検索結果 - 岡山大学学術成果リポジトリ

柿胃石の成分分析における標準物質としての柿渋の有用性

タイトル（別表記）	Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars
フルテキストURL	126_127.pdf
著者	岩室雅也\| 岡本裕子\| 村田年弘\| 河合良成\| 白羽英則\| 岡田裕之\| 山本和秀\|
抄録	The definite diagnosis of persimmon phytobezoar (i.e., diospyrobezoar) is often accomplished by a component analysis using infrared spectroscopy. However, no studies have been conducted to investigate which substance is the best as a standard for the component analysis. Here we analyzed tannic acid, Japanese persimmon (kaki), fermented persimmon extract (kaki-shibu), conventional dried persimmon, and dried persimmon smoked in sulfur (ampo-kaki) by infrared spectroscopy to determine which would be optimal as a component analysis standard. The spectrum between 1,600 to 600cm－1 of a persimmon phytobezoar was quite similar to the spectrum of kaki-shibu rather than that of tannic acid. Consequently, we conclude that kaki-shibu should be used as a standard for infrared spectroscopy analyses of persimmon phytobezoars.
キーワード	柿胃石（gastric phytobezoar）タンニン酸（tannic acid）消化管異物（gastrointestinal foreign body）成分分析（component analysis）
出版物タイトル	岡山医学会雑誌
発行日	2014-08-01
巻	126巻
号	2号
開始ページ	127
終了ページ	131
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.127
NAID	130004685263

Assessment of health-related quality of life predicts the outcome of pegylated interferon and ribavirin therapy for chronic hepatitis C

フルテキストURL	K0004917_abstract_review.pdf K0004917_fulltext.pdf
著者	松下浩志\|
発行日	2014-03-25
資料タイプ	学位論文
学位授与番号	甲第4917号
学位授与年月日	2014-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Serum levels of platelet-derived growth factor-BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure

フルテキストURL	K0004886_abstract_review.pdf K0004886_fulltext.pdf
著者	髙山裕基\|
発行日	2014-03-25
資料タイプ	学位論文
学位授与番号	甲第4886号
学位授与年月日	2014-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Assistant-Based Standardization of Prone Position Thoracoscopic Esophagectomy

JaLCDOI	10.18926/AMO/52407
フルテキストURL	68_2_111.pdf
著者	Shirakawa, Yasuhiro\| Noma, Kazuhiro\| Maeda, Naoaki\| Katsube, Ryoichi\| Tanabe, Shunsuke\| Ohara, Toshiaki\| Sakurama, Kazufumi\| Fujiwara, Toshiyoshi\|
抄録	Thoracoscopic esophagectomy in the prone position (TEPP) might enable solo-surgery in cases requiring resection of the esophagus and the surrounding lymph nodes due to the associated advantages of good exposure of the surgical field and ergonomic considerations for the surgeon. However, no one approach can be for all patients requiring extensive lymphadenectomy. We recently developed an assistant-based procedure to standardize exposure of the surgical field. Patients were divided into 1 of 2 groups:a pre-standardization group (n＝37) and a post-standardization group (n＝28). The thoracoscopic operative time was significantly shorter (p＝0.0037) in the post-standardization group (n＝28; 267±31min) than in the pre-standardization group (n＝37;301±53min). Further, learning curve analysis using the moving average method showed stabilization of the thoracoscopic operative time after the standardization. No significant differences were found in the number of mediastinal lymph nodes dissected or intraoperative blood loss between the 2 groups. There were also no significant differences in the complication rate. Assistant-based surgery and standardization of the procedure resulted in a well-exposed and safe surgical field. TEPP decreased the operative time, even in patients requiring extensive lymphadenectomy.
キーワード	thoracoscopic esophagectomy prone position standardization
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-04
巻	68巻
号	2号
出版者	Okayama University Medical School
開始ページ	111
終了ページ	117
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24743786
Web of Science KeyUT	000334652700006

