検索結果 - 岡山大学学術成果リポジトリ

Real-world comparative effectiveness of sarilumab versus Janus kinase inhibitors as monotherapy in rheumatoid arthritis

フルテキストURL	fulltext.pdf
著者	Nozaki, Yuji\| Kishimoto, Kazuya\| Itami, Tetsu\| Tomita, Daisuke\| Wada, Yumiko\| Kotani, Takuya\| Takeuchi, Tohru\| Hidaka, Toshihiko\| Hino, Shoichi\| Miyamoto, Toshiaki\| Miyake, Hirofumi\| Hatta, Kazunari\| Mamoto, Kenji\| Yamada, Yutaro\| Okano, Tadashi\| Okano, Takaichi\| Saegusa, Jun\| Horita, Masahiro\| Nishida, Keiichiro\| Kinoshita, Koji\| Rai, Shinya\|
キーワード	Rheumatoid arthritis Methotrexate Biological DMARDs
発行日	2026-01-02
出版物タイトル	Arthritis Research & Therapy
巻	28巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	32
ISSN	1478-6362
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2026.
論文のバージョン	publisher
PubMed ID	41484643
DOI	10.1186/s13075-025-03722-5
Web of Science KeyUT	001685294500001
関連URL	isVersionOf https://doi.org/10.1186/s13075-025-03722-5

Comparison of clinical practices during the transitional and young adult phases between patients with oligoarticular/polyarticular juvenile idiopathic arthritis and those with rheumatoid arthritis in Japan

フルテキストURL	fulltext.pdf
著者	Mori, Sho\| Shabana, Kosuke\| Matsui, Toshihiro\| Nozawa, Tomo\| Sugita, Yuko\| Tomiita, Minako\| Nakagishi, Yasuo\| Yamasaki, Yuichi\| Umebayashi, Hiroaki\| Yashiro, Masato\| Iwata, Naomi\| Yasumura, Junko\| Wakiguchi, Hiroyuki\| Yamamoto, Takeshi\| Takezaki, Shunichiro\| Okura, Yuka\| Yokoyama, Tadafumi\| Shimizu, Masaki\| Hirayama, Masahiro\| Tohma, Shigeto\| Okamoto, Nami\| Mori, Masaaki\|
キーワード	Juvenile idiopathic arthritis Rheumatoid arthritis Disease activity Biologics Methotrexate
発行日	2025-11-24
出版物タイトル	Pediatric Rheumatology
巻	23巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	120
ISSN	1546-0096
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025.
論文のバージョン	publisher
PubMed ID	41286783
DOI	10.1186/s12969-025-01164-6
Web of Science KeyUT	001622329200001
関連URL	isVersionOf https://doi.org/10.1186/s12969-025-01164-6

TeMPRA: advancing continuing professional development in pediatric rheumatology in Japan

フルテキストURL	fulltext.pdf
著者	Wakiguchi, Hiroyuki\| Hashimoto, Kunio\| Yashiro, Masato\| Nishimura, Kenichi\| Ebato, Takasuke\| Akamine, Keiji\| Uejima, Yoji\| Sato, Tomomi\| Yamasaki, Yuichi\| Yasumura, Junko\| Okazaki, Fumiko\| Kizawa, Toshitaka\| Yasuoka, Ryuhei\| Ishikawa, Tomoaki\| Yamamoto, Takeshi\| Fujita, Yuji\| Itoh, Naohiro\| Takasaki, Asami\| Sakurai, Nodoka\| Suzuki, Kazuo\| Tamai, Tasuku\| Hirano, Naoki\| Okamoto, Nami\| Shimizu, Masaki\|
キーワード	Child Education Juvenile idiopathic arthritis Practice Rheumatic diseases Systemic lupus erythematosus Team of mid-career pediatric rheumatologists alliance
発行日	2026-01-24
出版物タイトル	Pediatric Rheumatology
巻	24巻
号	1号
出版者	Springer Science and Business Media LLC
ISSN	1546-0096
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025.
論文のバージョン	publisher
PubMed ID	41580803
DOI	10.1186/s12969-025-01182-4
Web of Science KeyUT	001693782300001
関連URL	isVersionOf https://doi.org/10.1186/s12969-025-01182-4

Does perioperative discontinuation of anti-rheumatic drugs increase postoperative complications in orthopedic surgery for rheumatoid arthritis?

