検索結果 2820 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Mori, Izumi C.| |
| キーワード | Ca2+ signaling CDPK Signal decoding Stomata |
| 発行日 | 2026-04-29 |
| 出版物タイトル | Journal of Plant Research |
| 出版者 | Springer |
| ISSN | 0918-9440 |
| NCID | AA10900218 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2026 |
| 論文のバージョン | publisher |
| PubMed ID | 42053755 |
| DOI | 10.1007/s10265-026-01703-6 |
| 関連URL | isVersionOf https://doi.org/10.1007/s10265-026-01703-6 |
| フルテキストURL | fulltext.pdf |
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| 著者 | Noda, Kaho| Nishioka, Yukiko| Higuchi, Hitoshi| Hashimoto, Fumika| Miyake, Saki| Miyawaki, Takuya| |
| キーワード | Anesthesia, General Plastic Bronchitis Fontan Procedure Oral Surgical Procedures |
| 発行日 | 2026 |
| 出版物タイトル | Journal of Dental Anesthesia and Pain Medicine |
| 巻 | 26巻 |
| 号 | 2号 |
| 出版者 | XMLink |
| 開始ページ | 175 |
| 終了ページ | 180 |
| ISSN | 2383-9309 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 Journal of Dental Anesthesia and Pain Medicine |
| 論文のバージョン | publisher |
| PubMed ID | 41952912 |
| DOI | 10.17245/jdapm.2026.26.2.175 |
| 関連URL | isVersionOf https://doi.org/10.17245/jdapm.2026.26.2.175 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Huang, Sheng| Hori, Kiyosumi| Yamaji, Naoki| Yoshioka, Yuma| Ning, Min| Nagaya, Yu| Miyaji, Takaaki| Mitani-Ueno, Namiki| Inoue, Shin-ichiro| Kim, June-Sik| Kashino, Miho| Ma, Jian Feng| |
| キーワード | magnesium rice transporter |
| 発行日 | 2026-04-22 |
| 出版物タイトル | Proceedings of the National Academy of Sciences |
| 巻 | 123巻 |
| 号 | 17号 |
| 出版者 | Proceedings of the National Academy of Sciences |
| 開始ページ | e2536813123 |
| ISSN | 0027-8424 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 42018419 |
| DOI | 10.1073/pnas.2536813123 |
| 関連URL | isVersionOf https://doi.org/10.1073/pnas.2536813123 |
| JaLCDOI | 10.18926/AMO/70458 |
|---|---|
| フルテキストURL | 80_2_153.pdf |
| 著者 | Ueda, Yoshiyuki| Yumoto, Tetsuya| Hongo, Takashi| Obara, Takafumi| Nojima, Tsuyoshi| Tsukahara, Kohei| Hasegawa, Kosei| Futagawa, Natsuko| Naito, Hiromichi| Nakao, Atsunori| |
| 抄録 | Adrenal crisis is a life-threatening endocrine emergency that can progress within hours despite a prior diagnosis and maintenance therapy. We describe a fatal influenza-triggered adrenal crisis in two patients: a child with panhypopituitarism and an adult with prior pituitary surgery, both presenting in cardiac arrest. Despite resuscitation and intravenous hydrocortisone, a fatal hypoxic-ischemic injury or multiorgan failure occurred. These cases highlight the fulminant course of an adrenal crisis and underscore the importance of early recognition, clinician awareness, prompt parenteral hydrocortisone administration, and reinforcement of education for patients, caregivers, and healthcare providers to improve preparedness and prevent avoidable deaths. |
| キーワード | adrenal insufficiency cardiac arrest hydrocortisone influenza shock |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 153 |
| 終了ページ | 157 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/70457 |
|---|---|
| フルテキストURL | 80_2_147.pdf |
| 著者 | Sakamoto, Shinya| Tabuchi, Motoyasu| Hamada, Akira| Yoshimatsu, Rika| Saisaka, Yuichi| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| 抄録 | Common bile duct (CBD) injury after blunt abdominal trauma is rare and difficult to diagnose. Delayed recognition leads to severe morbidity. A 70-year-old Japanese man was admitted after sustaining blunt abdominal trauma. Ultrasonography revealed intra-abdominal fluid, suggesting bleeding. Contrast-enhanced computed tomography revealed pancreatic head injury, intra-abdominal bleeding, and pseudoaneurysm of the anterior superior pancreatoduodenal artery (ASPDA). Bile duct injury was not evident. The application of transarterial embolization (TAE) controlled the bleeding. Canulation into the pancreatic or biliary duct was not possible during endoscopic retrograde cholangiopancreatography. An emergency laparotomy revealed severe pancreatic head and extrahepatic bile duct injuries. Pancreaticoduodenectomy/Child reconstruction was performed. Complete CBD transection was confirmed. The patient was ultimately discharged without complications. Early recognition, timely surgical management, and intensive care are essential for favorable outcomes in patients who have sustained abdominal trauma. |
| キーワード | blunt abdominal trauma intensive care emergency laparotomy pancreatoduodenectomy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 147 |
| 終了ページ | 152 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Zago TM, Pereira BMT, Calderan TRA, Hirano ES and Fraga GP: Extrahepatic duct injury in blunt trauma: two case reports and a literature review. Indian J Surg (2014) 76: 303-307.| Feliciano DV: Biliary injuries as a result of blunt and penetrating trauma. Surg Clin North Am (1994) 74: 897-907.| Balzarotti R, Cimbanassi S, Chiara O, Zabbialini G and Smadja C: Isolated extrahepatic bile duct rupture: a rare consequence of blunt abdominal trauma. Case report and review of the literature. World J Emerg Surg (2012) 7: 16.| Ishida T, Hayashi E, Tojima Y and Sakakibara M: Rupture of the common bile duct due to blunt trauma, presenting difficulty in diagnosis. BMJ Case Rep (2018) 11: e227400.| Ghosh S, Kazi FN and Sharma JVP: Extrahepatic bile duct injury caused by blunt abdomen trauma: a case report. Cureus (2022) 14: e25748.| Sanford Z, Abdolmaali K, Robinson D and Denning D: Blunt trauma: an uncommon cause of common bile duct injury. Trauma Case Rep (2015) 1: 44-48.| Zakaria HM, Oteem A, Gaballa NK, Hegazy O, Nada A, Zakareya T, Omar H, Abdelkawy H, Abdeldayem H and Gad EH: Risk factors and management of different types of biliary injuries in blunt abdominal trauma: single-center retrospective cohort study. Ann Med Surg (Lond) (2020) 52: 36-43.| Agarwal H, Gupta A and Kumar S: An overview of Pancreatic Trauma. J Pancreatol (2020) 3: 139-146.| Iacono C, Zicari M, Conci S, Valdegamberi A, De Angelis M, Pedrazzani C, Ruzzenente A and Guglielmi A: Management of pancreatic trauma: a pancreatic surgeonʼs point of view. Pancreatology (2016) 16: 302-308.| Krige JE, Nicol AJ and Navsaria PH: Emergency pancreatoduodenectomy for complex injuries of the pancreas and duodenum. HPB (Oxford) (2014) 16: 1043-1049.| Leppäniemi A, Tolonen M, Tarasconi A, Segovia-Lohse H, Gamberini E, Kirkpatrick AW, Ball CG, Parry N, Sartelli M, Wolbrink D, van Goor H, Baiocchi G, Ansaloni L, Biffl W, Coccolini F, Di Saverio S, Kluger Y, Moore E and Catena F: 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg (2019) 14: 27.| Turan ÖF, Çankaya Gökdere D, Genç M, Bulut B, Akkanöz M, Mutlu H and Yazıcı R: Predictive factors of mortality in patients with abdominal trauma. Ulus Travma Acil Cerrahi Derg (2025) 31: 276-282.| van der Wilden GM, Yeh D, Hwabejire JO, Klein EN, Fagenholz PJ, King DR, de Moya MA, Chang Y and Velmahos GC: Trauma Whipple: do or donʼt after severe pancreaticoduodenal injuries? An analysis of the national trauma data bank (NTDB). World J Surg (2014) 38: 335-340.| Ylimartimo AT, Koskela M, Lahtinen S, Kaakinen T, Vakkala M and Liisanantti J: Outcomes in patients requiring intensive care unit (ICU) admission after emergency laparotomy: a retrospective study. Acta Anaesthesiol Scand (2022) 66: 954-960.| |
