Iryou Center in Okayama, Japan were retrospectively analyzed. Cobb angle, presence of hip dislocation and pelvic obliquity, and Gross Motor Function Classification System (GMFCS) were investigated. Severe CP was defined as GMFCS level IV or V. The mean observation period was 10.7 years. Thirtyfour severe CP patients presented with scoliosis and were divided into 3 groups based on their clinical courses: severe, moderate and mild. The mean Cobb angles at the final follow-up were 129°, 53°, and 13° in the severe, moderate, and mild groups, respectively. The average progressions from 18 to 25 years were 2.7°/year, 0.7°/year, and 0.1°/year in the severe, moderate, and mild curve groups, respectively. We observed the natural course of scoliosis and identified 3 courses based on the Cobb angle at 15 and 18 years of age. This method of classification may help clinicians predict the patients’ disease progression. |
| キーワード | severe cerebral palsy scoliosis natural course Cobb angle progression |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 119 |
| 終了ページ | 126 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420893 |
| JaLCDOI | 10.18926/AMO/54979 |
|---|---|
| フルテキストURL | 71_2_113.pdf |
| 著者 | Morikawa Tatsuya| Okabayashi Takehiro| Shima, Yasuo| Sumiyoshi, Tatsuaki| Kozuki, Akihito| Saisaka, Yuichi| Tokumaru, Teppei| Sui, Kenta| Iwata, Jun| Matsumoto, Manabu| Morita, Sojiro| Nishioka, Yutaka| |
| 抄録 | Some clinicians have proposed a relationship between gallbladder (GB) cancer and adenomyomatosis (ADM) of the gallbladder, although the latter condition is not considered to have malignant potential. We retrospectively reviewed the surgical pathology database of patients who underwent resection for ADM of the gallbladder at our institution from March 2005 to May 2015. In total, 624 patients underwent surgical resection of the gallbladder with Rokitansky-Aschoff sinuses. Of these cases, 93 were pathologically diagnosed with ADM of the gallbladder, with 44 (47.3%) classified macroscopically as fundal-type ADM, 26 (28.0%) as segmental type, and 23 (24.7%) as diffuse-type ADM. In 3 of the 93 (3.2%) resected specimens, early-stage GB carcinoma was detected, although preoperative imaging did not suggest a malignant neoplasm of the gallbladder in any of these patients. GB cancer subsequently developed in the mucosa of the fundal compartment distal to the annular stricture of the segmental-type ADM in 2 of these patients and against the background of the fundal-type ADM in 1 patient. This study revealed the difficulty of early diagnosis of primary GB cancer in the setting of concurrent ADM, and clinicians should be aware of this frequent coexistence. |
| キーワード | adenomyomatosis gallbladder carcinoma Rokitansky-Aschoff sinuses surgery carcinogenesis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 113 |
| 終了ページ | 118 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420892 |
| JaLCDOI | 10.18926/AMO/54976 |
|---|---|
| フルテキストURL | 71_2_91.pdf |
| 著者 | Ogawa, Nanako| Sato, Shuhei| Ida, Kentaro| Kato, Katsuya| Ariyoshi, Yuichi| Wada, Koichiro| Nasu, Yasutomo| Kanazawa, Susumu| |
| 抄録 | The aim of this study was to investigate the utility of single-source dual-energy computed tomography (SS-DECT) composition analysis in characterizing different types of urinary stones and differentiating them from phleboliths. This study included 29 patients with urinary stones who were scheduled for surgery. All patients were scanned, first using single-energy computed tomography acquisition and then DECT acquisition on SS-DECT. Dual-energy data were archived to a Gemstone spectral imaging (GSI) viewer (GE Healthcare, Milwaukee, WI, USA). Hounsfield units (HU) and effective atomic numbers (Zeff) were estimated using the GSI viewer. The results of dual-energy analysis were compared with the biochemical constitution of the stones. The chemical analysis determined that the stones included 32 calcium-based, 6 cystine and 1 struvite stone. Both HU and Zeff values were helpful in differentiating calcium-based stones from cystine and struvite stones and phleboliths. The Zeff values of phleboliths were significantly higher than those for struvite and cystine stones, whereas it was difficult to distinguish phleboliths from struvite and cystine stones using the HU values. Composition analysis using SS-DECT is helpful for distinguishing urinary stone types and discriminating phleboliths from urinary stones. Zeff values may be more useful than HU values for differentiating urinary stones from phleboliths. |
| キーワード | single-source dual-energy computed tomography effective atomic number urinary stone phlebolith |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 91 |
| 終了ページ | 96 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420889 |