検索結果 24438 件
フルテキストURL | olj_73_1_contents_eng.pdf |
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出版物タイトル | 岡山大學法學會雜誌 |
発行日 | 2023-08-18 |
巻 | 73巻 |
号 | 1号 |
ISSN | 0386-3050 |
言語 | 日本語 |
論文のバージョン | publisher |
フルテキストURL | olj_73_1_colophon.pdf |
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出版物タイトル | 岡山大學法學會雜誌 |
発行日 | 2023-08-18 |
巻 | 73巻 |
号 | 1号 |
ISSN | 0386-3050 |
言語 | 日本語 |
論文のバージョン | publisher |
フルテキストURL | olj_73_1_authors.pdf |
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出版物タイトル | 岡山大學法學會雜誌 |
発行日 | 2023-08-18 |
巻 | 73巻 |
号 | 1号 |
開始ページ | 71 |
終了ページ | 71 |
ISSN | 0386-3050 |
言語 | 日本語 |
論文のバージョン | publisher |
タイトル(別表記) | Die Übersetzung von Jherings Briefe(4) |
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フルテキストURL | olj_73_1_1_48.pdf |
著者 | 平田 公夫| |
出版物タイトル | 岡山大學法學會雜誌 |
発行日 | 2023-08-18 |
巻 | 73巻 |
号 | 1号 |
開始ページ | 48 |
終了ページ | 1 |
ISSN | 0386-3050 |
言語 | 日本語 |
論文のバージョン | publisher |
タイトル(別表記) | A Study on Surrender of Security by Creditor ⑵ : Focused on Creditor’s Duty to Surety in American Law. |
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フルテキストURL | olj_73_1_50_70.pdf |
著者 | 辻 博明| |
出版物タイトル | 岡山大學法學會雜誌 |
発行日 | 2023-08-18 |
巻 | 73巻 |
号 | 1号 |
開始ページ | 70 |
終了ページ | 50 |
ISSN | 0386-3050 |
言語 | 日本語 |
論文のバージョン | publisher |
フルテキストURL | olj_73_1_contents.pdf |
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出版物タイトル | 岡山大學法學會雜誌 |
発行日 | 2023-08-18 |
巻 | 73巻 |
号 | 1号 |
ISSN | 0386-3050 |
言語 | 日本語 |
論文のバージョン | publisher |
JaLCDOI | 10.18926/AMO/65757 |
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フルテキストURL | 77_4_439.pdf |
著者 | Shiwaku, Takahiro| Ishida, Hisashi| Tatebe, Yasuhisa| Tamefusa, Kosuke| Ochi, Motoharu| Fujiwara, Kaori| Kubo, Toshihide| Nakata, Eiji| Washio, Kana| Tsukahara, Hirokazu| |
抄録 | A three-year-old boy with Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ALL) presented with an osteolytic lesion in his right upper arm. Tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib are an essential component throughout the course of treatment for Ph+ALL. However, TKIs are reported to affect the bone metabolism. In the treatment course of the current patient, the osteolytic lesion quickly improved despite the continuous use of TKIs, even during the concomitant use of corticosteroids. This suggests that TKIs can be safely given with concomitant corticosteroids to children with Ph+ALL, even when osteolytic lesions are present. |
キーワード | acute lymphoblastic leukemia children tyrosine kinase inhibitor osteolysis |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 439 |
終了ページ | 442 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635146 |
Web of Science KeyUT | 001088434900002 |
JaLCDOI | 10.18926/AMO/65756 |
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フルテキストURL | 77_4_433.pdf |
著者 | Ono, Ryuki| Shiode, Yusuke| Kimura, Shuhei| Hosokawa, Mio| Matoba, Ryo| Kanzaki, Yuki| Kindo, Hiroya| Morita, Tetsuro| Morizane, Yuki| |
抄録 | A 23-year-old woman presented with a 1-month history of visual abnormalities in her right eye. A visual field test revealed temporal abnormalities in the right eye. Optical coherence tomography revealed an indistinct ellipsoid zone (EZ) on the B-scan image and hyporeflective areas in the EZ layer on the en face image in the right eye. We diagnosed the patient with acute zonal occult outer retinopathy. Visual field tests and B-scan images improved to almost normal at 6 months, but hyporeflective areas remained on the en face images. Thus, en face images may be more sensitive at detecting abnormalities in the outer retina than other modalities. |
キーワード | acute zonal occult outer retinopathy optical coherence tomography en face image ellipsoid zone |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 433 |
終了ページ | 437 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635145 |
Web of Science KeyUT | 001088434900001 |
JaLCDOI | 10.18926/AMO/65755 |
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フルテキストURL | 77_4_429.pdf |
著者 | Sasanami, Misa| Iida, Atsuyoshi| Iwamuro, Masaya| Hirai, Ryousuke| Obara, Takashi| Tsukahara, Kohei| Yumoto, Tetsuya| Naito, Hiromichi| Nakao, Atsunori| |
