検索結果 3961 件
| JaLCDOI | 10.18926/AMO/71343 |
|---|---|
| フルテキストURL | 80_5_333.pdf |
| 著者 | Yamamoto, Masahiro| Sada, Ken-ei| Kawada, Satoshi| Furihata, Taeko| Muramatsu, Sachiko| Miyamoto, Daichi| Yano, Akihiko| Miyashita, Kohei| Saisaka, Yuichi| Ishii, Takayuki| |
| 抄録 | A 79-year-old woman with severe fever with thrombocytopenia syndrome (SFTS) developed progressive atrioventricular (AV) conduction disturbances during hospitalization. On hospital day 6, first-degree AV block progressed to transient complete AV block, causing syncope and a 15-sec asystolic pause. Echocardiography showed preserved ventricular function, and cardiac magnetic resonance imaging did not support clinically overt myocarditis. A temporary transvenous pacemaker was inserted, and AV conduction recovered spontaneously; pacing was discontinued by day 9 without permanent pacemaker implantation. This case suggests that SFTS can cause reversible high-degree AV block and may warrant continuous twelve-lead electrocardiography (ECG) monitoring and timely temporary pacing. |
| キーワード | severe fever with thrombocytopenia syndrome atrioventricular block bradyarrhythmia temporary pacing myocarditis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-10 |
| 巻 | 80巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 333 |
| 終了ページ | 337 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QF, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Kan B, Wang SW, Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song JD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y and Li DX: Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 364: 1523-1532.| Yokomizo K, Tomozane M, Sano C and Ohta R: Clinical presentation and mortality of severe fever with thrombocytopenia syndrome in Japan: A systematic review of case reports. Int J Environ Res Public Health (2022) 19: 2271.| Song L, Zhao Y, Wang G, Huang D and Sai L: Analysis of risk factors associated with fatal outcome among severe fever with thrombocytopenia syndrome patients from 2015 to 2019 in Shandong, China. Eur J Clin Microbiol Infect Dis (2022) 41: 1415-1420.| Liu Q, Yang M, Shen S, Gong C and Lan Z: Cardiac abnormalities in patients with severe fever with thrombocytopenia syndrome: A systematic review. Open Forum Infect Dis (2023) 10: ofad509.| Deng B, Zhou B, Zhang S, Zhu Y, Han L, Geng Y, Jin Z, Liu H, Wang D, Zhao Y, Wen Y, Cui W, Zhou Y, Gu Q, Sun C, Lu X, Wang W, Wang Y, Li C, Wang Y, Yao W and Liu P: Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome Bunyavirus infection in Northeast China. PLoS One (2013) 8: e80802.| Aizawa Y, Komura S and Funazaki T: T-wave inversion after pacemaker implantation: a manifestation of cardiac memory. BMC Cardiovasc Disord (2026) 26: 351.| Lee PY, Garan H, Wan EY, Scully BE, Biviano A and Yarmohammadi H: Cardiac arrhythmias in viral infections. J Interv Card Electrophysiol (2023) 66: 1939-1953.| Caforio ALP, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, Fu M, Heliö T, Heymans S, Jahns R, Klingel K, Linhart A, Maisch B, McKenna W, Mogensen J, Pinto YM, Ristic A, Schultheiss H-P, Seggewiss H, Tavazzi L, Thiene G, Yilmaz A, Charron P and Elliott PM: Current state of knowledge on aetiolaetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J (2013) 34: 2636-2648, 2648a-2648d.| Sun J, Hao Y, Niu J, Du Z and Yang J: The characteristics of cardiac injury in patients with severe fever with thrombocytopenia syndrome. Jpn J Infect Dis (2025) 78: 156-163.| Gong L, Zhang L, Wu J, Lu S, Lyu Y, Zhu M, Liu B, Zhu Y, Song D, Su B and Liu Z: Clinical progress and risk factors for death from severe fever with thrombocytopenia syndrome: A multihospital retrospective investigation in Anhui, China. Am J Trop Med Hyg (2021) 104: 1425-1431.| |
| JaLCDOI | 10.18926/AMO/71342 |
|---|---|
| フルテキストURL | 80_5_327.pdf |
| 著者 | Hata, Yurika| Tabuchi, Motoyasu| Sakamoto, Shinya| Tamura, Shuta| Uemura, Sunao| Tokumaru, Teppei| Yoshimatu, Rika| Okabayashi, Takehiro| |
| 抄録 | A 67-year-old man presented with sudden-onset abdominal pain and hemorrhagic shock. Contrast-enhanced CT revealed a large hematoma in hepatic segments VI-VII with capsular rupture and hemoperitoneum. CT angiography demonstrated a saccular pseudoaneurysm in a posterior segmental branch of the right hepatic artery and a beaded appearance with irregular dilatation and segmental narrowing of the right hepatic artery branches, without inflammatory or atherosclerotic findings, supporting a diagnosis of segmental arterial mediolysis (SAM). Emergency angiography followed by coil embolization achieved hemostasis. Follow-up CT at 5 months showed complete exclusion of the aneurysmal lesions, with no evidence of recurrence or new vascular lesions. Coil embolization may be an effective, minimally invasive option for ruptured intrahepatic SAM lesions. |
| キーワード | segmental arterial mediolysis hepatic artery intra-abdominal hemorrhage |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-10 |
| 巻 | 80巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 327 |
| 終了ページ | 332 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Slavin RE and Gonzalez-Vitale JC: Segmental mediolytic arteritis: a clinical pathologic study. Lab Invest (1976) 35: 23-29.| Chao CP: Segmental arterial mediolysis. Semin Intervent Radiol (2009) 26: 224-232.| Shimohira M, Kondo H, Ogawa Y, Kawada H, Koganemaru M, Ikeda O, Yamamoto A, Komada T, Tanoue S, Muraoka N, Tanikake M, Hayashi S, Yamamoto S, Sato T, Mizunuma K, Ganaha F, Murakami Y and Ishiguchi T: Natural History of Unruptured Visceral Artery Aneurysms Due to Segmental Arterial Mediolysis and Efficacy of Transcatheter Arterial Embolization: A Retrospective Multiinstitutional Study in Japan. AJR Am J Roentgenol (2021) 216: 691-697.| Shenouda M, Riga C, Naji Y and Renton S: Segmental arterial mediolysis: a systematic review of 85 cases. Ann Vasc Surg (2014) 28: 269-277.| Naidu SG, Menias CO, Oklu R, Hines RS, Alhalabi K, Makar G, Shamoun FE, Henkin S and McBane RD: Segmental Arterial Mediolysis: Abdominal Imaging of and Disease Course in 111 Patients. AJR Am J Roentgenol (2018) 210: 899-905.| Ryan JM, Suhocki PV and Smith TP: Coil embolization of segmental arterial mediolysis of the hepatic artery. J Vasc Interv Radiol (2000) 11: 865-868.| van Twist DJL, Appelboom Y, Magro-Checa C, Haagmans M, Riedl R, Yazar O, Bouwman LH and Mostard GJM: Differentiating between segmental arterial mediolysis and other arterial vasculopathies to establish an early diagnosis - a systematic literature review and proposal of new diagnostic criteria. Postgrad Med (2024) 136: 1-13.