検索結果 1649 件
| JaLCDOI | 10.18926/AMO/62813 |
|---|---|
| フルテキストURL | 75_6_725.pdf |
| 著者 | Matsumoto, Hiroshi| Kimata, Yoshihiro| Ota, Tomoyuki| Sugiyama, Narushi| Onoda, Satoshi| Makino, Takuma| Takeda, Seiko| Mizukawa, Nobuyoshi| |
| 抄録 | The long-term changes in tissues implanted in the oral cavity and pharynx after head and neck reconstruction have not been fully evaluated. This study aimed to clarify the morphological changes, long-term durability, and potential for secondary carcinogenesis in such tissues. In our single-center study, the rough morphological changes in 54 cases of intraoral and pharyngeal skin and mucosal flaps were evaluated more than 10 years after flap transfer. In addition, the literature on the development of second carcinomas from skin flaps was reviewed. The mean follow-up period for transferred flaps was 148 months. The reconstruction areas and the probability of morphological changes were significantly correlated (p=0.006), especially in cases with tongue, lower gingiva, and buccal mucosal reconstruction. Free jejunal flap surfaces were well maintained, whereas tubed skin flaps showed severe morphological changes in cases with pharyngeal reconstruction. None of the flaps in our series developed second primary carcinomas. Skin flaps generally had good durability for > 10 years in intraoral environments, while mucosal flaps had better durability for pharyngeal reconstruction. Second squamous carcinomas arising from skin flaps are extremely rare; however, surgeons should take this possibility into consideration and conduct meticulous and long-term follow-up. |
| キーワード | skin flap mucosal flap oral reconstruction morphological change second primary carcinoma |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 725 |
| 終了ページ | 734 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955541 |
| NAID | 120007180279 |
| JaLCDOI | 10.18926/AMO/62812 |
|---|---|
| フルテキストURL | 75_6_719.pdf |
| 著者 | Uehara, Shinya| Fujio, Kei| Yamasaki, Tomoya| Otsuki, Hideo| |
| 抄録 | Differentiating patients by age and causative bacterial morphology might aid in making the appropriate choice of antimicrobial agent when treating acute uncomplicated cystitis. In this retrospective analysis, the non-susceptibility rates of the causative bacteria to cefcapene-pivoxil (CFPN-PI) and levofloxacin (LVFX) were determined after dividing patients with acute uncomplicated cystitis by age group (15-54 and 55-74 years old) and by bacterial morphology: gram-positive cocci (GPC) or gram-negative rod (GNR). The overall non-susceptibility rates for CFPN-PI and LVFX were 19.4% and 15.3%, respectively. When the subjects were divided by age, only the non-susceptibility rate for LVFX in the younger group significantly decreased (to 8.7%). When the groups were divided by both age and bacterial morphology, the younger GNR group had non-susceptibility rates of 6.9% to CFPN-PI and 7.8% to LVFX, whereas the younger GPC group showed 10.2% non-susceptibility to LVFX. The older GNR group showed 9.8% non-susceptibility to CFPN-PI, while the older GPC group showed 7.2% non-susceptibility to LVFX. All the non-susceptibility rates were lower than 10.2% in the sub-divided groups. Differentiating patients by age and the morphology of causative bacteria can aid in making the appropriate choice of antimicrobial agent and may improve treatment outcomes in patients with acute uncomplicated cystitis. |
| キーワード | acute uncomplicated cystitis oral antimicrobial agents antimicrobial susceptibility menopause Gram stain |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 719 |
| 終了ページ | 724 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955540 |
| Web of Science KeyUT | 000735297900008 |
| NAID | 120007180280 |
| JaLCDOI | 10.18926/AMO/62811 |
|---|---|
| フルテキストURL | 75_6_713.pdf |
| 著者 | Aoyama, Tatsuro| Ogiwara, Toshihiro| Ito, Kiyoshi| Miyaoka, Yoshinari| Fujii, Yu| Hanaoka, Yoshiki| Hasegawa, Takatoshi| Watanabe, Gen| Seguchi, Tatsuya| Hongo, Kazuhiro| |
