検索結果 1060 件
| フルテキストURL | fulltext20221102-1.pdf |
|---|---|
| 著者 | Miyoshi, Shin-ichi| Toko, Norie| Dodo, Tetsuya| Nanko, Ayako| Mizuno, Tamaki| |
| キーワード | Vibrio mimicus Serine protease Hemolysin Maturation |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11274-022-03436-9| This fulltext is available in Oct. 2023.| |
| 発行日 | 2022-10-22 |
| 出版物タイトル | World Journal of Microbiology and Biotechnology |
| 巻 | 38巻 |
| 号 | 12号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 241 |
| ISSN | 0959-3993 |
| NCID | AA10811107 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s), under exclusive licence to Springer Nature B.V. 2022 |
| 論文のバージョン | author |
| PubMed ID | 36271946 |
| DOI | 10.1007/s11274-022-03436-9 |
| Web of Science KeyUT | 000871180800001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s11274-022-03436-9 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Miyoshi, Tomoko| Ida, Hiromi| Nishimura, Yoshito| Ako, Soichiro| Otsuka, Fumio| |
| キーワード | stress burnout yoga mindfulness stress in healthcare workers self-compassion the COVID-19 pandemic |
| 発行日 | 2022-09-30 |
| 出版物タイトル | International Journal Of Environmental Research and Public Health |
| 巻 | 19巻 |
| 号 | 19号 |
| 出版者 | MDPI |
| 開始ページ | 12523 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36231820 |
| DOI | 10.3390/ijerph191912523 |
| Web of Science KeyUT | 000868048000001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph191912523 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsumoto, Kazuyuki| Mitsuhashi, Toshiharu| Kawamoto, Hirofumi| Ishida, Etsuji| Fujii, Masakuni| Akimoto, Yutaka| Seki, Hiroyuki| Ishihara, Yuki| Ogawa, Taiji| Yamazaki, Tatsuhiro| Fujii, Yuki| Kato, Hironari| |
| キーワード | bilateral drainage bile duct obstruction endoscopic biliary drainage neoplasms self-expandable metallic stents |
| 発行日 | 2022-10-07 |
| 出版物タイトル | Medicine |
| 巻 | 101巻 |
| 号 | 40号 |
| 出版者 | Lippincott Williams & Wilkins |
| 開始ページ | e30857 |
| ISSN | 0025-7974 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 36221399 |
| DOI | 10.1097/MD.0000000000030857 |
| Web of Science KeyUT | 000865518700110 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000030857 |
| フルテキストURL | fulltext20221020-1.pdf figure20221020-1.pdf table20221020-1.pdf ASO_Takata_Supplementary.pdf |
|---|---|
| 著者 | Takata, Nobuo| Kikuchi, Satoru| Kuroda, Shinji| Tanabe, Shunsuke| Maeda, Naoaki| Noma, Kazuhiro| Takahashi, Ayako| Umeda, Yuzo| Shikata, Kenichi| Ozaki, Kazuhide| Fujiwara, Toshiyoshi| |
| キーワード | Gastric cancer Gastrectomy Body weight loss Skeletal muscle loss Nutritional counseling |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1245/s10434-022-12572-3| This fulltext is available in Sep. 2023.| |
| 発行日 | 2022-09-25 |
| 出版物タイトル | Annals of Surgical Oncology |
| 巻 | 30巻 |
| 号 | 2号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 1110 |
| 終了ページ | 1118 |
| ISSN | 1068-9265 |
| NCID | AA11016573 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Society of Surgical Oncology 2022 |
| 論文のバージョン | author |
| PubMed ID | 36161371 |
| DOI | 10.1245/s10434-022-12572-3 |
| Web of Science KeyUT | 000858651900003 |
| 関連URL | isVersionOf https://doi.org/10.1245/s10434-022-12572-3 |
| フルテキストURL | fulltext20221017-3.pdf figure20221017-3.pdf |
|---|---|
| 著者 | Morizane, Shin| Sunagawa, Ko| Nomura, Hayato| Ouchida, Mamoru| |
| キーワード | Atopic dermatitis Serine protease Kallikrein-related peptidases Lympho-epithelial Kazal-type-related inhibitor Protease -activated receptor 2 |