| JaLCDOI | 10.18926/AMO/70456 |
|---|---|
| フルテキストURL | 80_2_141.pdf |
| 著者 | Sakamoto-Tokunaga, Moe| Katsuyama, Takayuki| Matoba, Masaki| Tamura, Tomokazu| Kubota, Natsuki| Terajima, Yuya| Shidahara, Kenta| Hirose, Kei| Matsumoto, Kazuya| Nawachi, Shoichi| Nakadoi, Takato| Katayama, Yu| Hayashi, Keigo| Miyawaki, Yoshia| Katsuyama, Eri| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Sada, Ken-Ei| Tsuji, Shuma| Gotoh, Kazuyoshi| Fukushima, Shinnosuke| Hagiya, Hideharu| Wada, Jun| |
| 抄録 | VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory somatic) syndrome has a poor prognosis, with infections being a major cause of death. Raoultella ornithinolytica is an environmental bacterium found predominantly in soil and water. Although R. ornithinolytica can cause various infections, necrotizing fasciitis due to this bacterium has not been reported. We describe the case of an 84-year-old Japanese male with VEXAS syndrome who developed septic shock and necrotizing fasciitis while he was under immunosuppressive therapy. The pathogen was initially misidentified as R. planticola by mass spectrometry but later confirmed by whole-genome sequencing as extended spectrum β-lactamase (ESBL) produced by R. ornithinolytica. Although a life-saving leg amputation was required, the patient recovered with appropriate antibiotic therapy. R. ornithinolytica is thus able to cause severe skin infections in immunocompromised individuals. |
| キーワード | necrotizing fasciitis Raoultella ornithinolytica VEXAS syndrome whole-genome sequence |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 141 |
| 終了ページ | 145 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/70455 |
|---|---|
| フルテキストURL | 80_2_131.pdf |
| 著者 | Nakata, Shunsuke| Takatsu, Fumiaki| Mikuriya, Yoshihiro| Kakishita, Tomokazu| Hato, Shinji| Ohta, Koji| Kobatake, Takaya| |
| 抄録 | Colorectal surgery is associated with a high incidence of postoperative complications regardless of the advances in surgical techniques and multidisciplinary treatment. Proteinuria is common in patients with malignancies, but few studies have investigated the association between preoperative proteinuria and patient prognoses, especially postoperative complications. We investigated the impact of proteinuria on patients undergoing colorectal surgery in a single-center, retrospective cohort study of 767 patients who underwent surgical resection for colorectal cancer between January 2016 and December 2022 at the National Hospital Organization Shikoku Cancer Center. Among them, 81 patients with preoperative proteinuria were compared with the control group of 686 patients without proteinuria. Our analyses revealed that the patients with proteinuria had malnutrition with a significantly lower prognostic nutritional index compared to the no-proteinuria control group (p<0.001). The proteinuria group had a significantly advanced tumor stage (p=0.005), experienced more bleeding during the surgery (p=0.002), and required more transfusions (p<0.001). Postoperative complications were significantly more frequent in the proteinuria group (p=0.03), thus demonstrating that proteinuria was independently associated with postoperative complications (p=0.045). Proteinuria in patients undergoing colorectal cancer surgery can therefore be considered a risk factor for postoperative complications. |
| キーワード | colorectal cancer surgery proteinuria complication malnutrition |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 131 |
| 終了ページ | 139 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA cancer J clin (2018) 68: 394-424.| Sukumar S, Roghmann F, Trinh VQ, Sammon JD, Gervais MK, Tan HJ, Ravi P, Kim SP, Hu JC, Karakiewicz PI, Noldus J, Sun M, Menon M and Trinh QD: National trends in hospital-acquired preventable adverse events after major cancer surgery in the USA. BMJ Open (2013) 3.| Richards SJG, Senadeera SC and Frizelle FA: Sarcopenia, as Assessed by Psoas Cross-Sectional Area, Is Predictive of Adverse Postoperative Outcomes in Patients Undergoing Colorectal Cancer Surgery. Dis colon and Rectum (2020) 63: 807-815.| Watanabe J, Tatsumi K, Ota M, Suwa Y, Suzuki S, Watanabe A, Ishibe A, Watanabe K, Akiyama H, Ichikawa Y, Morita S and Endo I: The impact of visceral obesity on surgical outcomes of laparoscopic surgery for colon cancer. Int J colorectal Dis (2014) 29: 343-351.| Nelson H, Sargent DJ, Wieand HS, Fleshman J, Anvari M, Stryker SJ, Beart RW Jr, Hellinger M, Flanagan R Jr, Peters W and Ota D: A comparison of laparoscopically assisted and open colectomy for colon cancer. New Engl J Med (2004) 350: 2050-2059.| Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Påhlman L, Cuesta MA, Msika S, Morino M and Lacy AM: Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. The Lancet Oncol (2005) 6: 477-484.| Frasson M, Flor-Lorente B, Rodríguez JL, Granero-Castro P, Hervás D, Alvarez Rico MA, Brao MJ, Sánchez González JM and Garcia-Granero E: Risk Factors for Anastomotic Leak After Colon Resection for Cancer: Multivariate Analysis and Nomogram From a Multicentric, Prospective, National Study With 3193 Patients. Ann Surg (2015) 262: 321-330.| Chapter 1: Definition and classification of CKD. Kidney international supplements (2013) 3: 19-62.| DʼAmico G and Bazzi C: Pathophysiology of proteinuria. Kidney Int (2003) 63: 809-825.| Pedersen LM and Milman N: Prevalence and prognostic significance of proteinuria in patients with lung cancer. Acta Oncol (1996) 35: 691-695.