| 抄録 | The consistency of spinal meningiomas is important to consider when performing tumor removal surgery. This study evaluated the correlations between spinal meningioma consistency and both preoperative computed tomography (CT) values and histopathological subtypes. Fifteen consecutive patients who underwent surgical resection of spinal meningioma at our institution were identified, and preoperative CT values and the signal intensity of T2-weighted magnetic resonance images of the tumor were determined retrospectively. The consistency of the spinal meningioma was defined based on the ultrasonic surgical aspirator output during tumor debulking. Patients were assigned to 2 groups: a soft group (n=4) and a hard group (n=11). The T2 signal intensity was significantly higher in the soft group than in the hard group (p=0.001). While the CT values were considerably higher in the hard group, the difference was not significant (p=0.19). Regarding the histopathological subtypes, psammomatous meningioma exhibited significantly higher CT values than meningothelial meningioma (p=0.019); however, there was a higher frequency of hard tumors in meningothelial meningioma cases than in psammomatous meningioma cases. Although neither robust correlations between tumor consistency and CT values nor a relationship between tumor consistency and histopathological subtype has been established, these results might help with the perioperative manegement of spinal tumors. |
| キーワード | calcification computed tomography psammoma body spinal meningioma |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 713 |
| 終了ページ | 718 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955539 |
| Web of Science KeyUT | 000735297900007 |
| NAID | 120007180281 |
| JaLCDOI | 10.18926/AMO/62808 |
|---|---|
| フルテキストURL | 75_6_691.pdf |
| 著者 | Kato, Yuji| Hayashi, Takeshi| Kato, Ritsushi| Uchino, Akira| Takao, Masaki| Takahashi, Shinichi| |
| 抄録 | Although diagnostic and therapeutic strategies for acute stroke patients in Japan depend largely on magnetic resonance imaging (MRI), patients with cardiac implantable electronic devices (CIED) must still rely on com-puted tomography (CT). We retrospectively analyzed clinical and neuroimaging data of ischemic stroke patients with CIED treated at our hospital. Forty-five patients were enrolled in the study. Patients were divided into two groups according to whether corresponding lesions were detected (group A, n = 21) or not detected (group B, n = 24) by the first brain CT. We also evaluated in detail the clinical courses of patients who arrived at hospital within therapeutic time windows for recanalization therapy. Negative fresh infarct in the first CT was associated, though not significantly, with early onset-to-arrival time and subcortical white matter infarction. Five patients did not undergo recanalization therapy because their families did not agree to the procedure. The reasons for their lack of consent included inadequate information about the safety and efficacy of recanalization therapy because MRI could not be performed. Our study confirmed delayed detection of the corresponding lesion and undertreatment for acute stroke in patients with CIED. |
| キーワード | stroke cardiac implantable electronic device computed tomography magnetic resonance imaging |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 691 |
| 終了ページ | 697 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955536 |
| Web of Science KeyUT | 000735297900004 |
| NAID | 120007180284 |
| JaLCDOI | 10.18926/AMO/62805 |
|---|---|
| フルテキストURL | 75_6_671.pdf |
| 著者 | Gao, Shangze| Nishibori, Masahiro| |
