検索結果 54 件
| JaLCDOI | 10.18926/AMO/57948 |
|---|---|
| フルテキストURL | 74_1_17.pdf |
| 著者 | Ishii, Kenzo| Morimatsu, Hiroshi| Ono, Kazumi| Miyasho, Koji| |
| 抄録 | We performed a retrospective cohort study of 911 high-energy trauma patients who underwent chest CT scans at least twice after admission. We hypothesized that in high-energy trauma patients, a high-inspired oxygen concentration delivered after admission results in dorsal atelectasis. The study’s primary outcome was dorsal atelectasis formation diagnosed based on CT images. We defined dorsal atelectasis as the presence of atelectasis at ≥ 10 mm thick on CT images. We defined high-inspired oxygen concentration as >60% oxygen delivered between two CT scans. Four hundred sixty-five patients (51.0%) developed atelectasis according to the second CT scan, and 338 (37.1%) received a high-inspired oxygen concentration. A univariate analysis showed that the rate of the high-inspired oxygen concentration in the atelectasis group was significantly higher than that in the non-atelectasis group (43.4% vs. 30.1%, p<0.001). However, a logistic regression analysis showed that there was no significant relationship between the oxygen concentration and the formation of dorsal atelectasis (OR: 1.197, 95%CI: 0.852-1.683, p=0.30). Age, the Injury Severity Score, BMI, and smoking were found to be risk factors of dorsal atelectasis formation in high-energy trauma patients. There was no relationship between the oxygen concentration and atelectasis formation in our series of high-energy trauma patients. |
| キーワード | trauma patient dorsal atelectasis oxygen concentration |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-02 |
| 巻 | 74巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 17 |
| 終了ページ | 26 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32099244 |
| Web of Science KeyUT | 000516606200003 |
| NAID | 120006795615 |
| JaLCDOI | 10.18926/AMO/57374 |
|---|---|
| フルテキストURL | 73_5_433.pdf |
| 著者 | Tamada, Shoko| Mitsui, Takashi| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eguchi, Takeshi| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi| |
| 抄録 | An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia. |
| キーワード | preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 433 |
| 終了ページ | 440 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649370 |
| Web of Science KeyUT | 000491886600009 |
| JaLCDOI | 10.18926/AMO/57371 |
|---|---|
| フルテキストURL | 73_5_413.pdf |
| 著者 | Yanagihara, Yutaka| Nishida, Keigo| Watanabe, Ryuta| Koyama, Kanae| Sawada, Yuichiro| Noda, Terutaka| Asai, Seiji | Fukumoto, Tetsuya| Miura, Noriyoshi| Miyauchi, Yuki| Kikugawa, Tadahiko| Saika, Takashi| |
| 抄録 | Laparoscopic radical cystectomy (LRC) is a standard surgical treatment for muscle-invasive bladder cancer and high-risk non-muscle-invasive bladder cancer. LRC is a less invasive modality than conventional open surgery. Therefore, even elderly patients with invasive bladder cancer may be candidates for LRC. In this study, a comparative analysis of perioperative/oncological outcomes between elderly patients and younger patients who underwent LRC was performed to assess the feasibility of LRC in elderly patients. Sixty-eight consecutive patients who underwent LRC between October 2013 and March 2018 were enrolled and stratified into those younger than 75 years (n=37) and those ≥ 75 years old (n=31). The median follow-up period was 28.2 months. The preoperative and operative parameters and complications were similar in both groups. The 2-year overall survival (OS) was 64.4% in the younger vs. 76.4% in the elderly group (p=0.053), cancer-specific survival (CSS) was 79.3% vs. 81.7% (p=0.187), and recurrence-free survival (RFS) was 58.2% vs. 75.7% (p=0.174), respectively. No significant differences were observed in OS, CSS, or RFS between the groups. No significant differences were found between the groups with respect to peri-surgical/oncological outcomes. We conclude that LRC is feasible in elderly patients. |
| キーワード | bladder cancer laparoscopic surgery radical cystectomy elderly patient |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 417 |