抄録 | Intramural esophageal dissection (IED), characterized by bleeding into the submucosal space, leads to mucosal separation and dissection. The most prevalent symptoms are sudden chest or retrosternal pain, hematemesis, and dysphagia. Therefore, acute coronary syndrome and aortic dissection are among its most notable differential diagnoses. A 31-year-old pregnant woman presented with acute chest pain, laryngeal discomfort, and hematemesis. Emergency esophagogastroscopy revealed longitudinal mucosal dissection (upper esophagus to esophagogastric junction). The patient was successfully treated by avoiding the ingestion of solid foods. Clinicians should consider a diagnosis of IED for pregnant patients with acute chest pain, especially if hematemesis is present. |
キーワード | chest pain dysphagia esophageal dissection hematemesis |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 429 |
終了ページ | 431 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635144 |
Web of Science KeyUT | 001163659800012 |
フルテキストURL | fulltext20230821-02.pdf fig1_20230821-02.pdf fig2_20230821-02.pdf fig3_20230821-02.pdf fig4_20230821-02.pdf fig5_20230821-02.pdf fig6_20230821-02.pdf |
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著者 | Kimura, Shuhei| Hosokawa, Mio Morizane| Shiode, Yusuke| Matoba, Ryo| Kanzaki, Yuki| Goto, Yasuhito| Kanenaga, Keisuke| Suzuki, Etsuji| Morizane, Yuki| |
キーワード | Axial length Rhegmatogenous retinal detachment Macular detachment Fourier-domain optic biometry Ultrasound |
備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10384-023-01018-2| This fulltext file will be available in Aug. 2024.| |
発行日 | 2023-08-10 |
出版物タイトル | Japanese Journal of Ophthalmology |
巻 | 67巻 |
号 | 6号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 645 |
終了ページ | 651 |
ISSN | 0021-5155 |
NCID | AA00691177 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © Japanese Ophthalmological Society 2023 |
論文のバージョン | author |
PubMed ID | 37561309 |
DOI | 10.1007/s10384-023-01018-2 |
Web of Science KeyUT | 001045669100002 |
関連URL | isVersionOf https://doi.org/10.1007/s10384-023-01018-2 |
JaLCDOI | 10.18926/AMO/65753 |
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フルテキストURL | 77_4_423.pdf |
著者 | Yamakawa, Yasuaki| Miyashita, Kohei| Morizane, Atsushi| Takeuchi, Masato| Kawashima, Yuta| Sugimura, Tomoko| Saisaka, Yuichi| |
抄録 | We report a case of a patient with severe pelvic fracture who showed concurrent ST elevation on electrocardiogram. A 70-year-old man incurred an unstable pelvic fracture from a motorcycle accident. On admission, he was hemodynamically unstable, and massive transfusion and noradrenaline were administered immediately. Although ST elevation was present in leads II, III, aVF, V5, and V6, cardiac function was preserved; thus, trans-arterial embolization and external fixation for pelvic fracture were given priority. Four days after the injury, he suffered a cardiac arrest, and coronary angiography revealed that the cause of ST elevation and cardiac arrest was coronary vasospasm. Physicians should be aware that pain-related stress and platelet activation as well as use of noradrenaline in severe trauma cases can induce coronary vasospasm. |
キーワード | coronary spasm angina noradrenaline severe trauma ST elevation treatment strategy |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 423 |
終了ページ | 427 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635143 |
Web of Science KeyUT | 001163659800004 |
JaLCDOI | 10.18926/AMO/65752 |
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フルテキストURL | 77_4_415.pdf |
著者 | Jelcic, Dzenis| Puzovic, Velibor| Benzon, Benjamin| Palada, Ivan| Jerković, Jelena| Vulic, Marko| |
抄録 | The aim of our study was to determine whether the immunohistochemical expression of placental vitamin D receptors is altered in pregnancies complicated by preeclampsia. Vitamin D receptor expression was immunohistochemically analysed in the placentas of three groups: a control group, and early- and late-onset preeclampsia groups. Total immunohistochemical intensity staining of placentas showed that the control group had a median vitamin D receptor (VDR) expression significantly higher than the placentas of mothers with early- and late-onset preeclampsia. There was no difference among the three groups in a semiquantitative analysis of VDR staining of the stroma only. Vitamin D receptors showed lower median expression in preeclampsia-affected pregnancies, especially early-onset preeclampsia. Therefore, Vitamin D receptor expression may be an important marker for normal placentation and preeclampsia onset. |
キーワード | vitamin D receptor immunohistochemistry early and late-onset preeclampsia |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 415 |