| 抄録 | Histidine-rich glycoprotein (HRG) is a 75 kDa plasma protein that is synthesized in the liver of many verte-brates and present in their plasma at relatively high concentrations of 100-150 μg/mL. HRG is an abundant and well-characterized protein having a multidomain structure that enable it to interact with many ligands, func-tion as an adaptor molecule, and participate in numerous physiological and pathological processes. As a plasma protein, HRG has been reported to regulate vascular biology, including coagulation, fibrinolysis and angiogenesis, through its binding with several ligands (heparin, FXII, fibrinogen, thrombospondin, and plas-minogen) and interaction with many types of cells (endothelial cells, erythrocytes, neutrophils and platelets). This review aims to summarize the roles of HRG in maintaining vascular homeostasis and regulating angiogen-esis in various pathological conditions. |
| キーワード | histidine-rich glycoprotein vascular biology coagulation angiogenesis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 671 |
| 終了ページ | 675 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955533 |
| Web of Science KeyUT | 000735297900001 |
| NAID | 120007180287 |
| フルテキストURL | mjou_064_187_190.pdf |
|---|---|
| 著者 | Puthenpurakal, Tony J. | |
| 抄録 | Let K be a field and consider the standard grading on A = K[X1, ... ,Xd]. Let I, J be monomial ideals in A. Let In(J) = (In : J∞) be the nth symbolic power of I with respect to J. It is easy to see that the function fI J (n) = e0(In(J)/In) is of quasi-polynomial type, say of period g and degree c. For n ≫ 0 say fIJ (n) = ac(n)nc + ac−1(n)nc−1 + lower terms, where for i = 0, ... , c, ai : N → Q are periodic functions of period g and ac ≠0. In [4, 2.4] we (together with Herzog and Verma) proved that dim In(J)/In is constant for n ≫ 0 and ac(−) is a constant. In this paper we prove that if I is generated by some elements of the same degree and height I ≥ 2 then ac−1(−) is also a constant. |
| キーワード | quasi-polynomials monomial ideals symbolic powers |
| 発行日 | 2022-01 |
| 出版物タイトル | Mathematical Journal of Okayama University |
| 巻 | 64巻 |
| 号 | 1号 |
| 出版者 | Department of Mathematics, Faculty of Science, Okayama University |
| 開始ページ | 187 |
| 終了ページ | 190 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright ©2022 by the Editorial Board of Mathematical Journal of Okayama University |
| フルテキストURL | mjou_064_047_061.pdf |
|---|---|
| 著者 | Yamanaka, Satoshi| |
| 抄録 | The notion of weakly separable extensions was introduced by N. Hamaguchi and A. Nakajima as a generalization of separable extensions. The purpose of this article is to give a characterization of weakly separable polynomials in skew polynomial rings. Moreover, we shall show the relation between separability and weak separability in skew polynomial rings of derivation type. |
| キーワード | separable extension weakly separable extension skew polynomial ring derivation |
| 発行日 | 2022-01 |
| 出版物タイトル | Mathematical Journal of Okayama University |
| 巻 | 64巻 |
| 号 | 1号 |
| 出版者 | Department of Mathematics, Faculty of Science, Okayama University |
| 開始ページ | 47 |
| 終了ページ | 61 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright ©2022 by the Editorial Board of Mathematical Journal of Okayama University |
| フルテキストURL | fulltext20211026-3.pdf Supplementary_Information_of_Nagaki_Rev.pdf |
|---|---|
| 著者 | Nagaki, Kiyotaka| Furuta, Tomoyuki| Yamaji, Naoki| Kuniyoshi, Daichi| Ishihara, Megumi| Kishima, Yuji| Murata, Minoru| Hoshino, Atsushi| Takatsuka, Hirotomo| |
| キーワード | Machine learning deep learning mitotic cell chromosome tetrad microscope |
| 備考 | This is an Accepted Manuscript of an article published by Springer. This fulltext is available in Oct. 2022.| |
| 発行日 | 2021-10-14 |
| 出版物タイトル | Chromosome Research |
| 巻 | 29巻 |
| 号 | 3-4号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 361 |
| 終了ページ | 371 |
| ISSN | 0967-3849 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s), under exclusive licence to Springer Nature B.V. 2021 |
| 論文のバージョン | author |
| DOI | 10.1007/s10577-021-09676-z |
| JaLCDOI | 10.18926/AMO/62780 |
|---|---|
| フルテキストURL | 75_5_653.pdf |
