検索結果 - 岡山大学学術成果リポジトリ

Stem Cell Therapy in Heart Disease: Limitations and Future Possibilities

JaLCDOI	10.18926/AMO/59948
フルテキストURL	74_3_185.pdf
著者	Sano, Toshikazu\| Ishigami, Shuta\| Ito, Tatsuo\| Sano, Shunji\|
抄録	Heart diseases are one of the major causes of morbidity and mortality worldwide. Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. Stem cell therapy has emerged as one option for the treatment of a variety of heart diseases. Although a large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach, the results obtained from these clinical studies are inconsistent, and stem cell-based improvements of heart performance and cardiac remodeling were found to be quite limited. Since the precise mechanisms underlying the therapeutic actions of stem cells are still under debate, researchers have developed a variety of strategies to improve and boost the potency of stem cells in repair. In this review, we summarize both the current therapeutic strategies using stem cells and future directions for enhancing stem cell potency.
キーワード	heart disease stem cell myocardial regeneration
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	185
終了ページ	190
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577015
Web of Science KeyUT	000543363400001
NAID	120006862790

Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome

フルテキストURL	fulltext.pdf
著者	Ogawa-Akiyama, Ayu\| Sugiyama, Hitoshi\| Kitagawa, Masashi\| Tanaka, Keiko\| Kano, Yuzuki\| Mise, Koki\| Otaka, Nozomu\| Tanabe, Katsuyuki\| Morinaga, Hiroshi\| Kinomura, Masaru\| Uchida, Haruhito A.\| Wada, Jun\|
発行日	2020-01-24
出版物タイトル	PLoS ONE
巻	15巻
号	1号
出版者	Public Library of Science
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 Ogawa-Akiyama et al.
論文のバージョン	publisher
PubMed ID	31978139
DOI	10.1371/journal.pone.0228337
Web of Science KeyUT	000534599100142
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0228337

Reference values for the locomotive syndrome risk test quantifying mobility of 8681 adults aged 20–89 years: A cross-sectional nationwide study in Japan

フルテキストURL	fulltext.pdf
著者	Yamada, Keiko\| Ito, Yoichi M.\| Akagi, Masao\| Chosa, Etsuo\| Fuji, Takeshi\| Hirano, Kenichi\| Ikeda, Shinichi\| Ishibashi, Hideaki\| Ishibashi, Yasuyuki\| Ishijima, Muneaki\| Itoi, Eiji\| Iwasaki, Norimasa\| Izumida, Ryoichi\| Kadoya, Ken\| Kamimura, Masayuki\| Kanaji, Arihiko\| Kato, Hiroyuki\| Kishida, Shunji\| Mashima, Naohiko\| Matsuda, Shuichi\| Matsui, Yasumoto\| Matsunaga, Toshiki\| Miyakoshi, Naohisa\| Mizuta, Hiroshi\| Nakamura, Yutaka\| Nakata, Ken\| Omori, Go\| Osuka, Koji\| Uchio, Yuji\| Ryu, Kazuteru\| Sasaki, Nobuyuki\| Sato, Kimihito\| Senda, Masuo\| Sudo, Akihiro\| Takahira, Naonobu\| Tsumura, Hiroshi\| Yamaguchi, Satoshi\| Yamamoto, Noriaki\| Nakamura, Kozo\| Takashi, Ohe\|
発行日	2020-03-12
出版物タイトル	Journal of Orthopaedic Science
出版者	Elsevier
ISSN	09492658
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
PubMed ID	32173180
DOI	10.1016/j.jos.2020.01.011

Mucinous Carcinoma of the Breast: Clinicopathological Features and Long-term Prognosis in Comparison with Invasive Ductal Cancer; A Single Hospital’s 30+-Year Experience

JaLCDOI	10.18926/AMO/58272
フルテキストURL	74_2_137.pdf
著者	Isozaki, Hiroshi\| Yamamoto, Yasuhisa\| Sakai, Kunihiko\| Sho, Tatuo\| Ishihara, Kiyohiro\| Murakami, Shigeki\| Matsumoto, Sasau\| Takama, Takehiro\|
抄録	Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer.
キーワード	breast cancer mucinous carcinoma clinicopathological features long-term prognosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	137
終了ページ	143
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341588
Web of Science KeyUT	000528278500007
NAID	120006839451