終了ページ | 422 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635142 |
Web of Science KeyUT | 001163659800006 |
JaLCDOI | 10.18926/AMO/65751 |
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フルテキストURL | 77_4_407.pdf |
著者 | Hotta, Kensuke| Kobayashi, Takaomi| |
抄録 | This study aimed to investigate the usefulness of force-controlled pelvic stress radiographs in the evaluation and treatment of fragility fractures of the pelvis (FFP) using a functional treatment strategy. We conducted a retrospective study of 55 geriatric patients with FFP who underwent pelvic stress radiographs on admission. The differences in the sacral width, pelvic ring width, and medial femoral head width between the radiographs with and without the Sam Sling II M size were defined as Δ sacral width, Δ pelvic ring width, and Δ medial femoral head width, respectively. We used Pearson’s correlation test to assess the relationship between the degree of radiographic instability and the Johns Hopkins highest level of mobility scale (JH-HLM) at 10-days postadmission. Conventional receiver-operating-characteristic curve analysis was used to identify cases requiring surgery using the best cutoff value for radiographic instability. The JH-HLM was significantly correlated with Δ sacral width (r=−0.401, p=0.017), but not with Δ pelvic ring width (r=−0.298, p=0.080) nor with Δ medial femoral head width (r= −0.261, p=0.128). The best cutoff value of Δ sacral width in identifying surgical cases was 10.7 mm (sensitivity 75.0%, specificity 98.0%). Force-controlled pelvic stress radiographs could be helpful in assessing the need for surgery on admission. |
キーワード | fragility fracture of the pelvis functional treatment strategy Sam Sling stress radiograph Johns Hopkins highest level of mobility scale |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 407 |
終了ページ | 414 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635141 |
Web of Science KeyUT | 001163659800001 |
JaLCDOI | 10.18926/AMO/65750 |
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フルテキストURL | 77_4_395.pdf |
著者 | Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana| |
抄録 | We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia. |
キーワード | tumor necrosis factor-alpha schizophrenia psychopathology immune system |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 395 |
終了ページ | 405 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635140 |
Web of Science KeyUT | 001163659800010 |
JaLCDOI | 10.18926/AMO/65749 |
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フルテキストURL | 77_4_387.pdf |
著者 | Kataoka, Takahiro| Habu, Hiroshi| Tanaka, Ayumi| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Takao, Soshi| Mitsunobu, Fumihiro| Yorifuji, Takashi| Yamaoka, Kiyonori| |
抄録 | No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis. |
キーワード | radon hot spring bathing habit self-rated health cross-section study |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 387 |
終了ページ | 394 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635139 |
Web of Science KeyUT | 001163659800003 |
JaLCDOI | 10.18926/AMO/65748 |
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フルテキストURL | 77_4_377.pdf |
著者 | Morimoto, Kosaku| Takeuchi, Yasuto| Takaki, Akinobu| Wada, Nozomu| Oyama, Atsushi| Adachi, Takuya| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| |
抄録 | Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker. |
キーワード | NAFLD NASH liver fibrosis chemokine FIB-4 |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 377 |
終了ページ | 385 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635138 |
Web of Science KeyUT | 001163659800009 |
フルテキストURL | fulltext.pdf |
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著者 | Miyoshi, Toru| Naoe, Satoko| Wakabayashi, Hiroyuki| Yano, Takashi| Mori, Takuya| Kanda, Shingo| Arita, Makoto| Ito, Hiroshi| |
キーワード | Eicosapentaenoic acid MND-2119 Metablolite Inflammation |
発行日 | 2023-12-01 |
出版物タイトル | Journal of Atherosclerosis and Thrombosis |
巻 | 30巻 |
号 | 12号 |
出版者 | Japan Atherosclerosis Society |
開始ページ | 1927 |
終了ページ | 1949 |
ISSN | 1340-3478 |
NCID | AA11018976 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | ©2023 Japan Atherosclerosis Society |
論文のバージョン | publisher |
PubMed ID | 37532570 |
DOI | 10.5551/jat.64135 |
Web of Science KeyUT | 001044716000001 |
関連URL | isVersionOf https://doi.org/10.5551/jat.64135 |
JaLCDOI | 10.18926/AMO/65746 |
