検索結果 3118 件
| JaLCDOI | 10.18926/AMO/64041 |
|---|---|
| フルテキストURL | 76_5_593.pdf |
| 著者 | Noumi, Taku| Watanabe, Hiromi| Ninomiya, Kiichiro| Ohashi, Kadoaki| Ichihara, Eiki| Kubo, Toshio| Makimoto, Go| Kato, Yuka| Fujii, Masanori| Tabata, Masahiro| Maeda, Yoshinobu| Hotta, Katsuyuki| Kiura, Katsuyuki| |
| 抄録 | We encountered a woman with re-enlarged axillary lymph nodes during a computed tomography (CT) scan for surveillance of lung adenocarcinoma with axillary lymph node metastasis at the initial diagnosis that had shrunk with standard chemotherapy. We first suspected cancer recurrence and considered a change in the chemotherapeutic regimen. However, after careful history taking regarding the timing of her Coronavirus Disease 2019 (COVID-19) vaccination, and subsequent careful, close follow-up, radiological shrinkage suggested a strictly benign cause. Especially in lung cancer with a medical history of axillary lymph node involvement, cliniciansshould be aware that vaccine-associated lymphadenopathy can mimic cancer recurrence and sometimesprompt serious misjudgment regarding a current treatment course and strategy. |
| キーワード | lung cancer COVID-19 vaccination axillary lymphadenopathy case report |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 593 |
| 終了ページ | 596 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352807 |
| Web of Science KeyUT | 000884907100013 |
| JaLCDOI | 10.18926/AMO/64040 |
|---|---|
| フルテキストURL | 76_5_585.pdf |
| 著者 | Choshi, Haruki| Watanabe, Mototsugu| Furukawa, Shinichi| Ujike, Hiroyuki| Kataoka, Kazuhiko| |
| 抄録 | Pulmonary metastatic resection is a standard therapy for renal cell carcinoma (RCC). Although patients with pulmonary metastases who do not undergo any treatment have poor prognoses, it has been reported that resection for pulmonary metastases yields good clinical outcomes. We investigated the prognoses of the 10 Japanese patients (eight males, two females) who underwent a surgical resection of pulmonary metastasectomy from RCC at our institution between April 1, 2012 and March 31, 2020 and analyzed the prognostic factors. We determined the prognoses and calculated the 5-year overall survival (OS) and disease-free survival (DFS) rates. To identify prognostic factors, we compared the median DFS duration for each factor. Elderly patients (median age, 75.5 years) were more predominant compared to previous studies, and all 10 patients underwent a complete resection. The 5-year DFS rate was 30.5% (95%CI: 0.045-0.63) and the 5-year OS rate was 80% (95%CI: 0.20-0.97). The following factors were associated with better prognosis: female, disease-free interval≥36 months, and metastases size<12 mm. These results indicate that complete resection for pulmonary metastases from RCC resulted in good clinical outcomes, particularly for patients with better prognostic factors. |
| キーワード | renal cell carcinoma pulmonary metastasis complete resection |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 585 |
| 終了ページ | 591 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352806 |
| Web of Science KeyUT | 000884907100012 |
| JaLCDOI | 10.18926/AMO/64039 |
|---|---|
| フルテキストURL | 76_5_577.pdf |
| 著者 | Okutani, Yuki| Fujita, Hiroshi| Harada, Hideto| Kataoka, Masanao| Murotani, Yoshiki| Shimizu, Yu| |
| 抄録 | The prevalence of preoperative deep vein thrombosis (DVT) has been reported to be relatively high in patients undergoing total hip arthroplasty. We investigated the prevalence of DVT, the association between hip function and preoperative DVT, and the effect of a history of surgery in patients who underwent primary total hip arthroplasty. We retrospectively analyzed the cases of the patients who underwent primary total hip arthroplasty between April 2013 and February 2020 at our institution. We evaluated the prevalence of preoperative DVT based on the results of the patients’ ultrasound screening. We performed univariate and multivariate analyses to investigate the association between the incidence of DVT and patient factors including age, sex, hip function, medical histories, and American Society of Anesthesiologists Physical Status classification. We analyzed 451 patients (494 hips). The prevalence of DVT was 14.2% (64 patients). The multivariate analysis demonstrated that increased age was an independent significant risk factor for DVT. The prevalence of preoperative DVT was relatively high among patients who underwent primary total hip arthroplasty. Preoperative DVT tended to be more prevalent in older patients. Hip function was not associated with the incidence of DVT. |
| キーワード | total hip arthroplasty deep vein thrombosis hip function ultrasound screening |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 577 |