| 備考 | © 2022 Japanese Society for Investigative Dermatology. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jdermsci.2022.06.004] . | This fulltext is available in July 2023.| |
| 発行日 | 2022-07 |
| 出版物タイトル | Journal of Dermatological Science |
| 巻 | 107巻 |
| 号 | 1号 |
| 出版者 | Elsevier BV |
| 開始ページ | 2 |
| 終了ページ | 7 |
| ISSN | 0923-1811 |
| NCID | AA1075636X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Japanese Society for Investigative Dermatology |
| 論文のバージョン | author |
| PubMed ID | 35817663 |
| DOI | 10.1016/j.jdermsci.2022.06.004 |
| Web of Science KeyUT | 000863858700001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jdermsci.2022.06.004 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tsuji, Hironori| Tetsunaga, Tomoko| Tetsunaga, Tomonori| Misawa, Haruo| Oda, Yoshiaki| Takao, Shinichiro| Nishida, Keiichiro| Ozaki, Toshifumi| |
| キーワード | caregiver burden chronic pain fear-avoidance model self-efficacy Zarit Burden Interview |
| 発行日 | 2022-09-30 |
| 出版物タイトル | Medicine |
| 巻 | 101巻 |
| 号 | 39号 |
| 出版者 | Lippincott Williams & Wilkins |
| 開始ページ | e30802 |
| ISSN | 0025-7974 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 36181114 |
| DOI | 10.1097/MD.0000000000030802 |
| Web of Science KeyUT | 000862039900121 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000030802 |
| フルテキストURL | fulltext20221017-1.pdf |
|---|---|
| 著者 | NEO, Sakurako| TAKEMURA-UCHIYAMA, Iyo| UCHIYAMA, Jumpei| MURAKAMI, Hironobu| SHIMA, Ayaka| KAYANUMA, Hideki| YOKOYAMA, Taiki| TAKAGI, Satoshi| KANAI, Eiichi| HISASUE, Masaharu| |
| キーワード | bile bile microbiota gallbladder hospitalized dog laboratory dog |
| 発行日 | 2022 |
| 出版物タイトル | Journal of Veterinary Medical Science |
| 巻 | 84巻 |
| 号 | 7号 |
| 出版者 | Japanese Society of Veterinary Science |
| 開始ページ | 1019 |
| 終了ページ | 1022 |
| ISSN | 0916-7250 |
| NCID | AA10796138 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©2022 The Japanese Society of Veterinary Science |
| 論文のバージョン | publisher |
| PubMed ID | 35650165 |
| DOI | 10.1292/jvms.22-0090 |
| Web of Science KeyUT | 000862768300020 |
| 関連URL | isVersionOf https://doi.org/10.1292/jvms.22-0090 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Muzembo, Basilua Andre| Kitahara, Kei| Ohno, Ayumu| Okamoto, Keinosuke| Miyoshi, Shin-Ichi| |
| キーワード | ESBL-EC Traveler's diarrhea International travelers India Meta-analysis |
| 発行日 | 2022-10-01 |
| 出版物タイトル | Tropical Diseases Travel Medicine And Vaccines |
| 巻 | 8巻 |
| 号 | 1号 |
| 出版者 | Springer Nature |
| 開始ページ | 22 |
| ISSN | 2055-0936 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 36180932 |
| DOI | 10.1186/s40794-022-00179-1 |
| Web of Science KeyUT | 000862402700001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s40794-022-00179-1 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Mochizuki, Yusuke| Yamamoto, Norio| Fujii, Tatsuya| Tomita, Yosuke| |
| キーワード | cement augmentation trochanteric fracture intertrochanteric fracture hip fracture proximal femoral fracture cumulated ambulation score mobility ambulance ADL pain |
| 発行日 | 2022-08-27 |
| 出版物タイトル | Journal Of Personalized Medicine |
| 巻 | 12巻 |
| 号 | 9号 |
| 出版者 | MDPI |
| 開始ページ | 1392 |
| ISSN | 2075-4426 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36143177 |
| DOI | 10.3390/jpm12091392 |
| Web of Science KeyUT | 000859577200001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jpm12091392 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tomonobu, Nahoko| Kinoshita, Rie| Wake, Hidenori| Inoue, Yusuke| Ruma, I. Made Winarsa| Suzawa, Ken| Gohara, Yuma| Komalasari, Ni Luh Gede Yoni| Jiang, Fan| Murata, Hitoshi| Yamamoto, Ken-Ichi| Sumardika, I. Wayan| Chen, Youyi| Futami, Junichiro| Yamauchi, Akira| Kuribayashi, Futoshi| Kondo, Eisaku| Toyooka, Shinichi| Nishibori, Masahiro| Sakaguchi, Masakiyo| |