| 終了ページ | 418 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649367 |
| Web of Science KeyUT | 000491886600006 |
| JaLCDOI | 10.18926/AMO/56930 |
|---|---|
| フルテキストURL | 73_4_285.pdf |
| 著者 | Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| 抄録 | Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion. |
| キーワード | glioma cytoskeletons invasion microtubules |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 285 |
| 終了ページ | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439951 |
| JaLCDOI | 10.18926/AMO/56649 |
|---|---|
| フルテキストURL | 73_2_135.pdf |
| 著者 | Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka| |
| 抄録 | The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization. |
| キーワード | collagen XVIII basement membrane wound healing re-epithelialization skin |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 135 |
| 終了ページ | 146 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015748 |
| JaLCDOI | 10.18926/AMO/56457 |
|---|---|
| フルテキストURL | 73_1_43.pdf |
| 著者 | Ikeda, Ailee| Takaki, Akinobu| Yasunaka, Tetsuya| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Ikeda, Fusao| Shiraha, Hidenori| Yoshida, Kazuhiro| Kuise, Takashi| Nobuoka, Daisuke| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Fujiwara, Toshiyoshi| Okada, Hiroyuki| |
| 抄録 | Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. A positive anti-hepatitis B surface antibody response was achieved in 29% (8/28) of the LC-B group, 88% (7/8) of the ALF-B group, and 44% (4/9) of the adult non-B ESLD group. All four non-B ESLD infants showed vaccine success. The predictive factors for a good response in LC-B were young age, marital donor, and high donor age. ALF-B and non-B ESLD infants are thus good vaccination candidates. LC-B patients with marital donors are also good candidates, perhaps because the donated liver maintains an efficient immune memory to HBV, as the donors had already been infected in adulthood and showed adequate anti-HBV immune responses. |
| キーワード | acute liver failure hepatitis B hepatitis B vaccine liver cirrhosis liver transplantation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 41 |
| 終了ページ | 50 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820053 |
| レファレンス | Ishigami M, Ogura Y, Hirooka Y and Goto H: Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation. World J Gastroenterol (2015) 21: 10290-10298.| Kennedy M and Alexopoulos SP: Hepatitis B virus infection and liver transplantation. Curr Opin Organ Transplant (2010) 15: 310-315.| Takaki A, Yagi T, Iwasaki Y, Sadamori H, Matsukawa H, Matsuda H, Shinoura S, Umeda Y, Miyake Y, Terada R, Kobashi H, Sakaguchi K, Tanaka N and Shiratori Y: Short-term high-dose followed by long-term low-dose hepatitis B immunoglobulin and lamivudine therapy prevented recurrent hepatitis B after liver transplantation. Transplantation (2007) 83: 231-233.| Takaki A, Yagi T and Yamamoto K: Safe and cost-effective control of post-transplantation recurrence of hepatitis B. Hepatol Res (2015) 45: 38-47.| Holmberg SD, Suryaprasad A and Ward W: Updated CDC recommendations for the management of hepatitis B virus-infected health-care providers and students. MMWR Recomm Rep (2012) 61: 1-12.| Rosenau J, Hooman N, Hadem J, Rifai K, Bahr MJ, Philipp G, Tillmann HL, Klempnauer J, Strassburg CP and Manns MP: Failure of hepatitis B vaccination with conventional HBsAg vaccine in patients with continuous HBIG prophylaxis after liver transplantation. Liver Transpl (2007) 13: 367-373.| Yang A, Guo Z, Ren Q, Wu L, Ma Y, Hu A, Wang D, Ye H, Zhu X, Ju W and He X: Active immunization in patients transplanted for hepatitis B virus related liver diseases: A prospective study. PLoS One (2017) 12: e0188190.| Egawa H, Tanabe K, Fukushima N, Date H, Sugitani A and Haga H: Current status of organ transplantation in Japan. Am J Transplant (2012) 12: 523-530.| Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T and Yamamoto K: Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation? J Gastroenterol (2013) 48: 1373-1383.| Mochida S: Indication criteria for liver transplantation for acute liver failure in Japan. Hepatol Res (2008) 38 Suppl 1: S52-55.