検索結果 - 岡山大学学術成果リポジトリ

Absolute lymphocyte count and neutrophil-to-lymphocyte ratio as predictors of CDK 4/6 inhibitor efficacy in advanced breast cancer

フルテキストURL	fulltext.pdf
著者	Nakamoto, Shogo\| Shien, Tadahiko\| Iwamoto, Takayuki\| Kubo, Shinichiro\| Yamamoto, Mari\| Yamashita, Tetsumasa\| Kuwahara, Chihiro\| Ikeda, Masahiko\|
発行日	2024-04-30
出版物タイトル	Scientific Reports
巻	14巻
号	1号
出版者	Nature Portfolio
開始ページ	9869
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38684839
DOI	10.1038/s41598-024-60101-x
Web of Science KeyUT	001211286800006
関連URL	isVersionOf https://doi.org/10.1038/s41598-024-60101-x

Prognostic impact of adjuvant endocrine therapy for estrogen receptor-positive and HER2-negative T1a/bN0M0 breast cancer

フルテキストURL	fulltext.pdf
著者	Sasada, Shinsuke\| Kondo, Naoto\| Hashimoto, Hiroya\| Takahashi, Yuko\| Terata, Kaori\| Kida, Kumiko\| Sagara, Yasuaki\| Ueno, Takayuki\| Anan, Keisei\| Suto, Akihiko\| Kanbayashi, Chizuko\| Takahashi, Mina\| Nakamura, Rikiya\| Ishiba, Toshiyuki\| Tsuneizumi, Michiko\| Nishimura, Seiichiro\| Naito, Yoichi\| Hara, Fumikata\| Shien, Tadahiko\| Iwata, Hiroji\|
キーワード	Breast cancer T1a/b Endocrine therapy Estrogen receptor Prognosis
備考	The version of record of this article, first published in Breast Cancer Research and Treatment, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10549-023-07097-6\|
発行日	2023-09-09
出版物タイトル	Breast Cancer Research and Treatment
巻	202巻
号	3号
出版者	Springer Science and Business Media LLC
開始ページ	473
終了ページ	483
ISSN	0167-6806
NCID	AA10623184
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37688665
DOI	10.1007/s10549-023-07097-6
Web of Science KeyUT	001065105700004
関連URL	isVersionOf https://doi.org/10.1007/s10549-023-07097-6

Pathological Complete Response Patients after Neoadjuvant Chemotherapy in Breast Cancer

JaLCDOI	10.18926/AMO/63403
フルテキストURL	76_2_105.pdf
著者	Takaoka, Megumi\| Ohsumi, Shozo\| Ikejiri, Haruka\| Shidahara, Tomohiro\| Miyoshi, Yuichiro\| Takahashi, Mina\| Takashima, Seiki\| Aogi, Kenjiro\|
抄録	Cases of breast cancer metastasis after achieving a pathological complete response (pCR) with neoadjuvant chemotherapy (NAC) are sometimes encountered in clinical practice. We investigated the prognostic factors for pCR in patients with breast cancer after NAC. This retrospective cohort study included patients with localized breast cancer who underwent NAC followed by surgery between 2004 and 2020 and achieved a pCR. The associations between clinical factors and distant metastasis-free survival rate were statistically analyzed. We analyzed data for 127 patients. Twelve patients (9.4%) had distant metastases, and seven (5.5%) died. For estrogen receptor (ER)-positive patients, the distant metastasis-free survival rate was 94.6% for both 5 and 8 years. In contrast, ER-negative patients had a distant metastasis-free survival rate of 87.6% and 85.4% for 5 and 8 years (p=0.094), respectively. In cT0-2 patients, the distant metastasis-free survival rate was 92.4% for 5 years and 90.5% for 8 years, whereas in cT3-4 patients, the distant metastasis-free survival rate was 83.5% for 5 years and 83.5% for 8 years (p=0.301). This study suggested that patients with ER-negative, pre-NAC cT3 or T4 breast cancer who had achieved a pCR after NAC tended to have a worse prognosis.
キーワード	breast carcinoma neoadjuvant therapy prognosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	105
終了ページ	111
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503437
Web of Science KeyUT	000792374900001

NSAS-BC02 substudy of chemotherapy-induced amenorrhea (CIA) in premenopausal patients who received either taxane alone or doxorubicin(A) cyclophosphamide(C) followed by taxane as postoperative chemotherapy