フルテキストURL	fulltext.pdf
著者	Ito, Hiromu\| Ishikawa, Hajime\| Tsuji, Shigeyoshi\| Nakayama, Masanori\| Nishida, Keiichiro\| Mochizuki, Takeshi\| Ebina, Kosuke\| Kojima, Toshihisa\| Matsumoto, Takumi\| Kubota, Ayako\| Nakajima, Arata\| Kaneko, Atsushi\| Matsushita, Isao\| Hara, Ryota\| Sakuraba, Koji\| Akasaki, Yukio\| Matsubara, Tsukasa\| Mochida, Yuichi\| Kanbe, Katsuaki\| Nakagawa, Natsuko\| Murata, Koichi\| Momohara, Shigeki\|
キーワード	Rheumatoid arthritis Orthopaedic surgery DMARD Perioperative complications
発行日	2025-11-21
出版物タイトル	Arthritis Research & Therapy
巻	27巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	219
ISSN	1478-6362
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025.
論文のバージョン	publisher
PubMed ID	41272853
DOI	10.1186/s13075-025-03683-9
関連URL	isVersionOf https://doi.org/10.1186/s13075-025-03683-9

Lyme neuroborreliosis in Japan: Borrelia burgdorferi sensu lato as a cause of meningitis of previously undetermined etiology in hospitalized patients outside of the island of Hokkaido, 2010–2021

フルテキストURL	fulltext.pdf suppl.pdf
著者	Ohira, Masayuki\| Takano, Ai\| Yoshi, Kentaro\| Arai, Akira\| Aso, Yashuhiro\| Furutani, Rikiya\| Hamano, Tadanori\| Takahashi‐Iwata, Ikuko\| Kaneko, Chikako\| Matsuura, Tohru\| Maeda, Norihisa\| Nakajima, Hideto\| Shindo, Katsuro\| Suenaga, Toshihiko\| Sugie, Kazuma\| Suzuki, Yasuhiro\| Yamashita, Toru\| Angulo, Frederick J.\| Edwards, Juanita\| Bender, Cody Matthew\| Harper, Lisa R.\| Nakayama, Yoshikazu\| Ito, Shuhei\| Pilz, Andreas\| Stark, James H.\| Moïsi, Jennifer C.\| Mizusawa, Hidehiro\| Takao, Masaki\|
キーワード	epidemiology disease burden Lyme neuroborreliosis meningitis tick-borne disease
発行日	2025-01
出版物タイトル	European Journal of Neurology
巻	32巻
号	1号
出版者	Wiley
開始ページ	e70005
ISSN	1351-5101
NCID	AA11015934
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Author(s).
論文のバージョン	publisher
PubMed ID	39807698
DOI	10.1111/ene.70005
Web of Science KeyUT	001397189700001
関連URL	isVersionOf https://doi.org/10.1111/ene.70005

Telemedicine as an alternative to in-person care in the field of rheumatic diseases: A systematic scoping review

フルテキストURL	fulltext.pdf suppl.docx
著者	Sada, Ken-ei\| Iwata, Shigeru\| Inoue, Yuzaburo\| Tanaka, Eiichi\| Nishida, Keiichiro\| Kawahito, Yutaka\| Abe, Asami\| Kawakami, Atsushi\| Miyamae, Takako\|
キーワード	Digital health telemedicine remote care rheumatic disease scoping review
発行日	2025-02-13
出版物タイトル	Modern Rheumatology
巻	35巻
号	4号
出版者	Oxford University Press (OUP)
開始ページ	715
終了ページ	721
ISSN	1439-7595
NCID	AA1157187X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Japan College of Rheumatology 2025.
論文のバージョン	publisher
PubMed ID	39943803
DOI	10.1093/mr/roaf012
Web of Science KeyUT	001425975100001
関連URL	isVersionOf https://doi.org/10.1093/mr/roaf012

A Preliminary Survey of Rheumatologists on the Management of Late-onset Rheumatoid Arthritis in Japan