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フルテキストURL | 77_4_371.pdf |
著者 | Iwamoto, Yosuke| Kaya, Mitsunori| Kijima, Hiroaki| Fujii, Masashi| Nagahata, Itsuki| Miyakoshi, Naohisa| |
抄録 | In recent publications on greater trochanteric pain syndrome (GTPS), the pathology receiving the most attention has been gluteus medius muscle tendinous injury, and surgical techniques such as gluteus medius tendon repair and their outcomes for GTPS have been reported. In our department-related facilities, arthroscopic surgeries are routinely performed for the patients with recalcitrant GTPS. A total of 51 patients were diagnosed with GTPS. Surgical treatment was carried out 22 patients (24 joints; 4 males and 18 females; mean age at surgery of 52.0 years). Arthroscopic findings confirmed bursitis in all 24 joints. In all cases, debridement of the greater trochanter bursa provided rapid relief of greater trochanter pain. The Numerical Rating Scale showed significant improvement, from the preoperative mean of 7.8 (range, 6-10) to the postoperative day 7 mean of 1.6 (range, 0-3). The modified Harris Hip Score was significantly improved from the preoperative mean of 65.5 (range, 52.5-78.3) to the final follow-up (average 2.9 months) mean of 96.0 (range, 85.2-100). Fascial damage of the gluteus medius muscle was observed in 21 joints while only 2 patients had a gluteus medius tendinous injury. Greater trochanteric bursitis and fascia or muscle-fiber injury of the gluteus medius muscle are the most common pathologies in patients with lateral hip pain. |
キーワード | greater trochanteric pain syndrome endoscopic findings bursitis |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 371 |
終了ページ | 375 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635137 |
Web of Science KeyUT | 001163659800005 |
JaLCDOI | 10.18926/AMO/65745 |
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フルテキストURL | 77_4_365.pdf |
著者 | Moldovan, Elena| Bănescu, Claudia| Cucerea, Manuela| Moldovan, Valeriu| Gozar, Liliana| Pușcașiu, Lucian| |
抄録 | Congenital heart disease is the most common malformative pathology in newborns, with a worldwide incidence at 0.4-5%. We investigated the possible relationship between variations in nucleotide sequences and specific cardiac malformations in the GATA-binding factor 4 (GATA4) exon 1 region by using Sanger sequencing. Forty-four newborns from a third-level neonatal intensive care unit who were diagnosed with nonsyndromic, ductal-dependent congenital heart disease (i.e., transposition of the great arteries or ductal-dependent coarctation of the aorta) were enrolled. Their DNA was extracted using commercial methods and tested using the multiplex ligation-dependent probe amplification (MLPA) technique. The Sanger sequencing for GATA4 exon 1 in the newborns’ DNA identified rs61277615, rs73203482, and rs35813172 variants not reported in the ClinVar archive of human variations in newborns previously diagnosed with transposition of the great arteries (n=5) and coarctation of the aorta (n=1). The identification of these novel variants in newborns with transposition of the great arteries or ductal-dependent coarctation of the aorta may be the first step in determining the variants’ contribution to the occurrence of congenital heart disease. However, these results may be inconclusive, since the observed variants within GATA4 gene were not previously reported. |
キーワード | transposition of the great arteries ductal-dependent coarctation of the aorta GATA4 MLPA Sanger sequencing |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 365 |
終了ページ | 370 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635136 |
Web of Science KeyUT | 001163659800008 |
フルテキストURL | fulltext.pdf |
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著者 | Sukegawa, Shintaro| Ono, Sawako| Tanaka, Futa| Inoue, Yuta| Hara, Takeshi| Yoshii, Kazumasa| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Katsumitsu, Shimada| Nakai, Fumi| Nakai, Yasuhiro| Miyazaki, Ryo| Murakami, Satoshi| Nagatsuka, Hitoshi| Miyake, Minoru| |
備考 | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-38343-y| |
発行日 | 2023-07-19 |
出版物タイトル | Scientific Reports |
巻 | 13巻 |
号 | 1号 |
出版者 | Nature Portfolio |
開始ページ | 11676 |
ISSN | 2045-2322 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 37468501 |
DOI | 10.1038/s41598-023-38343-y |
Web of Science KeyUT | 001033545700013 |
関連URL | isVersionOf https://doi.org/10.1038/s41598-023-38343-y |