検索結果 42660 件
| JaLCDOI | 10.18926/AMO/61896 |
|---|---|
| フルテキストURL | 75_2_169.pdf |
| 著者 | Nakada, Tetsuya| Kataoka, Takahiro| Nomura, Takaharu| Shuto, Hina| Yano, Junki| Naoe, Shota| Hanamoto, Katsumi| Yamaoka, Kiyonori| |
| 抄録 | The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Mice received whole-body low-dose-rate (0.6 or 3.0 mGy/h) of low-dose γ-irradiation for 1 week, followed by daily FSTs (5 days). The immobility rate on day 2 compared to day 1 was significantly lower in the 3.0 mGy/h irradiated mice than in sham irradiated mice. The FST significantly decreased the catalase (CAT) activity and total glutathione (t-GSH) content in the brain and kidney, respectively. The superoxide dismutase (SOD) activity and t-GSH content in the liver of the 3.0 mGy/h irradiated mice were significantly lower than those of the non-FST-treated mice. The CAT activity in the lungs of mice exposed to 3.0 mGy/h γ-irradiation was higher than that of non-FST treated mice and mice treated with FST. However, no significant differences were observed in the levels of these antioxidant markers between the sham and irradiated groups except for the CAT activity in lungs. These findings suggest that the effects of low-dose-rate and low-dose γ-irradiation on FST are highly organ-dependent. |
| キーワード | low-dose-rate γ-irradiation forced swim test antioxidant oxidative stress |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 169 |
| 終了ページ | 175 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953424 |
| NAID | 120007029890 |
| JaLCDOI | 10.18926/AMO/61895 |
|---|---|
| フルテキストURL | 75_2_177.pdf |
| 著者 | Inoue, Madoka| Noda, Tomoyuki| Uehara, Takenori| Tetsunaga, Tomonori| Yamada, Kazuki| Saito, Taichi| Shimamura, Yasunori| Yamakawa, Yasuaki| Ozaki, Toshifumi| |
| 抄録 | This retrospective study sought to elucidate the incidence rates of roof impaction (RI) and marginal impaction (MI) and radiological and clinical outcomes of open reduction and internal fixation (ORIF) for RI and MI in geriatric acetabular fractures. The cases of 68 patients aged ≥ 65 years (mean 71 years) treated with ORIF were analyzed. MI was present in 12 fractures (67%) and an RI of the weight-bearing surface was present in 24 (46%) of the potential fracture types. Regarding the reduction quality, 54% of the reductions were graded as anatomical, 37% as imperfect, and 9% as poor. In the clinical evaluations of the 45 patients who had > 1-year follow-up (follow-up rate: 66.2%), 18% were graded as excellent, 53% as good, 16% as fair, and 13% as poor. An anatomic reduction was strongly associated with good or excellent clinical and radiological outcomes. CT was superior to radiographs for detecting the residual displacement postoperatively. Postoperative deep infection occurred in four patients. Three patients (6.7%) underwent a total hip arthroplasty conversion due to secondary osteoarthritis of the hip. We recommend ORIF as the preferred surgical treatment option for displaced acetabular fractures in elderly patients. |
| キーワード | acetabular fracture osteosynthesis marginal impaction roof impaction elderly patient |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 177 |
| 終了ページ | 185 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953423 |
| NAID | 120007029891 |
| JaLCDOI | 10.18926/AMO/61894 |
|---|---|
| フルテキストURL | 75_2_153.pdf |
| 著者 | Shimaoka, Shigeyoshi| Hamaoka, Hitomi| Inoue, Junji| Asanuma, Masato| Tooyama, Ikuo| Kondo, Yoichi| |
| 抄録 | Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms. Other biological functions of Lf include immunomodulation and transcriptional regulation. However, the roles of Lf in the CNS have yet to be fully clarified. In this study, we raised an antiserum against mouse Lf and investigated the immunohistochemical localization of Lf-like immunoreactivity (Lf-LI) throughout the CNS of adult mice. Lf-LI was found in some neuronal populations throughout the CNS. Intense labeling was found in neurons in the olfactory systems, hypothalamic nuclei, entorhinal cortex, and a variety of brainstem nuclei. This study provides detailed information on the Lf-LI distribution in the CNS, and the findings should promote further understanding of both the physiological and pathological significance of Lf in the CNS. |
