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フルテキストURL fulltext.pdf suppl1.pdf suppl2.pdf suppl3.pdf suppl4.pdf suppl5.pdf suppl6.pdf suppl7.pdf suppl8.pdf suppl9.pdf suppl10.pdf suppl11.pdf
著者 Nakayama, Takafumi| Ogo, Keiko Ohta| Sugano, Yasuo| Yokokawa, Tetsuro| Kanamori, Hiromitsu| Ikeda, Yoshihiko| Hiroe, Michiaki| Hatakeyama, Kinta| Ishibashi-Ueda, Hatsue| Nakamura, Kazufumi| Dohi, Kaoru| Anzai, Toshihisa| Seo, Yoshihiro| Imanaka-Yoshida, Kyoko|
発行日 2025-01
出版物タイトル Open Heart
12巻
1号
出版者 BMJ
開始ページ e003250
ISSN 2053-3624
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Author(s) (or their employer(s)) 2025.
論文のバージョン publisher
PubMed ID 40081931
DOI 10.1136/openhrt-2025-003250
Web of Science KeyUT 001445014700001
関連URL isVersionOf https://doi.org/10.1136/openhrt-2025-003250
JaLCDOI 10.18926/AMO/69153
フルテキストURL 79_4_279.pdf
著者 Yoshikawa, Mao| Tao, Hiroyuki|
抄録 An 80-year-old male underwent an extended cholecystectomy for node-positive gallbladder adenocarcinoma. Two weeks later, hemoptysis revealed a left hilar tumor obstructing the bronchus, which was diagnosed as adenocarcinoma. Three months post-cholecystectomy, a left upper pulmonary lobectomy was performed. Histological similarity and positive thyroid transcription factor-1 (TTF-1) immunostaining in both tumors confirmed lung adenocarcinoma with gallbladder metastasis. Despite the generally poor prognosis for gallbladder metastasis from lung cancer, the patient achieved 3 years of survival. Patients with isolated synchronous gallbladder metastasis from lung cancer may benefit from oligometastasectomy.
キーワード gallbladder metastasis lung cancer oligometastatic disease
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2025-08
79巻
4号
出版者 Okayama University Medical School
開始ページ 279
終了ページ 282
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン publisher
査読 有り
フルテキストURL fulltext.pdf
著者 Nakashima, Mitsutaka| Miyoshi, Toru| Nishihara, Takahiro| Miki, Takashi| Ejiri, Kentaro| Hara, Shohei| Takaya, Yoichi| Nakayama, Rie| Ichikawa, Keishi| Osawa, Kazuhiro| Yuasa, Shinsuke|
キーワード coronary computed tomography angiography fat attenuation index heart failure inflammation
発行日 2025-05
出版物タイトル JACC: Advances
4巻
5号
出版者 Elsevier
開始ページ 101685
ISSN 2772-963X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2025 The Authors.
論文のバージョン publisher
PubMed ID 40286356
DOI 10.1016/j.jacadv.2025.101685
Web of Science KeyUT 001485014500001
関連URL isVersionOf https://doi.org/10.1016/j.jacadv.2025.101685
JaLCDOI 10.18926/AMO/66670
フルテキストURL 78_1_047.pdf
著者 Shimomura, Manabu| Shinozaki, Katsunori| Yano, Takuya| Akabane, Shintaro| Ohdan, Hideki| Hiroshima Surgical study group of Clinical Oncology (HiSCO)|
抄録 Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen.
キーワード metastatic colorectal cancer chemotherapy S-1 prospective phase II study
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 47
終了ページ 52
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419314
Web of Science KeyUT 001203658200005
JaLCDOI 10.18926/AMO/66156
フルテキストURL 77_6_635.pdf
著者 Ikeda, Tomohiro| Okamura, Kazunori| Hasegawa, Masaki| Tanaka, Satoshi| Kanai, Shusaku|
抄録 In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted.