Multicentred surgical site infection surveillance using partitioning analysis

著者	Fujiwara, Y.\| Yamada, T.\| Naomoto, Y.\| Yamatsuji, T.\| Shirakawa, Y.\| Tanabe, S.\| Noma, K.\| Kimura, T.\| Aoki, H.\| Matsukawa, H.\| Kimura, M.\| Nonaka, Y.\| Sasaki, H.\| Onoda, T.\| Otawa, Y.\| Takaoka, M.\| Fukazawa, T.\| Ohno, Y.\| Fujiwara, T.\|
発行日	2013-12
出版物タイトル	Journal of Hospital Infection
巻	85巻
号	4号
資料タイプ	学術雑誌論文

食道原発悪性黒色腫の１切除例

タイトル（別表記）	A patient with primary malignant melanoma of the esophagus who underwent esophagectomy
フルテキストURL	126_45.pdf
著者	前田直見\| 白川靖博\| 國府島健\| 大原利章\| 田邊俊輔\| 野間和広\| 櫻間教文\| 藤原俊義\|
抄録	We report the case of a 61-old-man with a primary malignant melanoma of the esophagus, an extremely rare and highly aggressive malignancy. He presented with dysphagia, and we performed an upper gastrointestinal endoscopy that detected a tumor in the thoracic part of the esophagus. The biopsy showed malignant melanoma. PET/CT, endoscopy and an esophagogram showed that a 70-mm scaled type 2+1 tumor in the thoracic esophagus and no metastases. We diagnosed a cT3cN0cM0 cStage II tumor. We then performed a subtotal esophagectomy with two-field lymph node dissection and esophagogastrostomy via a retrosternal route. The pathological examination of the resected specimens confirmed that the type 2+1 tumor was PMME (pT2N0M0 pStage II). We administered six courses of postoperative adjuvant chemotherapy with dacarbazine, and the patient has had no recurrence for 17 months after the surgery.
キーワード	食道（esophagus）悪性黒色腫（malignant melanoma）
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	45
終了ページ	48
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.45
NAID	130004505808

術前DCF療法が著効した食道原発内分泌細胞癌の１切除例

タイトル（別表記）	Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil
フルテキストURL	126_39.pdf
著者	前田直見\| 白川靖博\| 國府島健\| 大原利章\| 田邊俊輔\| 野間和広\| 櫻間教文\| 藤原俊義\|
抄録	Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3.
キーワード	食道癌（esophageal cancer）内分泌細胞癌（endocrine cell carcinoma） DCF療法（DCF treatment）
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	39
終了ページ	43
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.39
NAID	130004505807

Long-term Observation of Osteomalacia Caused by Adefovir-Induced Fanconi’s Syndrome

JaLCDOI	10.18926/AMO/52145
フルテキストURL	68_1_53.pdf
著者	Terasaka, Tomohiro\| Ueta, Eijiro\| Ebara, Hirotaka\| Waseda, Koichi\| Hanayama, Yoshihisa\| Takaki, Akinobu\| Kawabata, Tomoko\| Sugiyama, Hitoshi\| Hidan, Ko\| Otsuka, Fumio\|
抄録	A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patientʼs serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconiʼs syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis.
キーワード	adefovir dipivoxil (ADV) eldecalcitol Fanconi's syndrome hypophosphatemia osteomalacia
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2014-02
巻	68巻
号	1号
出版者	Okayama University Medical School
開始ページ	53
終了ページ	56
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24553490

Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor

JaLCDOI	10.18926/AMO/52139
フルテキストURL	68_1_17.pdf
著者	Moritou, Yuki\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Baba, Nobuyuki\| Takaguchi, Kouichi\| Senoh, Tomonori\| Nagano, Takuya\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Ohnishi, Hideki\| Miyake, Yasuhiro\| Takaki, Akinobu\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
抄録	The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy.
キーワード	hepatic steatosis genetic polymorphism interferon HCV
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-02
巻	68巻
号	1号
出版者	Okayama University Medical School
開始ページ	17
終了ページ	22
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24553484
Web of Science KeyUT	000331592800003

Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma

著者	Kinugasa, Hideaki\| Nouso, Kazuhiro\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Onishi, Hideki\| Nakamura, Shin-ichiro\| Shiraha, Hidenori\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Ikeda, Fusao\| Miyake, Yasuhiro\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
発行日	2012-04
出版物タイトル	Journal of Gastroenterology
巻	47巻
号	4号
資料タイプ	学術雑誌論文

Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population

著者	Kubota, Junichi\| Ikeda, Fusao\| Terada, Ryo\| Kobashi, Haruhiko\| Fujioka, Shin-ichi\| Okamoto, Ryoichi\| Baba, Shinsuke\| Morimoto, Youichi\| Ando, Masaharu\| Makino, Yasuhiro\| Taniguchi, Hideaki\| Yasunaka, Tetsuya\| Miyake, Yasuhiro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
発行日	2009-09
出版物タイトル	Journal of Gastroenterology
巻	44巻
号	9号
資料タイプ	学術雑誌論文

Des-gamma-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma

著者	Matsubara, Minoru\| Shiraha, Hidenori\| Kataoka, Jyunro\| Iwamuro, Masaya\| Horiguchi, Shigeru\| Nishina, Shin-ichi\| Takaoka, Nobuyuki\| Uemura, Masayuki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Kobayashi, Yoshiyuki\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2012-10
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	27巻
号	10号
資料タイプ	学術雑誌論文

Management of Occluded Metallic Stents in Malignant Hilar Biliary Stricture

著者	Fujii, Masakuni\| Kawamoto, Hirofumi\| Tsutsumi, Koichiro\| Kato, Hironari\| Hirao, Ken\| Kurihara, Naoko\| Mizuno, Osamu\| Ishida, Etsuji\| Ogawa, Tsuneyoshi\| Fukatsu, Hirotoshi\| Yamamoto, Kazuhide\|
発行日	2013-05
出版物タイトル	Hepato-Gastroenterology
巻	60巻
号	123号
資料タイプ	学術雑誌論文

Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis

JaLCDOI	10.18926/AMO/52006
フルテキストURL	67_6_333.pdf
著者	Tazawa, Hiroshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
キーワード	oncolytic adenovirus autophagy E2F1 microRNA
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2013-12
巻	67巻
号	6号
出版者	Okayama University Medical School
開始ページ	333
終了ページ	342
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24356717
Web of Science KeyUT	000328915700001

Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma

フルテキストURL	K0004842_abstract_review.pdf K0004842_fulltext.pdf
著者	衣笠秀明\|
発行日	2013-09-30
資料タイプ	学位論文
学位授与番号	甲第4842号
学位授与年月日	2013-09-30
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

Des-γ-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma

フルテキストURL	K0004825_abstract_review.pdf K0004825_fulltext.pdf
著者	松原稔\|
発行日	2013-09-30
資料タイプ	学位論文
学位授与番号	甲第4825号
学位授与年月日	2013-09-30
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	日本語英語

第19回日本遺伝子治療学会学術集会学会報告

著者	藤原俊義\|
発行日	2013-12-02
出版物タイトル	岡山医学会雑誌
巻	125巻
号	3号
資料タイプ	一般雑誌記事

組織形成因子Fgf10

著者	大内淑代\|
発行日	2013-12-02
出版物タイトル	岡山医学会雑誌
巻	125巻
号	3号
資料タイプ	学術雑誌論文

免疫学的便潜血定量法による潰瘍性大腸炎の粘膜治癒評価

著者	半井明日香\| 加藤順\| 平岡佐規子\| 栗山宗彰\| 井口俊博\| 竹井大介\| 森藤由記\| 秋田光洋\| 高橋索真\| 原田馨太\| 岡田裕之\| 山本和秀\|
発行日	2013-12-02
出版物タイトル	岡山医学会雑誌
巻	125巻
号	3号
資料タイプ	学術雑誌論文

腫瘍融解アデノウイルスによるE2F1-マイクロRNA-7-EGFR経路を介したオートファジー細胞死の誘導分子機構

著者	田澤大\| 矢野修也\| 吉田亮介\| 山崎泰源\| 佐々木剛\| 橋本悠里\| 黒田新士\| 大内正明\| 大西哲平\| 宇野太\| 香川俊輔\| 浦田泰生\| 藤原俊義\|
発行日	2013-12-02
出版物タイトル	岡山医学会雑誌
巻	125巻
号	3号
資料タイプ	学術雑誌論文