| キーワード | lactoferrin immunohistochemistry brain mapping |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 153 |
| 終了ページ | 167 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953422 |
| NAID | 120007029892 |
| JaLCDOI | 10.18926/interdisciplinary/61892 |
|---|---|
| タイトル（別表記） | Cross-border research exchange activities |
| フルテキストURL | interdisciplinary_1_81_82.pdf |
| 著者 | 葛 睿| |
| 出版物タイトル | 統合科学 |
| 発行日 | 2021-03-31 |
| 巻 | 1巻 |
| 開始ページ | 81 |
| 終了ページ | 82 |
| ISSN | 2436-3227 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120007029893 |
| JaLCDOI | 10.18926/interdisciplinary/61891 |
|---|---|
| タイトル（別表記） | Interdisciplinary Science and Engineering in Health Systems Initiatives through Okayama Living Lab |
| フルテキストURL | interdisciplinary_1_77_79.pdf |
| 著者 | 志水 武史| |
| 出版物タイトル | 統合科学 |
| 発行日 | 2021-03-31 |
| 巻 | 1巻 |
| 開始ページ | 77 |
| 終了ページ | 79 |
| ISSN | 2436-3227 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120007029894 |
| JaLCDOI | 10.18926/interdisciplinary/61890 |
|---|---|
| タイトル（別表記） | Advanced Hospital Training Activities in Fiscal 2020 |
| フルテキストURL | interdisciplinary_1_65_75.pdf |
| 著者 | 兵藤 好美| |
| 出版物タイトル | 統合科学 |
| 発行日 | 2021-03-31 |
| 巻 | 1巻 |
| 開始ページ | 65 |
| 終了ページ | 75 |
| ISSN | 2436-3227 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120007029895 |
| JaLCDOI | 10.18926/interdisciplinary/61889 |
|---|---|
| タイトル（別表記） | Information and communication technology equipment and services for remote monitoring and health management: Survey of services and their classification for use in home care nursing |
| フルテキストURL | interdisciplinary_1_47_63.pdf |
| 著者 | 坂本 年生| 平田 晶奈| 森田 瑞樹| |
| 抄録 | This study aims to improve the quality of home nursing care for the elderly. The report presents web-based information about devices and services for remote monitoring and health management using information and communication technology and about how they can improve home care nursing station efficiency in Japan. The search terms "elderly people," "watch over," and "service," plus "sensor" were used to narrow the search. After repeating the search using a chained search for materials and links extracted from those search results, services for home care stations particularly addressing the remote monitoring of elderly people were selected and extracted. Early detection of abnormalities for support by home health nurse responsibilities for observing the general condition of the patient was chosen as the main evaluation index of usefulness. The contractor and service cost were secondary evaluation axes. Results show 9 information communication devices and services for real-time monitoring of the elderly persons’ vital signs in real time for 24 hr, 2 of which are highly useful for early detection of abnormalities and subsequent response. Results suggest that other services might be more useful, depending on how they are used, and that general-purpose services with minimum functions and low cost of introduction and maintenance can provide more opportunities for utilization. Providing these services on a BtoBtoC model and responding to patients’ medical needs can supplement home care nursing station work, increase human resource and time efficiencies, and give patients "the feeling that a nurse is always at their bedside,” even when far away. |
| キーワード | elderly people watch over sensor in home care support telenursing |
| 出版物タイトル | 統合科学 |
| 発行日 | 2021-03-31 |
| 巻 | 1巻 |
| 開始ページ | 47 |
| 終了ページ | 63 |
| ISSN | 2436-3227 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120007029896 |
| JaLCDOI | 10.18926/interdisciplinary/61888 |
|---|---|
| タイトル（別表記） | Consideration about recognition of factors causing lack of confirmation in the nursing scene |
| フルテキストURL | interdisciplinary_1_29_45.pdf |
| 著者 | 左 婉馨| 兵藤 好美| ⽥中 共⼦| 五福 明夫| |