Risk of Gynecologic Cancer as Second versus First Primary Cancer in Japan

JaLCDOI	10.18926/AMO/58268
フルテキストURL	74_2_109.pdf
著者	Ogawa, Chikako\| Nakamura, Keiichiro\| Matsuoka, Hirofumi\| Matsubara, Yuko\| Haraga, Junko\| Masuyama, Hisashi\|
抄録	This study aimed to determine whether the risk conferred by gynecologic cancer (GC) as second primary cancer (SPC) differs from that associated with GC as first primary cancer (FPC). We investigated the correlations between FPC/SPC and the characteristics and prognoses of 1,645 GC patients (701 with cervical cancer [CC], 641 with endometrial cancer [EM], and 303 with ovarian cancer [OV]). The χ2 test and the Kaplan–Meier method were used to determine whether FPC/SPC and the characteristics and prognoses of GC patients. Of the SPC patients, 26 (3.7%) had CC, 53 (8.3%) had EM, and 31 (10.2%) had OV. The most common previous cancer type in SPC of GC patients was breast cancer, which was observed in 13 patients (50.0%) with CC, 23 (43.4%) with EM, and 16 (51.6%) with OV. In all patients with CC, EM, and OV as SPC, the stage was significantly associated with recurrence. There were no significant differences in the morbidity or mortality of CC, EM, or OV patients between those with FPC and those with SPC. The risk of SPC development in GC patients varied, ranging from 3.5% (CC) to 10.3% (OV) of patients.
キーワード	second primary cancer gynecologic cancer prognosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	109
終了ページ	114
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341584
Web of Science KeyUT	000528278500003
NAID	120006839447

The hypoglycemia-prevention effect of sensor-augmented pump therapy with predictive low glucose management in Japanese patients with type 1 diabetes mellitus: a short-term study

フルテキストURL	fulltext.pdf
著者	Katayama, Akihiro\| Tone, Atsuhito\| Watanabe, Mayu\| Teshigawara, Sanae\| Miyamoto, Satoshi\| Eguchi, Jun\| Nakatsuka, Atsuko\| Shikata, Kenichi\| Wada, Jun\|
キーワード	Hypoglycemia Predictive low glucose management (PLGM) Type 1 diabetes mellitus (T1DM) Sensor-augmented pump therapy (SAP)
備考	This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13340-019-00408-7.\|
発行日	2019-09-16
出版物タイトル	Diabetology International
巻	11巻
号	2号
出版者	Springer
開始ページ	97
終了ページ	104
ISSN	2190-1678
NCID	AA12503387
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32206479
DOI	10.1007/s13340-019-00408-7
NAID	40022198977
Web of Science KeyUT	000520711100004
関連URL	isVersionOf https://doi.org/10.1007/s13340-019-00408-7

The Prevalence and Characteristics of Older Japanese Adults with Polypharmacy, Based on Regionally Representative Health Insurance Claims Data

JaLCDOI	10.18926/AMO/57951
フルテキストURL	74_1_41.pdf
著者	Amano, Hoichi\| Fujimoto, Kenichi\| Fujimori, Makoto\| Saka, Natsumi\| Nomura, Kyoko\| Tanihara, Shinichi\|
抄録	We aimed to clarify the prevalence of polypharmacy among elderly individuals in Japan. We used the data obtained from a large-scale population-based representative database of health insurance claims in a single prefecture in Japan. We examined all of the outpatient and pharmaceutical health insurance claims for National Health Insurance and those for Late-stage Elderly Health Insurance in Nagasaki Prefecture, Japan between April and June 2016. When two or more claim forms were issued for a patient in a single month, we combined the data and identified the number of prescribed drugs for each person. The definition of polypharmacy is a the prescription of six or more drugs per month. We investigated the prevalence of polypharmacy among the beneficiaries of the two insurance systems. Of the 605,406 beneficiaries of the 2 insurance systems, 121,033 (20.0%) patients with polypharmacy were identified. The prevalence of polypharmacy increased with age, especially among the beneficiaries aged > 85 years, with about half of the beneficiaries having polypharmacy status. About half of the people aged > 85 years in the database had polypharmacy status. When a drug is prescribed to an elderly individual, it is necessary to consider the possibility of polypharmacy-related problems.
キーワード	health insurance claims late-stage elderly health insurance national health insurance Japan polypharmacy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-02
巻	74巻
号	1号
出版者	Okayama University Medical School
開始ページ	41
終了ページ	48
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32099247
Web of Science KeyUT	000516606200006
NAID	120006795618

“Active Guide” Brochure Reduces Sedentary Behavior of Elderly People: A Randomized Controlled Trial