| Furukawa H, Shimamura T, Suzuki T, Taniguchi M, Nakanishi K, Yamashita K, Kamiyama T, Matsushita M and Todo S: Liver transplantation for hepatocellular carcinoma: the Japanese experience. J Hepatobiliary Pancreat Sci (2010) 17: 533-538.| Kasahara M, Sakamoto S, Horikawa R, Koji U, Mizuta K, Shinkai M, Takahito Y, Taguchi T, Inomata Y, Uemoto S, Tatsuo K and Kato S: Living donor liver transplantation for pediatric patients with metabolic disorders: the Japanese multicenter registry. Pediatr Transplant (2014) 18: 6-15.| Manini MA, Whitehouse G, Bruce M, Passerini M, Lim TY, Carey I, Considine A, Lampertico P, Suddle A, Heaton N, Heneghan M and Agarwal K: Entecavir or tenofovir monotherapy prevents HBV recurrence in liver transplant recipients: A 5-year follow-up study after hepatitis B immunoglobulin withdrawal. Dig Liver Dis (2018) 50: 944-953.| Schumann A, Lindemann M, Valentin-Gamazo C, Lu M, Elmaagacli A, Dahmen U, Knop D, Broelsch CE, Grosse-Wilde H, Roggendorf M and Fiedler M: Adoptive immune transfer of hepatitis B virus specific immunity from immunized living liver donors to liver recipients. Transplantation (2009) 87: 103-111.| Hu X, Ma S, Huang X, Jiang X, Zhu X, Gao H, Xu M, Sun J, Abbott WG and Hou J: Interleukin-21 is upregulated in hepatitis B-related acute-on-chronic liver failure and associated with severity of liver disease. J Viral Hepat (2011) 18: 458-467.| Li Y, Tang L and Hou J: Role of interleukin-21 in HBV infection: friend or foe? Cell Mol Immunol (2015) 12: 303-308.| Soejima Y, Ikegami T, Taketomi A, Yoshizumi T, Uchiyama H, Harada N, Yamashita Y and Maehara Y: Hepatitis B vaccination after living donor liver transplantation. Liver Int (2007) 27: 977–982.| Chang SH, Suh KS, Yi NJ, Choi SH, Lee HJ, Seo JK and Lee KU: Active immunization against de novo hepatitis B virus infection in pediatric patients after liver transplantation. Hepatology (2003) 37: 1329-1334.| Kwon CH, Suh KS, Yi NJ, Chang SH, Cho YB, Cho JY, Lee HJ, Seo JK and Lee KU: Long-term protection against hepatitis B in pediatric liver recipients can be achieved effectively with vaccination after transplantation. Pediatr Transplant (2006) 10: 479-486.| Lee S, Kim JM, Choi GS, Park JB, Kwon CH, Choe YH, Joh JW and Lee SK: De novo hepatitis b prophylaxis with hepatitis B virus vaccine and hepatitis B immunoglobulin in pediatric recipients of core antibody-positive livers. Liver Transpl (2016) 22: 247-251.| Lin CC, Chen CL, Concejero A, Wang CC, Wang SH, Liu YW, Yang CH, Yong CC, Lin TS, Jawan B, Cheng YF and Eng HL: Active immunization to prevent de novo hepatitis B virus infection in pediatric live donor liver recipients. Am J Transplant (2007) 7: 195-200.| Yoshizawa A, Yamashiki N, Ueda Y, Kaido T, Okajima H, Marusawa H, Chiba T and Uemoto S: Long-term efficacy of hepatitis B vaccination as post-transplant prophylaxis in hepatitis B surface antigen (HBsAg) positive recipients and HBsAg negative recipients of anti-hepatitis B core positive grafts. Hepatol Res (2016) 46: 541-551.| Ota MO, Vekemans J, Schlegel-Haueter SE, Fielding K, Whittle H, Lambert PH, McAdam KP, Siegrist CA and Marchant A: Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults. Vaccine (2004) 22: 511-519.| Tuaillon E, Tabaa YA, Petitjean G, Huguet MF, Pajeaux G, Fondere JM, Ponseille B, Ducos J, Blanc P and Vendrell JP: Detection of memory B lymphocytes specific to hepatitis B virus (HBV) surface antigen (HBsAg) from HBsAg-vaccinated or HBVimmunized subjects by ELISPOT assay. J Immunol Methods (2006) 315: 144-152.| Bauer T, Gunther M, Bienzle U, Neuhaus R and Jilg W: Vaccination against hepatitis B in liver transplant recipients: pilot analysis of cellular immune response shows evidence of HBsAg-specific regulatory T cells. Liver Transpl (2007) 13: 434-442.| Rosenau J, Hooman N, Rifai K, Solga T, Tillmann HL, Grzegowski E, Nashan B, Klempnauer J, Strassburg CP, Wedemeyer H and Manns MP: Hepatitis B virus immunization with an adjuvant containing vaccine after liver transplantation for hepatitis B-related disease: failure of humoral and cellular immune response. Transpl Int (2006) 19: 828-833.| Di Paolo D, Lenci I, Cerocchi C, Tariciotti L, Monaco A, Brega A, Lotti L, Tisone G and Angelico M: One-year vaccination against hepatitis B virus with a MPL-vaccine in liver transplant patients for HBV-related cirrhosis. Transpl Int (2010) 23: 1105-1112.| Sintusek P, Posuwan N, Wanawongsawad P, Jitraruch S, Poovorawan Y and Chongsrisawat V: High prevalence of hepatitis B-antibody loss and a case report of de novo hepatitis B virus infection in a child after living-donor liver transplantation. World J Gastroenterol (2018) 24: 752-762.| |