| Olivares E, Vingan H and Zhou Q: Spontaneous hemoperitoneum resulting from segmental arterial mediolysis. Radiol Case Rep (2018) 13: 732-735.| Kato H, Hagiwara S, Nishida N, Komeda Y, Yoshida A and Kudo M: A case of transcatheter arterial embolization for intraperitoneal hemorrhage due to giant hepatic segmental arterial mediolysis. Clin J Gastroenterol (2023) 16: 397-401.| Tomonaga T, Eguchi S, Hidaka M, Takatsuki M, Soyama A, Muraoka I, Mizutani A, Fukui H and Kanematsu T: A case of ruptured segmental arterial mediolysis of the hepatic artery: report of a case. Hepatogastroenterology (2011) 58: 1912-1914.| Beerle C, Soll C, Breitenstein S and Grieder F: Spontaneous rupture of an intrahepatic aneurysm of the right hepatic artery caused by segmental arterial mediolysis. BMJ Case Rep (2016) 2016: bcr2015214109.| Marshall L, OʼRourke T, McCann A, Finch R and Strong R: Spontaneous intrahepatic haemorrhage: two cases of segmental arterial mediolysis. ANZ J Surg (2015) 85: 49-52.| |
| JaLCDOI | 10.18926/AMO/71341 |
|---|---|
| フルテキストURL | 80_5_317.pdf |
| 著者 | Saito, Hayato| Fukui, Ryohei| Sugihara, Hanako| Tada, Akihiro| Nagao, Shoji| Iguchi, Toshihiro| |
| 抄録 | This study evaluated the feasibility of predicting pathogenic BRCA1/2 variants in ovarian cancer using radiogenomic analysis of contrast-enhanced MRI. Twenty six patients were analyzed, including 14 with pathogenic BRCA1/2 variants and 12 without. Contrast enhanced MRI was used to generate two dimensional (2D) and three dimensional (3D) tumor segmentations. Radiomic features extracted with PyRadiomics were reduced using least absolute shrinkage and selection operator (LASSO) regression, yielding two selected features. Linear discriminant analysis (LDA) models were trained on 18 patients and tested on 8, with performance assessed using sensitivity, specificity, accuracy, and the area under the receiver operating characteristic (ROC) curve. The DeLong test compared AUCs between segmentation methods. Automated machine learning (AutoML) was performed with a training set of 20 patients and a test set of 6, with multiple performance metrics calculated. LDA achieved approximately 60% accuracy in both 2D and 3D test datasets. AUCs were 0.80 (3D) and 0.77 (2D), with no significant difference (p=0.85). AutoML identified CatBoost_BAG_L2_FULL as the optimal model, achieving accuracy above 80%. MRI-based radiogenomic analysis demonstrated moderate classification performance for identifying pathogenic BRCA1/2 variants in ovarian cancer. These preliminary findings suggest a potential role for noninvasive prediction, warranting further validation in larger cohorts. |
| キーワード | ovarian cancer BRCA1/2 radiogenomics machine learning MRI |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-10 |
| 巻 | 80巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 317 |
| 終了ページ | 325 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71340 |
|---|---|
| フルテキストURL | 80_5_309.pdf |
| 著者 | Egashira, Saki| Nakano, Takafumi| Irie, Keiichi| Ushio, Soichiro| Manabe, Akiko| Masaki, Ayuko| Mukai, Rie| Nakamura, Yoshihiko| Hosokawa, Masato| Satho, Tomomitsu| Sano, Kazunori| Mishima, Kenichi| |
| 抄録 | This study examined the dynamics of serum amyloid A (SAA) levels in the blood, brain, and liver over time using a mouse model of focal cerebral ischemia induced by occlusion of the middle cerebral artery (MCA) for 4 h followed by reperfusion. Blood SAA concentrations increased transiently after cerebral infarction, coinciding with changes in brain and liver SAA gene expression and protein levels. SAA concentrations in the brain, liver, and blood increased at similar time points after cerebral infarction, suggesting that SAA may serve as an important indicator of the associated pathological condition. |
| キーワード | stroke cerebral ischemia serum amyloid A temporal dynamics |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-10 |
| 巻 | 80巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 309 |
| 終了ページ | 316 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71339 |
|---|---|
| フルテキストURL | 80_5_299.pdf |
| 著者 | Xu, Tao| Zheng, Ying| Huang, Xuemei| Luo, Hong| |
| 抄録 | This study evaluated the prognostic significance of the C-reactive protein–albumin–lymphocyte (CALLY) index and systemic immune-inflammation (SII) index in predicting postoperative outcomes in patients with esophageal squamous cell carcinoma (ESCC). A retrospective analysis was performed on clinical data from 102 patients with ESCC who underwent surgical resection at Western Theater General Hospital of China between January 2020 and July 2023. The associations between preoperative CALLY and SII indices and relapse-free survival (RFS) and overall survival (OS) were examined. Survival curves were generated using the Kaplan–Meier method, and prognostic factors were identified using Cox proportional hazards regression analysis. Patients with a high CALLY index had significantly longer RFS (HR=0.30, 95% CI: 0.13-0.71), and those with a low SII index also had significantly longer RFS (HR=2.23, 95% CI: 1.12-4.41). Similarly, patients with a high CALLY index had significantly longer OS (HR=0.27, 95% CI: 0.13-0.55), and those with a low SII index had significantly longer OS (HR=2.27, 95% CI: 1.09-4.71). When patients were stratified into four groups, the low-CALLY–high-SII group showed significantly shorter RFS than the high-CALLY–low-SII group (HR=0.26, 95% CI: 0.11-0.61; p=0.013), and OS was also significantly worse in the low-CALLY–high-SII group (HR=0.22, 95% CI: 0.09-0.54; p=0.016). Univariate Cox regression analysis identified both CALLY and SII as significant prognostic factors. In multivariate analysis, the CALLY index and N stage were independently associated with RFS, whereas only tumor size remained independently associated with OS. The combined assessment of preoperative CALLY and SII indices may be useful for prognostic stratification in patients with ESCC undergoing upfront surgical resection. It may help identify high-risk patient subgroups with distinct survival outcomes, thereby providing a potential rationale for stratifying postoperative surveillance and tailoring individualized adjuvant strategies, although validation in larger prospective cohorts is warranted. |
| キーワード | CALLY index SII index esophageal squamous cell carcinoma prognosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-10 |
| 巻 | 80巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 299 |