| Pedersen LM and Sørensen PG: Increased urinary albumin excretion rate in breast cancer patients. Acta Oncol (2000) 39: 145-149.| Pedersen LM and Sørensen PG: Clinical significance of urinary albumin excretion in patients with non-Hodgkinʼs lymphoma. Br J Haematol (1999) 107: 889-891.| Pedersen LM, Terslev L, SŁrensen PG and Stokholm KH: Urinary albumin excretion and transcapillary escape rate of albumin in malignancies. Med Oncol (2000) 17: 117-122.| Deans DA, Wigmore SJ, Gilmour H, Paterson-Brown S, Ross JA and Fearon KC: Elevated tumour interleukin-1beta is associated with systemic inflammation: A marker of reduced survival in gastro-oesophageal cancer. Br J Cancer (2006) 95: 1568-1575.| Barber MD, Fearon KC and Ross JA: Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer. Clin Sci (1999) 96: 83-87.| Sawyer N, Wadsworth J, Wijnen M and Gabriel R: Prevalence, concentration, and prognostic importance of proteinuria in patients with malignancies. Br Med J (1988) 296: 1295-1298.| Kim MJ, Kang YU, Kim CS, Choi JS, Bae EH, Ma SK, Kweon SS and Kim SW: Proteinuria as a risk factor for mortality in patients with colorectal cancer. Yonsei Med J (2013) 54: 1194-201.| Japanese Classification of Colorectal, Appendiceal and Anal Carcinoma: the 3d English Edition [Secondary Publication]. J Anus Rectum Colon (2019) 3: 175-195.| Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H and Hishida A; Collaborators developing the Japanese equation for estimated GFR: Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis (2009) 53: 982-992.| Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, de Santibañes E, Pekolj J, Slankamenac K, Bassi C, Graf R, Vonlanthen R, Padbury R, Cameron JL and Makuuchi M: The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surge (2009) 250: 187-196.| Dindo D, Demartines N and Clavien PA: Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surge (2004) 240: 205-213.| Kanda Y: Investigation of the freely available easy-to-use software ʻEZRʼ for medical statistics. Bone marrow transplantation (2013) 48: 452-458.| Roumen RM and Wijnen MH: Proteinuria: a frequent paraneoplastic phenomenon in colorectal cancer? Eur J Cancer (1998) 34: 206-207.| Puolijoki H, Mustonen J, Pettersson E, Pasternack A and Lahdensuo A: Proteinuria and haematuria are frequently present in patients with lung cancer. Nephrol Dial Transplant (1989) 4: 947-950.| Georgiannos SN, Weston PM and Goode AW: Correlation between albuminuria and positively charged amino acids in gastrointestinal cancer. Int Surg (1995) 80: 49-52.| Matsuoka S, Kaneko H, Okada A, Fukui A, Yano Y, Itoh H, Morita K, Fujiu K, Michihata N, Jo T, Takeda N, Morita H, Yamaguchi S, Nakamura S, Nishiyama A, Yokoo T, Node K, Yamauchi T, Nangaku M, Yasunaga H and Komuro I: Association between proteinuria and incident colorectal cancer: analysis of a nationwide population-based database. BMJ Open (2022) 12: e056250.| DeJong CH, Busquets S, Moses AG, Schrauwen P, Ross JA, Argiles JM and Fearon KC: Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia. Oncol Rep (2005) 14: 257-263.| Thibaut MM, Sboarina M, Roumain M, Pötgens SA, Neyrinck AM, Destrée F, Gillard J, Leclercq IA, Dachy G, Demoulin JB, Tailleux A, Lestavel S, Rastelli M, Everard A, Cani PD, Porporato PE, Loumaye A, Thissen JP, Muccioli GG, Delzenne NM and Bindels LB: Inflammation-induced cholestasis in cancer cachexia. J Cachexia Sarcopenia Muscle (2021) 12: 70-90.| Ishihara S, Matsuda K, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Kanazawa T, Yamaguchi H, Sunami E, Kitayama J, Hashiguchi Y and Watanabe T: Patient factors predisposing to complications following laparoscopic surgery for colorectal cancers. Surg Laparosc Endosc Percutan Tech (2015) 25: 168-172.| Grosso G, Biondi A, Marventano S, Mistretta A, Calabrese G and Basile F: Major postoperative complications and survival for colon cancer elderly patients. BMC Surg (2012) 12 Suppl 1: S20.| Larson DW, Abd El Aziz MA, Perry W, D'Angelo AL, Behm KT, Mathis KL and Grass F: Additional Value of Preoperative Albumin for Surgical Risk Stratification among Colorectal Cancer Patients. Ann Nutr Metab (2020) 76: 422-430.| Poon JT, Law WL, Chow LC, Fan JK and Lo SH: Outcome of laparoscopic resection for colorectal cancer in patients with high operative risk. Ann Surg Oncol (2011) 18: 1884-1890.| Nishizawa Y, Akagi T, Inomata M, Katayama H, Mizusawa J, Yamamoto S, Ito M, Masaki T, Watanabe M, Shimada Y and Kitano S: Risk factors for early postoperative complications after D3 dissection for stage II or III colon cancer: Supplementary analysis of a multicenter randomized controlled trial in Japan (JCOG0404). Ann Gastroenterol Surg (2019) 3: 310-317.| Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S and Baracos VE: Definition and classification of cancer cachexia: an international consensus. Lancet Oncol (2011) 12: 489-495.| Rausch V, Sala V, Penna F, Porporato PE and Ghigo A: Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia. Oncogenesis (2021) 10: 1.| |
| JaLCDOI | 10.18926/AMO/70454 |
|---|---|
| フルテキストURL | 80_2_119.pdf |
| 著者 | Ikuma, Hisanori| Hirose, Tomohiko| Kawasaki, Keisuke| Otsuka, Kazutoshi| |
| 抄録 | We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in the lateral decubitus position in patients aged > 75 years with thoracolumbar vertebral collapse. The cases of 30 consecutive patients who underwent this procedure and had ≥ 1-year follow-up were retrospectively analyzed. The mean operative time was 78.8 min and the estimated blood loss was 115.7 ml per level. The complications included adjacent junctional failure (n=9, 30%), deep venous thrombosis (n=3, 10%), delirium (n=3, 10%), pleural injury (n=2, 6%), screw backout (n=1, 3%) kidney injury (n=1, 3%), chylothorax (n=1, 3%), and wound dehiscence (n=1, 3%). Seven cases (23.3%) required reoperation. Local kyphosis showed significant improvement (p<0.05) that was maintained at the final follow-up. The Japanese Orthopaedic Association Back Pain Evaluation Questionnaire and a visual analogue scale indicated significant improvement in all categories at the final follow-up (p<0.05). The use of mini-open corpectomy and posterior fixation with SPAPS can thus provide reliable radiological correction and good postoperative clinical outcomes even in patients aged > 75 years. However, a limitation of this procedure is the rate of reoperation (23.3%) for osteoporosis-related adjacent segment fracture and screw backout. |
