検索条件

閉じる

検索結果 8487 件

フルテキストURL K0006031_abstract_review.pdf K0006031_fulltext.pdf
著者 岩田 菜穂子|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6031号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006030_abstract_review.pdf K0006030_fulltext.pdf K0006030_other_1 supplemantary Information.pdf
著者 森廣 俊昭|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6030号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006029_abstract_review.pdf K0006029_fulltext.pdf
著者 桒田 和也|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6029号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006028_abstract_review.pdf K0006028_fulltext_org.pdf K0006028_summary.pdf
著者 大西 章史|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6028号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 © 2019 Akifumi Onishi et al.
フルテキストURL K0006027_abstract_review.pdf K0006027_fulltext.pdf
著者 松三 博明|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6027号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006026_abstract_review.pdf K0006026_fulltext.pdf
著者 西村 慎吾|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6026号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006025_abstract_review.pdf K0006025_fulltext.pdf
著者 清水 俊彦|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6025号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006024_abstract_review.pdf K0006024_fulltext.pdf K0006024_other_1 figure.pdf K0006024_other_2 Supplementary figures and legends.pdf
著者 渡邉 伸一郎|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6024号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006023_abstract_review.pdf K0006023_summary.pdf
著者 梅野 潤子|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6023号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 日本語
JaLCDOI 10.18926/AMO/57378
フルテキストURL 73_5_463.pdf
著者 Shibata, Kiyo| Hamasaki, Ichiro| Shimizu, Takehiro| Kono, Reika| Ohtsuki, Hiroshi| Morizane, Yuki| Shiraga, Fumio|
抄録 To permit noose movement without fraying the sutures following strabismus surgery, we designed a new sliding noose, the “twist knot” and investigated its advantages and disadvantages. We measured the tensile strength required to move the twist knot in a tightly tied state (134±19 gf) and in a loosened state (21±7 gf), and that required to move the conventional sliding noose in a tightly tied state (48±14 gf), and used the Kruskal-Wallis test to compare them. A significant difference was observed among the three tensile strengths (p<0.001). The twist knot technique allowed easy sliding without the multifilament braided suture becoming frayed and a knot to be firmly fixed without slipping. However, if the 2 strings of the pole sutures exit from the sclera at 2 widely separated positions, the sliding noose may become slack. Therefore, the distance between the pole sutures should be small. The simple twist knot technique was found to be an effective approach following adjustable surgery of strabismus.
キーワード adjustable suture the new sliding noose method tensile strength strabismus surgery esotropia
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 463
終了ページ 468
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649374
Web of Science KeyUT 000491886600013
JaLCDOI 10.18926/AMO/57374
フルテキストURL 73_5_433.pdf
著者 Tamada, Shoko| Mitsui, Takashi| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eguchi, Takeshi| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi|
抄録 An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia.
キーワード preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 433
終了ページ 440
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649370
Web of Science KeyUT 000491886600009
JaLCDOI 10.18926/AMO/57372
フルテキストURL 73_5_419.pdf
著者 Hishii, Shuhei| Miyatake, Nobuyuki| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Koumoto, Kiichi| Suzuki, Hiromi| Hashimoto, Hiroo|
抄録 We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups’ clinical parameters. We compared the groups’ survival rates by using Kaplan-Meier curves and the log-rank test, and we performed multivariate analyses by a Cox-proportional hazard model to evaluate the relationship between the sedentary behavior and the survival rate. Twenty patients (28.2%) died during the observation period. The survival rate of the short-SB group was significantly higher than that of the long-SB group. Sedentary behavior was thus an important factor for all-cause mortality even after adjusting for confounding factors by a Cox-proportional hazard model. Sedentary behavior is closely linked to all-cause mortality, especially total days and non-hemodialysis days, and reducing sedentary behavior may be beneficial to reduce the all-cause mortality of patients on chronic hemodialysis.