JaLCDOI	10.18926/AMO/57373
フルテキストURL	73_5_427.pdf
著者	Owari, Yutaka\| Suzuki, Hiromi\| Miyatake, Nobuyuki\|
抄録	The aim of this study was to examine in a randomized controlled trial how much the sedentary behavior (sitting time) of community-dwelling elderly Japanese subjects decreased as a result of using the “Active Guide” brochure published by the Ministry of Health, Labour and Welfare (2013) and additional documents related to the benefits of reducing sedentary behavior. A total of 86 elderly people who participated in health-club activities for one year were randomly allocated to two groups. Subjects in the intervention group received explanations of the importance of physical activity using the “Active Guide” brochure (n=42) and additional documents, while subjects in the control group did not (n=44). Physical activity was measured using a triaxial accelerometer for two weeks at baseline and again after one year. After one year of intervention, the difference in the sedentary behavior rate from baseline was −2.2% for the intervention group (n=40) and +2.5% for controls (n=40) (Welch’s t-test, p=0.007). Use of the “Active Guide” brochure and additional documents may reduce the sedentary behavior of community dwelling elderly people in Japan.
キーワード	Active Guide sedentary behavior elderly people randomized controlled trial health promotion
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	427
終了ページ	432
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649369
Web of Science KeyUT	000491886600008

Construction and Characterization of a PGN_0297 Mutant of Porphyromonas gingivalis: Evidence of the Contribution of PGN_0297 to Gingipain Activity

JaLCDOI	10.18926/AMO/56933
フルテキストURL	73_4_315.pdf
著者	Ono, Shintaro\| Nakayama, Masaaki\| Tachibana, Masato\| Abu Saleh Muhammad Shahriar\| Heling, Wang\| Takashiba, Shogo\| Ohara, Naoya\|
抄録	The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains.
キーワード	periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	315
終了ページ	323
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439954

Dynamic Reorganization of Microtubule and Glioma Invasion

JaLCDOI	10.18926/AMO/56930
フルテキストURL	73_4_285.pdf
著者	Otani, Yoshihiro\| Ichikawa, Tomotsugu\| Kurozumi, Kazuhiko\| Date, Isao\|
抄録	Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
キーワード	glioma cytoskeletons invasion microtubules
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	285
終了ページ	297
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439951

Safety of Surgical Treatment for Elderly Patients with Gallbladder Carcinoma

JaLCDOI	10.18926/AMO/56867
フルテキストURL	73_3_241.pdf
著者	Utsumi, Masashi\| Aoki, Hideki\| Nishimura, Seitaro\| Une, Yuta\| Kashima, Hajime\| Kimura, Yuji\| Taniguchi, Fumitaka\| Arata, Takashi\| Katsuda, Koh\| Tanakaya, Kohji\|
抄録	Gallbladder carcinoma (GBC) is a common malignancy with a poor prognosis. With the average life expectancy increasing globally, the incidence of GBC is predicted to increase as well. We investigated the safety and feasibility of surgical treatment for elderly patients with GBC. We retrospectively compared clinical pathological data and treatment outcomes in 45 consecutive GBC patients (23 patients ≥ 75 years [elderly group] and 22 patients < 75 years [younger group]) who underwent curative resection at the Iwakuni Center from January 2008 to December 2017. The proportion of preoperative comorbidities and anticoagulant use was significantly higher in the elderly group. The American Society of Anesthesiologists score was higher in the elderly versus the younger group, and the elderly group had significantly shorter operation times. Reduced activities of daily living was more common in the elderly versus younger group. The percentage of radical resection and overall 3-year survival (66.6% younger vs. 64.4% elderly) were similar between the groups. Controlling Nutritional Status (CONUT) score ≥ 3 and R0 resection were identified as prognostic factors for overall survival rate among all patients. After careful patient selection,
キーワード	elderly patient gallbladder carcinoma prognostic factor surgical treatment
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-06
巻	73巻
号	3号
出版者	Okayama University Medical School
開始ページ	241
終了ページ	246
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31235972

Diagnosing Pancreatic Tumors Using Contrast-enhanced Harmonic Endoscopic Ultrasonography with Sonazoid

JaLCDOI	10.18926/AMO/54513
フルテキストURL	70_4_323.pdf
著者	Yamamoto, Naoki\| Kato, Hironari\| Mizukawa, Sho\| Muro, Shinichiro\| Akimoto, Yutaka\| Uchida, Daisuke\| Tomoda, Takeshi\| Matsumoto, Kazuyuki\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Okada, Hiroyuki\|
抄録	Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) with contrast agent enabled us to assess the hemodynamics closely, despite limited data in pancreatic tumors. We have initiated a prospective, single arm, and non-randomized study to clarify the accuracy and safety of CH-EUS with Sonazoid and time-intensity curve (TIC) analysis for diagnosing benign or malignant pancreatic tumors. A total of 200 patients will undergo CH-EUS and TIC analysis. Receiver operating characteristic (ROC) analysis will be used to determine the optimal parameter cutoff values for TIC analysis. This will clarify whether CH-EUS and TIC can further improve the diagnosis of pancreatic tumors over conventional EUS.
キーワード	CH-EUS pancreatic tumor TIC
Amo Type	Clinical Study Protocols
出版物タイトル	Acta Medica Okayama
発行日	2016-08
巻	70巻
号	4号
出版者	Okayama University Medical School
開始ページ	323
終了ページ	325
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27549682
Web of Science KeyUT	000384748600017