| キーワード | S100A8/A9 HRG metastasis |
| 発行日 | 2022-09-07 |
| 出版物タイトル | International Journal Of Molecular Sciences |
| 巻 | 23巻 |
| 号 | 18号 |
| 出版者 | MDPI |
| 開始ページ | 10300 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36142212 |
| DOI | 10.3390/ijms231810300 |
| Web of Science KeyUT | 000858719600001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms231810300 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nishimura, Takeshi| Suga, Masafumi| Nakao, Atsunori| Ishihara, Satoshi| Naito, Hiromichi| |
| キーワード | AAM Endotracheal intubation JTDB supraglottic airway traumatic cardiac arrest |
| 発行日 | 2022-09-16 |
| 出版物タイトル | Acute Medicine & Surgery |
| 巻 | 9巻 |
| 号 | 1号 |
| 出版者 | Wiley |
| 開始ページ | e786 |
| ISSN | 2052-8817 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36176323 |
| DOI | 10.1002/ams2.786 |
| Web of Science KeyUT | 000854253100001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ams2.786 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Abe, Makoto| Sakae, Hiroyuki| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Tanaka, Takehiro| Kawano, Seiji| Otsuka, Fumio| Kawahara, Yoshiro| Yanai, Hiroyuki| Okada, Hiroyuki| |
| キーワード | eradication flow cytometry Helicobacter pylori T lymphocytes |
| 発行日 | 2022-08-26 |
| 出版物タイトル | Medicine |
| 巻 | 101巻 |
| 号 | 34号 |
| 出版者 | Lippincott Williams & Wilkins |
| 開始ページ | e30241 |
| ISSN | 0025-7974 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 36042652 |
| DOI | 10.1097/MD.0000000000030241 |
| Web of Science KeyUT | 000847532100050 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000030241 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hagiya, Hideharu| Koyama, Toshihiro| Otsuka, Fumio| |
| 発行日 | 2022-09-13 |
| 出版物タイトル | Scientific Reports |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 15391 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 36100649 |
| DOI | 10.1038/s41598-022-19798-x |
| Web of Science KeyUT | 000855580800036 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-022-19798-x |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ejiri, Kentaro| Miyoshi, Toru| Kihara, Hajime| Hata, Yoshiki| Nagano, Toshihiko| Takaishi, Atsushi| Toda, Hironobu| Namba, Seiji| Nakamura, Yoichi| Akagi, Satoshi| Sakuragi, Satoru| Minagawa, Taro| Kawai, Yusuke| Nishii, Nobuhiro| Fuke, Soichiro| Yoshikawa, Masaki| Nakamura, Kazufumi| Ito, Hiroshi| The MUSCAT-HF Study Investigators| |
| 発行日 | 2022-09-14 |
| 出版物タイトル | Scientific Reports |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 15449 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 36104378 |
| DOI | 10.1038/s41598-022-19371-6 |
| Web of Science KeyUT | 000853934100018 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-022-19371-6 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsuoka-Uchiyama, Natsumi| Tsuji, Kenji| Sang, Yizhen| Takahashi, Kensaku| Fukushima, Kazuhiko| Takeuchi, Hidemi| Inagaki, Kenichi| Uchida, Haruhito A.| Kitamura, Shinji| Sugiyama, Hitoshi| Wada, Jun| |
| 発行日 | 2022-09-02 |
| 出版物タイトル | Scientific Reports |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 14999 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 36056164 |
| DOI | 10.1038/s41598-022-19226-0 |
| Web of Science KeyUT | 000849436000046 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-022-19226-0 |
| JaLCDOI | 10.18926/AMO/63908 |
|---|---|