キーワード sedentary behavior hemodialysis mortality physical activity
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 419
終了ページ 425
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649368
Web of Science KeyUT 000491886600007
JaLCDOI 10.18926/AMO/57371
フルテキストURL 73_5_413.pdf
著者 Yanagihara, Yutaka| Nishida, Keigo| Watanabe, Ryuta| Koyama, Kanae| Sawada, Yuichiro| Noda, Terutaka| Asai, Seiji | Fukumoto, Tetsuya| Miura, Noriyoshi| Miyauchi, Yuki| Kikugawa, Tadahiko| Saika, Takashi|
抄録 Laparoscopic radical cystectomy (LRC) is a standard surgical treatment for muscle-invasive bladder cancer and high-risk non-muscle-invasive bladder cancer. LRC is a less invasive modality than conventional open surgery. Therefore, even elderly patients with invasive bladder cancer may be candidates for LRC. In this study, a comparative analysis of perioperative/oncological outcomes between elderly patients and younger patients who underwent LRC was performed to assess the feasibility of LRC in elderly patients. Sixty-eight consecutive patients who underwent LRC between October 2013 and March 2018 were enrolled and stratified into those younger than 75 years (n=37) and those ≥ 75 years old (n=31). The median follow-up period was 28.2 months. The preoperative and operative parameters and complications were similar in both groups. The 2-year overall survival (OS) was 64.4% in the younger vs. 76.4% in the elderly group (p=0.053), cancer-specific survival (CSS) was 79.3% vs. 81.7% (p=0.187), and recurrence-free survival (RFS) was 58.2% vs. 75.7% (p=0.174), respectively. No significant differences were observed in OS, CSS, or RFS between the groups. No significant differences were found between the groups with respect to peri-surgical/oncological outcomes. We conclude that LRC is feasible in elderly patients.
キーワード bladder cancer laparoscopic surgery radical cystectomy elderly patient
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 417
終了ページ 418
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649367
Web of Science KeyUT 000491886600006
JaLCDOI 10.18926/AMO/57370
フルテキストURL 73_5_403.pdf
著者 Ando, Akemi| Mitsuhashi, Toshiharu| Honda, Mitsugi| Hanayama, Yoshihisa| Hasegawa, Kou| Obika, Mikako| Kataoka, Hitomi| Otsuka, Fumio|
抄録 Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual’s bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients’ BMD values and changes in the patients’ physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients’ gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level.
キーワード bone mineral density (BMD) body mass index (BMI) female gender hypercalcemia osteoporosis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 403
終了ページ 411
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649366
Web of Science KeyUT 000491886600005
JaLCDOI 10.18926/AMO/57368
フルテキストURL 73_5_387.pdf
著者 Inoue, Miyabi| Yokoyama, Teruhiko|
抄録 To assess the efficacy and safety of 2 drugs for overactive bladder (OAB), solifenacin and mirabegron. Fortyseven female OAB patients were randomized into 2 groups. Twenty-three patients were initially prescribed solifenacin for 4 weeks, followed by mirabegron for 4 weeks (group S). The other 24 patients were initially prescribed mirabegron for 4 weeks, followed by solifenacin for 4 weeks (group M). Evaluations included clinical determination of the OAB symptom score (OABSS), International Prostate Symptom Score (IPSS), and Visual Analog Scale. The IPSS significantly improved after the administration of solifenacin in both groups. The OABSS significantly improved in both groups after 4 weeks. In group M, the OABSS after eight weeks was significantly improved compared to that after 4 weeks. However, in group S, it was not significantly improved. Twelve patients experienced adverse events during the solifenacin treatment, while 2 patients experienced adverse events during the mirabegron treatment. Both solifenacin and mirabegron led to improved OAB symptoms. Switching from mirabegron to solifenacin significantly improved the OABSS. However, mirabegron led to fewer adverse events than solifenacin. We recommend that mirabegron be prescribed first for OAB patients. If patients are not satisfied with mirabegron, solifenacin should be used.
キーワード overactive bladder, randomized crossover study solifenacin mirabegron
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 387
終了ページ 392
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649364
Web of Science KeyUT 000491886600003
JaLCDOI 10.18926/AMO/57366
フルテキストURL 73_5_379.pdf
著者 Wake, Hidenori|
抄録 Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.