| 著者 | Tsuchie, Hiroyuki | Miyakoshi, Naohisa| Nagasawa, Hiroyuki| Nanjo, Hiroshi| Shimada, Yoichi| |
| 抄録 | We present an extremely rare case of deep angiomyxoma (DAM) in the thigh that was misdiagnosed as desmoid-type fibromatosis. A 40-year-old Japanese woman presented with a mass on the left thigh. The histological diagnosis by needle biopsy was desmoid-type fibromatosis; the tumor grew slowly and was resected 4 years later. The histological diagnosis from the resected tumor was DAM. As of 16 months post-surgery, the patient has not noticed any local recurrence. Although DAM in a lower extremity is extremely rare, clinicians must be aware of its possible occurrence in areas relatively close to the pelvis. |
| キーワード | deep angiomyxoma thigh desmoid-type fibromatosis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 653 |
| 終了ページ | 657 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703050 |
| Web of Science KeyUT | 000711568400005 |
| NAID | 120007166665 |
| JaLCDOI | 10.18926/AMO/62776 |
|---|---|
| フルテキストURL | 75_5_631.pdf |
| 著者 | Yamamoto, Koichiro| Omura, Daisuke| Yamane, Mai| Son, Reina| Hasegawa, Kou| Honda, Hiroyuki| Obika, Mikako| Minao, Nozomu| Edahiro, Satoru| Yamada, Norihito| Otsuka, Fumio| |
| 抄録 | Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypoglycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN. |
| キーワード | anorexia nervosa glucagon hypoglycemic coma insulin-like growth factor-I liver injury |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 631 |
| 終了ページ | 636 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703046 |
| Web of Science KeyUT | Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa 000711568400001 |
| NAID | 120007166676 |
| JaLCDOI | 10.18926/AMO/62773 |
|---|---|
| フルテキストURL | 75_5_601.pdf |
| 著者 | Mitsuhashi, Toshiharu| |
| 抄録 | Research suggests that the fundamental concepts of epidemiology cannot be sufficiently learned in traditional lectures, and interactive learning is necessary. However, few studies have investigated interactive epidemiology education in general, or peer instruction (PI) in particular. This study investigated the effect of PI. Study par-ticipants were fourth-year medical students. The attitude of participants in regard to PI learning was examined in a non-PI and a PI group. The Survey of Attitudes Toward Statistics (SATS) (containing six sub-categories) was conducted as a learning-attitudes index. The pre- and post-lecture scores were compared between the non-PI and PI groups using double robust (DR) estimation. The non-PI and PI groups consisted of 20 and 121 student participants, respectively. In DR estimation, affect exhibited the lowest SATS score changes, at −0.51 (95% confidence interval −0.78 to −0.24; p-value < 0.001), whereas effort exhibited the highest score changes of 0.01 (95% confidence interval −0.30 to 0.32; p-value = 0.952). The epidemiology lecture with PI did not increase the SATS scores. This might be due to issues related to the experimental design. Further research investigating the effects of interactive epidemiology education, it will be necessary to develop tools for assessing the learning of epidemiological concepts and to improve the research design. |
| キーワード | medical students peer instruction epidemiological education learning attitude double robust esti-mation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 601 |
| 終了ページ | 609 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703043 |
| Web of Science KeyUT | 000711561600007 |
| NAID | 120007166673 |
| JaLCDOI | 10.18926/AMO/62771 |
|---|---|
| フルテキストURL | 75_5_585.pdf |
| 著者 | Omiya, Hiroki| Takatori, Makoto| Yunoki, Keiji| Morimatsu, Hiroshi| |