| キーワード | single postion surgery osteoporotic vertebral collapse anterior and posterior combined surgery minimum invasive surgery |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 119 |
| 終了ページ | 129 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Oishi Y, Nakamura E, Murase M, Doi K, Takeuchi Y, Hamawaki J and Sakai A: Lower lumbar osteoporotic vertebral fractures with neurological symptoms might have two different pathogeneses according to early magnetic resonance images. Acta Neurochir (2019) 161: 2211-2222.| Tamai K, Terai H, Suzuki A and Nakamura H: Risk factors for proximal junctional fracture following fusion surgery for osteoporotic vertebral collapse with delayed neurological deficits: A retrospective cohort study of 403 patients. Spine Surg Relat Res (2018) 19: 171-177.| Smith JS, Shaffrey CI, Ames CP and Lenke LG: Treatment of adult thoracolumbar spinal deformity: past, present, and future. J Neurosurg Spine (2019) 30: 551-678.| Kaneda K, Taneichi H, Abumi K, Hashimoto T, Satoh S and Fujiya M: Anterior decompression and stabilization with the Kaneda device for thoracolumbar burst fractures associated with neurological deficits. J Bone Joint Surg Am Z (1997) 79: 69-83.| Kanayama M, Ishida T, Hashimoto T, Shigenobu K, Togawa D, Oha F and Kaneda K: Role of major spine surgery using Kaneda anterior instrumentation for osteoporotic vertebral collapse. J Spinal Disord Tech (2010) 23: 53-56.| Terai H, Takahashi S, Yasuda H, Konishi S, Maeno T, Kono H, Matsuyama A, Namikawa T, Kato M, Hoshino M, Tamai K, Toyota H, Suzuki A and Nakamura H: Differences in surgical outcome after anterior corpectomy and reconstruction with an expandable cage with rectangular footplates between thoracolumbar and lumbar osteoporotic vertebral fracture. NASSJ (2021) 6: 100071.| Ohba T, Ohba H, Oda K, Tanaka N and Haro H: Surgical Outcomes After Minimally Invasive Direct Lateral Corpectomy with Percutaneous Pedicle Screws for Osteoporotic Thoracolumbar Vertebral Collapse with Neurologic Deficits in the Thoracolumbar Spine Compared with Those After Posterior Spinal Fusion with Vertebroplasty. Spine (phila Pa 1976) (2021) 15: 1271-1278.| Fukuda K, Katoh H, Takahashi Y, Kitamura K and Ikeda D: Minimally invasive anteroposterior combined surgery using lateral lumbar interbody fusion without corpectomy for treatment of lumbar spinal canal stenosis associated with osteoporotic vertebral collapse. J Neurosurg Spine (2021) 35: 154-162.| Ohba T, Oba H, Oda K, Tanaka N and Haro H: Surgical outcomes after minimally invasive direct lateral corpectomy with percutaneous pedicle screws for osteoporotic thoracolumbar vertebral collapse with neurologic deficits in the thoracolumbar spine compared with those after posterior spinal fusion with vertebroplasty. Spine (Phila Pa 1976) (2021) 46: 1271-1278.| Nakashima H, Imagama S, Yukawa Y, Kanemura T, Kamiya M, Deguchi M, Wakao N, Sato T, Matsuzaki K, Yoshida G, Matsuyama Y, Ishiguro N and Kato F: Comparative study of 2 surgical procedures for osteoporotic delayed vertebral collapse: anterior and posterior combined surgery versus posterior spinal fusion with vertebroplasty. Spine (Phila Pa 1976) (2015) 40: E120-E126.| Ozgur BM, Aryan HE, Pimenta L and Taylor WR: Extreme Lateral Interbody Fusion (XLIF): a novel surgical technique for anterior lumbar interbody fusion. Spine J (2006) 6: 435-443.| Ohba T, Ebata S and Haro H: Comparison of serum markers for muscle damage, surgical blood loss, postoperative recovery, and surgical site pain after extreme lateral interbody fusion with percutaneous pedicle screws or traditional open posterior lumbar interbody fusion. BMC Musculoskelet Disord (2017) 18: 415.| Bailey CS, Sjovold SG, Dvorak MF, Fisher CG and Oxland TR: The strength profile of the thoracolumbar endplate reflects the sagittal contours of the spine. Spine (Phila Pa1976) (2011) 36: 124-128.| Grant JP, Oxland TR and Dvorak MF: Mapping the structural properties of the lumbosacral vertebral endplates. Spine (Phila Pa 1976) (2001) 26: 889-896.| Pekmezci M, McDonald E, Kennedy A, Dedini R, McClellan T. Ames C and Deviren V: Can A novel rectangular footplate provide higher resistance to subsidence than circular footplates? An ex vivo biomechanical study. Spine (PhilaPa1976) (2012) 37: E1177-E1181.| Ikuma H, Hirose T, Takao S, Otsuka K and Kawasaki K: The usefulness and safety of the simultaneous parallel anterior and posterior combined lumbar spine surgery using intraoperative 3D fluoroscopy-based navigation (SPAPS). N Am Spine Soc J (2020) 5: 100047.| Ikuma H, Takao S, Inoue Y, Hirose T, Matsukawa K and Kawasaki K: Treatment of thoracolumbar spinal fracture accompanied by diffuse idiopathic skeletal hyperostosis using transdiscal screws for diffuse idiopathic skeletal hyperostosis: preliminary results. Asian Spine J (2021) 15: 340-348.| Dripps RD, Lamont A and Eckenhoff JE; The role of anesthesia in surgical mortality. JAMA (1961) 178: 261-266.| Schnake KJ, Blattert TR, Hahn P, Frank A, Hartmann F and Ullrich B: Classification of osteoporotic thoracolumbar spine fractures: recommendations of the spine section of the German society for orthopaedics and trauma (DGOU). Global Spine Journal (2018) 8: 46S-49S.| Roberts TT, Leonard GR and Cepela DJ: Classifications in brief: American spinal injury association (ASIA) impairment scale. Clin Orthop Relat Res (2017) 475: 1499-1504.| Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M and Seichi A: JOA back pain evaluation questionnaire (JOABPEQ)/JOA cervical myelopathy evaluation questionnaire (JOACMEQ). The report on the development of revised versions. April 16, 2007. The subcommittee of the clinical outcome committee of the japanese orthopaedic association on low back pain and cervical myelopathy evaluation. J Orthop Sci (2009) 14: 348-365.| Jo DJ, Kim KT, Kim SM, Lee SH, Cho MG and Seo EM: Single-stage posterior subtotal corpectomy and circumferential reconstruction for the treatment of unstable thoracolumbar burst fractures. J Korean Neurosurg Soc (2016) 59: 122-128.| Yasuda T, Hasegawa T, Yamato Y, Kobayashi S, Togawa T, Banno T, Arima H, Oe S and Matsuyama Y: Lumbosacral junctional failures after long spinal fusion for adult spinal deformity-which vertebra is the preferred distal instrumented vertebra?. Spine Deform (2016) 4: 378-384.| |
| JaLCDOI | 10.18926/AMO/70453 |
|---|---|