キーワード whey protein electrical stimulation muscle strength healthy volunteers
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-12
77巻
6号
出版者 Okayama University Medical School
開始ページ 635
終了ページ 645
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38145938
Web of Science KeyUT 001164631200009
JaLCDOI 10.18926/AMO/65979
フルテキストURL 77_5_553.pdf
著者 Murokawa, Takahiro| Sakamoto, Shinya| Tabuchi, Motoyasu| Sui, Kenta| Ozaki, Kazuhide| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| Yoshida, Hiroshi|
抄録 Gastric cancer with peritoneal metastases is typically a devastating diagnosis. Ligamentum teres hepatis (LTH) metastasis is an extremely rare presentation with only four known cases. Herein, we report salvage surgery of successive metastases to the abdominal wall and LTH in a patient originally presenting with advanced gastric cancer with peritoneal metastasis, leading to long-term survival. A 72-year-old man with advanced gastric cancer underwent curative-intent distal gastrectomy with D2 lymph node dissection for gastric outlet obstruction. During this procedure, three small peritoneal metastases were detected in the lesser omentum, the small mesentery, and the mesocolon; however, intraoperative abdominal lavage cytology was negative. We added cytoreductive surgery for peritoneal metastasis. The pathological diagnosis of the gastric cancer was tubular adenocarcinoma with pT4aN1pM1(PER/P1b)CY0 stage IV (Japanese classification of gastric carcinoma/JCGC 15th), or T4N1M1b stage IV (UICC 7th). Post-operative adjuvant chemotherapy with S-1 (TS-1)+cisplatin (CDDP) was administered for 8 months followed by S-1 monotherapy for 4 months. At 28 months after the initial surgery, a follow-up computed tomography (CT) detected a small mass beneath the upper abdominal wall. The ass showed mild avidity on 18F-fluorodeoxyglucose positron-emission (FDG-PET) CT. Salvage resection was performed for diagnosis and treatment, and pathological findings were consistent with primary gastric cancer metastasis. At 49 months after the initial gastrectomy, a new lesion was detected in the LTH with a similar level of avidity on FDG-PET CT as the abdominal wall metastatic lesion. We performed a second salvage surgery for the LTH tumor, which also showed pathology of gastric cancer metastasis. There has been no recurrence up to 1 year after the LTH surgery. With multidisciplinary treatment the patient has survived almost 5 years after the initial gastrectomy. Curative-intent gastrectomy with cytoreductive surgery followed by adjuvant chemotherapy for advanced gastric cancer with localized peritoneal metastasis might have had a survival benefit in our patient. Successive salvage surgeries for oligometastatic lesions in the abdominal wall and the LTH also yielded favorable outcomes.
キーワード gastric cancer peritoneal metastasis ligamentum teres hepatis oligometastasis salvage surgery
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2023-10
77巻
5号
出版者 Okayama University Medical School
開始ページ 553
終了ページ 559
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37899267
Web of Science KeyUT 001110832700001
フルテキストURL fulltext.pdf
著者 Kato, Hironari| Matsumoto, Kazuyuki| Okada, Hiroyuki|
キーワード biliary drainage EUS-BD malignant hilar biliary obstruction side-by-side stent-in-stent
発行日 2021-09-07
出版物タイトル DEN Open
2巻
1号
出版者 Wiley
開始ページ e33
ISSN 2692-4609
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 The Authors.
論文のバージョン publisher
PubMed ID 35310763
DOI 10.1002/deo2.33
Web of Science KeyUT 001047024900042
関連URL isVersionOf https://doi.org/10.1002/deo2.33
フルテキストURL fulltext.pdf
著者 Tanabe, Yoshinori| Kiritani, Michiru| Deguchi, Tomomi| Hira, Nanami| Tomimoto, Syouta|
キーワード Patient-specific respiratory motion management Stereotactic body radiotherapy Four-dimensional computed tomography Fiducial marker Lung cancer Gating window
発行日 2023-01
出版物タイトル Physics and Imaging in Radiation Oncology
25巻
出版者 Elsevier
開始ページ 100405
ISSN 2405-6316
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Author(s).
論文のバージョン publisher
PubMed ID 36655212
DOI 10.1016/j.phro.2022.12.002
Web of Science KeyUT 000974743600001
関連URL isVersionOf https://doi.org/10.1016/j.phro.2022.12.002
JaLCDOI 10.18926/AMO/64367
フルテキストURL 77_1_85.pdf
著者 Matsuda, Yuki| Otani, Yoshihiro| Yasuhara, Takao| Ando, Mizuo| Higaki, Takaya| Makino, Takuma| Matsumoto, Hiroshi| Oyama, Tadashi| Nishimori, Hisakazu| Date, Isao|
抄録 A 35-year-old female presented with headache, photophobia and developed sudden loss of vision after having undergone right-side ophthalmectomy and radiochemotherapy for retinoblastoma in infancy. A neoplastic lesion was found in the left middle cranial fossa and was surgically removed. The diagnosis was radiation-induced osteosarcoma with RB1 gene alteration. Although she received chemotherapy for the residual tumor, it progressed 17 months later. Maximal surgical resection with craniofacial reconstruction was required. We utilized two three-dimensional models for surgical planning. She was discharged without neurological deficits other than loss of light perception subsequent to left ophthalmectomy. In cases where retinoblastoma is treated with radiotherapy, long-term follow-up is necessary to monitor for radiation-induced tumor development.