| 抄録 | Many patients develop acute kidney injury (AKI) after vascular surgery. In this retrospective observational study, we investigated the risk factors for AKI defined using the Kidney Disease Improving Global Outcomes criteria after total arch replacement (TAR). Additionally, we investigated the influence of temperature manage-ment during cardiopulmonary bypass (CPB) on postoperative renal function by propensity score-matched anal-ysis. We retrospectively analyzed 161 consecutive patients who underwent TAR between 2016 and 2019. Postoperative AKI occurred in 48.7% of the patients. In the multivariate analysis, male sex (odds ratio [OR] 3.95, 95% confidence interval [95%CI] 1.56-8.27, p = 0.002), ACE inhibitors/ARB medication (OR 3.19, 95%CI 1.49-6.82, p = 0.003), preoperative chronic kidney disease (OR 2.47, 95%CI 1.17-5.23, p = 0.02), pro-longed CPB time (OR 2.36, 95%CI 1.05-5.34, p = 0.04), and lower body ischemic time during CPB (OR 2.20, 95%CI 1.05-4.46, p = 0.04) were identified as independent risk factors for AKI. Propensity score-matched anal-ysis showed no significant difference in the risk of AKI following TAR between mild hypothermia or normo-thermia and moderate hypothermia (37.2% vs. 41.9%, p = 0.83). In conclusion, modifiable risk factors for AKI included prolonged CPB time and lower body ischemic time. Temperature management during CPB had no clear effect on outcomes. |
| キーワード | acute kidney injury total arch replacement cardiopulmonary bypass lower body ischemic time |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 585 |
| 終了ページ | 593 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703041 |
| Web of Science KeyUT | 000711561600005 |
| NAID | 120007166671 |
| JaLCDOI | 10.18926/AMO/62770 |
|---|---|
| フルテキストURL | 75_5_575.pdf |
| 著者 | Suzuki, Hayato| Imai, Norio| Hirano, Yuki| Endo, Naoto| |
| 抄録 | HipCOMPASS, a mechanical intraoperative support device used in total hip arthroplasty (THA), improves the cup-alignment accuracy. However, the alignment accuracy achieved by HipCOMPASS has not been specifically examined in obese patients. In this study, we retrospectively evaluated the relation between alignment accuracy and several obesity-related parameters in 448 consecutive patients who underwent primary THA using HipCOMPASS. We used computed tomography (CT) to measure the preoperative soft-tissue thickness of the anterior-superior iliac spine (ASIS) and pubic symphysis and the differences between preoperative and postoperative cup angle based on the cup-alignment error. We found significant correlations between the absolute value of radiographic anteversion difference and body mass index (r = 0.205), ASIS thickness (r = 0.419), and pubic symphysis thickness (r = 0.434). The absolute value of radiographic inclination difference was significantly correlated with ASIS (r = 0.257) and pubic symphysis thickness (r = 0.202). The receiver operating characteristic curve showed a pubic symphysis thickness of 37.2 mm for a ≥ 5° implantation error in both radiographic inclination and anteversion simultaneously. The cup-alignment error for HipCOMPASS was large in patients whose pubic symphysis thickness was ≥ 37.2 mm on preoperative CT. Our results indicate that methods other than HipCOMPASS, including computed tomography-based navigation systems, might be preferable in obese patients. |
| キーワード | HipCOMPASS total hip arthroplasty cup-alignment accuracy body mass index soft-tissue thickness |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 575 |
| 終了ページ | 583 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703040 |
| Web of Science KeyUT | 000711561600004 |
| NAID | 120007166670 |
| JaLCDOI | 10.18926/AMO/62769 |
|---|---|
| フルテキストURL | 75_5_567.pdf |
| 著者 | Takase, Ryosuke| Hagiya, Hideharu| Honda, Hiroyuki| Nakano, Yasuhiro| Ogawa, Hiroko| Obika, Mikako| Ueda, Keigo| Kataoka, Hitomi| Hanayama, Yoshihisa| Otsuka, Fumio| |