| 抄録 | In the work process of nurses with high risk, it is very urgent to take countermeasures against the “lack of confirmation” of the main factors. Therefore, the purpose of this study is to clarify the details of the factors leading to the lack of confirmation, grasp the number of near misses, and to explore what kind of factors the individual characteristics of the nurse who acts as a stopper. We recruited 500 nurses on the Web and asked about the frequency of near misses due to lack of confirmation, the awareness of the causes of lack of confirmation, self-evaluation of stoppers, and the reasons why near misses did not lead to accidents. As a result, three factors were extracted regarding the recognition of the factors of lack of confirmation: "lack of consciousness", "inability to concentrate", and "lack of knowledge / experience". Three factors were extracted for self-evaluation of stopper characteristics: "awareness," "verification," and "cautiousness". In order to reduce the lack of confirmation, it is necessary to secure and allocate appropriate personnel and create an environment where treatment can be concentrated. Nurses should also raise knowledge and the awareness of the importance of confirmation. In addition, it is necessary to improve the clinical judgment of new nurses in order to prevent near misses. And it is thought that new nurses will become more confident by accumulating experience and affirming their abilities from their superiors, seniors and colleagues. |
| キーワード | lack of confirmation stoppers nurse |
| 出版物タイトル | 統合科学 |
| 発行日 | 2021-03-31 |
| 巻 | 1巻 |
| 開始ページ | 29 |
| 終了ページ | 45 |
| ISSN | 2436-3227 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120007029897 |
| JaLCDOI | 10.18926/interdisciplinary/61887 |
|---|---|
| タイトル（別表記） | Business Case: Tourism Campaigning Process of the Shimanami Kaido Expressway over the Setouchi Inner Sea in Japan |
| フルテキストURL | interdisciplinary_1_21_28.pdf |
| 著者 | 中尾 光| 藤井 大児| |
| 抄録 | The Shimanami Kaido Expressway was visioned as a national project in the early 1970s after two tragic maritime accidents in the Setouchi Inner Sea. Since the express way connecting several islands between Hiroshima and Ehime prefecture was placed in use in 1999, it has always been a valuable means of transportation for islanders and commuters to date. In addition, with the proactive efforts made by local governments, such as Imabari City, Onomichi City, let alone with the central and prefectural governments, it has come to be acknowledged to be a sanctuary for sport cyclists. Eventually, it attracts attentions from all over Japan as a successful benchmark for both businesspeople as well as policy makers who are interested in destination management practices as part of promotion policies of reginal economies. This eventual success, however, had not been envisioned as such for a long time since the commencement of its public usage. It would rather seem that the plan had taken on its shape after a long period of many twists and turns. Furthermore, while local governments have been closely cooperating with different types of stakeholders including the actual islanders to promote the development plans, their ways of thinking are still far from unanimous. The purpose of this article is to provide business and policy students with materials that draw lessons for viewing lengthy socioeconomic processes like this case which eventually converted a nation-level, large-scale infrastructure development plan into an area-specific destination management project. |
| キーワード | しまなみ海道 観光資源 サイクリング DMO |
| 出版物タイトル | 統合科学 |
| 発行日 | 2021-03-31 |
| 巻 | 1巻 |
| 開始ページ | 21 |
| 終了ページ | 28 |
| ISSN | 2436-3227 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120007029898 |
| JaLCDOI | 10.18926/interdisciplinary/61886 |
|---|---|
| タイトル（別表記） | Rolling stockpile of medical supplies for pandemic preparedness: modeling and simulation |
| フルテキストURL | interdisciplinary_1_17_20.pdf |
| 著者 | 森⽥ 瑞樹| |