キーワード bone model skull base surgery radiation-induced osteosarcoma RB1 gene alteration
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2023-02
77巻
1号
出版者 Okayama University Medical School
開始ページ 85
終了ページ 90
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36849151
Web of Science KeyUT 000952978000001
フルテキストURL fulltext.pdf
著者 Kubota, Satoshi| Aoyama, Eriko| Takigawa, Masaharu| Nishida, Takashi|
キーワード fibroblast growth factor cellular communication network factor cartilage skeletal development CCN2
発行日 2022-08-02
出版物タイトル International Journal Of Molecular Sciences
23巻
15号
出版者 MDPI
開始ページ 8592
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 35955724
DOI 10.3390/ijms23158592
Web of Science KeyUT 000839283400001
関連URL isVersionOf https://doi.org/10.3390/ijms23158592
フルテキストURL fulltext.pdf
著者 Hashimoto, Masashi| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Tanaka, Takehiro| Maeda, Naoaki| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi|
キーワード Esophagectomy Verrucous carcinoma Esophageal squamous cell carcinoma
発行日 2022-07-04
出版物タイトル Surgical Case Reports
8巻
1号
出版者 Springer
開始ページ 128
ISSN 2198-7793
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022.
論文のバージョン publisher
PubMed ID 35781764
DOI 10.1186/s40792-022-01486-7
Web of Science KeyUT 000820644000001
関連URL isVersionOf https://doi.org/10.1186/s40792-022-01486-7
JaLCDOI 10.18926/AMO/62819
フルテキストURL 75_6_759.pdf
著者 Shimizu, Dai| Yamamoto, Hiromasa| Shien, Kazuhiko| Taniguchi, Kohei| Miyoshi, Kentaroh| Namba, Kei| Mesaki, Kumi| Sugimoto, Seiichiro| Soh, Junichi| Yamane, Masaomi| Toyooka, Shinichi|
抄録 Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.
キーワード non-small cell lung cancer somatic mutations pulmonary adenocarcinoma with enteric differentiation non-V600E BRAF mutation next-generation sequencing
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 759
終了ページ 762
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955547
Web of Science KeyUT 000735319800005
NAID 120007180273
JaLCDOI 10.18926/AMO/62818
フルテキストURL 75_6_755.pdf
著者 Takagi, Kosei| Kuise, Takashi| Umeda, Yuzo| Yoshida, Ryuichi| Yoshida, Kazuhiro| Nagai, Yasuo| Noma, Kazuhiro| Tanabe, Shunsuke| Maeda, Naoaki| Yagi, Takahito| Fujiwara, Toshiyoshi|
抄録 Approximately 4% of patients with esophageal cancer develop a second primary malignancy in the upper gastrointestinal trunk. However, hepatectomy following esophagectomy for esophageal cancer has rarely been reported. We report the case of a 70-year-old man who underwent an esophagectomy for esophageal cancer with retrosternal gastric tube reconstruction. Nine years later, he developed hepatocellular carcinoma with tumor thrombus involving the left portal vein, and was successfully treated with left hemihepatectomy. Special attention should be paid to avoiding incidental injury of the gastric tube as well as the right gastroepiploic artery during the hepatectomy.
キーワード liver resection, esophagectomy, retrosternal gastric tube reconstruction
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 755
終了ページ 758
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955546
Web of Science KeyUT 000735319800004
NAID 120007180274
JaLCDOI 10.18926/AMO/61906
フルテキストURL 75_2_231.pdf
著者 Endo, Motochika| Yano, Shuya| Asano, Hiroaki| Takeda, Sho| Hamada, Yuki| Kondo, Yoshitaka| Kuroda, Shinji| Shigeyasu, Kunitoshi| Kikuchi, Satoru| Tanaka, Takehiro| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
抄録 Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
キーワード primary gastrointestinal melanoma laparoscopic surgery immune checkpoint antibody-blockade inhibitor
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-04
75巻
2号
出版者 Okayama University Medical School
開始ページ 231
終了ページ 238
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33953431
NAID 120007029881
フルテキストURL fulltext.pdf
著者 Ichihara, Eiki| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki|
キーワード lung cancer interstitial pneumonia
発行日 2020-01-15
出版物タイトル Internal Medicine
59巻
2号
出版者 日本内科学会
開始ページ 163
終了ページ 167
ISSN 0918-2918
NCID AA10827774
資料タイプ 学術雑誌論文
言語 英語
著作権者 © 2020 by The Japanese Society of Internal Medicine
論文のバージョン publisher
PubMed ID 31534086
DOI 10.2169/internalmedicine.3481-19
NAID 130007785095
Web of Science KeyUT 000507577600002
関連URL isVersionOf https://doi.org/10.2169/internalmedicine.3481-19
JaLCDOI 10.18926/AMO/61212
フルテキストURL 74_6_525.pdf
著者 Aoki, Hideki| Utsumi, Masashi| Kimura, Yuji| Takahashi, Yosuke| Nagahisa, Seiichi| Nishimura, Seitaro| Une, Yuta| Watanabe, Megumi| Taniguchi, Fumitaka| Arata, Takashi| Katsuda, Koh| Tanakaya, Kohji|
抄録 Cardiac metastasis originating from hepatocellular carcinoma (HCC) is a rare condition with a poor prognosis. No therapeutic standards for cardiac metastasis originating from HCC have been established. At 19 months after a curative hepatectomy, a 64-year-old Japanese hepatitis B virus-positive male patient experienced solitary cardiac metastasis originating from HCC. The cardiac tumor was discovered in the right ventricle. The patient received three courses of radiotherapy and chemotherapy and survived > 3 years after the initial diagnosis of cardiac metastasis. His case demonstrates that radiotherapy combined with chemotherapy can be an effective treatment for cardiac metastasis.