著者	Iwamoto, Takayuki\| Hara, Fumikata\| Uemura, Yukari\| Mukai, Hirofumi\| Watanabe, Toru\| Ohashi, Yasuo\|
キーワード	Chemotherapy-induced amenorrhea Taxane Taxane Breast cancer Guarantee-time bias Premenopause
発行日	2020-05-28
出版物タイトル	Breast Cancer Research and Treatment
巻	182巻
号	2号
出版者	Springer
開始ページ	325
終了ページ	332
ISSN	0167-6806
NCID	AA10623184
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32462261
DOI	10.1007/s10549-020-05692-5
Web of Science KeyUT	000539434600002
関連URL	isVersionOf https://doi.org/10.1007/s10549-020-05692-5

The efficacy of sequential second-line endocrine therapies (ETs) in postmenopausal estrogen receptor-positive and HER2-negative metastatic breast cancer patients with lower sensitivity to initial ETs

フルテキストURL	fulltext.pdf
著者	Iwamoto, Takayuki\| Fujisawa, Tomomi\| Shien, Tadahiko\| Araki, Kazuhiro\| Sakamaki, Kentaro\| Sangai, Takafumi\| Kikawa, Yuichiro\| Takao, Shintaro\| Nishimura, Reiki\| Takahashi, Masato\| Aihara, Tomohiko\| Mukai, Hirofumi\| aira, Naruto\|
キーワード	Metastatic breast cancer Endocrine therapies Estrogen receptor-positive HER2-negative Resistance
発行日	2020-05-11
出版物タイトル	Breast Cancer
巻	27巻
号	5号
出版者	Springer
開始ページ	973
終了ページ	981
ISSN	13406868
NCID	AA1103354X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32394413
DOI	10.1007/s12282-020-01095-y
Web of Science KeyUT	000531780600002
関連URL	isVersionOf https://doi.org/10.1007/s12282-020-01095-y

Associations in tumor infiltrating lymphocytes between clinicopathological factors and clinical outcomes in estrogen receptor-positive/human epidermal growth factor receptor type 2 negative breast cancer

フルテキストURL	OL17_2_2177.pdf
著者	Miyoshi, Yuichiro\| Shien, Tadahiko\| Ogiya, Akiko\| Ishida, Naoko\| Yamazaki, Kieko\| Horii, Rie\| Horimoto, Yoshiya\| Masuda, Norikazu\| Yasojima, Hiroyuki\| Inao, Touko\| Osako, Tomofumi\| Takahashi, Masato\| Tomioka, Nobumoto\| Wanifuchi‑Endo, Yumi\| Hosoda, Mitsuchika\| Doihara, Hiroyoshi\| Yamashita, Hiroko\|
キーワード	breast cancer estrogen receptor positive human epidermal growth factor receptor type 2 negative prognosis tumor infiltrating lymphocytes
発行日	2018-12-19
出版物タイトル	Oncology Letters
巻	17巻
号	2号
出版者	Spandidos Publications
開始ページ	2177
終了ページ	2186
ISSN	1792-1074
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher
PubMed ID	30675282
DOI	10.3892/ol.2018.9853
Web of Science KeyUT	000459551800096
関連URL	isVersionOf https://doi.org/10.3892/ol.2018.9853

Molecular Subtypes of Breast Cancers from Myanmar Women: A Study of 91 Cases at Two Pathology Centers

フルテキストURL	K0005596_other1.pdf
著者	Thar Htet San\| Fujisawa, Masayoshi\| Fushimi, Soichiro\| Soe, Lamin\| Ngu Wah Min\| Yoshimura, Teizo\| Ohara, Toshiaki\| Myint Myint Yee\| Oda, Shinsuke\| Matsukawa , Akihiro\|
キーワード	Breast cancer molecular subtypes Ki-67 expression Myanmar
備考	学位審査副論文\|
発行日	2017-06-25
出版物タイトル	Asian Pacific journal of cancer prevention
巻	18巻
号	6号
出版者	Asian Pacific Organization for Cancer Prevention
開始ページ	1617
終了ページ	1621
ISSN	1513-7368
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	publisher
PubMed ID	28670879
DOI	10.22034/APJCP.2017.18.6.1617
関連URL	isVersionOf https://doi.org/10.22034/APJCP.2017.18.6.1617 isPartOf http://ousar.lib.okayama-u.ac.jp/55521

Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence

フルテキストURL	K0005471_abstract_review.pdf K0005471_summary.pdf K0005471_fulltext.pdf
著者	三好雄一郎\|
発行日	2017-03-24
資料タイプ	学位論文
学位授与番号	甲第5471号
学位授与年月日	2017-03-24
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Correlation between 18F-fluorodeoxyglucose Positron Emission Tomography/computed Tomography and Clinicopathological Features in Invasive Ductal Carcinoma of the Breast