| 抄録 | When a global pandemic of infectious diseases occurs, demand for medical supplies such as masks, disinfectants, and personal protective equipment will exceed the production capacity in normal times, consequently leading to serious shortages. Stockpiling is necessary to prepare for such situations. However, because pandemics are infrequent and might occur at any time, stockpile freshness is an important concern. As described in this paper, a “rolling stockpile” of medical supplies is proposed to prevent the medical supply stockpile from becoming too old. A formulation of a model and simulations based on it is presented. Results demonstrate that the method is applicable to the design of warehouses for rolling stockpiles, monitoring stockpile depletion during emergencies, and monitoring the process of recovery from emergencies. |
| キーワード | 感染症と備蓄 ローリングストック 備蓄倉庫の設計 緊急時の備蓄量の計算 |
| 出版物タイトル | 統合科学 |
| 発行日 | 2021-03-31 |
| 巻 | 1巻 |
| 開始ページ | 17 |
| 終了ページ | 20 |
| ISSN | 2436-3227 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120007029899 |
| JaLCDOI | 10.18926/interdisciplinary/61885 |
|---|---|
| タイトル（別表記） | Transcending into Profound and Nishida Kitaro's "The 'I' and the 'Thou'" |
| フルテキストURL | interdisciplinary_1_3_16.pdf |
| 著者 | 鈴木 亮三| |
| キーワード | life profound "I and Thou" dialectic |
| 出版物タイトル | 統合科学 |
| 発行日 | 2021-03-31 |
| 巻 | 1巻 |
| 開始ページ | 3 |
| 終了ページ | 16 |
| ISSN | 2436-3227 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120007029900 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ichikawa, Keishi| Miyoshi, Toru| Osawa, Kazuhiro| Miki, Takashi| Ito, Hiroshi| |
| キーワード | malondialdehyde low-density lipoprotein high-risk plaque coronary computed tomography angiography statin |
| 発行日 | 2021-04-02 |
| 出版物タイトル | Journal of Clinical Medicine |
| 巻 | 10巻 |
| 号 | 7号 |
| 出版者 | MDPI |
| 開始ページ | 1480 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/jcm10071480 |
| NAID | 120007029901 |
| Web of Science KeyUT | 000638623700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm10071480 |
| JaLCDOI | 10.18926/AMO/61881 |
|---|---|
| フルテキストURL | 75_2_147.pdf |
| 著者 | Xue, Haowei | Furumatsu, Takayuki| Okazaki, Yuki | Hiranaka, Takaaki | Kintaka, Keisuke | Fujii, Masataka | Zhang, Ximing| Ozaki, Toshifumi| |
| 抄録 | Medial meniscus posterior root tears (MMPRTs) have recently attracted considerable interest in orthopedics. To date, no in vivo human study has investigated suture translation changes in repaired MMPRTs with different degrees of knee flexion. This study examined suture translation at various degrees of knee flexion in 30 patients undergoing medial meniscus posterior root repair using the modified Mason-Allen suture technique between August 2016 and September 2017. Intraoperatively, sutures were provisionally fixed to an isometric positioner at the tibial site of the desired meniscal attachment, and the suture translation was measured at 0°, 30°, 60°, and 90° of knee flexion. The results showed significant increases in mean suture translation at the knee flexion positions from 0° to 30°, 30° to 60°, and 60° to 90° (p<0.01 for all). Our findings indicate that surgeons should carefully assess the degree of knee flexion at the moment when the meniscus is refixed by surgical sutures. |
| キーワード | medial meniscus posterior root tear suture translation knee flexion arthroscopic repair |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 147 |
| 終了ページ | 152 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953421 |
| NAID | 120007029902 |
| JaLCDOI | 10.18926/AMO/61880 |
|---|---|
| フルテキストURL | 75_2_139.pdf |
| 著者 | Hamada, Kentaro| Kuroda, Masahiro| Yoshimura, Yuuki | Khasawneh, Abdullah| Barham, Majd| Tekiki, Nouha| Sugianto, Irfan| Bamgbose, Babatunde O.| Konishi, Kohei| Sugimoto, Kohei| Ishizaka, Hinata| Kurozumi, Akira| Matsushita, Toshi | Ohno, Seiichiro| Kanazawa, Susumu| Asaumi, Junichi| |