キーワード htidine-rich glycoprotein septic pathogenesis immunothrombosis
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 379
終了ページ 382
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649362
Web of Science KeyUT 000491886600001
フルテキストURL fulltext.pdf
著者 Hayami, Hiroshi| Takahashi, Satoshi| Ishikawa, Kiyohito| Yasuda, Mitsuru| Yamamoto, Shingo| Wada, Koichiro| Kobayashi, Kanao| Hamasuna, Ryoichi| Minamitani, Shinichi| Matsumoto, Tetsuya| Kiyota, Hiroshi| Tateda, Kazuhiro| Sato, Junko| Hanaki, Hideaki| Masumori, Naoya| Nishiyama, Hiroyuki| Miyazaki, Jun| Fujimoto, Kiyohide| Tanaka, Kazushi| Uehara, Shinya| Matsubara, Akio| Ito, Kenji| Hayashi, Kenji| Kurimura, Yuichiro| Ito, Shin| Takeuchi, Toshimi| Narita, Harunori| Izumitani, Masanobu| Nishimura, Hirofumi| Kawahara, Motoshi| Hara, Makoto| Hosobe, Takahide| Takashima, Kenji| Chokyu, Hirofumi| Matsumura, Masaru| Ihara, Hideari| Uno, Satoshi| Monden, Koichi| Sumii, Toru| Kawai, Shuichi| Kariya, Satoru| Sato, Takashi| Yoshioka, Masaru| Kadena, Hitoshi| Matsushita, Shinji| Nishi, Shohei| Hosokawa, Yukinari| Shirane, Takeshi| Yoh, Mutsumasa| Watanabe, Syuji| Makinose, Shinichi| Uemura, Tetsuji| Goto, Hirokazu|
キーワード Surveillance Susceptibility Resistance Acute uncomplicated cystitis
発行日 2019-06
出版物タイトル Journal of Infection and Chemotherapy
25巻
6号
出版者 Elsevier
開始ページ 413
終了ページ 422
ISSN 1341-321X
NCID AA11057978
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
論文のバージョン publisher
PubMed ID 30905628
DOI 10.1016/j.jiac.2019.02.021
Web of Science KeyUT 000466427000002
関連URL isVersionOf https://doi.org/10.1016/j.jiac.2019.02.021
フルテキストURL Gastroenterology156_6_1753.pdf fig.pdf
著者 Tomoda, Takeshi| Kato, Hironari| Ueki, Toru| Akimoto, Yutaka| Hata, Hidenori| Fujii, Masakuni| Harada, Ryo| Ogawa, Tsuneyoshi| Wato, Masaki| Takatani, Masahiro| Matsubara, Minoru| Kawai, Yoshinari| Okada, Hiroyuki|
キーワード Drug Inflammation Pancreas Smooth-Muscle Relaxant
発行日 2019-05-31
出版物タイトル Gastroenterology
156巻
6号
出版者 W B SAUNDERS CO-ELSEVIER
開始ページ 1753
終了ページ 1760
ISSN 00165085
NCID AA0065394X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 30772342
DOI 10.1053/j.gastro.2019.01.267
Web of Science KeyUT 10.1053/j.gastro.2019.01.267
関連URL isVersionOf https://doi.org/10.1053/j.gastro.2019.01.267
フルテキストURL JOS_24_2_337.pdf
著者 Fujiwara, Tomohiro| Kunisada, Toshiyuki| Takeda, Ken| Hasei, Joe| Nakata, Eiji| Mochizuki, Yusuke| Kiyono, Masahiro| Yoshida, Aki| Ozaki, Toshifumi|
発行日 2019-03
出版物タイトル Journal of Orthopaedic Science
24巻
2号
出版者 Elsevier
開始ページ 337
終了ページ 341
ISSN 0949-2658
NCID AA11627828
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2018 The Japanese Orthopaedic Association.
論文のバージョン author
PubMed ID 30857616
DOI 10.1016/j.jos.2018.09.017
Web of Science KeyUT 000460662100026
関連URL isVersionOf https://doi.org/10.1016/j.jos.2018.09.017
JaLCDOI 10.18926/AMO/56939
フルテキストURL 73_4_361.pdf
著者 Watanabe, Ayako| Kadowaki, Yoshihiko| Hattori, Kenji| Ohmori, Mika| Tsukayama, Hiroyuki| Kubota, Nobuhito| Okumoto, Tatsuo| Ishido, Nobuhiro| Okino, Takeshi|
抄録 A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis.
キーワード phlebosclerotic colitis colorectal cancer signet ring cell carcinoma young colorectal cancer
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 361
終了ページ 365
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439960