| フルテキストURL | 80_2_109.pdf |
| 著者 | Sonoi, Mika| Sonoi, Norihiro| Koyama, Yoko| |
| 抄録 | This study examined the effects of interprofessional education (IPE) on dietetics students during clinical training, focusing on changes in their attitudes toward IPE and their fundamental competencies. Eighty third-year female students (mean age, 21.0 years) at a Japanese women’s university participated. Self-administered surveys were conducted before and after clinical training to assess attitudes toward IPE using the Readiness for Interprofessional Learning Scale (RIPLS) and the Shakaijin Kisoryoku (SKL; Fundamental Competencies for Working Persons) scale. Quantitative data were analyzed using paired t-tests, chi-squared tests, and cluster analyses. Qualitative data from open-ended responses were analyzed thematically. RIPLS and SKL scores increased significantly, from 65.3 to 68.9, and from 28. 4 to 33. 2, respectively (p<0.001). All 12 SKL items showed significant improvement. In free responses, “initiative” (66 mentions), “communication” (10), and “execution” (8) were the most frequently cited as improved competencies. Cluster analysis identified three groups: increasing scores (n=25), high baseline (n=30), and minimal change (n=25). No significant correlation was found between changes in RIPLS and SKL scores (r=−0.108, p=0.355). IPE integrated into clinical training may enhance dietetics students’ attitudes toward interprofessional collaboration and contribute to the development of professional identity. Individualized, phased IPE implementation is recommended to accommodate differences in learner readiness. |
| キーワード | interprofessional education dietetics students clinical training professional competencies transformative learning |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 109 |
| 終了ページ | 117 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/70452 |
|---|---|
| フルテキストURL | 80_2_099.pdf |
| 著者 | Nguyen Trung Thanh| Nakamichi, Ryo| Shimamura, Yasunori| Saito, Taichi| Ishihara, Takeshi| Furutani, Tomoki| Shitozawa, Hisakazu| Noda, Tomoyuki| Ozaki, Toshifumi| |
| 抄録 | Although the performance of minimally invasive plate osteosynthesis (MIPO) via the anteroinferior approach is increasingly adopted for midshaft clavicle fractures, the influence of fracture morphology on clinical outcomes under a standardized protocol is unclear. We retrospectively analyzed the cases of 54 patients who underwent anteroinferior MIPO for an acute midshaft clavicle fracture (AO/OTA types B1, B2, B3) performed by a single surgeon across three affiliated institutions (2009-2022). We evaluated the clinical outcomes, i.e., the surgical time, incision length, radiographic union, reduction accuracy, range of motion, pain (visual analog scale [VAS]), and complications and compared them among the three AO/OTA subtypes. The mean incision length (3.4 cm) and surgical time (71-79 min) were similar among the groups (both p>0.2). All fractures achieved radiographic union at a mean of 3.5 months. Postoperative alignment and clavicular length were maintained (length reduction −1.0±2.2 mm [B1], −0.5±2.0 mm [B2], −0.6±1.8 mm [B3]; p=0.825; angulation −0.8±3.4°, −1.1±3.1°, −0.3±3.3°; p=0.888). At 3 months, shoulder elevation and abduction were 169°-175° (p=0.079) and 164°-175° (p=0.324). Pain was minimal (100-mm VAS: ≤1 mm; p=0.782). One plate-fatigue failure occurred; no supraclavicular-nerve symptoms were recorded. Anteroinferior MIPO yielded consistent outcomes across AO/OTA types, with excellent union rates, functional recovery, and few complications, indicating that this technique is safe and reproducible for the surgical management of midshaft clavicle fractures. |
| キーワード | clavicle fracture minimally invasive plate osteosynthesis anteroinferior plating AO/OTA classification |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 99 |
| 終了ページ | 107 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Robinson CM: Fractures of the clavicle in the adult. Epidemiology and classification. J Bone Joint Surg Br (1998) 80: 476-484.| Postacchini F, Gumina S, De Santis P and Albo F: Epidemiology of clavicle fractures. J Shoulder Elbow Surg (2002) 11: 452-456.| Canadian Orthopaedic Trauma Society: Nonoperative treatment compared with plate fixation of displaced midshaft clavicular fractures. A multicenter, randomized clinical trial. J Bone Joint Surg Am (2007) 89: 1-10.| Ferran NA, Hodgson P, Vannet N, Williams R and Evans RO: Locked intramedullary fixation vs plating for displaced and shortened mid-shaft clavicle fractures: a randomized clinical trial. J Shoulder Elbow Surg (2010) 19: 783-789.| Wijdicks FJ, Van der Meijden OA, Millett PJ, Verleisdonk EJ and Houwert RM: Systematic review of the complications of plate fixation of clavicle fractures. Arch Orthop Trauma Surg (2012) 132: 617-625.| Havet E, Duparc F, Tobenas-Dujardin AC, Muller JM and Fréger P: Morphometric study of the shoulder and subclavicular innervation by the intermediate and lateral branches of supraclavicular nerves. Surg Radiol Anat (2007) 29: 605-610.| Sands TT, Martin JB, Simms E, Henderson MM, Friedlander PL and Chiu ES: Supraclavicular artery island flap innervation: anatomical studies and clinical implications. J Plast Reconstr Aesthet Surg (2012) 65: 68-71.| Sohn HS, Shin SJ and Kim BY: Minimally invasive plate osteosynthesis using anterior-inferior plating of clavicular midshaft fractures. Arch Orthop Trauma Surg (2012) 132: 239-244.| Sohn HS, Shon MS, Lee KH and Song SJ: Clinical comparison of two different plating methods in minimally invasive plate osteosynthesis for clavicular midshaft fractures: A randomized controlled trial. Injury (2015) 46: 2230-2238.| Jirangkul P, Kosiyatrakul A and Lorsuwannarat N: Minimally invasive plate osteosynthesis for displaced midshaft clavicle fractures: An indirect reduction using joystick technique. J Orthop Sci (2023) 28: 1365-1372.| Ok S, Yoon SM and Choi S: Intuitive and Minimally Invasive Surgical Technique for Comminuted Mid-Shaft Clavicle Fractures: Fixation with an Anterior Mini Plate and Superior Locking Compression Plate. J Clin Med (2025) 14.| Zhang Y, Xu J, Zhang C and Sun Y: Minimally invasive plate osteosynthesis for midshaft clavicular fractures using superior anatomic plating. J Shoulder Elbow Surg (2016) 25: e7-12.| Kundangar RS, Mohanty SP and Bhat NS: Minimally invasive plate osteosynthesis (MIPO) in AO/OTA type B displaced clavicle fractures. Musculoskelet Surg (2019) 103: 191-197.