| 抄録 | Diffusion-weighted imaging may be used to obtain the apparent diffusion coefficient (ADC), which aids the diagnosis of cerebral infarction and tumors. An ADC reflects elements of free diffusion. Diffusion kurtosis imaging (DKI) has attracted attention as a restricted diffusion imaging technique. The ADC subtraction method (ASM) was developed to visualize restricted diffusion with high resolution by using two ADC maps taken with different diffusion times. We conducted the present study to provide a bridge between the reported basic ASM research and clinical research. We developed new imaging software for clinical use and evaluated its performance herein. This software performs the imaging process automatically and continuously at the pixel level, using ImageJ software. The new software uses a macro or a plugin which is compatible with various operating systems via a Java Virtual Machine. We tested the new imaging software’s performance by using a Jurkat cell bio-phantom, and the statistical evaluation of the performance clarified that the ASM values of 99.98% of the pixels in the bio-phantom and physiological saline were calculated accurately (p<0.001). The new software may serve as a useful tool for future clinical applications and restricted diffusion imaging research. |
| キーワード | apparent diffusion coefficient ADC subtraction method restricted diffusion ImageJ plugin |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 139 |
| 終了ページ | 145 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953420 |
| NAID | 120007029903 |
| JaLCDOI | 10.18926/AMO/61879 |
|---|---|
| フルテキストURL | 75_2_133.pdf |
| 著者 | Hashida, Shinsuke| Tanaka, Norimitsu| Takahashi, Yuta| Onoda, Yuji| Colvin, Hugh Shunsuke| Ohashi, Ryuichiro| Okamoto, Kunio | |
| 抄録 | As the nanoparticle albumin-bound paclitaxel (nab-PTX) is free of ethanol and premedication, the duration of administration is shorter and patients can drive themselves to and from the hospital. In the 2018 Japanese gastric cancer treatment guidelines, ramucirumab (RAM) plus weekly nab-PTX is conditionally recommended for previously treated patients with advanced gastric cancer. Here, we retrospectively analysed the efficacy and safety of RAM+nab-PTX for such patients in community hospitals. From January 2018 to December 2019, 43 patients with metastatic and recurrent gastric cancer received RAM+nab-PTX treatment. Six patients (13.9%) were older than 80 years and 9 patients (20.9%) showed ECOG-PS 2. Progression-free survival (PFS), overall survival (OS), overall response rate (ORR), disease control rate (DCR), and adverse events (AEs) were reviewed retrospectively. Median PFS was 114 days (95% confidence interval [CI]: 84-190) and median OS was 297 days (95% CI: 180-398). ORR and DCR were 32.4% and 72.2%, respectively. The incidence rates of ≥grade 3 neutropenia and febrile neutropenia were 53.5% and 2.3%, respectively. No treatment-related deaths occurred. RAM plus nab-PTX combination therapy demonstrated manageable toxicity even patients who were elderly or had an ECOG-PS 2. This treatment is useful in community hospital settings. |
| キーワード | gastric cancer ramucirumab nab-paclitaxel |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 133 |
| 終了ページ | 138 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953419 |
| NAID | 120007029904 |
| JaLCDOI | 10.18926/AMO/61878 |
|---|---|
| フルテキストURL | 75_2_125.pdf |
| 著者 | Kijima, Yasufumi| Kondo, Naoki| Okumura, Go| Endo, Naoto| |
| 抄録 | Rheumatoid arthritis (RA) affects the hip joints. The microarchitecture of the cancellous bone in RA-affected hip joints has been unclear. Here we investigated the bone metabolism changes in the subcapital cancellous bone of destructive hips of RA patients (n=26 patients; 28 hip joints) which were classified by Larsen grade on X-ray into the groups: destructive hip (Des) (Larsen grade IV, n=18) and neck fracture (Fx) (Larsen grade 0 or 1, n=10). The femoral heads of the Des-group showed significantly higher trabecular thickness versus those of the Fx-group (179±30.8 vs. 151±23.5 μm, p=0.02). The Des-group had significantly higher osteoid volume/tissue volume (OV/TV) and osteoid volume/bone volume (OV/BV) ratios than the Fx-group (OV/TV: 0.72±0.70% vs. 0.27±0.32%, p=0.028; OV/BV: 2.96±2.85% vs. 1.24±1.31%, p=0.039). The osteoblast and osteoclast surface areas of the Des-group were remarkably higher than those of the Fx-group (9.80±10.9 vs. 0.15±0.15%, p=0.0005; 0.34±0.48 vs. 0.06±0.06%, p=0.0285, respectively). The T-scores of hip (femoral neck) bone mineral density (BMD) of the Fx-group were significantly lower versus those of the Des-group (−3.1±0.76 vs. −1.6±1.17, p<0.01). Increased osteoid and resorption parameters and higher femoral neck BMD demonstrate a high bone-turnover state in response to destructive changes in the hips of RA patients. |