| 終了ページ | 308 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71338 |
|---|---|
| フルテキストURL | 80_5_289.pdf |
| 著者 | Komuta, Yuki| Imai, Norio| Homma, Daisuke| Funayama, Kazuhisa| Hirano, Yuki| Horigome, Yoji| Minato, Izumi| Kawashima, Hiroyuki| |
| 抄録 | The “CR Alignment” function was recently introduced in ZedHip®, the hip joint module of ZedView®, to evaluate pelvic tilt in non-supine positions via two-dimensional (2D)‒3D matching using radiographs. However, its ccuracy has not been validated. This study therefore evaluated the accuracy of pelvic tilt measurements using the CR Alignment function in dry pelvic bone specimens. Two cadaveric pelvic bone models were placed in nine orientations (anterior/posterior tilt and left/right rotation). Both radiographic and CT images were acquired in each position. In Study 1, pelvic tilt measured directly from CT images was defined as the “true value.” Three observers used the CR Alignment function to calculate pelvic tilt on radiographs, and measurement errors were determined relative to the true values. In Study 2, measurement errors were compared between matched (same position) and mismatched (different position) imaging. In Study 1, the mean measurement error was 1.28±0.64°. Intra- and interobserver intraclass correlation coefficients were 0.996-0.998 and 0.997, respectively. In Study 2, the mean errors were 1.20±0.88° (matched) and 1.32±1.03° (mismatched). This software exhibited high accuracy and reproducibility in 2D‒3D matching of pelvic tilt, with lower variability under matched acquisition, demonstrating its utility for pre- and postoperative assessment in joint arthroplasty. |
| キーワード | total hip arthroplasty pelvic tilt three-dimensional planning software two-dimensional and threedimensional matching radiographic analysis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-10 |
| 巻 | 80巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 289 |
| 終了ページ | 298 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71337 |
|---|---|
| フルテキストURL | 80_5_279.pdf |
| 著者 | Miyamoto, Satoshi| Matsumoto, Naomi| Mitsuhashi, Toshiharu| Takao, Soshi| Yorifuji, Takashi| |
| 抄録 | Diabetes mellitus is a well-established risk factor for severe COVID-19; however, few studies have examined this association during the Omicron-dominant period. We conducted a population-based study using surveillance data from the Okayama City Public Health Center in Japan to compare the risk of severe COVID-19 and pneumonia among patients with diabetes mellitus between the pre-Omicron (March 2020–December 2021) and Omicron-dominant (January–September 2022) periods. Among 98,905 COVID-19 patients aged 10 years or older, we calculated adjusted odds ratios (aORs) controlling for age, sex, smoking status, comorbidities, obesity, and the number of COVID-19 vaccine doses received. In the pre-Omicron period, diabetes mellitus was significantly associated with severe COVID-19 (aOR: 1.36; 95% CI: 1.03-1.78), and this association persisted in the Omicron-dominant period (aOR: 1.54; 95% CI: 1.10-2.17). Similar findings were observed for pneumonia. The association was more pronounced among patients aged 40-69 years than among those aged 70 years or older. These findings suggest that diabetes mellitus remains an important risk factor for severe COVID-19 even during the Omicron-dominant period, highlighting the need for continued clinical vigilance and early intervention in patients with diabetes mellitus. |
| キーワード | COVID-19 diabetes mellitus Omicron variant severity population-based study |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-10 |
| 巻 | 80巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 279 |
| 終了ページ | 288 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71336 |
|---|---|
| フルテキストURL | 80_5_271.pdf |
| 著者 | Sato, Ryosuke| Matsumoto, Kazuyuki| Otsuka, Motoyuki| |
| 抄録 | Peroral cholangioscopy (POCS) enables direct intraductal visualization and targeted biopsies for indeterminate biliary strictures. However, its diagnostic performance remains operator-dependent and is limited by sampling error. As artificial intelligence (AI) has rapidly advanced in gastrointestinal endoscopy, AI-assisted cholangioscopy has progressed from proof-of-concept image classification to multicenter validation, feature detection, and real-time application. Recent studies using digital single-operator cholangioscopy have reported diagnostic accuracy comparable to that of experts in differentiating malignant from benign strictures, and feature-based approaches can automatically detect tumor vessels and other key visual characteristics. Beyond classification, generative models may enhance mucosal and margin visualization through virtual chromoendoscopy, potentially improving lesion-margin assessment. Furthermore, new models compatible with multiple systems are emerging to address device heterogeneity, which is a key barrier to routine practice. This review summarizes the current evidence on AI-assisted POCS, discusses practical considerations for clinical translation, and highlights future directions, including real-time integration and multimodal decision support. |
| キーワード | peroral cholangioscopy artificial intelligence biliary stricture deep learning virtual chromoendoscopy |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-10 |
| 巻 | 80巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 271 |
| 終了ページ | 277 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71071 |
|---|---|
| フルテキストURL | 80_4_265.pdf |
| 著者 | Yamasaki, Takuto| Sugaya, Akiko| Naoi, Yuto| Kariya, Shin| Ando, Mizuo| |
| 抄録 | Cochlear implantation (CI) in patients with CHARGE syndrome presents unique surgical challenges due to complex external, middle, and inner ear malformations. We describe the case of a 3-year-old Japanese boy for whom simultaneous transcanal CI under endoscopic guidance and external auditory canal closure were performed. This approach enabled safe electrode placement and resulted in favorable auditory outcomes, representing a potential novel surgical option for CI in patients with CHARGE syndrome. There are few reports of this type of surgical intervention, and the present case highlights the feasibility and clinical benefits of individualized surgical planning for CI in anatomically complex patients. |
| キーワード | CHARGE syndrome cochlear implantation transcanal approach temporal bone anomaly pediatric otologic surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 265 |
| 終了ページ | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71070 |
|---|---|