| Amaral FMD, Malavolta EA, Silva F, Altoé LS, Nunes CV and Pécora JR: MINIMALLY INVASIVE OSTEOSYNTHESIS FOR CLAVICULAR FRACTURE WITH LOCKED PLATE. Acta Ortop Bras (2023) 31: e263742.| Meinberg EG, Agel J, Roberts CS, Karam MD and Kellam JF: Fracture and Dislocation Classification Compendium-2018. J Orthop Trauma (2018) 32 Suppl 1: S1-s170.| Lee GB, Kim H, Jeon IH and Koh KH: Long-term outcomes of initially conservatively treated midshaft clavicle fractures. Clin Shoulder Elb (2021) 24: 9-14.| Zhao B, Zhao W, Assan I and Bi R: Conoid tubercle angle: attention should be paid to supraclavicular plate fixation. J Orthop Surg Res (2022) 17: 105.| Meeuwis MA, Pull Ter Gunne AF, Verhofstad MH and van der Heijden FH: Construct failure after open reduction and plate fixation of displaced midshaft clavicular fractures. Injury (2017) 48: 715-719.| Zhuang Y, Zhang Y, Zhou L, Zhang J, Jiang G and Wu J: Management of comminuted mid-shaft clavicular fractures: Comparison between dual-plate fixation treatment and single-plate fixation. J Orthop Surg (Hong Kong) (2020) 28: 2309499020915797.| Thorsmark AH, Muhareb Udby P, Ban I and Frich LH: Bone shortening of clavicular fractures: comparison of measurement methods. BMC Musculoskelet Disord (2017) 18: 537.| Ribas GGO, Dau L, Gonçalves FF, Oliveira MHS, Marques NSH and Souza GAL: Measurement of Clavicular Symmetry in Healthy Subjects Using Tomographic Database of Public Hospitals. Rev Bras Ortop (Sao Paulo) (2023) 58: e617-e624.| Zhang X, Tan J, Li N, Kelsang B, Han X, Cao R, Zhang Y and Jiang X: Measurement of clavicular symmetry: A hint for midshaft clavicle fracture management. Injury (2025) 56: 112023.| Abdel Fatah EE, Shirley NR, Mahfouz MR and Auerbach BM: A three-dimensional analysis of bilateral directional asymmetry in the human clavicle. Am J Phys Anthropol (2012) 149: 547-559.| Xu Y, Guo X, Peng H, Dai H, Huang Z and Zhao J: Different internal fixation methods for unstable distal clavicle fractures in adults: a systematic review and network meta-analysis. J Orthop Surg Res (2022) 17: 43.| Marín Fermín T, Migliorini F, Papakostas E, Al-Khelaifi K, Maldonado DR, Hovsepian JM and Maffulli N: Concomitant glenohumeral injuries in patients with distal clavicle fractures undergoing arthroscopic-assisted surgery: a systematic review. J Orthop Surg Res (2022) 17: 31.| |
| JaLCDOI | 10.18926/AMO/70451 |
|---|---|
| フルテキストURL | 80_2_085.pdf |
| 著者 | Shiba, Takahiko| Takamori, Mitsuhito| Katagiri, Sayaka| Kobayashi, Ryota| Kawauchi, Aki| Ohsugi, Yujin| Lin, Peiya| Ekuni, Daisuke| Egusa, Masahiko| Iwata, Takanori| Maeda, Shigeru| |
| 抄録 | Individuals with Down syndrome (DS) are more susceptible to periodontal disease; however, microbial changes following treatment remain insufficiently understood. This study evaluated the effects of nonsurgical periodontal therapy on clinical outcomes and oral microbiome dynamics in 6 patients with DS using 16S rRNA gene amplicon sequencing. Bacterial diversity, composition, network structure, and predicted functional pathways were analyzed using dental plaque samples. Bleeding on probing decreased significantly (p=0.047) after treatment, with a trend toward reduction in periodontal inflamed surface area (p=0.05). The abundance of Fusobacteria at the class level decreased significantly after treatment. The abundance of Mogibacterium timidum was higher in the pretreatment group than in the posttreatment group. M. timidum was positively correlated with Treponema denticola and associated with multiple bacterial taxa in the network during pretreatment. Predicted functional pathways related to aromatic compound degradation were more abundant in posttreatment samples than in pretreatment samples. An increase in the abundance of Fusobacterium and the positive correlation between T. denticola and M. timidum, together with their associations with other periodontal pathogens before treatment, may contribute to the development of periodontitis in individuals with DS. Nonsurgical periodontal therapy produces measurable clinical improvement and promotes microbial shifts in patients with DS. |
| キーワード | Down Syndrome 16S rRNA Gene Amplicon Sequencing periodontitis nonsurgical periodontal treatment oral microbiome |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 85 |
| 終了ページ | 97 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Patterson D: Molecular genetic analysis of Down syndrome. Hum Genet (2009) 126: 195-214.| Desingu V, Adapa, A, Kumar, S and Devi S: Dental Anomalies in Down Syndrome Individuals: A Review. J Sci Dent (2019) 9: 6-8.| Macho V, Coelho A, Areias C, Macedo P and Andrade D: Craniofacial features and specific oral characteristics of Down syndrome children. Oral Health Dent Manag (2014) 13: 408-411.| Scalioni FAR, Carrada CF, Tavares MC, Abreu LG, Ribeiro RA and Paiva SM: Oral health characteristics in children and adolescents with Down syndrome. Spec Care Dentist (2024) 44: 542-549.| Pihlstrom BL, Michalowicz BS and Johnson NW: Periodontal diseases. Lancet (2005) 366: 1809-1820.| Kolenbrander PE, Andersen RN, Blehert DS, Egland PG, Foster JS and Palmer RJ, Jr.: Communication among oral bacteria. Microbiol Mol Biol Rev (2002) 66: 486-505.| Slade GD, Offenbacher S, Beck JD, Heiss G and Pankow JS: Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res (2000) 79: 49-57.| Humphrey LL, Fu R, Buckley DI, Freeman M and Helfand M: Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J Gen Intern Med (2008) 23: 2079-2086.| Hatasa M, Yoshida S, Takahashi H, Tanaka K, Kubotsu Y, Ohsugi Y, Katagiri T, Iwata T and Katagiri S: Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response. Int J Mol Sci (2021) 22: 3728.| Lin P, Liu A, Tsuchiya Y, Noritake K, Ohsugi Y, Toyoshima K, Tsukahara Y, Shiba T, Nitta H, Aoki A, Iwata T and Katagiri S: Association between periodontal disease and chronic obstructive pulmonary disease. Jpn Dent Sci Rev (2023) 59: 389-402.| Sakellari D, Arapostathis KN and Konstantinidis A: Periodontal conditions and subgingival microflora in Down syndrome patients. A case-control study. J Clin Periodontol (2005) 32: 684-690.| Yehia Z, Silbereisen A, Koletsi D, Arabzadehtousi M, Tsilingaridis G and Bostanci N: Efficacy of periodontal treatment modalities in Down syndrome patients: a systematic review and meta-analysis. Evid Based Dent (2024) 25: 213-214.