フルテキストURL	fulltext.pdf suppl1.tif suppl2.pdf suppl3.pdf
著者	Takanashi, Satoshi\| Kaneko, Yuko\| Kawahito, Yutaka\| Kida, Takashi\| Sugihara, Takahiko\| Kojima, Toshihisa\| Harada, Ryozo\| Ishitoku, Michinori\| Hirata, Shintaro\| Hashimoto, Motomu\| Hidaka, Toshihiko\| Abe, Asami\| Ishikawa, Hajime\| Ito, Hiromu\| Kishimoto, Mitsumasa\| Matsui, Kazuo\| Matsui, Toshihiro\| Matsushita, Isao\| Onishi, Akira\| Morinobu, Akio\| Nishida, Keiichiro\| Asai, Shuji\| Tanaka, Eiichi\| Harigai, Masayoshi\| Kojima, Masayo\|
キーワード	late-onset rheumatoid arthritis ageing society questionnaire
発行日	2024-12-15
出版物タイトル	Internal Medicine
巻	63巻
号	24号
出版者	Japanese Society of Internal Medicine
開始ページ	3299
終了ページ	3306
ISSN	0918-2918
NCID	AA10827774
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	38692915
DOI	10.2169/internalmedicine.3288-23
CRID	1390021072388391552
Web of Science KeyUT	001388887300002
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.3288-23

Evaluating the Patterns of FAPI Uptake in the Shoulder Joint: a Preliminary Study Comparing with FDG Uptake in Oncological Studies

フルテキストURL	fulltext.pdf
著者	Matsusaka, Yohji\| Werner, Rudolf A.\| Serfling, Sebastian E.\| Buck, Andreas K.\| Kosmala, Aleksander\| Sasaki, Takanori\| Weich, Alexander\| Higuchi, Takahiro\|
キーワード	Fibroblast activation inhibitor Shoulder Acromioclavicular joints F-18 fluorodeoxyglucose Positron emission tomography FAP Ga-68 FAPI-04 Rheumatoid arthritis Osteoarthritis
発行日	2024-01-04
出版物タイトル	Molecular Imaging and Biology
巻	26巻
号	2号
出版者	Springer Science and Business Media LLC
開始ページ	294
終了ページ	300
ISSN	1536-1632
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38177615
DOI	10.1007/s11307-023-01893-8
Web of Science KeyUT	001136274500001
関連URL	isVersionOf https://doi.org/10.1007/s11307-023-01893-8

Continuous Stimulation with Glycolaldehyde-derived Advanced Glycation End Product Reduces Aggrecan and COL2A1 Production via RAGE in Human OUMS-27 Chondrosarcoma Cells

JaLCDOI	10.18926/AMO/68723
フルテキストURL	79_3_157.pdf
著者	Hatipoglu, Omer Faruk\| Nishinaka, Takashi\| Yaykasli, Kursat Oguz\| Mori, Shuji\| Watanabe, Masahiro\| Toyomura, Takao\| Nishibori, Masahiro\| Hirohata, Satoshi\| Takahashi, Hideo\| Wake, Hidenori\|
抄録	Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3.
キーワード	advanced glycation end product aging cartilage collagen aggrecan
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-06
巻	79巻
号	3号
出版者	Okayama University Medical School
開始ページ	157
終了ページ	166
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40574254
Web of Science KeyUT	001524768800002

Clinical practice pattern of Pneumocystis pneumonia prophylaxis in systemic lupus erythematosus: a cross-sectional study from lupus registry of nationwide institutions (LUNA)

フルテキストURL	fulltext.pdf
著者	Onishi, Takahisa\| Sada, Ken-Ei\| Hayashi, Keigo\| Miyawaki, Yoshia\| Yoshimi, Ryusuke\| Shimojima, Yasuhiro\| Ohno, Shigeru\| Kajiyama, Hiroshi\| Ichinose, Kunihiro\| Sato, Shuzo\| Fujiwara, Michio\| Yajima, Nobuyuki\| Kida, Takashi\| Matsuo, Yusuke\| Nishimura, Keisuke\| Yamane, Takashi\|
キーワード	Systemic lupus erythematosus Pneumocystis jirovecii pneumonia Glucocorticoid Immunosuppressant Practice pattern
備考	The version of record of this article, first published in Arthritis Research & Therapy, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13075-024-03434-2\|
発行日	2024-11-12
出版物タイトル	Arthritis Research & Therapy
巻	26巻
号	1号
出版者	BMC
開始ページ	198
ISSN	1478-6354
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024.
論文のバージョン	publisher
PubMed ID	39533345
DOI	10.1186/s13075-024-03434-2
Web of Science KeyUT	001354057800004
関連URL	isVersionOf https://doi.org/10.1186/s13075-024-03434-2

Association between discontinuity of care and patient trust in the usual rheumatologist among patients with systemic lupus erythematosus: a cross-sectional study

