検索結果 - 岡山大学学術成果リポジトリ

Cross-feeding between beneficial and pathogenic bacteria to utilize eukaryotic host cell-derived sialic acids and bacteriophages shape the pathogen-host interface milieu

フルテキストURL	fulltext.pdf
著者	Ghadimi, Darab\| Fölster-Holst, Regina\| Blömer, Sophia\| Ebsen, Michael\| Röcken, Christoph\| Uchiyama, Jumpei\| Matsuzaki, Shigenobu\| Bockelmann, Wilhelm\|
キーワード	Bacterial sialidase Inflammation Cytokines Infection Bifidobacteria Phages
発行日	2025-06
出版物タイトル	Experimental and Molecular Pathology
巻	142巻
出版者	Elsevier BV
開始ページ	104967
ISSN	0014-4800
NCID	AA00641168
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Author(s).
論文のバージョン	publisher
PubMed ID	40286772
DOI	10.1016/j.yexmp.2025.104967
Web of Science KeyUT	001481708300001
関連URL	isVersionOf https://doi.org/10.1016/j.yexmp.2025.104967

Bloodstream Infections Caused by Gram-Negative Bacteria in Geriatric Patients: Epidemiology, Antimicrobial Resistance and The Factors Affecting Mortality

JaLCDOI	10.18926/AMO/69148
フルテキストURL	79_4_231.pdf
著者	Kardan, M Enes \| Erdem, Ilknur\| Yildiz, Emre\| Kiraz, Nuri\| Çelikkol, Aliye\|
抄録	Bloodstream infections (BSIs) are an important cause of morbidity and mortality in geriatric patients. We retrospectively analyzed the cases of geriatric patients who developed BSIs due to gram-negative bacteria in order to evaluate the epidemiology, antimicrobial resistance, and the factors affecting mortality. The cases of 110 patients aged ≥ 65 years admitted to our hospital between January 1, 2017, and December 31, 2022 were assessed; 70 (63.6%) of the BSIs were healthcare-associated BSIs. The urinary system was the most common detectable source of infection at 43.6%. The most frequently isolated bacteria were Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, in that order. Carbapenem resistance was detected in 17 patients (15.5%), and extended-spectrum beta-lactamase (ESBL) production from Enterobacterales family members was detected in 37 (51.4%) patients. Multivariate analysis revealed that (i) the probability of mortality in the patients with total bilirubin was increased by approx. sixfold and (ii) the likelihood of mortality for those with a Pitt bacteremia score (PBS) ≥ 4 points was approx. 17 times higher. PBS and simplified qPitt scores can help predict mortality and manage geriatric patients. There is a significant increase in mortality among patients with procalcitonin (PCT) levels at ≥ 2 nm/ml.
キーワード	geriatrics gram-negative bacteria epidemiology antimicrobial resistance mortality
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-08
巻	79巻
号	4号
出版者	Okayama University Medical School
開始ページ	231
終了ページ	242
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り

Nutrient Requirements Shape the Preferential Habitat of Allorhizobium vitis VAR03-1, a Commensal Bacterium, in the Rhizosphere of Arabidopsis thaliana

フルテキストURL	fulltext.pdf
著者	Hemelda, Niarsi Merry\| Bao, Jiyuan\| Watanabe, Megumi\| Matsui, Hidenori\| Toyoda, Kazuhiro\| Ichinose, Yuki\| Noutoshi, Yoshiteru\|
キーワード	Commensal bacteria Nutrient requirements Organic acids Plant-microbe interactions Rhizosphere Sugars
発行日	2024-08-24
出版物タイトル	Plant And Cell Physiology
巻	65巻
号	11号
出版者	Oxford University Press (OUP)
開始ページ	1769
終了ページ	1786
ISSN	0032-0781
NCID	AA0077511X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024.
論文のバージョン	publisher
PubMed ID	39185583
DOI	10.1093/pcp/pcae091
Web of Science KeyUT	001313907100001
関連URL	isVersionOf https://doi.org/10.1093/pcp/pcae091

Siderophore for Lanthanide and Iron Uptake for Methylotrophy and Plant Growth Promotion in Methylobacterium aquaticum Strain 22A

フルテキストURL	fulltext.pdf
著者	Juma, Patrick Otieno\| Fujitani, Yoshiko\| Alessa, Ola\| Oyama, Tokitaka\| Yurimoto, Hiroya\| Sakai, Yasuyoshi\| Tani, Akio\|
キーワード	Methylobacterium species lanthanide lanthanophore siderophore plant growth promoter heavy metal sequestration
発行日	2022-07-07
出版物タイトル	Frontiers In Microbiology
巻	13巻
出版者	Frontiers Media SA
開始ページ	921635
ISSN	1664-302X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Juma, Fujitani, Alessa, Oyama, Yurimoto, Sakai and Tani.
論文のバージョン	publisher
PubMed ID	35875576
DOI	10.3389/fmicb.2022.921635
Web of Science KeyUT	000831270000001
関連URL	isVersionOf https://doi.org/10.3389/fmicb.2022.921635