| Amano A, Kishima T, Kimura S, Takiguchi M, Ooshima T, Hamada S and Morisaki I: Periodontopathic bacteria in children with Down syndrome. J Periodontol (2000) 71: 249-255.| Amano A, Kishima T, Akiyama S, Nakagawa I, Hamada S and Morisaki I: Relationship of periodontopathic bacteria with early-onset periodontitis in Downʼs syndrome. J Periodontol (2001) 72: 368-373.| Willis JR, Iraola-Guzman S, Saus E, Ksiezopolska E, Cozzuto L, Bejarano LA, Andreu-Somavilla N, Alloza-Trabado M, Puig-Sola A, Blanco A, Broglio E, Carolis C, Hecht J, Ponomarenko J and Gabaldón T: Oral microbiome in down syndrome and its implications on oral health. J Oral Microbiol (2020) 13: 1865690.| Nagai T, Shiba T, Komatsu K, Watanabe T, Nemoto T, Maekawa S, Kobayashi R, Matsumura S, Ohsugi Y, Katagiri S, Takeuchi Y and Iwata T: Optimal 16S rRNA gene amplicon sequencing analysis for oral microbiota to avoid the potential bias introduced by trimming length, primer, and database. Microbiol Spectr (2024) e0351223.| Schloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, Hollister EB, Lesniewski RA, Oakley BB, Parks DH, Robinson CJ, Sahl JW, Stres B, Thallinger GG, Horn DJV and Weber CF: Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol (2009) 75: 7537-7541.| Nemoto T, Shiba T, Komatsu K, Watanabe T, Shimogishi M, Shibasaki M, Koyanagi T, Nagai T, Katagiri S, Takeuchi Y and Iwata T: Discrimination of Bacterial Community Structures among Healthy, Gingivitis, and Periodontitis Statuses through Integrated Metatranscriptomic and Network Analyses. Msystems (2021) 6: e0088621.| Katagiri S, Ohsugi Y, Shiba T, Yoshimi K, Nakagawa K, Nagasawa Y, Uchida A, Liu A, Lin P, Tsukahara Y, Iwata T and Tohara H: Homemade blenderized tube feeding improves gut microbiome communities in children with enteral nutrition. Front Microbiol (2023) 14: 1215236.| Khocht A, Janal M and Turner B: Periodontal health in Down syndrome: contributions of mental disability, personal, and professional dental care. Spec Care Dentist (2010) 30: 118-123.| Zaldivar-Chiapa RM, Arce-Mendoza AY, De La Rosa-Ramirez M, Caffesse RG and Solis-Soto JM: Evaluation of surgical and non-surgical periodontal therapies, and immunological status, of young Downʼs syndrome patients. J Periodontol (2005) 76: 1061-1065.| Johnston W, Rosier BT, Artacho A, Paterson M, Piela K, Delaney C, Brown JL, Ramage G, Mira A and Culshaw S: Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients. Sci Rep (2021) 11: 9796.| Jiang S, Nie J, Chen YX, Wang XY and Chen F: Structure and Composition of Candidate Phyla Radiation in Supragingival Plaque of Caries Patients. Chin J Dent Res (2022) 25: 107-118.| Quirynen M, Gizani S, Mongardini C, Declerck D, Vinckier F and Van Steenberghe D: The effect of periodontal therapy on the number of cariogenic bacteria in different intra-oral niches. J Clin Periodontol (1999) 26: 322-327.| Duran-Pinedo AE, Solbiati J, Teles F and Frias-Lopez J: Subgingival host-microbiome metatranscriptomic changes following scaling and root planing in grade II/III periodontitis. J Clin Periodontol (2023) 50: 316-330.| Ovsepian A, Kardaras FS, Skoulakis A and Hatzigeorgiou AG: Microbial signatures in human periodontal disease: a metatranscriptome meta-analysis. Front Microbiol (2024) 15: 1383404.| Phale PS, Malhotra H and Shah BA: Degradation strategies and associated regulatory mechanisms/features for aromatic compound metabolism in bacteria. Adv Appl Microbiol (2020) 112: 1-65.| Suvorova IA and Gelfand MS: Comparative Genomic Analysis of the Regulation of Aromatic Metabolism in Betaproteobacteria. Front Microbiol (2019) 10: 642.| Wang Y, Yang F, Wang Y, Deng S and Zhu R: Alterations and correlations in dental plaque microbial communities and metabolome characteristics in patients with caries, periodontitis, and comorbid diseases. BMC Oral Health (2024) 24: 132.| Visser MB and Ellen RP: New insights into the emerging role of oral spirochaetes in periodontal disease. Clin Microbiol Infect (2011) 17: 502-512.| Liu Y, Hou Y, Wang G, Zheng X and Hao H: Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host-Microbe Interplay. Trends Endocrinol Metab (2020) 31: 818-834.| |
| JaLCDOI | 10.18926/AMO/70450 |
|---|---|
| フルテキストURL | 80_2_075.pdf |
| 著者 | Lin, Deting| Horita, Masahiro| Watanabe, Masahito| Hasei, Joe| Ohtsuki, Takashi| Otsuka, Noriaki| Ichikawa, Chinatsu| Shimizu, Noriyuki| Naniwa, Shuichi| Ozaki, Toshifumi| Nishida, Keiichiro| |
| 抄録 | A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared with OA and healthy control (HC) synovial tissues. The effect of inflammatory cytokines (TNF-α, TGF-β1, and PDGF-BB) on ADAM12 expression in RASFs from RA patients was examined by real-time RT-PCR. The effect of ADAM12 knock-down by ADAM12 siRNA and ADAM12 overexpression on cell proliferation of RASFs were examined by WST-1 assay. ADAM12 was identified predominantly in RA synovial tissue rather than OA and HC synovial tissues. Stimulation with TGF-β1 upregulated the expression of ADAM12 and cell proliferation of RASFs. ADAM12 siRNA suppressed TGF-β1-induced cell proliferation of RASFs, while ADAM12 overexpression promoted the cell proliferation of RASFs. These findings demonstrate that ADAM12 may have a key role in TGF-β1-induced cell proliferation of synovial fibroblasts in patients with RA. |
| キーワード | rheumatoid arthritis synovial tissue TGF-β1 ADAM12 cell proliferation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 75 |
| 終了ページ | 83 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Scott DL, Wolfe F and Huizinga TW: Rheumatoid arthritis. Lancet (2010) 24: 1094-1108.| Scherer HU, Haupl T and Burmester GR: The etiology of rheumatoid arthritis. J Autoimmun (2020) 110: 102400.| Cheon H, Yu SJ, Yoo DH, Chae IJ, Song GG and Sohn J: Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin Exp Immunol (2002) 127: 547-552.| Rosengren S, Corr M and Boyle DL: Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes. Arthritis Res Ther (2010) 12: R65.| Kveiborg M, Frohlich C, Albrechtsen R, Tischler V, Dietrich N, Holck P, Kronqvist P, Rank F, Mercurio AM and Wewer UM: Cancer Res (2005) 65: 4754-4761.| Loechel F, Gilpin BJ, Engvall E, Albrechtsen R and Wewer UM: Human ADAM 12 (meltrin alpha) is an active metalloprotease. J Biol Chem (1998) 273: 16993-16997.| Okada A, Mochizuki S, Yatabe T, Kimura T, Shiomi T, Fujita Y, Matsumoto H, Sehara-Fujisawa A, Iwamoto Y and Okada Y: ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage. Arthritis Rheum (2008) 58: 778-789.| Kerna I, Kisand K, Suutre S, Murde M, Tamm A, Kumm J and Tamm A: The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis. Joint Bone Spine (2014) 81: 51-56.| Wang J, Zhang Z, Li R, Mao F, Sun W, Chen J, Zhang H, Bartsch JW, Shu K and Lei T: ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway. Biomed Pharmacother (2018) 97: 1066-1077.| Xu J, Wang Y, Jiang J, Yin C and Shi B: ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway. 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| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tsunata, Ren| Takemoto, Masatsugu| Imai, Jun| Saito, Tatsuya| Ueno, Tomoyuki| |