JaLCDOI	10.18926/AMO/53907
フルテキストURL	69_6_333.pdf
著者	Ito, Maiko\| Shien, Tadahiko\| Kaji, Mitsumasa\| Mizoo, Taeko\| Iwamoto, Takayuki\| Nogami, Tomohiro\| Motoki, Takayuki\| Taira, Naruto\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\|
抄録	We evaluated the usefulness of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) examinations to predict the pathological features in primary breast cancer. In particular, we evaluated the correlation between the maximum standardized uptake values (SUVmax) obtained by 18F-FDG PET/CT and the Ki67 expression in estrogen receptor (ER)-positive invasive ductal carcinoma (IDC). Primary IDC patients operated between March 2009 and July 2013 at Okayama University Hospital were enrolled. We evaluated the correlations between the SUVmax and age, postoperative pT, histological grade, lymph vascular invasion, status of hormone receptor, human epidermal growth factor receptor 2 (HER2), Ki67 expression and node status. The Ki67 expression was classified as high (>14%) versus low (<14%). We enrolled 138 patients with IDC. Their median SUVmax was 3.85 (range:0-52.57). In a univariate analysis, the SUVmax was significantly related to age, pT, histological grade, lymphovascular invasion, hormone receptor status, HER2 status, node status and Ki67. In the 113 patients with ER-positive IDC, there was a significant correlation between Ki67 and SUVmax (p=0.0030). The preoperative 18F-FDG PET/CT results of IDC patients had significant relationships with pathological status parameters. The determination of the preoperative SUVmax might help classify Luminal A and Luminal B patients among luminal-type breast cancer patients.
キーワード	breast cancer invasive ductal carcinoma 18F-fluorodeoxyglucose positron emission tomography/computed tomography maximum standardized uptake values clinicopathological features
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-12
巻	69巻
号	6号
出版者	Okayama University Medical School
開始ページ	333
終了ページ	338
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26690243
Web of Science KeyUT	000368434500002

Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers

著者	Itoh, Mitsuya\| Iwamoto, Takayuki\| Matsuoka, Junji\| Nogami, Tomohiro\| Motoki, Takayuki\| Shien, Tadahiko\| Taira, Naruto\| Niikura, Naoki\| Hayashi, Naoki\| Ohtani, Shoichiro\| Higaki, Kenji\| Fujiwara, Toshiyoshi\| Doihara, Hiroyoshi\| Symmans, W. Fraser\| Pusztai, Lajos\|
発行日	2014-01
出版物タイトル	Breast Cancer Research and Treatment
巻	143巻
号	2号
資料タイプ	学術雑誌論文

p53 Expression in Pretreatment Specimen Predicts Response to Neoadjuvant Chemotherapy Including Anthracycline and Taxane in Patients with Primary Breast Cancer.

JaLCDOI	10.18926/AMO/50409
フルテキストURL	67_3_165.pdf
著者	Shien, Tadahiko\| Kinoshita, Takayuki\| Seki, Kunihiko\| Yoshida, Miwa\| Hojo, Takashi\| Shimizu, Chikako\| Taira, Naruto\| Doihara, Hiroyoshi\| Akashi-Tanaka, Sadako\| Tsuda, Hitoshi\| Fujiwara, Yasuhiro\|
抄録	While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p＝0.045) and histological grade 3 (p＝0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC.
キーワード	breast cancer neoadjuvant chemotherapy predictors
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-06
巻	67巻
号	3号
出版者	Okayama University Medical School
開始ページ	165
終了ページ	170
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23804139
Web of Science KeyUT	Pretreatment Specimen Predicts

肺癌と分子標的薬

著者	木浦勝行\| 谷本光音\|
発行日	2013-04-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	1号
資料タイプ	学術雑誌論文

Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1–3 lymph node metastases

著者	Nogami, Tomohiro\| Shien, Tadahiko\| Tanaka, Takehiro\| Nishiyama, Keiko\| Mizoo, Taeko\| Iwamto, Takayuki\| Ikeda, Hirokuni\| Taira, Naruto\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\|
発行日	2012-03-10
出版物タイトル	Breast Cancer
資料タイプ	学術雑誌論文

ニガウリ抽出物の血糖降下作用に関する文献的考察

著者	万倉三正\| 野田泰子\| 森昭胤\|
発行日	2012-04-01
出版物タイトル	岡山医学会雑誌
巻	124巻
号	1号
資料タイプ	学術雑誌論文

I 乳がんの診断と治療

著者	土井原博義\| 平成人\|
発行日	2008-01-04
出版物タイトル	岡山医学会雑誌
巻	119巻
号	3号
資料タイプ	学術雑誌論文