フルテキストURL	fulltext.pdf
著者	Katayama, Yu\| Miyawaki, Yoshia\| Shidahara, Kenta\| Nawachi, Shoichi\| Asano, Yosuke\| Katsuyama, Eri\| Katsuyama, Takayuki\| Takano-Narazaki, Mariko\| Matsumoto, Yoshinori\| Oguro, Nao\| Yajima, Nobuyuki\| Ishikawa, Yuichi\| Sakurai, Natsuki\| Hidekawa, Chiharu\| Yoshimi, Ryusuke\| Ohno, Shigeru\| Ichikawa, Takanori\| Kishida, Dai\| Shimojima, Yasuhiro\| Sada, Ken-Ei\| Wada, Jun\| Thom, David H.\| Kurita, Noriaki\|
キーワード	Systemic lupus erythematosus Patient-physician relationship Outpatient visits Patient trust Discontinuity of care
備考	The version of record of this article, first published in Arthritis Research & Therapy, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13075-024-03428-0\|
発行日	2024-11-11
出版物タイトル	Arthritis Research & Therapy
巻	26巻
号	1号
出版者	BMC
開始ページ	195
ISSN	1478-6354
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024.
論文のバージョン	publisher
PubMed ID	39529181
DOI	10.1186/s13075-024-03428-0
Web of Science KeyUT	001352382300001
関連URL	isVersionOf https://doi.org/10.1186/s13075-024-03428-0

Survey of Osteoarthritis of the Shoulder in Patients who Underwent Knee Arthroplasty for Knee Osteoarthritis

JaLCDOI	10.18926/AMO/66153
フルテキストURL	77_6_613.pdf
著者	Miyake, Yoshiaki\| Namba, Yoshifumi\| Mitani, Shigeru\| Umehara, Norifumi\| Kawamoto, Toyohiro\| Furuichi, Shuro\|
抄録	The relationship between osteoarthritis (OA) of the lower extremity and shoulder OA has not been established. This study evaluated the prevalence of shoulder OA in patients with knee OA. We collected contrast-enhanced computed tomography (CECT) images of the shoulder joints of 105 patients with knee OA that were taken 1 week after they underwent primary knee arthroplasty to check for venous thromboembolism (VTE). The images were compared with CECT images of 110 control-group patients that were taken for the purpose of differentiating VTE. Shoulder OA was present in a significantly higher percentage of patients with knee arthroplasty than controls (29% versus 15%), and the difference was particularly pronounced in patients in their 70s (33%) compared to age-matched controls (11%). Patients with knee OA often use arm support to stand up or walk due to knee joint pain and muscle weakness, which places the weight-bearing shoulder at risk of developing OA.
キーワード	shoulder osteoarthritis knee osteoarthritis weight-bearing shoulder knee arthroplasty
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-12
巻	77巻
号	6号
出版者	Okayama University Medical School
開始ページ	613
終了ページ	618
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38145935
Web of Science KeyUT	001164631200006

Relationship between the Hip Abductor Muscles and Abduction Strength in Patients with Hip Osteoarthritis

JaLCDOI	10.18926/AMO/65968
フルテキストURL	77_5_461.pdf
著者	Homma, Daisuke\| Minato, Izumi\| Imai, Norio\| Miyasaka, Dai\| Sakai, Yoshinori\| Horigome, Yoji\| Suzuki, Hayato\| Dohmae, Yoichiro\| Endo, Naoto\|
抄録	This study aimed to determine which muscle the gluteus maximus, gluteus medius, gluteus minimus (Gmin), or tensor fasciae latae (TFL) contributes most to hip abduction strength and to identify effective sites for cross-sectional area (CSA) Gmin and TFL measurement in hip osteoarthritis (OAhip) patients. Twenty-eight patients with OAhip were included. The muscle CSA and volume were determined using magnetic resonance imaging. Peak isometric strength was determined using hand-held dynamometry. Muscle volumes were normalized to the total muscle volume of hip abductors. Multiple regression analysis was performed. The difference between the CSA of Gmin and TFL was calculated, and correlations with volume and muscle strength were determined. Gmin volume was related to abductor muscle strength (p=0.042). The peak CSA of the Gmin correlated with muscle volume and strength. The CSA of the TFL correlated with volume, with no difference between the CSA of the most protruding part of the lesser trochanter and peak CSA. Gmin volume was strongly related to abductor muscle strength. Peak CSA is a useful parameter for assessing the CSA of the Gmin among patients with OAhip. The CSA of the TFL should be measured at the most protruding part of the lesser trochanter.
キーワード	gluteus minimus tensor fasciae latae cross-sectional area muscle volume hip osteoarthritis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-10
巻	77巻
号	5号
出版者	Okayama University Medical School
開始ページ	461
終了ページ	469
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37899257
Web of Science KeyUT	001108661600003