| キーワード | Axial-flux machine coreless rotor structure C-shaped core efficiency (IE5 class) permanent magnet synchronous machine (PMSM) short axial length soft magnetic composite (SMC) transverse-flux machine ultra-flat shape |
| 発行日 | 2026-04 |
| 出版物タイトル | IEEE Transactions on Industrial Electronics |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Institute of Electrical and Electronics Engineers (IEEE) |
| 開始ページ | 5942 |
| 終了ページ | 5953 |
| ISSN | 0278-0046 |
| NCID | AA10629318 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Authors. |
| 論文のバージョン | publisher |
| DOI | 10.1109/tie.2025.3629360 |
| Web of Science KeyUT | 001643533800001 |
| 関連URL | isVersionOf https://doi.org/10.1109/tie.2025.3629360 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ishizaki, Takuma| Hashida, Yoichi| Hirabayashi, Hideyuki| Sasaki, Kazuhiro| Tokunaga, Hiroki| Simon‐Ada, Eliza Vie M.| Wakayama, Masataka| Takai, Toshiyuki| Saito, Hiroki| Nagano, Atsushi J.| Sakakibara, Hitoshi| Kojima, Mikiko| Takebayashi, Yumiko| Kim, Sung‐Ryul| Matsushima, Ryo| Thomson, Michael J.| Sugimoto, Kazuhiko| Hibara, Ken‐Ichiro| Ishimaru, Tsutomu| |
| キーワード | EARLY-MORNING FLOWERING 3 flower opening time heat stress rice seed setting rate |
| 発行日 | 2026-04-09 |
| 出版物タイトル | Plant Biotechnology Journal |
| 出版者 | Wiley |
| ISSN | 1467-7644 |
| NCID | AA11805223 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 41954325 |
| DOI | 10.1111/pbi.70653 |
| 関連URL | isVersionOf https://doi.org/10.1111/pbi.70653 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nakata, Hironobu| Adachi, Shunsuke| Yamada, Kyohei| Randall, Michael| Kasai, Yutaro| Arnold, Kam| Bixler, Bryce| Chinone, Yuji| Crowley, Kevin T.| Dachlythra, Nadia| Day-Weiss, Samuel| Galitzki, Nicholas| Giardiello, Serena| Johnson, Bradley R.| Keating, Brian| Koopman, Brian J.| Kusaka, Akito| Lashner, Jack| Nati, Federico| Page, Lyman| Sasaki, Daichi| Sueno, Yoshinori| Suzuki, Junya| Tajima, Osamu| Tsan, Tran| |
| 発行日 | 2026-04-01 |
| 出版物タイトル | The Astrophysical Journal Supplement Series |
| 巻 | 283巻 |
| 号 | 2号 |
| 出版者 | American Astronomical Society |
| 開始ページ | 78 |
| ISSN | 0067-0049 |
| NCID | AA00553297 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026. The Author(s). |
| 論文のバージョン | publisher |
| DOI | 10.3847/1538-4365/ae4ddf |
| 関連URL | isVersionOf https://doi.org/10.3847/1538-4365/ae4ddf |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Eto, Eriko| Kato, Masakazu| Kirino, Satoe| Kuriyama, Chiaki| Sakata, Shujiro| Nakato, Hikari| Mishima, Sakurako| Ohira, Akiko| Masuyama, Hisashi| |
| キーワード | maternal body composition newborn birth weight pre-pregnancy body mass index fat-free mass fat mass gain |
| 発行日 | 2026 |
| 出版物タイトル | JMA Journal |
| 巻 | 9巻 |
| 号 | 1号 |
| 出版者 | Japan Medical Association |
| 開始ページ | 189 |
| 終了ページ | 197 |
| ISSN | 2433-3298 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Japan Medical Association |
| 論文のバージョン | publisher |
| PubMed ID | 41676827 |
| DOI | 10.31662/jmaj.2025-0060 |
| Web of Science KeyUT | 001617980800001 |
| 関連URL | isVersionOf https://doi.org/10.31662/jmaj.2025-0060 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsuda, Yoshihiro| Morizane, Shin| Takezaki, Daiki| Sakamoto, Yuma| Baba, Nobuyasu| Iseki, Masanori| Kawakami, Yoshio| Shiomi, Tatsushi| Mukai, Tomoyuki| |
| キーワード | psoriasis obesity aerobic exercise imiquimod high-fat diet |
| 発行日 | 2026-02-28 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 27巻 |
| 号 | 5号 |
| 出版者 | MDPI AG |
| 開始ページ | 2308 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 41828533 |
| DOI | 10.3390/ijms27052308 |
| Web of Science KeyUT | 001713645500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms27052308 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Leon, Elizabeth| Nakamura, Shin| Shindo, Satoru| Pastore, Maria Rita| Kumagai, Tomoki| Heidari, Alireza| Abdolahinia, Elaheh Dalir| Ueda, Tomoya| Memida, Takumi| Duran-Pinedo, Ana| Frias-Lopez, Jorge| Han, Xiaozhe| Chen, Xin| Huang, Shengyuan| Cao, Guoqin| Ruiz, Sunniva| Potempa, Jan| Kawai, Toshihisa| |
| キーワード | Porphyromonas gingivalis outer membrane vesicle periodontitis pathogenesis macrophage polarization osteoclastogenesis OC/MΦ unit |
| 発行日 | 2026-01-14 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 27巻 |
| 号 | 2号 |
| 出版者 | MDPI AG |
| 開始ページ | 831 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 41596482 |
| DOI | 10.3390/ijms27020831 |
| Web of Science KeyUT | 001670605700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms27020831 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Li, Tiantian| Yoshimura, Teizo| Tian, Miao| Nishida, Gakushi| Li, Chunning| Fujisawa, Masayoshi| Ohara, Toshiaki| Matsukawa, Akihiro| |
| キーワード | breast cancer neutrophils CD8+ T cells chemokines chemokine receptors tumor microenvironment |
| 発行日 | 2026-03-30 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 27巻 |
| 号 | 7号 |
| 出版者 | MDPI AG |
| 開始ページ | 3143 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/ijms27073143 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms27073143 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kuwagi, Serika| Gotoh, Kazuyoshi| Komatsubara, Marina| Tsuji, Shuma| Okanoue, Shyoutarou| Okada, Hiroyuki| Uchiyama, Jumpei| Watanabe, Akari| Yokota, Kenji| |
| キーワード | Helicobacter pylori infection gastric cancer nitrate-reducing bacteria gastritis |
| 発行日 | 2026-03-27 |
| 出版物タイトル | Microorganisms |
| 巻 | 14巻 |
| 号 | 4号 |
| 出版者 | MDPI AG |
| 開始ページ | 760 |
| ISSN | 2076-2607 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/microorganisms14040760 |
| 関連URL | isVersionOf https://doi.org/10.3390/microorganisms14040760 |