| 抄録 | Influenza potentially has a high mortality rate when it affects the elderly. We aimed to examine the differences in clinical manifestations in patients with influenza according to their age. This multicenter prospective study was performed in six medical institutions in Okayama and Kagawa prefectures (Japan). Between December 1, 2019 and March 31, 2020, we collected data on adult patients diagnosed with influenza type A, who were strat-ified into younger (20-49 years), middle-aged (50-64 years), and older groups (≥ 65 years). We compared the presence or absence of fever, respiratory symptoms, and extrapulmonary symptoms according to age group. In total, 203 patients (113, younger; 51, middle-aged; and 39, older) were eligible for the analysis. The maxi-mum body temperature and temperature at first physician visit in the older group were significantly lower than those in the younger group. The incidence of respiratory symptoms was not different among the three groups. Chills, muscle pain, and arthralgia as systemic symptoms were noted significantly more frequently in the younger (80.9%) and middle-aged (75.5%) groups than in the older group (51.3%) (p = 0.002). Fever and sys-temic symptoms were less likely to appear in older patients, possibly resulting in the delaying of hospital visits among older adults. |
| キーワード | influenza, elderly fever respiratory symptom |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 567 |
| 終了ページ | 574 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703039 |
| Web of Science KeyUT | 000711561600003 |
| NAID | 120007166669 |
| JaLCDOI | 10.18926/AMO/62768 |
|---|---|
| フルテキストURL | 75_5_557.pdf |
| 著者 | Takeshima Kohara, Hiroko| Ikeda, Mitsunori | Okawa, Masami| |
| 抄録 | This study examined the relationship between skin physiological indices and pressure ulcers in elderly people. The subjects were 55 bedridden elderly Japanese patients with a median age of 85 years. The following parame-ters were measured using non-invasive devices: skin surface temperature, moisture content in the stratum corneum, moisture content in the dermis, transepidermal water loss as an index of skin barrier function, skin erythema and skin elasticity. The sacral and 2 heel areas were observed as sites predisposed to pressure ulcers. Within one month after measuring the skin physiological indices, we confirmed pressure ulcers of National Pressure Ulcer Advisory Panel classification Stage II or worse based on medical records. Among the 55 patients, 4 (7.3%) prospectively developed a total of 5 pressure ulcers within 16 days. Only the skin erythema score was significantly higher with than without pressure ulcers (p < 0.001). We performed a binary logistic regression analysis and confirmed a significant relationship between pressure-ulcer development and the level of erythema (odds ratio = 1.026; 95% confidence interval: 1.011-1.042). Skin erythema increased before the development of pressure ulcers. Taken together, our results show that the high skin erythema score can be a predictive indicator of pressure ulcers. |
| キーワード | elderly people erythema pressure ulcer skin |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 557 |
| 終了ページ | 565 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703038 |
| Web of Science KeyUT | 000711561600002 |
| NAID | 120007166668 |
| JaLCDOI | 10.18926/AMO/62767 |
|---|---|
| フルテキストURL | 75_5_549.pdf |
| 著者 | Isooka, Nami| Miyazaki, Ikuko| Asanuma, Masato| |
| 抄録 | Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells. |
| キーワード | Parkinson’s disease astrocyte enteric glial cell neurotrophic factor antioxidative molecule |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 549 |
| 終了ページ | 556 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703037 |
| Web of Science KeyUT | 000711561600001 |
| NAID | 120007166678 |
| フルテキストURL | fulltext20210924-1.pdf |
|---|---|
| 著者 | Ho, Dung Thi| Pham, Hung Hoang Son| Aota, Wataru| Matsubayashi, Makoto| Tsuji, Naotoshi| Hatabu, Toshimitsu| |
| キーワード | Eimeria tenella Local immune response Macrophage |
| 備考 | © 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.rvsc.2021.07.003. | |
| 発行日 | 2021-10 |
| 出版物タイトル | Research in Veterinary Science |