| フルテキストURL | 80_4_259.pdf |
| 著者 | Yabuno, Satoru| Yunoki, Masatoshi| Takeuchi, Saori| Hirashita, Koji| |
| 抄録 | Diffuse idiopathic skeletal hyperostosis (DISH) predisposes the spine to highly unstable fractures because of long lever-arm biomechanics. Unstable injuries, including AO Spine Osteoporotic Fracture (OF) type 5, are typically treated with long-segment posterior instrumentation; however, pedicle-screw fixation may be infeasible in very elderly patients with severe osteoporosis, critically narrow pedicles, and/or significant comorbidities. A 93-year-old Japanese woman presented with severe back pain without apparent trauma. Computed tomography (CT) revealed a T12 fracture with DISH, classified as OF5. The pedicles were critically narrow (3.7-4.1 mm), and dual-energy X-ray absorptiometry confirmed severe osteoporosis. Because conventional pedicle-screw fixation was considered technically unsafe and excessively invasive, limited posterior stabilization was performed using a single spinous process plate spanning T10-L1. The operative time was 48 min and the estimated blood loss was 10 ml. Immediate postoperative CT confirmed appropriate implant positioning and maintained alignment. At the 1-year follow-up, CT demonstrated solid bony union with preserved alignment and no implant failure; the patient had remained pain-free and ambulatory. This case demonstrates that spinous process-plate fixation can be a minimally invasive salvage option for carefully selected very-elderly patients with DISH when pedicle-screw instrumentation is not feasible. |
| キーワード | DISH vertebral fracture osteoporosis spinous process plate |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 259 |
| 終了ページ | 264 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Resnick D and Niwayama G: Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology (1976) 119: 559-568.| Wu Y, Ye Q, He D, Wei Y, Pan Y and Wang Y: Effect of Diffuse Idiopathic Skeletal Hyperostosis on the Occurrence of Thoracolumbar Vertebral Fragility Fractures at Different Ages. Global Spine J (2025) 15: 2075-2086.| Harlianto NI, Ezzafzafi S, Foppen W, Kuperus JS, van der Horst-Bruinsma IE, de Jong PA and Verlaan JJ: The prevalence of vertebral fractures in diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis: A systematic review and meta-analysis. N Am Spine Soc J (2024) 17: 100312.| Blattert TR, Schnake KJ, Gonschorek O, Gercek E, Hartmann F, Katscher S, Mork S, Morrison R, Muller M, Partenheimer A, Piltz S, Scherer MA, Ullrich BW, Verheyden A, Zimmermann V and the Spine Section of the German Society for Orthopaedics and Trauma. Nonsurgical and Surgical Management of Osteoporotic Vertebral Body Fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU). Global Spine J (2018) 8: 50-55.| Tomii M, Itoh Y, Numazawa S, Watanabe K and Nakagawa H: Spinous process plate (S-plate) fixation after posterior interbody fusion for lumbar canal stenosis due to spondylolisthesis. Neurosurg Rev (2013) 36: 139-143.| Diederichs G, Engelken F, Marshall LM, Peters K, Black DM, Issever AS, Barrett-Connor E, Orwoll E, Hamm B, Link TM and Osteoporotic Fractures in Men (MrOs) Research Group: Diffuse idiopathic skeletal hyperostosis (DISH): relation to vertebral fractures and bone density. Osteoporos Int (2011) 22: 1789-1797.| Page PS, Greeneway GP, Lake WB, Brooks NP, Josiah DT, Hanna AS and Resnick DK: Outcomes following conservative treatment of extension fractures in the setting of diffuse idiopathic skeletal hyperostosis: is external orthosis alone a reasonable option? J Neurosurg Spine (2022) 37: 927-931.| Solitro GF, Whitlock K, Amirouche F, Mehta AI and McDonnell A: Currently Adopted Criteria for Pedicle Screw Diameter Selection. Int J Spine Surg (2019) 13: 132-145.| Matsukawa K, Yato Y, Hynes RA, Imabayashi H, Hosogane N, Asazuma T, Matsui T, Kobayashi Y and Nemoto K: Cortical Bone Trajectory for Thoracic Pedicle Screws: A Technical Note. Clin Spine Surg (2017) 30: 497-504.| Wang H, Wang H, Sribastrav SS, Ye F, Liang C, Li Z, Wang J, Liu H, Wang X and Zheng Z: Comparison of pullout strength of the thoracic pedicle screw between intrapedicular and extrapedicular technique: a meta-analysis and literature review. Int J Clin Exp Med (2015) 8: 22237-22245.| Ikuma H, Takao S, Inoue Y, Hirose T, Matsukawa K and Kawasaki K: Treatment of Thoracolumbar Spinal Fracture Accompanied by Diffuse Idiopathic Skeletal Hyperostosis Using Transdiscal Screws for Diffuse Idiopathic Skeletal Hyperostosis: Preliminary Results. Asian Spine J (2021) 15: 340-348.| Hishiya T, Ishikawa T and Ota M: Posterior spinal fixation using penetrating endplate screws in patients with diffuse idiopathic skeletal hyperostosis-related thoracolumbar fractures. J Neurosurg Spine (2021) 34: 936-941.| Nakao Y SS, Kimura M, Yamada T, Yamamoto Y and Takashiba K: Spinal fusion using a spinous process plate (S-plate)- clinical results and mechanical strength. The journal of the Japan Spine Research Society (2006) 17: 119.| Ugawa R, Fujiwara Y and Matsumoto T: Clinical Outcomes of Transdiscal Screws for Thoracolumbar Spinal Fractures with Marked Anterior Distraction Gap Accompanied by Diffuse Idiopathic Skeletal Hyperostosis. Medicina (Kaunas) (2025) 61: 1-9.| |
| JaLCDOI | 10.18926/AMO/71069 |
|---|---|
| フルテキストURL | 80_4_253.pdf |
| 著者 | Ishikami, Sachiko| Tamura, Shuta| Tabuchi, Motoyasu| Yamamoto, Nao| Okamoto, Yuki| Yoshimatsu, Rika| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| 抄録 | Lymphangioma is a benign tumor arising from lymphatic vessel proliferation and most commonly occurs in the head, neck, or axilla. Involvement of the small intestine is rare and is often overlooked as a source of obscure gastrointestinal bleeding. Because jejunal lymphangiomas frequently present with nonspecific symptoms and may escape detection by conventional upper and lower gastrointestinal endoscopy or cross-sectional imaging, diagnosis is often delayed. Advances in balloon-assisted enteroscopy have enabled direct visualization of small intestinal lesions, facilitating accurate diagnosis and appropriate therapeutic decision-making. Here, we report a case of jejunal lymphangioma presenting with severe anemia due to active bleeding, which was detected by double-balloon endoscopy and successfully managed by laparoscopic-assisted resection. This case highlights the importance of considering small intestinal lymphangioma in the differential diagnosis of unexplained gastrointestinal bleeding and underscores the clinical utility of deep enteroscopy in identifying rare but clinically significant small bowel tumors. |