Glial Cells as Possible Targets of Neuroprotection through Neurotrophic and Antioxidative Molecules in the Central and Enteric Nervous Systems in Parkinson’s Disease

JaLCDOI	10.18926/AMO/62767
フルテキストURL	75_5_549.pdf
著者	Isooka, Nami\| Miyazaki, Ikuko\| Asanuma, Masato\|
抄録	Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells.
キーワード	Parkinson’s disease astrocyte enteric glial cell neurotrophic factor antioxidative molecule
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2021-10
巻	75巻
号	5号
出版者	Okayama University Medical School
開始ページ	549
終了ページ	556
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34703037
Web of Science KeyUT	000711561600001
NAID	120007166678

Lactoferrin-like Immunoreactivity in Distinct Neuronal Populations in the Mouse Central Nervous System

JaLCDOI	10.18926/AMO/61894
フルテキストURL	75_2_153.pdf
著者	Shimaoka, Shigeyoshi\| Hamaoka, Hitomi\| Inoue, Junji\| Asanuma, Masato\| Tooyama, Ikuo\| Kondo, Yoichi\|
抄録	Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms. Other biological functions of Lf include immunomodulation and transcriptional regulation. However, the roles of Lf in the CNS have yet to be fully clarified. In this study, we raised an antiserum against mouse Lf and investigated the immunohistochemical localization of Lf-like immunoreactivity (Lf-LI) throughout the CNS of adult mice. Lf-LI was found in some neuronal populations throughout the CNS. Intense labeling was found in neurons in the olfactory systems, hypothalamic nuclei, entorhinal cortex, and a variety of brainstem nuclei. This study provides detailed information on the Lf-LI distribution in the CNS, and the findings should promote further understanding of both the physiological and pathological significance of Lf in the CNS.
キーワード	lactoferrin immunohistochemistry brain mapping
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-04
巻	75巻
号	2号
出版者	Okayama University Medical School
開始ページ	153
終了ページ	167
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33953422
NAID	120007029892

Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy

フルテキストURL	fulltext.pdf
著者	Kajiwara, Koichiro\| Sawa, Yoshihiko\| Fujita, Takahiro\| Tamaoki, Sachio\|
キーワード	P. gingivalis LPS Diabetic nephropathy VCAM-1 E-selectin ACE2 FGF23
発行日	2021-01-06
出版物タイトル	BMC Nephrology
巻	22巻
号	1号
出版者	BMC
開始ページ	3
ISSN	1471-2369
NCID	AA12035314
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	33407253
DOI	10.1186/s12882-020-02203-y
Web of Science KeyUT	000608270800002
関連URL	isVersionOf https://doi.org/10.1186/s12882-020-02203-y

Alteration of chemokine production in bovine endometrial epithelial and stromal cells under heat stress conditions

フルテキストURL	fulltext.pdf
著者	Sakai, Shunsuke\| Hatabu, Toshimitsu\| Yamamoto, Yuki\| Kimura, Koji\|
キーワード	chemokine cow endometrial cells endometritis heat stress
発行日	2020-11-23
出版物タイトル	Physiological Reports
巻	8巻
号	22号
出版者	Wiley
開始ページ	e14640
ISSN	2051-817X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
PubMed ID	33230953
DOI	10.14814/phy2.14640
Web of Science KeyUT	000596091500001
関連URL	isVersionOf https://doi.org/10.14814/phy2.14640

D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects: A Chewing Gum Pilot Study and Randomized Clinical Trial