| 終了ページ | 584 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352805 |
| Web of Science KeyUT | 000884907100011 |
| JaLCDOI | 10.18926/AMO/64037 |
|---|---|
| フルテキストURL | 76_5_557.pdf |
| 著者 | Pan, Yu| Song, Qingqing| Kanazawa, Tomoyuki| Morimatsu, Hiroshi| |
| 抄録 | Some pediatric cardiac patients might experience low regional cerebral oxygen saturation (rSO2) during surgery. We investigated whether a pediatric patient’s mean arterial pressure (MAP) can affect the rSO2 value during cardiopulmonary bypass (CPB). We retrospectively analyzed the cases of the pediatric patients who underwentcardiac surgery at our hospital (Jan. –Dec. 2019; n=141). At each MAP stage, we constructed line charts through the mean of the rSO2 values corresponding to each MAP and then calculated the correlation coefficients. We next divided the patients into age subgroups (neonates, infants, children) and into cyanotic congenital heart disease (CHD) and acyanotic CHD groups and analyzed these groups in the same way. The analyses of all 141 patients revealed that during CPB the rSO2 value increased with an increase in MAP (r=0.1626). There was a correlation between rSO2 and MAP in the children (r=0.2720) but not in the neonates (r=0.06626) or infants (r=0.05260). Cyanotic CHD or acyanotic CHD did not have a significant effect on the rSO2/MAP correlation. Our analysis demonstrated different patterns of a correlation between MAP and rSO2 in pediatric cardiac surgery patients, depending on age. MAP was positively correlated with rSO2 typically in children but not in neonate or infant patients. |
| キーワード | mean arterial pressure cerebral oxygen saturation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 557 |
| 終了ページ | 564 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352803 |
| Web of Science KeyUT | 000884907100009 |
| JaLCDOI | 10.18926/AMO/64036 |
|---|---|
| フルテキストURL | 76_5_547.pdf |
| 著者 | Kagawa, Hidetoshi| Yamanaka, Ryutaro| Hiromasa, Tsutomu| |
| 抄録 | This observational study aimed to clarify the long-term results of the combination of mizoribine (MZB), tacrolimus (TAC) and prednisolone as first-line therapy for lupus nephritis (LN). This was our institution’s standard therapy between 2009 and 2015, when we saw 36 patients with LN. When a patient thus treated achieved SLEDAI remission (= 0) and/or the prednisolone dose could be tapered to 5 mg/day, either MZB or TAC was stopped, and the other was continued for maintenance therapy. If treatment failure or relapse occurred, second-line therapy was introduced. At years 1 and 5, overall complete renal response and SLEDAI remission were 94% and 88%, and 50% and 62%, respectively. Excluding 2 cases lost to follow-up, medications after 5 years were as follows: 20 (59%) were stable on 1 drug (MZB or TAC), 11 (32%) required continuation of both drugs (MZB + TAC), and 3 (9%) required second-line therapy. The 5-year retention rate was 91% (non-secondline), with 0% of relapse in this group. Our first-line combination strategy showed high remission rates in the induction phase, and subsequent maintenance therapy demonstrated good outcomes for up to 5 years. Research that fine-tunes the order of therapeutic agents and institutes appropriate treatment goals may further improve long-term outcomes for patients with LN. |
| キーワード | combination therapy first-line therapy lupus nephritis mizoribine tacrolimus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 547 |
| 終了ページ | 555 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352802 |
| Web of Science KeyUT | 000884907100008 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nakano, Yasuhiro| Otsuka, Yuki| Honda, Hiroyuki| Sunada, Naruhiko| Tokumasu, Kazuki| Sakurada, Yasue| Matsuda, Yui| Hasegawa, Toru| Ochi, Kanako| Hagiya, Hideharu| Kataoka, Hitomi| Ueda, Keigo| Otsuka, Fumio| |
| キーワード | dysgeusia dysosmia myalgic encephalomyelitis/chronic fatigue syndrome Omicron variant and post COVID-19 condition |
| 発行日 | 2022-10-05 |
| 出版物タイトル | Medicina-Lithuania |
| 巻 | 58巻 |
| 号 | 10号 |
| 出版者 | MDPI |
| 開始ページ | 1393 |
| ISSN | 1010-660X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36295554 |
| DOI | 10.3390/medicina58101393 |
| Web of Science KeyUT | 000875069800001 |
| 関連URL | isVersionOf https://doi.org/10.3390/medicina58101393 |
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| フルテキストURL | 76_5_503.pdf |
| 著者 | Ogawa, Hirohito| Honda, Tomoyuki| |
| 抄録 | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| キーワード | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 503 |
| 終了ページ | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| フルテキストURL | 76_5_489.pdf |