| キーワード | jejunal lymphangioma double-balloon endoscopy surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 253 |
| 終了ページ | 257 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Galifer RB, Pous JG, Juskiewenski S, Pasquie M and Gaubert J: Intra-abdominal cystic lymphangiomas in childhood. Prog Pediatr Surg (1978) 11: 173-238.| Chin CC, Shiau J, Luo CW and Hou MF: Lymphangioma of the small bowel in adults: a rare cause of abdominal symptoms. Asian J Surg (2023) 46: 863-867.| Kida A, Matsuda K, Hirai S, Shimatani A, Horita Y, Hiramatsu K, Matsuda M, Ogino H, Ishizawa S and Noda Y: A pedunculated polyp-shaped small-bowel lymphangioma causing gastrointestinal bleeding and treated by double-balloon enteroscopy. World J Gastroenterol (2012) 18: 4798-4800.| Zhao N, Fu Y, Wang Z, An Q and Jia W: Submucosal cavernous lymphangioma causing jejuno-jejunal intussusception in an adult: a case report. Front Surg (2022) 9: 953840.| Hanagiri T, Baba M, Shimabukuro T, Hashimoto M, Takemoto H, Inoue A, Sugitani A and Shirakusa T: Lymphangioma in the small intestine: report of a case and review of the Japanese literature. Surg Today (1992) 22: 363-367.| Cheung DY and Choi MG: Current advances in small bowel tumors. Clin Endosc (2011) 44: 13-21.| Yamamoto H, Sekine Y, Sato Y, Higashizawa T, Miyata T, Iino S, Ido K and Sugano K: Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest Endosc (2001) 53: 216-220.| Pennazio M, Spada C, Eliakim R, Keuchel M, May A, Mulder CJ, Rondonotti E, Adler SN, Albert J, Baltes P, Barbaro F, Cellier C, Charton JP, Delvaux M, Despott EJ, Domagk D, Klein A, McAlindon M, Rosa B, Rowse G, Sanders DS, Saurin JC, Sidhu R, Dumonceau JM, Hassan C and Gralnek IM: Small-bowel capsule endoscopy and device-assisted enteroscopy. Endoscopy (2015) 47: 352-376.| Peters FT, Rutgers EJ and Driessen WM: Intra-abdominal lymphangiomatous cysts in adults. Neth J Med (1987) 31: 152-157.| Wang ZZ, Shen LY, Zhou JJ, Tang JL, Ye LP, Shen CB, Li SW and Zhou XB: Clinical manifestation and treatment of small intestinal lymphangioma: a single-center analysis of 15 cases. Front Med (Lausanne) (2022) 9: 975698.| Iwabuchi A, Otaka M, Okuyama A, Jin M, Otani S, Itoh S, Sasahara H, Odashima M, Kotanagi H, Satoh M, Masuda H and Masamune O: Disseminated intra-abdominal cystic lymphangiomatosis with severe intestinal bleeding: a case report. J Clin Gastroenterol (1997) 25: 383-386.| Tan B, Zhang SY, Wang YN, Li Y, Shi XH and Qian JM: Jejunal cavernous lymphangioma manifested as gastrointestinal bleeding with hypogammaglobulinemia in an adult: a case report and literature review. World J Clin Cases (2020) 8: 140-148.| Meşină C, Paşalega M, Calotă F, Comănescu V, Vîlcea D, Tenea T, Mirea C and Vasile I: Hemorrhagic intestinal lymphangioma: report of a case. Chirurgia (Bucur) (2006) 101: 201-204.| Lim DR, Kuk JC, Kim T and Shin EJ: Surgery of multiple lymphangioma in the small bowel: a rare case report of chronic gastrointestinal bleeding. Ann Surg Treat Res (2018) 94: 52-56.| Barquist ES, Apple SK, Jensen DM and Ashley SW: Jejunal lymphangioma: an unusual cause of chronic gastrointestinal bleeding. Dig Dis Sci (1997) 42: 1179-1183.| Xiao NJ, Ning SB, Li T, Li BR and Sun T: Small intestinal hemolymphangioma treated with enteroscopic injection sclerotherapy: a case report and review of the literature. World J Gastroenterol (2020) 26: 1540-1545.| Yang J, Zhang Y, Kou G and Li Y: Jejunum hemolymphangioma causing refractory anemia in a young woman. Am J Gastroenterol (2020) 115: 810.| Yang SX, Zhou YH, Zhang J, Miao L, Zhong JW, Wang WX, Xu CL, Cai ZZ and Lu GR: Haemorrhagic ileal haemolymphangioma: a case report and review of the literature. J Int Med Res (2021) 49: 300060520986677.| Tomizawa Y, Garner K and Sohnen A: Lymphangioma of the small bowel mesentery: a rare intra-abdominal tumor causing anemia. Clin Gastroenterol Hepatol (2013) 11: e57.| Fang YF, Qiu LF, Du Y, Jiang ZN and Gao M: Small intestinal hemolymphangioma with bleeding: a case report. World J Gastroenterol (2012) 18: 2145-2146.| Park JG, Aubry MC, Godfrey JA and Midthun DE: Mediastinal lymphangioma: Mayo Clinic experience of 25 cases. Mayo Clin Proc (2006) 81: 1197-1203.| Landing BH and Farber S: Tumors of the cardiovascular system. Atlas of tumor pathology Armed forces Inst. Path. Washington D. C 1956.| |
| JaLCDOI | 10.18926/AMO/71068 |
|---|---|
| フルテキストURL | 80_4_247.pdf |
| 著者 | Shiina, Tsuyoshi| Watanabe, Hirokazu| Yoshimoto, Junko| Sato, Takeshi| Morimoto, Daisaku| Okamura, Tomoka| Tanimoto, Terutaka| Washio, Yosuke| Oyama, Takanori| Tsukahara, Hirokazu| Noda, Takuo| |
| 抄録 | The long-term survival of individuals with trisomy 18 has improved, and the need for tracheostomy in this population has thus increased. We describe the case of a 3-year-old Japanese boy with trisomy 18 who developed a tracheoarterial fistula involving the left common carotid artery (LCCA). He underwent an emergency tracheostomy for respiratory failure secondary to pneumonia. Massive hemorrhage from the tracheostoma occurred on postoperative day 31, leading to his death. The autopsy revealed that the LCCA originated from the brachiocephalic trunk and coursed medially, forming a fistulous connection with the trachea. This case highlights the clinical importance of preoperative vascular mapping in patients with chromosomal abnormalities. |
| キーワード | tracheoarterial fistula tracheocarotid fistula trisomy 18 |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 247 |
| 終了ページ | 252 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71067 |
|---|---|
| フルテキストURL | 80_4_241.pdf |
| 著者 | Hasegawa, Yuta| Tsujimoto, Hironori| Uehata, Naoyuki| Kariya, Risa| Ide, Asuma| Suzuki, Takafumi| Fujishima, Seiichiro| Kouzu, Keita| Yaguchi, Yoshihisa| Miyai, Kosuke| Kurihara, Ayumu| Ogata, Sho| Matsukuma, Susumu| Ueno, Hideki| |