| 巻 | 139巻 |
| 出版者 | Elsevier BV |
| ISSN | 0034-5288 |
| NCID | AA00816614 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Elsevier Ltd. |
| 論文のバージョン | author |
| PubMed ID | 34252703 |
| DOI | 10.1016/j.rvsc.2021.07.003 |
| Web of Science KeyUT | 000692610100009 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.rvsc.2021.07.003 |
| JaLCDOI | 10.18926/AMO/62410 |
|---|---|
| フルテキストURL | 75_4_543.pdf |
| 著者 | Yoshida, Ryuichi| Yagi, Takahito| Yasui, Kazuya| Umeda, Yuzo| Yoshida, Kazuhiro| Fuji, Tomokazu| Takagi, Kosei| Kumano, Kenjiro| Yoshimoto, Masashi| Fujiwara, Toshiyoshi| |
| 抄録 | The outcomes of pancreatectomy with resection and reconstruction of the involved arteries for locally advanced pancreatic cancer following chemotherapy have improved in recent years. In pancreatic head cancers in which there is contact with the common and proper hepatic arteries, margin-negative resection requires pancreati-coduodenectomy, with the resection of these arteries and the restoration of hepatic arterial flow. Here, we describe a middle colic artery transposition technique in hepatic arterial reconstruction during pancreatoduo-denectomy for an initially unresectable locally advanced pancreatic cancer. This technique was effective and may provide a new option for hepatic artery reconstruction in such cases. |
| キーワード | hepatic artery locally advanced pancreatic cancer middle colic artery pancreatoduodenectomy reconstruction technique |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 543 |
| 終了ページ | 548 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511625 |
| Web of Science KeyUT | 000696755800004 |
| NAID | 120007146036 |
| JaLCDOI | 10.18926/AMO/62409 |
|---|---|
| フルテキストURL | 75_4_539.pdf |
| 著者 | Yamamoto, Yukichika| Otsuka, Yuki| Katsuyama, Takayuki| Nishimura, Yoshito| Oka, Kosuke| Hasegawa, Kou| Hagiya, Hideharu| Otsuka, Fumio| |
| 抄録 | Primary Sjögren’s syndrome (SS) is an autoimmune disease that usually affects the exocrine glands in mid-dle-aged women. Fifteen percent of SS patients experience severe systemic extraglandular complications, and pleuritis is one of the rare complications of SS. We report the case of an elderly Japanese man who initially pre-sented with a prolonged fever and chest pain and was finally diagnosed with primary SS-associated pleuritis. Of the nine reported cases of primary SS that initially presented with pleuritis, up to six cases were elderly males. This case highlights the complication of pleuritis among elderly males with primary SS. |
| キーワード | Sjögren’s syndrome pleuritis elderly male |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 539 |
| 終了ページ | 542 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511624 |
| Web of Science KeyUT | 000696755800003 |
| NAID | 120007146035 |
| JaLCDOI | 10.18926/AMO/62408 |
|---|---|
| フルテキストURL | 75_4_533.pdf |
| 著者 | Tsuchie, Hiroyuki| Miyakoshi, Naohisa| Nagasawa, Hiroyuki| Shimada, Yoichi| |
| 抄録 | Tumor lysis syndrome (TLS) is a complication of cancer treatment that requires urgent intervention. It is extremely rare in the treatment of soft tissue sarcoma (STS) of the limbs or trunk, and there are currently no reports of TLS occurrence from eribulin therapy. We report the case of a 78-year-old woman with an undiffer-entiated pleomorphic sarcoma on the right buttock. We initiated chemotherapy with intravenous eribulin mesylate. Deterioration of renal function, mild hyperkalemia, hyperuricemia, hypocalcemia, and hyperphos-phatemia were confirmed on examination, suggesting the presence of TLS. We present an extremely rare case of TLS from eribulin for STS. |
| キーワード | tumor lysis syndrome eribulin soft tissue sarcoma cancer chemotherapy metastasis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 533 |
| 終了ページ | 538 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511623 |
| Web of Science KeyUT | 000696755800002 |
| NAID | 120007146034 |