キーワード hepatocellular carcinoma cardiac metastasis radiotherapy chemotherapy
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2020-12
74巻
6号
出版者 Okayama University Medical School
開始ページ 525
終了ページ 530
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33361873
Web of Science KeyUT 000601203600009
NAID 120006948951
フルテキストURL APL_117_101103.pdf
著者 Iida, Takumi | Ishikawa, Atsushi| Tanaka, Takuo| Muranaka, Atsuya| Uchiyama, Masanobu| Hayashi, Yasuhiko| Tsuruta, Kenji|
備考 This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Takumi Iida et. al. Super-chiral vibrational spectroscopy with metasurfaces for high-sensitive identification of alanine enantiomers. Appl. Phys. Lett. 117, 101103 (2020) and may be found at https://doi.org/10.1063/5.0012331.|
発行日 2020-09-09
出版物タイトル Applied Physics Letters
117巻
10号
出版者 American Institute of Physics
開始ページ 101103
ISSN 0003-6951
NCID AA00543431
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
DOI 10.1063/5.0012331
Web of Science KeyUT 000571581400002
関連URL isVersionOf https://doi.org/10.1063/5.0012331
フルテキストURL cis_5_2847.pdf
著者 Matsuo, Toshihiko|
キーワード Trabeculectomy Filtering surgery In-the-bag intraocular lens dislocation Intraocular lens-suturing Conjunctiva-sparing
発行日 2020-06-15
出版物タイトル Clinics in Surgery
5巻
出版者 Remedy
開始ページ 2847
ISSN 2474-1647
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 ©2020 Toshihiko Matsuo
論文のバージョン publisher
オフィシャル URL http://www.clinicsinsurgery.com/|
JaLCDOI 10.18926/AMO/59948
フルテキストURL 74_3_185.pdf
著者 Sano, Toshikazu| Ishigami, Shuta| Ito, Tatsuo| Sano, Shunji|
抄録 Heart diseases are one of the major causes of morbidity and mortality worldwide. Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. Stem cell therapy has emerged as one option for the treatment of a variety of heart diseases. Although a large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach, the results obtained from these clinical studies are inconsistent, and stem cell-based improvements of heart performance and cardiac remodeling were found to be quite limited. Since the precise mechanisms underlying the therapeutic actions of stem cells are still under debate, researchers have developed a variety of strategies to improve and boost the potency of stem cells in repair. In this review, we summarize both the current therapeutic strategies using stem cells and future directions for enhancing stem cell potency.
キーワード heart disease stem cell myocardial regeneration
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2020-06
74巻
3号
出版者 Okayama University Medical School
開始ページ 185
終了ページ 190
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32577015
Web of Science KeyUT 000543363400001
NAID 120006862790
フルテキストURL fulltext.pdf
著者 Murase, Yurika| Kishimoto, Koji| Yoshida, Shoko| Kunisada, Yuki| Kadoya, Koichi| Ibaragi, Soichiro| Sasaki, Akira|
発行日 2020-03-28
出版物タイトル Journal of Surgical Case Reports
3号
出版者 Oxford University Press
開始ページ rjaa061
ISSN 2042-8812
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2020.
論文のバージョン publisher
PubMed ID 32257103
DOI 10.1093/jscr/rjaa061
Web of Science KeyUT 000535663800034
関連URL isVersionOf https://doi.org/10.1093/jscr/rjaa061