| フルテキストURL | 76_4_479.pdf |
| 著者 | Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi| |
| 抄録 | A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance. |
| キーワード | hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 479 |
| 終了ページ | 483 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123164 |
| Web of Science KeyUT | 000882167300012 |
| JaLCDOI | 10.18926/AMO/63907 |
|---|---|
| フルテキストURL | 76_4_473.pdf |
| 著者 | Tsuboi, Nobushige| Ishida, Joji| Shimazu, Yosuke| Edaki, Hisanori| Uneda, Atsuhito| Otani, Yoshihiro| Fujii, Kentaro| Kurozumi, Kazuhiko| Ennishi, Daisuke| Yanai, Hiroyuki| Date, Isao| |
| 抄録 | Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully. |
| キーワード | glioneuronal tumor with neuropil-like islands genomic profiling |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 473 |
| 終了ページ | 477 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123163 |
| JaLCDOI | 10.18926/AMO/63903 |
|---|---|
| フルテキストURL | 76_4_439.pdf |
| 著者 | Miyaji, Chikara| Takao, Soshi| Noguchi, Masayuki| Okazaki, Tsubasa| Sato, Shunsuke| Yorifuji, Takashi| |
| 抄録 | This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex. |
| キーワード | social capital post-traumatic stress disorder disaster flooding |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 439 |
| 終了ページ | 446 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123159 |
| Web of Science KeyUT | 000882167300010 |
| JaLCDOI | 10.18926/AMO/63894 |
|---|---|
| フルテキストURL | 76_4_399.pdf |
| 著者 | Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| 抄録 | According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67. |
| キーワード | breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 399 |
| 終了ページ | 408 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123154 |
| Web of Science KeyUT | 000882167300005 |
| JaLCDOI | 10.18926/AMO/63893 |
|---|---|
| フルテキストURL | 76_4_391.pdf |
| 著者 | Habu, Hiroshi| Mitsuhashi, Toshiharu| Tokinobu, Akiko| Yorifuji, Takashi| Takao, Soshi| |
| 抄録 | Tanden breathing, an ancient health technique, involves expiratory abdominal pressure breathing is practiced in Japan. In this study we examined the ability of Tanden breathing to relieve constipation. The study was designed as a stratified-block randomized controlled trial enrolling 20 participants. Nineteen were female and one was male, none were elderly. During the 6-week intervention period, the participants performed video-guided Tanden breathing about 10 min once day. We evaluated constipation using the Constipation Assessment Scale (CAS). There were significant differences in the mean CAS score between time points (baseline, 3 weeks after baseline, 6 weeks after baseline), groups (intervention and control), and their interaction (time×group) using repeated-measures analysis of variance. The control group showed no change in the mean CAS score; the mean CAS scores of the intervention group changed from 7.2 at baseline to 3.9 at 3 weeks and 3.1 at 6 weeks after baseline. A regression analysis of the difference in the mean CAS between baseline and 6 weeks later showed that the CAS of the intervention group was 4.3 points lower than that of the control group (95% confidence interval, 2.5-6.1). The results suggested that Tanden breathing is effective in relieving constipation among young women. |
| キーワード | Tanden breathing Dantian breathing exercises constipation mind−body therapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 391 |
| 終了ページ | 398 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123153 |
| Web of Science KeyUT | 000882167300001 |