Nuclear dynamics of topoisomerase II beta reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain

著者	Onoda, Akihisa\| Hosoya, Osamu\| Sano, Kuniaki\| Kiyama, Kazuko\| Kimura, Hiroshi\| Kawano, Shinji\| Furuta, Ryohei\| Miyaji, Mary\| Tsutsui, Ken\| Tsutsui, Kimiko M.\|
発行日	2014-07-17
出版物タイトル	Nucleic Acids Research
巻	42巻
号	14号
資料タイプ	学術雑誌論文

The Bright Side and Dark Side of Workplace Social Capital: Opposing Effects of Gender on Overweight among Japanese Employees

著者	Kobayashi, Tomoko\| Suzuki, Etsuji\| Oksanen, Tuula\| Kawachi, Ichiro\| Takao, Soshi\|
発行日	2014-01-31
出版物タイトル	PLoS ONE
巻	9巻
号	1号
資料タイプ	学術雑誌論文

Cutaneous lymphoma in Japan: A nationwide study of 1733 patients

著者	Hamada, Toshihisa\| Iwatsuki, Keiji\|
発行日	2014-01
出版物タイトル	The Journal of Dermatology
巻	41巻
号	1号
資料タイプ	学術雑誌論文

Urinary angiotensinogen is a marker for tubular injuries in patients with type 2 diabetes

著者	Terami, Takahiro\| Wada, Jun\| Inoue, Kentaro\| Nakatsuka, Atsuko\| Ogawa, Daisuke\| Teshigawara, Sanae\| Murakami, Kazutoshi\| Katayama, Akihiro\| Eguchi, Jun\| Makino, Hirofumi\|
発行日	2013-10-22
出版物タイトル	International Journal of Nephrology and Renovascular Disease
巻	6巻
資料タイプ	学術雑誌論文

Low-grade B-cell lymphoma presenting primarily in the bone marrow

著者	Iwatani, Kayoko\| Takata, Katsuyoshi\| Sato, Yasuharu\| Miyata-Takata, Tomoko\| Iwaki, Noriko\| Cui, Wei\| Sawada-Kitamura, Seiko\| Sonobe, Hiroshi\| Tamura, Maiko\| Saito, Katsuhiko\| Miyatani, Katsuya\| Yamasaki, Rie\| Yamadori, Ichiro\| Fujii, Nobuharu\| Terasaki, Yasushi\| Maeda, Yoshinobu\| Tanimoto, Mitsune\| Nakamura, Naoya\| Yoshino, Tadashi\|
発行日	2014-07
出版物タイトル	Human Pathology
巻	45巻
号	7号
資料タイプ	学術雑誌論文

Type D Personality Is Associated with Psychological Distress and Poor Self-Rated Health among the Elderly: A Population-Based Study in Japan

著者	Kasai, Yosuke\| Suzuki, Etsuji\| Iwase, Toshihide\| Doi, Hiroyuki\| Takao, Soshi\|
発行日	2013-10-17
出版物タイトル	PLoS ONE
巻	8巻
号	10号
資料タイプ	学術雑誌論文

Factors Associated with Remission and/or Regression of Microalbuminuria in Type 2 Diabetes Mellitus

JaLCDOI	10.18926/AMO/52789
フルテキストURL	68_4_235.pdf
著者	Ono, Tetsuichiro\| Shikata, Kenichi\| Obika, Mikako\| Miyatake, Nobuyuki\| Kodera, Ryo\| Hirota, Daisyo\| Wada, Jun\| Kataoka, Hitomi\| Ogawa, Daisuke\| Makino, Hirofumi\|
抄録	The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice.
キーワード	microalbuminuria type 2 diabetes mellitus remission regression
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-08
巻	68巻
号	4号
出版者	Okayama University Medical School
開始ページ	235
終了ページ	241
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25145409
Web of Science KeyUT	000340687500005
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/52828

Functional analysis of NPHS1 mutations in Japanese patients

著者	Miyai, Takayuki\| Aya, Kunihiko\| Takaiwa, Masanori\| Yan, Kunimasa\| Sado, Yoshikazu\| Tanaka, Hiroyuki\| Morishima, Tsuneo\|
発行日	2014-02
出版物タイトル	Histology and Histopathology
巻	29巻
号	2号
資料タイプ	学術雑誌論文