| 抄録 | Primary hyperparathyroidism (pHPT) is typically caused by a parathyroid adenoma, although some cases arise from ectopic glands. Accurate preoperative localization is essential for guiding surgical strategy, particularly for mediastinal lesions. We report successful video-assisted thoracoscopic surgery (VATS) for an upper mediastinal parathyroid adenoma. A 68-year-old woman was referred for hypercalcemia during evaluation for recurrent ureteral stones. Laboratory tests revealed elevated serum calcium (13.2 mg/dl) and intact parathyroid hormone (iPTH) levels (266 pg/ml). Contrast-enhanced computed tomography, magnetic resonance imaging, and 99mTc-methoxyisobutylisonitrile scintigraphy identified a 20-mm mass adjacent to the right esophageal wall. VATS was performed due to the tumor’s mediastinal location. The lesion was resected with intraoperative nerve monitoring (IONM) to avoid recurrent laryngeal nerve damage. Postoperatively, iPTH and calcium levels rapidly normalized. Transient hypocalcemia and mild hoarseness occurred but resolved with calcium supplementation and conservative management. Pathological examination confirmed a parathyroid adenoma without malignancy. VATS offers a safe and minimally invasive approach for upper mediastinal parathyroid adenomas. IONM and vigilant calcium management are crucial for minimizing these complications. This case highlights the importance of comprehensive imaging, surgical planning, and postoperative care in managing upper mediastinal pHPT. |
| キーワード | primary hyperparathyroidism parathyroid neoplasm ectopic tissue video-assisted thoracoscopic surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 241 |
| 終了ページ | 246 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71066 |
|---|---|
| フルテキストURL | 80_4_233.pdf |
| 著者 | Ogawa, Sakura| Fukushima, Shinnosuke| Akazawa, Hidemasa| Namba, Sachie| Hirota, Chiyoko| Kishiue, Tomoyoshi| Ibara, Shohei| Kondo, Takayuki| Fukuda, Genshi| Iio, Koji| Tsuji, Shuma| Gotoh, Kazuyoshi| Otsuka, Fumio| Hagiya, Hideharu| |
| 抄録 | Carbapenemase-producing Enterobacterales (CPE) and extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-E) are representative antimicrobial-resistant pathogens. We investigated the prevalence of CPE and ESBL-E in Okayama, Japan to clarify their current epidemiology and potential clinical burden. Active surveillance for CPE and ESBL-E was performed first, using stool samples submitted to the Okayama Medical Laboratory (Japan) in the years 2024-2025. Screening was performed using a selective agar (CHROMagar mSuper CARBA/ESBL). Phenotypic identification was conducted with the use of a modified carbapenem inactivation method and double-disk phenotypic confirmatory tests. Clinical information including patient age, sex, sampling date, and hospital address were collected, and the data were analyzed according to specimen origin (hospitals, clinics, and health checkups). A total of 2,000 stool samples were screened, of which two CPE isolates (0.1%) and 285 ESBL-E isolates (14.3%) were identified. By specimen origin, the ESBL-E positivity rate was significantly higher in hospitals (17.4%) than in clinics (11.8%). By age category, the late elderly (> 75 years) exhibited the highest ESBL-E positivity rate (22.6%) compared to other age groups. In the clinics and health checkups, infants (0 years) demonstrated high ESBL-E positivity rates (18.2% and 14.3%, respectively). Escherichia coli was the most common ESBL-E organism in the hospitals (77.2%), clinics (88.8%), and health checkups (87.5%). Our active screening demonstrated that the prevalences of CPE and ESBL-E were within the reported ranges; however, in this era of increasing internationalization, continuous surveillance of these notifiable pathogens is warranted. |
| キーワード | antimicrobial resistance carbapenem-resistant Enterobacteriaceae extended-spectrum β-lactamase infection prevention and control Okayama Medical Laboratory |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 233 |
| 終了ページ | 240 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Jean SS, Harnod D and Hsueh PR: Global threat of carbapenem-resistant Gram-negative bacteria. Front Cell Infect Microbiol (2022) 12: 823684.| Baek MS, Kim JH, Park JH, Kim TW, Jung HI and Kwon YS: Comparison of mortality rates in patients with carbapenem-resistant Enterobacterales bacteremia according to carbapenemase production: a multicenter propensity-score matched study. Sci Rep (2024) 14: 597.| Takei K, Ogawa M, Sakata R and Kanamori H: Epidemiological characteristics of carbapenem-resistant Enterobacterales in Japan: a nationwide analysis of data from a clinical laboratory center (2016-2022). Pathogens (2023) 12: 1246.| Yamamoto N, Asada R, Kawahara R, Hagiya H, Akeda Y and Shanmugakani RK: Prevalence of, and risk factors for, carriage of carbapenem-resistant Enterobacteriaceae among hospitalized patients in Japan. J Hosp Infect (2017) 97: 212-217.| Hagiya H, Yamamoto N, Kawahara R, Akeda Y, Shanmugakani RK and Ueda A: Risk factors for fecal carriage of IMP-6-producing Enterobacteriaceae at a long-term care hospital in Japan: a follow-up report from the northern Osaka multicentre study group. J Infect Chemother (2018) 24: 769-772.| Ohno Y, Nakamura A, Hashimoto E, Noguchi N, Matsumoto G and Fukuda S: Fecal carriage and molecular epidemiologic characteristics of carbapenemase-producing Enterobacterales in a primary care hospital in a Japanese city. J Infect Chemother (2020) 26: 928-932.| Ishii Y, Aoki K, Tateda K and Kiyota H: Multicenter collaboration study on the β-lactam-resistant Enterobacteriaceae in Japan ‒ the 65th anniversary public interest purpose project of the Japanese Society of Chemotherapy. J Infect Chemother (2017) 23: 583-586.| Nakai M, Oka K, Watanabe G, Kamei K, Tsukada N and Mori R: Epidemiology and molecular characterization of fecal carriage of third-generation cephalosporin-resistant Enterobacterales among elderly residents in Japan. J Infect Chemother (2022) 28: 569-575.| Hagiya H, Onishi Y, Shinohara N, Tokuyasu M, Imanishi A and Fukushima S: High frequency of extended-spectrum beta-lactamase-producing Enterobacteriaceae carriers at a Japanese long-term care hospital. J Infect Chemother (2022) 28: 1578-1581.| Fukushima S, Hagiya H, Uda K, Gotoh K and Otsuka F: Current prevalence of antimicrobial resistance in Okayama from a national database between 2018 and 2021. Acta Med Okayama (2023) 77: 255-262.| Fukushima S, Hagiya H, Gotoh K, Tsuji S, Iio K and Matsushita O: Detection of imported clinical strain of blaNDM-1-harbouring ST147 Klebsiella pneumoniae from a Ukrainian immigrant. J Travel Med (2024) 31: taae011.| Gotoh K, Hagiya H, Iio K, Yamada H, Matsushita O and Otsuka F: Detection of Enterobacter cloacae complex strain with a blaNDM-1-harboring plasmid from an elderly resident at a long-term care facility in Okayama, Japan. J Infect Chemother (2022) 28: 1697-1699.| Gotoh K, Miyoshi M, I Putu Bayu Mayura, Tsuji S, Iio K and Fukushima S: Phenotypic and genetic characteristics of carbapenemase-producing Enterobacterales isolates at Okayama University Hospital. Acta Med Okayama (2024) 78: 371-376.| Pierce VM, Simner PJ, Lonsway DR, Roe-Carpenter DE, Johnson JK and Brasso WB: Modified carbapenem inactivation method for phenotypic detection of carbapenemase production among Enterobacteriaceae. J Clin Microbiol (2017) 55: 2321-2333.| Kanda Y: Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant (2013) 48: 452-458.| Bezabih YM, Bezabih A, Dion M, Batard E, Teka S and Obole A: Comparison of the global prevalence and trend of human intestinal carriage of ESBL-producing Escherichia coli between healthcare and community settings: a systematic review and meta-analysis. JAC Antimicrob Resist (2022) 4: dlac048.| Ng RWY, Yang L, Lau SH, Hawkey P and Ip M: Global prevalence of human intestinal carriage of ESBL-producing Escherichia coli during and after the COVID-19 pandemic. JAC Antimicrob Resist (2025) 7: dlaf001.| Raffelsberger N, Buczek DJ, Svendsen K, Småbrekke L, Pöntinen AK and Löhr IH: Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates. mSphere (2023) 8: e00025-23.| Islam K, Heffernan AJ, Naicker S, Henderson A, Chowdhury MAH and Roberts JA: Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia. Future Microbiol (2021) 16: 521-535.| Rahaman A, Mimi A, Antor MTH, Bakhtiyar Z, Hasan MAE and Fahim NAI: Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated from animals in Bangladesh: a systematic review and meta-analysis. One Health (2025) 21: 101237.| Xie Y, Srivastava IM, Jing F, Ma C, Wu X, Chen Y, Du Y, Low XYC, Ping Y, Pan J, Gupta A, Graves N and Mo Y: One Health perspective of antibiotic resistance in Enterobacterales from Southeast Asia: a systematic review and meta-analysis. Res Sq (2025) 16: 1694.| Jia P, Zhu Y, Li X, Kudinha T, Yang Y and Zhang G: High prevalence of extended-spectrum beta-lactamases in Escherichia coli strains collected from strictly defined community-acquired urinary tract infections in adults in China: a multicenter prospective clinical microbiological and molecular study. Front Microbiol (2021) 12: 663033.| Chao CM, Lai CC and Yu WL: Epidemiology of extended-spectrum β-lactamases in Enterobacterales in Taiwan for over two decades. Front Microbiol (2022) 13: 1060050.| Chaisaeng S, Chopjitt P, Kasemsiri P, Putthanachote N, Boueroy P and Takeuchi D: High prevalence of ESBL-producing Escherichia coli phylogroup B2 clinical isolates in northeastern Thailand. BMC Microbiol (2024) 24: 425.| Sawatwong P, Sapchookul P, Whistler T, Gregory CJ, Sangwichian O and Makprasert S: High burden of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae bacteremia in older adults: a seven-year study in two rural Thai provinces. Am J Trop Med Hyg (2019) 100: 943-951.| Sunarno S, Puspandari N, Fitriana F, Nikmah UA, Idrus HH and Panjaitan NSD: Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Indonesia and Southeast Asian countries: GLASS data 2018. AIMS Microbiol (2023) 9: 218-227.| Kawamura K, Nagano N, Suzuki M, Wachino JI, Kimura K and Arakawa Y: ESBL-producing Escherichia coli and its rapid rise among healthy people. Food Saf (2017) 5: 122-150.| Shibuki R, Nishiyama M, Mori M, Baba H, Kanamori H and Watanabe T: Characterization of extended-spectrum β-lactamase-producing Escherichia coli isolated from municipal and hospital wastewater in Japan. J Glob Antimicrob Resist (2023) 32: 145-151.| Kawata S, Morimoto S, Kosai K, Kawamoto Y, Nakashima Y and Morinaga Y: The fecal carriage rate of extended-spectrum β-lactamase-producing or carbapenem-resistant Enterobacterales among Japanese infants in the community at the 4-month health examination in a rural city. Front Cell Infect Microbiol (2023) 13: 1168451.| |
| JaLCDOI | 10.18926/AMO/71065 |
|---|---|
| フルテキストURL | 80_4_227.pdf |
| 著者 | Kashihara, Kenichi| Hamaguchi, Toshikazu| Takeda, Yasuko| |
| 抄録 | The impact of migraines as a risk factor for cervicocerebral artery dissection was retrospectively investigated in patients who had a cervicocerebral artery dissection. We first evaluated the patients’ medical records and history of migraine and then calculated the proportion of patients with migraine as well as the relevant vascular risk factors. The prevalence of migraine with respect to the location of the cervicocerebral artery dissection was also identified. Sixty-two patients (37 men, 25 women) had both a cerebral artery dissection and a record of migraine. Among them, 93.5% presented with an isolated headache, and 6.5% presented with a related stroke. Regarding the locations of the artery dissection, 56 (90.3%) were in the intracranial vertebral artery (VA), three (4.8%) were in the internal carotid artery, and one case each (1.6%) was in an anterior cerebral artery, basilar artery (BA), and both the VA and BA. Among the patients with VA dissection, 42 (73.7%) presented with migraines. Among the four patients with dissection of an artery of anterior circulation, only one (25%) had a migraine history. The frequency of migraines tended to be higher in the patients with VA dissection compared to those with a dissection of arteries of anterior circulation. These data suggest that (i) migraine is a potent risk factor for cerebral artery dissection, especially intracranial VA dissection, and (ii) the intracranial VA may be more susceptible to dissection compared to arteries of anterior circulation. |
| キーワード | cervicocerebral artery dissection isolated headache migraine risk factor vertebral artery |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 227 |
| 終了ページ | 231 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/70859 |
|---|---|
| フルテキストURL | 80_3_225.pdf |
| 著者 | Suzawa, Ken| Yamamoto, Haruchika| Nakajima, Kumi| Tanaka, Shin| Torigoe, Hidejiro| Shien, Kazuhiko| Miyoshi, Kentaroh| Okazaki, Mikio| Sugimoto, Seiichiro| Toyooka, Shinichi| |
| 抄録 | Simultaneous bilateral spontaneous pneumothorax associated with pleuro-pleural communication is a rare but potentially life-threatening condition, most commonly occurring after major thoracic surgery. We report the case of an 81-year-old man with severe emphysema and a history of esophagectomy who presented with sudden-onset dyspnea. Chest computed tomography revealed bilateral pneumothorax with pleuro-pleural communication. Although bilateral chest tube drainage was performed, the primary side of air leakage could not be identified preoperatively. After induction of general anesthesia, a double-lumen endotracheal tube clamping test identified the right pleural cavity as the source of air leakage, thereby enabling appropriate thoracoscopic surgery. |
| キーワード | simultaneous bilateral spontaneous pneumothorax pleuro-pleural communication |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-06 |