First-line Combination Strategy Provides Favorable 5-year Outcomes for Patients with Lupus Nephritis: A Single-center Observational Study

JaLCDOI	10.18926/AMO/64036
フルテキストURL	76_5_547.pdf
著者	Kagawa, Hidetoshi\| Yamanaka, Ryutaro\| Hiromasa, Tsutomu\|
抄録	This observational study aimed to clarify the long-term results of the combination of mizoribine (MZB), tacrolimus (TAC) and prednisolone as first-line therapy for lupus nephritis (LN). This was our institution’s standard therapy between 2009 and 2015, when we saw 36 patients with LN. When a patient thus treated achieved SLEDAI remission (= 0) and/or the prednisolone dose could be tapered to 5 mg/day, either MZB or TAC was stopped, and the other was continued for maintenance therapy. If treatment failure or relapse occurred, second-line therapy was introduced. At years 1 and 5, overall complete renal response and SLEDAI remission were 94% and 88%, and 50% and 62%, respectively. Excluding 2 cases lost to follow-up, medications after 5 years were as follows: 20 (59%) were stable on 1 drug (MZB or TAC), 11 (32%) required continuation of both drugs (MZB + TAC), and 3 (9%) required second-line therapy. The 5-year retention rate was 91% (non-secondline), with 0% of relapse in this group. Our first-line combination strategy showed high remission rates in the induction phase, and subsequent maintenance therapy demonstrated good outcomes for up to 5 years. Research that fine-tunes the order of therapeutic agents and institutes appropriate treatment goals may further improve long-term outcomes for patients with LN.
キーワード	combination therapy first-line therapy lupus nephritis mizoribine tacrolimus
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	547
終了ページ	555
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352802
Web of Science KeyUT	000884907100008

Immunomodulatory Effects of Radon Inhalation on Lipopolysaccharide-Induced Inflammation in Mice

フルテキストURL	fulltext.pdf
著者	Kataoka, Takahiro\| Naoe, Shota\| Murakami, Kaito\| Fujimoto, Yuki\| Yukimine, Ryohei\| Tanaka, Ayumi\| Yamaoka, Kiyonori\|
キーワード	autoimmune diseases cytokine antioxidant function lipopolysaccharide radon inhalation
発行日	2022-08-26
出版物タイトル	International Journal Of Environmental Research And Public Health
巻	19巻
号	17号
出版者	MDPI
開始ページ	10632
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	36078348
DOI	10.3390/ijerph191710632
Web of Science KeyUT	000851073300001
関連URL	isVersionOf https://doi.org/10.3390/ijerph191710632

Therapeutic Approaches Targeting miRNA in Systemic Lupus Erythematosus

JaLCDOI	10.18926/AMO/63887
フルテキストURL	76_4_359.pdf
著者	Hiramatsu-Asano, Sumie\| Wada, Jun\|
抄録	Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE.
キーワード	systemic lupus erythematosus miRNA miRNA targeting therapy
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	359
終了ページ	371
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123150
Web of Science KeyUT	000882167300002

Survey of Shoulder Osteoarthritis in Patients who Underwent Total Hip Arthroplasty for Hip Osteoarthritis

JaLCDOI	10.18926/AMO/63411
フルテキストURL	76_2_173.pdf
著者	Miyake, Yoshiaki\| Mitani, Shigeru\| Namba, Yoshifumi\| Umehara, Norifumi\| Kawamoto, Toyohiro\| Furuichi, Shuro\|
抄録	To the best of our knowledge, no previous studies have reported a relationship between osteoarthritis (OA) of the lower limbs and OA of the shoulder joints. We evaluated the correlation between shoulder OA and hip OA. We collected contrast-enhanced computed tomography (CECT) images of the shoulder joints of 159 patients with hip OA who underwent primary total hip arthroplasty (THA). The images, taken 1 week after THA to monitor venous thromboembolism (VTE), were used to examine the prevalence of shoulder OA. They were compared with those of 103 controls who underwent CECT during the same period to monitor VTE. Shoulder OA was observed in 15% of the controls and 24% of the THA patients. Although the rate was somewhat higher in the THA group, the difference was not significant. However, in the THA group, significantly more patients with bilateral hip OA (33%) had shoulder OA than those with unilateral hip OA (17%). In summary, the prevalence of shoulder OA was significantly higher in patients with bilateral hip OA. In these patients, pain and instability in the hip joints require them to use arm support to stand up or walk, putting the weight-bearing shoulder at risk of developing OA.
キーワード	shoulder osteoarthritis hip osteoarthritis weight-bearing shoulder total hip arthroplasty
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	173
終了ページ	177
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503445
Web of Science KeyUT	000792374900009

Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model

フルテキストURL	fulltext20220414-1.pdf
著者	Kataoka, Takahiro\| Naoe, Shota\| Murakami, Kaito\| Yukimine, Ryohei\| Fujimoto, Yuki\| Kanzaki, Norie\| Sakoda, Akihiro\| Mitsunobu, Fumihiro\| Yamaoka, Kiyonori\|
キーワード	radon cytokine oxidative stress rheumatoid arthritis immunomodulation function
発行日	2022
出版物タイトル	Journal of Clinical Biochemistry and Nutrition
巻	70巻
号	2号
出版者	The Society for Free Radical Research Japan
開始ページ	154
終了ページ	159
ISSN	0912-0009
NCID	AA10710201
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 JCBN
論文のバージョン	publisher
PubMed ID	35400822
DOI	10.3164/jcbn.21-91
Web of Science KeyUT	000763105900009
関連URL	isVersionOf https://doi.org/10.3164/jcbn.21-91

The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis

フルテキストURL	fulltext.pdf
著者	Tabuchi, Masako\| Inoue, Katsumi\| Usui-Kataoka, Hitomi\| Kobayashi, Kazuko\| Teramoto, Misako\| Takasugi, Koji\| Shikata, Kenichi\| Yamamura, Masahiro\| Ando, Kenji\| Nishida, Keiichiro\| Kasahara, Junko\| Kume, Noriaki\| Lopez, Luis R.\| Mitsudo, Kazuaki\| Nobuyoshi, Masakiyo\| Yasuda, Tatsuji\| Kita, Toru\| Makino, Hirofumi\| Matsuura, Eiji\|
キーワード	beta 2-glycoprotein I oxidized LDL/beta 2-glycoprotein I complexes diabetes mellitus oxidized LDL
発行日	2007-04
出版物タイトル	Journal Of Lipid Research
巻	48巻
号	4号
出版者	ELSEVIER
開始ページ	768
終了ページ	781
ISSN	0022-2275
NCID	AA00701215
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2007 by the American Society for Biochemistry and Molecular Biology, Inc.
論文のバージョン	publisher
PubMed ID	17261875
DOI	10.1194/jlr.M600414-JLR200
Web of Science KeyUT	000245627100003
関連URL	isVersionOf https://doi.org/10.1194/jlr.M600414-JLR200

Guideline-based Treatment of Glucocorticoid-induced Osteoporosis in Patients with Rheumatoid Arthritis: A Retrospective Study with the AORA Registry

JaLCDOI	10.18926/AMO/62809
フルテキストURL	75_6_699.pdf
著者	Kawano, Tetsuya\| Miyakoshi, Naohisa\| Tsuchie, Hiroyuki\| Kashiwagura, Takeshi\| Kobayashi, Moto\| Aonuma, Hiroshi\| Sugimura, Yusuke\| Shimada, Yoichi\|
抄録	Glucocorticoid-induced osteoporosis (GIOP) is one of the side effects associated with glucocorticoid (GC) therapy. In 2014, the Japanese Society for Bone and Mineral Research (JSBMR) provided new guidelines for the management and treatment of GIOP. The aim of the present study was to clarify the prevalence of patients with rheumatoid arthritis (RA) requiring treatment according to the new guidelines and to identify risk factors associated with lack of treatment in these patients. Patients in the 2018 Akita Orthopedic group on Rheumatoid Arthritis (AORA) database were enrolled. Of 2,234 patients with RA in the database, 683 (30.6%) met the 2014 JSBMR guideline treatment criteria, and 480 (70.3%) had been treated. The untreated group included a larger number of males, younger patients, and patients treated in clinics rather than hospital (p<0.001, p=0.015, and p<0.001, respectively). Multivariate analyses found that male sex, younger age, and clinic-based RA care were significant risk factors associated with lack of treatment (p<0.001, p=0.013, and p<0.001, respectively). Thus, male sex, younger age, and clinic-based care were identified as risk factors
キーワード	glucocorticoid glucocorticoid-induced osteoporosis rheumatoid arthritis osteoporosis osteopenia
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	699
終了ページ	704
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955537
Web of Science KeyUT	000735297900005
NAID	120007180283