| タイトル（別表記） | Mechanosensor |
|---|---|
| フルテキストURL | 128_61.pdf |
| 著者 | 高橋 賢| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2016-04-01 |
| 巻 | 128巻 |
| 号 | 1号 |
| 開始ページ | 61 |
| 終了ページ | 62 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.128.61 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2016 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.128.61 |
| NAID | 130005149609 |
| タイトル（別表記） | Drug interaction (35. Opioid-analgesic drug interactions) |
|---|---|
| フルテキストURL | 128_53.pdf |
| 著者 | 佐田 光| 鍛治園 誠| 北村 佳久| 千堂 年昭| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2016-04-01 |
| 巻 | 128巻 |
| 号 | 1号 |
| 開始ページ | 53 |
| 終了ページ | 59 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.128.53 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2016 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.128.53 |
| NAID | 130005149610 |
| タイトル（別表記） | Non-high-output cardiac failure in patients undergoing hemodialysis through an arteriovenous shunt |
|---|---|
| フルテキストURL | 127_203.pdf |
| 著者 | 鵜川 豊世武| |
| 抄録 | Background: Hemodialysis-related heart failure has been considered to be associated with excessive blood flow through the arteriovenous (AV) shunt used for vascular access. However, some patients undergoing dialysis have heart failure in the absence of an increase in cardiac output (CO) related to shunt blood-flow loading because the loading cannot be compensated for by increasing CO. This condition may be challenging to manage ; thus, early diagnosis is important. Methods and Results: Twelve patients (mean age, 71 years ; 9 men) with end-stage renal disease, dialysis-related heart failure, a high brain natriuretic peptide (BNP) level, and a mean New York Heart Association (NYHA) class of II underwent AV shunt closure. Their cardiac index (CI), pre- and post-dialysis BNP levels, and several cardiac variables were assessed pre- and postoperatively. All patients achieved relief of heart failure symptoms and a reduction in NYHA class after AV closure, but six patients had a postoperative increase in CI (the "non-high-output" cardiac failure group), whereas the other six had a decrease in CI (the "high-output" cardiac failure group). The high-output patients had greater improvements in BNP levels and most cardiac variables compared to the non-high-output group ; therefore, the heart failure in the non-high-output patients was considered more serious than that in the high-output group. Conclusions: The selection of effective strategies for treating dialysis-related heart failure may depend partly on identifying which patients have non-high-output failure. Such identification requires serial measurements of BNP levels and evaluations of cardiac variables other than the ejection fraction. |
| キーワード | 心拍出量（cardiac output） 心不全（heart failure） 脳性ナトリウム利尿ペプチド（brain natriuretic peptide） 非過大シャント心不全（non-high-output cardiac failure） 腎臓（kidney） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-12-01 |
| 巻 | 127巻 |
| 号 | 3号 |
| 開始ページ | 203 |
| 終了ページ | 207 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.127.203 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.203 |
| NAID | 130005116810 |
| タイトル（別表記） | The origin of infra-slow oscillations of oxygenated hemoglobin observed in functional near-infrared spectroscopy |
|---|---|
| フルテキストURL | 126_117.pdf |
| 著者 | 所司 睦文| 上野 浩司| 久保 正子| 小田 真珠子| 平田 直也| 武本 梨佳| 衣笠 和孜| 岡本 基| |