| 著者 | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| 抄録 | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| キーワード | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 489 |
| 終了ページ | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nakahara, Momoko| Toyama, Naoki| Ekuni, Daisuke| Takeuchi, Noriko| Maruyama, Takayuki| Yokoi, Aya| Fukuhara, Daiki| Sawada, Nanami| Nakashima, Yukiho| Morita, Manabu| |
| キーワード | self-rated oral health oral health behaviors caries gingivitis oral hygiene oral health behavioral sciences |
| 発行日 | 2022-10-20 |
| 出版物タイトル | International Journal of Environmental Research and Public Health |
| 巻 | 19巻 |
| 号 | 20号 |
| 出版者 | MDPI |
| 開始ページ | 13580 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36294160 |
| DOI | 10.3390/ijerph192013580 |
| Web of Science KeyUT | 000873221100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph192013580 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Shigehiro, Tsukasa| Ueno, Maho| Kijihira, Mayumi| Takahashi, Ryotaro| Umemura, Chiho| Taha, Eman A.| Kurosaka, Chisaki| Asayama, Megumi| Murakami, Hiroshi| Satoh, Ayano| Nakamura, Yoshimasa| Futami, Junichiro| Masuda, Junko| |
| キーワード | breast cancer cells dendritic cells mesenteric lymph node myeloid-derived suppressor cells |
| 発行日 | 2022-09-20 |
| 出版物タイトル | International Journal Of Molecular Sciences |
| 巻 | 23巻 |
| 号 | 19号 |
| 出版者 | MDPI |
| 開始ページ | 11035 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36232335 |
| DOI | 10.3390/ijms231911035 |
| Web of Science KeyUT | 000867767200001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms231911035 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Miyoshi, Tomoko| Ida, Hiromi| Nishimura, Yoshito| Ako, Soichiro| Otsuka, Fumio| |
| キーワード | stress burnout yoga mindfulness stress in healthcare workers self-compassion the COVID-19 pandemic |
| 発行日 | 2022-09-30 |
| 出版物タイトル | International Journal Of Environmental Research and Public Health |
| 巻 | 19巻 |
| 号 | 19号 |
| 出版者 | MDPI |
| 開始ページ | 12523 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36231820 |
| DOI | 10.3390/ijerph191912523 |
| Web of Science KeyUT | 000868048000001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph191912523 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tokumitsu, Hiroshi| Sakagami, Hiroyuki| |
| キーワード | CaMKK CaM-kinase cascade Ca2+ signaling phosphorylation |
| 発行日 | 2022-09-20 |
| 出版物タイトル | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| 巻 | 23巻 |
| 号 | 19号 |
| 出版者 | MDPI |
| 開始ページ | 11025 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36232320 |
| DOI | 10.3390/ijms231911025 |
| Web of Science KeyUT | 000867778400001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms231911025 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fu, Jingwen| Kosaka, Junko| Morimatsu, Hiroshi| |
| キーワード | acute kidney injury KDIGO definition serum creatine urine output early identification |
| 発行日 | 2022-09-23 |
| 出版物タイトル | JOURNAL OF CLINICAL MEDICINE |
| 巻 | 11巻 |
| 号 | 19号 |
| 出版者 | MDPI |
| 開始ページ | 5589 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36233456 |
| DOI | 10.3390/jcm11195589 |
| Web of Science KeyUT | 000867903000001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm11195589 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Wang, Dengli| Ousaka, Daiki| Qiao, Handong| Wang, Ziyi| Zhao, Kun| Gao, Shangze| Liu, Keyue| Teshigawara, Kiyoshi| Takada, Kenzo| Nishibori, Masahiro| |
| キーワード | intracerebral hemorrhage HMGB1 antibody therapy non-human primate |
| 発行日 | 2022-09-23 |
| 出版物タイトル | Cells |
| 巻 | 11巻 |
| 号 | 19号 |
| 出版者 | MDPI |
| 開始ページ | 2970 |
| ISSN | 2073-4409 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36230933 |
| DOI | 10.3390/cells11192970 |
| Web of Science KeyUT | 000866922400001 |
| 関連URL | isVersionOf https://doi.org/10.3390/cells11192970 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Togo, Hidetoshi| Asanuma, Kohei| Nishi, Tatsushi| Liu, Ziang| |
| キーワード | multi-objective scheduling estimation weighting factors machine learning simulated annealing inverse optimization |
| 発行日 | 2022-09-21 |
| 出版物タイトル | Applied Sciences - Basel |
| 巻 | 12巻 |
| 号 | 19号 |
| 出版者 | MDPI |
| 開始ページ | 9472 |
| ISSN | 2076-3417 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/app12199472 |
| Web of Science KeyUT | 000866634100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/app12199472 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kataoka, Takahiro| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Tanaka, Ayumi| Yamaoka, Kiyonori| |
| キーワード | autoimmune diseases cytokine antioxidant function lipopolysaccharide radon inhalation |
| 発行日 | 2022-08-26 |
| 出版物タイトル | International Journal Of Environmental Research And Public Health |