JaLCDOI	10.18926/AMO/60369
フルテキストURL	74_4_307.pdf
著者	Nagamine, Yuichi\| Hasibul, Khaleque\| Ogawa, Takaaki\| Tada, Ayano\| Kamitori, Kazuyo\| Hossain, Akram\| Yamaguchi, Fuminori\| Tokuda, Masaaki\| Kuwahara, Tomomi\| Miyake, Minoru\|
抄録	We examined the effect of D-Tagatose on the growth of oral bacteria including Streptococcus mutans (S. mutans). Saliva collected from 10 healthy volunteers was plated on BHI medium (to culture total oral bacteria) and MBS medium (to culture S. mutans, specifically). Agar plates of BHI or MBS containing xylitol or D-Tagatose were cultured under aerobic or anaerobic conditions. We then counted the number of colonies. In BHI plates containing D-Tagatose, a complete and significant reduction of bacteria occurred under both aerobic and anaerobic conditions. In MSB medium, significant reduction of S. mutans was also observed. We then performed a doubleblind parallel randomized trial with 19 healthy volunteers. They chewed gum containing xylitol, D-Tagatose, or both for 4 weeks, and their saliva was collected weekly and plated on BHI and MSB media. These plates were cultured under anaerobic conditions. Total bacteria and S. mutans were not effectively reduced in either the D-Tagatose or xylitol gum group. However, S. mutans was significantly reduced in volunteers chewing gum containing both D-Tagatose and xylitol. Thus, D-Tagatose inhibited the growth of S. mutans and many types of oral bacteria, indicating that D-Tagatose intake may help prevent dental caries, periodontitis, and many oral diseases.
キーワード	D-Tagatose xylitol Streptococcus mutans oral bacteria chewing gum
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-08
巻	74巻
号	4号
出版者	Okayama University Medical School
開始ページ	307
終了ページ	317
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32843762
Web of Science KeyUT	000562508700006
NAID	120006880208

水素水は怪しい水でしょうか？

タイトル（別表記）	Does hydrogen-rich water really work?
フルテキストURL	129_9.pdf
著者	中尾篤典\|
キーワード	水素水抗酸化作用抗炎症作用臨床応用疑似科学
出版物タイトル	岡山医学会雑誌
発行日	2017-04-03
巻	129巻
号	1号
開始ページ	9
終了ページ	15
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2017 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.129.9
NAID	130005632038

Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis

JaLCDOI	10.18926/AMO/52006
フルテキストURL	67_6_333.pdf
著者	Tazawa, Hiroshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
キーワード	oncolytic adenovirus autophagy E2F1 microRNA
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2013-12
巻	67巻
号	6号
出版者	Okayama University Medical School
開始ページ	333
終了ページ	342
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24356717
Web of Science KeyUT	000328915700001

緩衝液の種類及び濃度と細菌の呼吸との関係

著者	矢部芳郎\| 秋田悦示\| 秋田和男\|
発行日	1957-06-30
出版物タイトル	岡山医学会雑誌
巻	69巻
号	6号
資料タイプ	学術雑誌論文

細菌のグルタミン酸代謝に関する研究第二篇白色ブドウ球菌のグルタミン酸代謝

著者	秋田悦示\|
発行日	1957-02-28
出版物タイトル	岡山医学会雑誌
巻	69巻
号	2号
資料タイプ	学術雑誌論文

細菌のグルタミン酸代謝に関する研究第一編大腸菌のグルタミン酸代謝とその定量分析への応用

著者	秋田悦示\|
発行日	1957-02-28
出版物タイトル	岡山医学会雑誌
巻	69巻
号	2号
資料タイプ	学術雑誌論文

抗生物質耐性菌の生理学的研究第2編オーレオマイシン耐性大腸菌の生理学的研究

著者	林生\|
発行日	1958-12-31
出版物タイトル	岡山医学会雑誌
巻	70巻
号	12号
資料タイプ	学術雑誌論文

抗生物質耐性菌の生理学的研究第1編ストレプトマイシン依存性大腸菌の生理学的研究

著者	林生\|
発行日	1958-12-31
出版物タイトル	岡山医学会雑誌
巻	70巻
号	12号
資料タイプ	学術雑誌論文

発育電位時間曲線による細菌代謝の研究第1編チフス菌による電位降下物質の研究

著者	植田真臣\|
発行日	1959-01-31
出版物タイトル	岡山医学会雑誌
巻	71巻
号	1号
資料タイプ	学術雑誌論文

ストレプトマイシン耐性赤痢菌の生理学的研究第1編ストレプトマイシン耐性赤痢菌駒込ＢⅢの糖代謝

著者	川井潔\|
発行日	1960-02-28
出版物タイトル	岡山医学会雑誌
巻	72巻
号	3号
資料タイプ	学術雑誌論文

緑膿菌産生色素 "Pyocianine" に関する研究―特にPyocianine生合成に影響する因子について―

著者	坂野才蔵\|
発行日	1965-07-30
出版物タイトル	岡山医学会雑誌
巻	77巻
号	7号
資料タイプ	学術雑誌論文

X線照射による異常長大菌の生理学的研究

著者	西井怜\|
発行日	1965-04-30
出版物タイトル	岡山医学会雑誌
巻	77巻
号	4号
資料タイプ	学術雑誌論文