| 抄録 | There is increasing interest in the intrinsic activity of the resting brain, especially the activity slower than 0.1Hz (i.e., low-frequency oscillations, or LFOs). To investigate the origin of LFOs observed in functional near-infrared spectroscopy (fNIRS), we recorded multichannel fNIRS and electroencephalography (EEG) from the frontal cortex of 11 healthy young volunteers in the resting state. Electrocardiography (ECG), electro-oculography and respiration were also measured. Synchronous oscillations of oxy-hemoglobin (oxy-Hb) around 1.0Hz were detected in all fNIRS channels, and their frequency was consistent with a peak frequency of ECG, suggesting the changes of cerebral blood flow due to heart beats. In addition, oxy-Hb oscillations around 0.1Hz (i.e., LFOs) appeared in the fNIRS. The channels where LFOs appeared differed among the subjects, and the LFOs appeared or disappeared even in the same fNIRS channels. The appearance of LFOs in fNIRS channels was significantly higher when the LFOs appeared on the EEG in the adjacent EEG electrodes compared to when LFOs did not appear on EEG. The amplitude and coherence (synchronicity) of the LFOs were increased by changing the subjects' position from dorsal to the sitting position in both fNIRS and EEG, and the coherence in particular was increased in the homologous fNIRS channels on the bilateral hemispheres. These results suggest that LFOs of oxy-Hb couple with resting-state EEG activity. |
| キーワード | fNIRS EEG LFOs コヒーレンス解析（Coherence analysis） 連続ウェーブレット解析（continuous wavelet transforms） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2014-08-01 |
| 巻 | 126巻 |
| 号 | 2号 |
| 開始ページ | 117 |
| 終了ページ | 126 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2014 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.126.117 |
| NAID | 130004685262 |
| 著者 | 森本 展年| 阿部 康二| |
|---|---|
| 発行日 | 2014-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 126巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 木浦 勝行| 谷本 光音| |
|---|---|
| 発行日 | 2013-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 125巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 中司 敦子| 和田 淳| 槇野 博史| |
|---|---|
| 発行日 | 2012-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 124巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 朝倉 昇司| 橋本 大吾| 高嶋 秀一郎| 杉山 暖子| 前田 嘉信| 赤司 浩一| 谷本 光音| 豊嶋 崇徳| |
|---|---|
| 発行日 | 2012-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 124巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 遠西 大輔| 谷本 光音| |
|---|---|
| 発行日 | 2011-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 谷本 安| 谷本 光音| |
|---|---|
| 発行日 | 2011-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 山田 浩司| Padilla-Parra, Sergi| 朴 宣奏| 伊藤 俊樹| Chaineau, Mathilde| Monaldi, Ilaria| Cremona, Ottavio| Benfenati, Fabio| Camilli, Pietro De| Coppey-Moisan, Maïté| Tramier, Marc| Galli, Thierry| 竹居 孝二| |
|---|---|
| 発行日 | 2011-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 原田 聡介| 武本 充広| 吉尾 浩太郎| 児島 克英| 片山 敬久| 勝井 邦彰| 黒田 昌宏| 松尾 俊彦| 金澤 右| |
|---|---|
| 発行日 | 2010-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/32310 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Emdadul, Haque M| Fujisawa, Tomomi| Yamamoto, Masamichi| Ohmori, Shinji| |
| 抄録 | We present here a reliable and sensitive method for the determination of acidic opines such as meso-alanopine, beta-alanopine, tauropine and strombine in biological samples. Interfering primary amino acids were eliminated by reaction with o-phthalaldehyde, and the derivatized compounds were passed through Sep-Pak Plus PS-1 cartridges. The acidic opines were recovered by flushing the cartridges with water, then determined by high performance liquid chromatography after a second derivatization with phenylisothiocyanate. All 4 acidic opines were detected within 30 min. This method ensured good separation and guaranteed almost full recovery of all acidic opines. This method was applied to analyze opines in marine animals and to test whether opines are metabolized in the livers of the rat and fish. |
| キーワード | opines high-performance liquid chromatography determination marine animals phenylisothiocyanate Sep-Pak cartridge |
| Amo Type | Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2000-02 |
| 巻 | 54巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 10709616 |
| Web of Science KeyUT | 000085526000001 |
| 著者 | 渡辺 信之| 髙岡 宗徳| 櫻間 一史| 友野 靖子| 畠山 慎二| 大森 修| 元木 崇之| 白川 靖博| 山辻 知樹| 羽井佐 実| 松岡 順治| Beer, David G.| 長塚 仁| 田中 紀章| 猶本 良夫| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |