検索結果 5282 件
| JaLCDOI | 10.18926/AMO/64123 |
|---|---|
| フルテキストURL | 76_6_723.pdf |
| 著者 | Zhang, Quan| Yang, Lixia| Wan, Guozhen| Zhang, Xiaoqiang| Wang, Ying| Zhao, Guannan| |
| 抄録 | The diagnostic value of microRNA-377 (miR-377) in patients with acute coronary syndrome (ACS) and explored miR-377’s potential mechanisms. We performed an qRT-PCR to assess serum miR-377 levels in ACS patients and coronary artery ligation rat models. The diagnostic value of miR-377 was evaluated by determining the ROC curve. An ELISA assay was conducted to detect the model rat endothelial damage markers von Willebrand factor (vWF) and heart-type fatty acid binding protein (H-FABP), and proinflammatory cytokines TNF-α, IL-6, and IL-1β. The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats. MiR-377 has a high diagnostic value in ACS patients, with a 0.844 ROC, 76.47% specificity, and 87.10% sensitivity. MiR-377 was positively correlated with the expressions of vWF, H-FABP, cTnI, TNF-α, IL-6, and IL-1β. In ACS rats, reducing the expression of miR-377 significantly inhibited the increases in vWF, H-FABP, TNF-α, IL-6, and IL-1β. An elevated miR-377 level can be used as a diagnostic marker in patients with ACS. A reduction of miR-377 may alleviate ACS by improving myocardial damage such as endothelial injury and the inflammatory response. |
| キーワード | microRNA-377 acute coronary syndrome diagnosis endothelial injury inflammatory |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 723 |
| 終了ページ | 730 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549775 |
| Web of Science KeyUT | 000905195100013 |
| JaLCDOI | 10.18926/AMO/64122 |
|---|---|
| フルテキストURL | 76_6_715.pdf |
| 著者 | Mohammed Zahedul Islam Nizami| Gorduysus, Melahat| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Nishina, Yuta| Takashiba, Shogo| Arias, Zulema| |
| 抄録 | The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall. |
| キーワード | bioactive sealer graphene oxide mineral deposition antimicrobial activity radiopacity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 715 |
| 終了ページ | 721 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549774 |
| Web of Science KeyUT | 000905195100012 |
| JaLCDOI | 10.18926/AMO/64121 |
|---|---|
| フルテキストURL | 76_6_705.pdf |
| 著者 | Higashikawa, Toshihiro| Ito, Tomohiko| Mizuno, Takurou| Ishigami, Keiichiro| Kuroki, Kengo| Maekawa, Naoto| Usuda, Daisuke| Izumida, Toshihide| Yamada, Shinya| Sangen, Ryusho| Hamada, Kazu| Kiyosawa, Jun| Saito, Atsushi| Iguchi, Masaharu| Kasamaki, Yuji| Nakahashi, Takeshi| Fukuda, Akihiro| Saito, Hitoshi| Kanda, Tsugiyasu| Okuro, Masashi| |
| 抄録 | The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function. |
| キーワード | tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 705 |
| 終了ページ | 713 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549773 |
| Web of Science KeyUT | 000905195100011 |
| JaLCDOI | 10.18926/AMO/64118 |
|---|---|
| フルテキストURL | 76_6_679.pdf |
| 著者 | Asagi, Akinori| Sakaguchi, Chihiro| Nadano, Seijin| Nishina, Tomohiro| Hamamoto, Yasushi| Kataoka, Masaaki| Yamashita, Natsumi| Tanimizu, Masahito| Hyodo, Ichinosuke| |
| 抄録 | Chemotherapy is insufficient to treat macroscopic vascular invasion (MVI) of hepatocellular carcinoma (HCC). We retrospectively investigated the treatment outcomes of patients who underwent three-dimensional conformal radiotherapy (3D-CRT) for HCC MVI and analyzed prognostic factors by multivariate analysis using a Cox proportional hazard model. Sixty-five patients were studied. MVI sites were the portal vein (n=48 patients), portal and hepatic veins (n=8), and hepatic vein (n=9). The median irradiation dose was 50 Gy. The median survival time (MST) was 7.5 months. Performance status 2 or 3, modified albumin-bilirubin grade 2b or 3, and massive/diffuse type were poor prognostic factors. Nineteen patients (29%) with a treatment effect of 3 or 4 (≥ 50% of tumor necrosis or regression) at the irradiation sites according to the Response Evaluation Criteria in Cancer of the Liver showed longer survival than those with an effect of 1 or 2 (MST 18.7 vs. 5.9 months, p<0.001). No treatment-related death occurred. The hepatic function reserve was preserved in more than 70% of patients. 3D-CRT controlled HCC MVI safely and was suggested to be a good treatment option. |
| キーワード | hepatocellular carcinoma macroscopic vascular invasion portal vein tumor thrombosis hepatic vein tumor thrombosis three-dimensional conformal radiotherapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 679 |
| 終了ページ | 688 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549770 |
| Web of Science KeyUT | 000905195100008 |
| JaLCDOI | 10.18926/AMO/64117 |
|---|---|
| フルテキストURL | 76_6_673.pdf |
| 著者 | Okazawa-Sakai, Mika| Yamamoto, Yasuko| Futagawa, Mashu| Okamura, Miki| Miyawaki, Satoko| Nishina, Tomohiro| Takehara, Kazuhiro| Kozuki, Toshiyuki| Tomida, Shuta| Hyodo, Ichinosuke| Ohsumi, Shozo| Hirasawa, Akira| |
| 抄録 | Patients found to have presumed germline pathogenic variants (PGPVs) during comprehensive genomic profiling (CGP) require genetic counseling (GC) referrals. We retrospectively investigated the outcomes of patients with PGPVs. Among 159 patients who underwent CGP, we recommended GC for the 16 patients with PGPVs (3 with [FG group] and 13 without [G Group] a family/personal history of hereditary cancer) as well as for the 8 patients with no PGPVs, but a history (F group); 2 (67%), 5 (38%), and 3 (38%) patients received GC in the FG, G, and F groups, respectively. Germline testing results were positive in 1 and 2 patients of the FG and G groups, respectively. Among the patients recommended for GC, 58% did not receive GC due to lack of interest, poor performance status, or death. CGP contributes to the identification of germline variants in patients without a history of hereditary cancer. However, the proportion of patients who undergo GC should be improved. |
| キーワード | comprehensive genomic profiling hereditary cancer germline findings presumed germline pathogenic variant(s) genetic counseling |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 673 |
| 終了ページ | 678 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549769 |
| Web of Science KeyUT | 000905195100007 |
| JaLCDOI | 10.18926/AMO/64116 |
|---|---|
| フルテキストURL | 76_6_661.pdf |
| 著者 | Abe, Yuko| Taira, Naruto| Kashiwabara, Kosuke| Tsurutani, Junji| Kitada, Masahiro| Takahashi, Masato| Kato, Hiroaki| Kikawa, Yuichiro| Sakata, Eiko| Naito, Yoichi| Hasegawa, Yoshie| Saito, Tsuyoshi| Iwasa, Tsutomu| Takashima, Tsutomu| Aihara, Tomohiko| Mukai, Hirofumi| Hara, Fumikata| Shien, Tadahiko| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| 抄録 | Chemotherapy-induced peripheral neuropathy (CIPN) is an important clinical challenge that threatens patients’ quality of life. This sub-study of the ABROAD trial investigated the influence of single nucleotide polymorphisms (SNPs) on CIPN, using genotype data from a randomized study to determine the optimal dose of a 3-week-cycle regimen of nab-paclitaxel (q3w nab-PTX) in patients with metastatic breast cancer (MBC). Patients with HER2-negative MBC were randomly assigned to three doses of q3w nab-PTX (SD: 260 mg/m2 vs. MD: 220 mg/m2 vs. LD: 180 mg/m2). Five SNPs (EPHA4-rs17348202, EPHA5-rs7349683, EPHA6-rs301927, LIMK2-rs5749248, and XKR4-rs4737264) were analyzed based on the results of a previous genome-wide association study. Per-allele SNP associations were assessed by a Cox regression to model the cumulative dose of nab-PTX up to the onset of severe or worsening sensory neuropathy. A total of 141 patients were enrolled in the parent study; 91(65%) were included in this sub-study. Worsening of CIPN was significantly greater in the cases with XKR4 AC compared to those with a homozygote AA (HR 1.86, 95%CI: 1.00001−3.46, p=0.049). There was no significant correlation of CIPN with any other SNP. A multivariate analysis showed that the cumulative dose of nab-PTX was most strongly correlated with CIPN (p<0.01). |
| キーワード | metastatic breast cancer taxane-induced peripheral neuropathy chemotherapy-induced peripheral neuropathy nab-paclitaxel single nucleotide polymorphism |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 661 |
| 終了ページ | 671 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549768 |
| Web of Science KeyUT | 000905195100006 |
| JaLCDOI | 10.18926/AMO/64114 |
|---|---|
| フルテキストURL | 76_6_645.pdf |
| 著者 | Tada, Katsuhiko| Miyagi, Yasunari| Komatsu, Reina| Okimoto, Naoki| Tsukahara, Saya| Tateishi, Yoko| Ooka, Naomi| Yoshida, Mizuho| Kumazawa, Kazumasa| |
| 抄録 | We used biomathematics to describe and compare cerebellar growth in normally developing and trisomy 18 Japanese fetuses. This retrospective study included 407 singleton pregnancies with fetuses at 14-39 weeks of gestation and 33 fetuses with trisomy 18 at 17-35 weeks. We used ultrasonography to measure fetal transverse cerebellar diameter (TCD) and anteroposterior cerebellar diameter (APCD). We hypothesized that cerebellar growth is proportional to cerebellar length at any given time point. We determined the formula L(t) ≒Keat+r, where e is Napier’s number, t is time, L is cerebellar length, and a, K, and r are constants. We then obtained regression functions for each TCD and APCD in all fetuses. The regression equations for TCD and APCD values in normal fetuses, expressed as exponential functions, were TCD(t)=27.85e0.02788t−28.62 (mm) (adjusted R2=0.997), and APCD(t)=324.29e0.00286t−322.62 (mm) (adjusted R2=0.995). These functions indicated that TCD and APCD grew at constant rates of 2.788%/week and 0.286%/week, respectively, throughout gestation. TCD (0.0153%/week) and APCD (0.000430%/week) grew more slowly in trisomy 18 fetuses. This study demonstrates the potential of biomathematics in clinical research and may aid in biological understanding of fetal cerebellar growth. |
| キーワード | biomathematics cerebellum fetus trisomy 18 syndrome ultrasonography |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 645 |
| 終了ページ | 650 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549766 |
| Web of Science KeyUT | 000905195100004 |
| JaLCDOI | 10.18926/AMO/64113 |
|---|---|
| フルテキストURL | 76_6_635.pdf |
| 著者 | Zhang, Cuicui| Ji, Yanan| Wang, Qin| Ruan, Lianying| |
| 抄録 | To investigate the association between serum miR-338-3p levels and neonatal acute respiratory distress syndrome (ARDS) and its mechanism. The relative miR-338-3p expression in serum was detected by quantitative real-time RT-PCR. Interleukin-1beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) levels were detected by ELISAs. A receiver operating characteristic (ROC) curve analysis of serum miR-338-3p evaluated the diagnosis of miR-338-3p in neonatal ARDS. Pearson’s correlation analysis evaluated the correlation between serum miR-338-3p and neonatal ARDS clinical factors. Flow cytometry evaluated apoptosis, and a CCK-8 assay assessed cell viability. A luciferase assay evaluated the miR-338-3p/AKT3 relationship. The miR- 338-3p expression was decreased in neonatal ARDS patients and in lipopolysaccharide (LPS)-treated cells. The ROC curve showed the accuracy of miR-338-3p for evaluating neonatal ARDS patients. The correlation analysis demonstrated that miR-338-3p was related to PRISM-III, PaO2/FiO2, oxygenation index, IL-1β, IL-6, and TNF-α in neonatal ARDS patients. MiR-338-3p overexpression inhibited the secretion of inflammatory components, stifled cell apoptosis, and LPS-induced advanced cell viability. The double-luciferase reporter gene experiment confirmed that miR-338-3p negatively regulates AKT3 mRNA expression. Serum miR-338-3p levels were related to the diagnosis and severity of neonatal ARDS, which may be attributed to its regulatory effect on inflammatory response in ARDS. |
| キーワード | miR-338-3p AKT3 neonatal ARDS inflammation diagnosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 635 |
| 終了ページ | 643 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549765 |
| Web of Science KeyUT | 000905195100003 |
| フルテキストURL | O0004545_abstract_review.pdf O0004545_fulltext.pdf |
|---|---|
| 著者 | 大川 百合子| |
| 発行日 | 2022-09-22 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4545号 |
| 学位授与年月日 | 2022-09-22 |
| 学位・専攻分野 | 博士（看護学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2023 Japan Society of Nursing Research |
| フルテキストURL | K0006687_abstract_review.pdf K0006687_fulltext.pdf K0006687_summary.pdf |
|---|---|
| 著者 | 韓 言言| |
| 発行日 | 2022-09-22 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6687号 |
| 学位授与年月日 | 2022-09-22 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2020 by The Japanese Society for Lymphoreticular Tissue Research |
| JaLCDOI | 10.18926/AMO/64044 |
|---|---|
| フルテキストURL | 76_5_609.pdf |
| 著者 | Matsumoto, Ken| Fujishita, Keigo| Matsuda, Masayuki| Oka, Satoshi| Fujisawa, Yuka| Imai, Toshi| Machida, Takuya| |
| 抄録 | A 69-year-old Japanese man with acute leukemia received post-transplant cyclophosphamide-based haploidentical stem cell transplantation (PTCY-haplo-SCT) but was readmitted with dyspnea and ground-glass-opacities of the lungs. Bronchoscopy showed inflammatory changes with no signs of infection. He received steroids but required intubation as his condition deteriorated. In addition to antithymocyte globulin and cyclophosphamide, we administered ruxolitinib but failed to save him. Autopsy findings revealed fibrotic nonspecific interstitial pneumonia (NSIP) without evidence of organizing pneumonia or infection. Thus, we diagnosed idiopathic pneumonia syndrome (IPS). As far as our knowledge, this is the first case of IPS with NSIP histology after PTCY-haplo-SCT. |
| キーワード | idiopathic pneumonia syndrome ruxolitinib post-transplant cyclophosphamide-based haploidentical stem cell transplantation nonspecific interstitial pneumonia |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 609 |
| 終了ページ | 615 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352810 |
| Web of Science KeyUT | 000884907100016 |
| JaLCDOI | 10.18926/AMO/64039 |
|---|---|
| フルテキストURL | 76_5_577.pdf |
| 著者 | Okutani, Yuki| Fujita, Hiroshi| Harada, Hideto| Kataoka, Masanao| Murotani, Yoshiki| Shimizu, Yu| |
| 抄録 | The prevalence of preoperative deep vein thrombosis (DVT) has been reported to be relatively high in patients undergoing total hip arthroplasty. We investigated the prevalence of DVT, the association between hip function and preoperative DVT, and the effect of a history of surgery in patients who underwent primary total hip arthroplasty. We retrospectively analyzed the cases of the patients who underwent primary total hip arthroplasty between April 2013 and February 2020 at our institution. We evaluated the prevalence of preoperative DVT based on the results of the patients’ ultrasound screening. We performed univariate and multivariate analyses to investigate the association between the incidence of DVT and patient factors including age, sex, hip function, medical histories, and American Society of Anesthesiologists Physical Status classification. We analyzed 451 patients (494 hips). The prevalence of DVT was 14.2% (64 patients). The multivariate analysis demonstrated that increased age was an independent significant risk factor for DVT. The prevalence of preoperative DVT was relatively high among patients who underwent primary total hip arthroplasty. Preoperative DVT tended to be more prevalent in older patients. Hip function was not associated with the incidence of DVT. |
| キーワード | total hip arthroplasty deep vein thrombosis hip function ultrasound screening |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 577 |
| 終了ページ | 584 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352805 |
| Web of Science KeyUT | 000884907100011 |
| JaLCDOI | 10.18926/AMO/64036 |
|---|---|
| フルテキストURL | 76_5_547.pdf |
| 著者 | Kagawa, Hidetoshi| Yamanaka, Ryutaro| Hiromasa, Tsutomu| |
| 抄録 | This observational study aimed to clarify the long-term results of the combination of mizoribine (MZB), tacrolimus (TAC) and prednisolone as first-line therapy for lupus nephritis (LN). This was our institution’s standard therapy between 2009 and 2015, when we saw 36 patients with LN. When a patient thus treated achieved SLEDAI remission (= 0) and/or the prednisolone dose could be tapered to 5 mg/day, either MZB or TAC was stopped, and the other was continued for maintenance therapy. If treatment failure or relapse occurred, second-line therapy was introduced. At years 1 and 5, overall complete renal response and SLEDAI remission were 94% and 88%, and 50% and 62%, respectively. Excluding 2 cases lost to follow-up, medications after 5 years were as follows: 20 (59%) were stable on 1 drug (MZB or TAC), 11 (32%) required continuation of both drugs (MZB + TAC), and 3 (9%) required second-line therapy. The 5-year retention rate was 91% (non-secondline), with 0% of relapse in this group. Our first-line combination strategy showed high remission rates in the induction phase, and subsequent maintenance therapy demonstrated good outcomes for up to 5 years. Research that fine-tunes the order of therapeutic agents and institutes appropriate treatment goals may further improve long-term outcomes for patients with LN. |
| キーワード | combination therapy first-line therapy lupus nephritis mizoribine tacrolimus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 547 |
| 終了ページ | 555 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352802 |
| Web of Science KeyUT | 000884907100008 |
| JaLCDOI | 10.18926/AMO/64034 |
|---|---|
| フルテキストURL | 76_5_535.pdf |
| 著者 | Matsuda, Tadashi| Akezaki, Yoshiteru| Tsuji, Yoko| Hamada, Kazunori| Ookura, Mitsuhiro| |
| 抄録 | The purpose of this study was to investigate the psychological impact of various positionings in subjects with cerebral palsy (CP). The participants were 17 individuals with severe motor and intellectual disability due to CP. They began in a sitting position in their wheelchair, and were placed consecutively in prone or supine positions, with no intervals between placements. Physiological observations were made in each position, and included salivary α-amylase activity, pulse, percutaneous oxygen saturation, respiratory rate, learance or not of airway secretions, and occurrence or not of adverse events. Salivary α-amylase activity values were higher in the prone position than in the baseline and supine positions (p<0.05). Clearance of airway secretions was significantly more prevalent in the prone position than in the baseline and supine positions (p <0.05). The participants’ pulse was significantly lower in the supine and prone positions than in the baseline position (p<0.05). Greater prevalence of airway secretion clearance and significantly higher stress levels as indicated by saliva amylase were observed in the prone position than in the other two positions. Therefore, when such patients are placed in a prone position, close attention to airway management and the potential for psychological stress may be necessary. |
| キーワード | alpha-amylase stress positioning cerebral palsy severe motor and intellectual disability |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 535 |
| 終了ページ | 540 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352800 |
| Web of Science KeyUT | 000884907100006 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Cong, Yingnan| Zhu, Chen| Hou, Yufei| Tian, Shuairu| Cai, Xiaojing| |
| キーワード | ESG investment carbon emission carbon productivity regional effect green transition |
| 発行日 | 2022-10-12 |
| 出版物タイトル | Frontiers In Environmental Science |
| 巻 | 10巻 |
| 出版者 | Frontiers Media |
| 開始ページ | 977049 |
| ISSN | 2296-665X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Cong, Zhu, Hou, Tian and Cai. |
| 論文のバージョン | publisher |
| DOI | 10.3389/fenvs.2022.977049 |
| Web of Science KeyUT | 000876485500001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fenvs.2022.977049 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Seya, Mizuki| Aokage, Toshiyuki| Nojima, Tsuyoshi| Nakao, Atsunori| Naito, Hiromichi| |
| キーワード | Bile pigments Emergency and critical care medicine Antioxidant therapy |
| 発行日 | 2022-10-29 |
| 出版物タイトル | European Journal Of Medical Research |
| 巻 | 27巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 224 |
| ISSN | 0949-2321 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 36309733 |
| DOI | 10.1186/s40001-022-00863-0 |
| Web of Science KeyUT | 000876312700004 |
| 関連URL | isVersionOf https://doi.org/10.1186/s40001-022-00863-0 |
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| フルテキストURL | 76_5_503.pdf |
| 著者 | Ogawa, Hirohito| Honda, Tomoyuki| |
| 抄録 | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| キーワード | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 503 |
| 終了ページ | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| フルテキストURL | 76_5_489.pdf |
| 著者 | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| 抄録 | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| キーワード | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 489 |
| 終了ページ | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamada, Hiroshi| Abe, Tadashi| Nagaoka, Hikaru| Takashima, Eizo| Nitta, Ryo| Yamamoto, Masahiro| Takei, Kohji| |
| キーワード | IFN-inducible GTPase Irgb6 GTPase membrane T gondii |
| 発行日 | 2022-09-09 |
| 出版物タイトル | Frontiers In Cellular And Infection Microbiology |
| 巻 | 12巻 |
| 出版者 | Frontiers Media |
| 開始ページ | 992198 |
| ISSN | 2235-2988 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Yamada, Abe, Nagaoka, Takashima, Nitta, Yamamoto and Takei. |
| 論文のバージョン | publisher |
| PubMed ID | 36159643 |
| DOI | 10.3389/fcimb.2022.992198 |
| Web of Science KeyUT | 000873786000001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fcimb.2022.992198 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Araki, Hiroyuki| Tazawa, Hiroshi| Kanaya, Nobuhiko| Kajiwara, Yoshinori| Yamada, Motohiko| Hashimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 発行日 | 2022-12-15 |
| 出版物タイトル | Molecular Therapy - Oncolytics |
| 巻 | 27巻 |
| 出版者 | Cell Press |
| 開始ページ | 3 |
| 終了ページ | 13 |
| ISSN | 2372-7705 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 36212775 |
| DOI | 10.1016/j.omto.2022.09.003 |
| Web of Science KeyUT | 000870232500001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.omto.2022.09.003 |