| 巻 | 19巻 |
| 号 | 17号 |
| 出版者 | MDPI |
| 開始ページ | 10632 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36078348 |
| DOI | 10.3390/ijerph191710632 |
| Web of Science KeyUT | 000851073300001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph191710632 |
| JaLCDOI | 10.18926/AMO/63906 |
|---|---|
| フルテキストURL | 76_4_465.pdf |
| 著者 | Bekku, Kensuke| Tsugawa, Takuji| Tsuboi, Kazuma| Noda, Gaku| Inoue, Yousuke| Murao, Wataru| Ebara, Shin| |
| 抄録 | We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk. |
| キーワード | metastatic renal cell carcinoma molecular-targeted therapy immuno-checkpoint inhibitor real-world setting |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 465 |
| 終了ページ | 472 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123162 |
| JaLCDOI | 10.18926/AMO/63905 |
|---|---|
| フルテキストURL | 76_4_457.pdf |
| 著者 | Sun, Weiying| Hasebe, Satoshi| |
| 抄録 | To clarify the preventive effects of 0.01% atropine eye drops against myopia progression and axial elongation in children, a meta-analysis was carried out based on data obtained from PubMed and Web of Science as of August 1, 2021. Randomized controlled trials (RCTs) that enrolled myopic children who had received atropine for at least one year were included in this study, Key search terms included myopia, children, and 0.01% or low-dose atropine. Heterogeneity was quantified by I2 statistics, and meta-analyses were performed using the fixed-effect model. Five RCTs involving 809 unique children were analyzed. One trial was excluded because of a poor Jadad score and markedly rapid myopia progression in controls. The mean effect sizes for 12 months in myopia progression and axial elongation synthesized from the remaining 4 RCTs were 0.20 (95% CI: 0.13 to 0.27) D and −0.08 (−0.11 to −0.04) mm, respectively (p<0.0001). The corresponding inhibition ratios were 28% and 19%. I2 statistics were 6% or less. Sensitivity analysis and funnel plots demonstrated the robustness of the estimation. The 0.01% atropine-induced inhibition ratio for myopia progression in Asian children was roughly half of that originally reported and did not reach the minimum requirement for clinical treatment. |
| キーワード | myopia 0.01% atropine low-dose atropine axial length myopia progression |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 457 |
| 終了ページ | 463 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123161 |
| Web of Science KeyUT | 000882167300011 |
| JaLCDOI | 10.18926/AMO/63903 |
|---|---|
| フルテキストURL | 76_4_439.pdf |
| 著者 | Miyaji, Chikara| Takao, Soshi| Noguchi, Masayuki| Okazaki, Tsubasa| Sato, Shunsuke| Yorifuji, Takashi| |
| 抄録 | This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex. |
| キーワード | social capital post-traumatic stress disorder disaster flooding |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 439 |
| 終了ページ | 446 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123159 |
| Web of Science KeyUT | 000882167300010 |
| JaLCDOI | 10.18926/AMO/63902 |
|---|---|
| フルテキストURL | 76_4_429.pdf |
| 著者 | Yamadori, Yusuke| Hirao, Tomohiro| Nlandu R. Ngatu| Kanda, Kanae| Syed Mahfuz Al Hasan| Murakami, Akitsu| Mashima, Yukinori| Shirakami, Gotaro| |
| 抄録 | Blood pressure (BP) often rises before surgery. This study investigated whether BP elevation immediately before surgery was associated with adverse outcomes. Medical records of 11,732 patients (average age: 61 years; male: 47.4%) who underwent non-cardiac elective inpatient surgery under general anesthesia at Kagawa University Hospital between January 2011 and June 2019 were reviewed. Differences between the first BP values measured on the day before surgery and the first BP values in the operating room were defined as Δ systolic BP (ΔSBP) and Δ diastolic BP (ΔDBP). The relationships between ΔSBP/ΔDBP and 30-day mortality, 30-day readmission, and over-the-standard length of hospital stay (OSLOS) were assessed. OSLOS was defined as a hospital stay longer than mean+2 standard deviations and was calculated using the Japanese Diagnosis Procedure Combination data. In univariate analysis, the differences in ΔSBP and ΔDBP between the OSLOS and standard LOS groups were both 2 mmHg. In multivariate logistic regression analysis, only ΔDBP was associated with OSLOS. The adjusted odds ratio (95% confidence interval) for the largest quartile was 1.31 (1.02-1.69) (p<0.05). ΔDBP was associated with OSLOS; however, there may be little need to worry about large ΔSBPs and ΔDBPs in clinical practice. |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 429 |
| 終了ページ | 437 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123158 |
| Web of Science KeyUT | 000882167300009 |