| 巻 | 80巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 225 |
| 終了ページ | 228 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 42374756 |
| Web of Science KeyUT | 001812989700009 |
| JaLCDOI | 10.18926/AMO/70858 |
|---|---|
| フルテキストURL | 80_3_219.pdf |
| 著者 | Higashi, Kaitaro| Tabuchi, Motoyasu| Sakamoto, Shinya| Tamura, Shuta| Uemura, Sunao| Tokumaru, Teppei| Okabayashi, Takehiro| |
| 抄録 | An 86-year-old man presented with epigastric pain. He had previously undergone distal gastrectomy with Roux-en-Y reconstruction. Computed tomography (CT) revealed a 32×17 mm common bile duct (CBD) stone with an internal 20 mm linear hyperdense component. Endoscopic removal was unsuccessful due to the size and impaction of the stone. Open choledochotomy retrieved multiple stones and a calcified fish bone, which was confirmed by infrared spectroscopy using the potassium bromide (KBr) wafer method. Although fish bone ingestion is relatively common, this case highlights that such foreign bodies can occasionally serve as a nidus for CBD stone formation, leading to unexpected and clinically significant pathologies. When CT demonstrates a linear high-attenuation intraductal structure, clinicians should suspect a bone fragment and follow a stepwise approach, considering early surgical intervention when endoscopic extraction is unsuccessful or likely to be challenging. |
| キーワード | common bile duct stone fish bone Roux-en-Y choledochotomy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-06 |
| 巻 | 80巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 219 |
| 終了ページ | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 42374755 |
| Web of Science KeyUT | 001812989700008 |
| JaLCDOI | 10.18926/AMO/70857 |
|---|---|
| フルテキストURL | 80_3_213.pdf |
| 著者 | Imai, Toshiro| Watanabe, Toshiyuki| Watanabe, Shiho| Hayashi, Masanobu| Tominaga, Yusuke| Namba, Yuzaburo| |
| 抄録 | Phalloplasty is one of the most challenging procedures in gender-affirming surgery, and urethral complications remain common despite numerous preventive efforts. No definitive solution has been established, and many patients still require subsequent corrective procedures. We designed a novel anterolateral thigh flap that creates a planned external fistula at the penile base to mitigate urethral complications. The fistula was closed in a second-stage procedure one year later, and the postoperative course was uneventful. We report a case of a transgender man treated with this two-stage “pipe flap” technique, resulting in satisfactory urinary function. This approach may offer a safe and less invasive option for mitigating urethral complications in phalloplasty. |
| キーワード | phalloplasty surgical flaps transgender persons |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-06 |
| 巻 | 80巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 213 |
| 終了ページ | 217 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 42374754 |
| Web of Science KeyUT | 001812989700007 |
| JaLCDOI | 10.18926/AMO/70856 |
|---|---|
| フルテキストURL | 80_3_203.pdf |
| 著者 | Aoyama, Shingo| Ikeda, Terumasa| Nango, Nobuhito| Goto, Koji| |
| 抄録 | Dropped head syndrome, which has been increasingly reported in recent years, requires correction of cervical kyphosis and may require long-range fixation extending from the cervical to the thoracic spine. Assessing vertebral bone structure may be important for preventing instrumentation failure in the upper thoracic spine, which is a potential complication of surgery. In this study, we evaluated volumetric bone mineral density, trabecular bone porosity, and cortical calcification in the cervical and upper thoracic spine using three-dimensional (3D) trabecular structure measurement software. The study included 79 patients with cervical spine disorders who underwent various surgical procedures and preoperative imaging, including dual-energy X-ray absorptiometry and computed tomography (CT) scans from C3 to Th3. Quantitative analysis using specialized software assessed volumetric bone mineral density and trabecular and cortical bone parameters, and statistical analyses were performed to examine correlations between imaging metrics and indicators of bone fragility. Two-dimensional CT evaluation revealed different trends between cancellous and cortical bone in the cervical and thoracic spine, suggesting that detailed 3D evaluation may also be important. |
| キーワード | cervical spine volumetric bone mineral density three-dimensional trabecular structure measurement |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-06 |
| 巻 | 80巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 203 |
| 終了ページ | 212 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 42374753 |
| Web of Science KeyUT | 001812989700006 |
| JaLCDOI | 10.18926/AMO/70855 |
|---|---|
| フルテキストURL | 80_3_195.pdf |
| 著者 | Tei, Yoshiaki| Imai, Norio| Kimura, Keishi| Hirano, Yuki| Horigome, Yoji| Suda, Ken| Kawashima, Hiroyuki| |
| 抄録 | HIP COMPASS® has demonstrated improved accuracy in intraoperative support for the acetabular component insertion angle. We assessed long-term revision-free implant survivorship following total hip arthroplasty (THA) using HIP COMPASS, with ≥10 years of follow-up. We retrospectively analyzed 210 hips of 186 patients who underwent cementless THA with ceramic-on-ceramic bearing couples, with or without HIP COMPASS. The mean follow-up duration was 10.8 years in the HIp COMPASS group and 12.7 years in the control group. Overall, 86.0% and 78.2% of cups were placed within Lewinnek’s safe zone with and without HIP COMPASS, respectively. Variability in radiographic inclination and anteversion was greater in the control group than in the HIP COMPASS group. Dislocation rates were 3.2% in the control group and 1.2% in the HIP COMPASS group, with no significant difference between groups. The control group had a significantly higher revision rate than the HIP COMPASS group (7.3% vs. 1.2%). Use of HIP COMPASS was associated with improved long-term revision-free implant survivorship over ≥ 10 years and more consistent acetabular component positioning at an appropriate insertion angle, which may contribute to stable initial fixation. |
| キーワード | HIP COMPASS® survivorship total hip arthroplasty ceramic-on-ceramic |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-06 |
| 巻 | 80巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 195 |
| 終了ページ | 202 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 42374752 |
| Web of Science KeyUT | 001812989700005 |