| キーワード | bone histomorphometry rheumatoid arthritis destructive hip femoral neck fracture bone turnover |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 125 |
| 終了ページ | 131 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953418 |
| NAID | 120007029905 |
| JaLCDOI | 10.18926/AMO/61877 |
|---|---|
| フルテキストURL | 75_2_115.pdf |
| 著者 | Hitomi, Nishizaki| Yoshinari, Morimoto| Yamada, Shin-ichi| Kurita, Hiroshi| Tanaka, Akira| Yamaguchi, Akira| Miyata, Masaru| Yoshikawa, Hiromasa | Yanamoto, Souichi| Imai, Yutaka| |
| 抄録 | The aim of this study was to investigate the awareness and experience, among dental practitioners, of adverse events resulting from dental treatment of patients undergoing therapy with drugs that affect the immune system [angiogenesis inhibitors, biological agents, immunosuppressants, and disease-modifying anti-rheumatic drugs (DMARDs)]. For this purpose, a nationwide questionnaire survey was conducted. Questionnaires were sent to 2,050 dentists, of which 206 (10.1%) were completed and returned. The results showed that most dentists were aware of complications associated with dental treatment of patients treated with drugs that affect the immune system, and about half had actually experienced such complications. Delayed wound healing, osteonecrosis of the jaw (ONJ), and postoperative infections were reported. Whereas approximately 50% of dentists did not discontinue the drugs during dental treatment, about 18% did. During temporary drug discontinuation, some patients experienced aggravation of the primary disease, such as worsening of rheumatism, growth of tumors, and rejection reactions of transplanted organs. As for medical cooperation, only less than half of the dentists were asked for oral hygiene management by a physician prior to starting the drug treatment. Prospective studies are needed because evidence for dental treatments in patients treated with these drugs remains limited. |
| キーワード | angiogenesis inhibitor biological agent disease-modifying antirheumatic drug (DMARD) immunosuppressant medication-related osteonecrosis of the jaw (MRONJ) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 115 |
| 終了ページ | 123 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953417 |
| NAID | 120007029906 |
| タイトル（別表記） | HIF-1 alpha controls palatal wound healing by regulating macrophage motility via S1P/S1P(1) signaling axis |
|---|---|
| フルテキストURL | fulltext20210421_1.pdf figure20210421_1.pdf |
| 著者 | Hutami, Islamy Rahma| Izawa, Takashi| Khurel‐Ochir, Tsendsuren| Sakamaki, Takuma| Iwasa, Akihiko| Tomita, Shuhei| Tanaka, Eiji| |
| キーワード | HIF-1α S1P receptor hypoxia wound healing M1/M2 macrophage DMOG |
| 備考 | This is an Accepted Manuscript of an article published by Wiley. This is the peer reviewed version of the following article: [Hutami, IR, Izawa, T, Khurel-Ochir, T, et al. HIF-1α controls palatal wound healing by regulating macrophage motility via S1P/S1P1 signaling axis. Oral Dis. 2021; 00: 1– 13. https://doi.org/10.1111/odi.13856], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| 発行日 | 2021-4 |
| 出版物タイトル | Oral Diseases |
| 巻 | 28巻 |
| 号 | 4号 |
| 出版者 | Wiley |
| 開始ページ | 1157 |
| 終了ページ | 1169 |
| ISSN | 1354-523X |
| NCID | AA11044105 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 33759275 |
| DOI | 10.1111/odi.13856 |
| Web of Science KeyUT | 000635801500001 |
| 関連URL | isVersionOf https://doi.org/10.1111/odi.13856 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Watanabe, Haruki| Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Dobashi, Hiroaki| Takasaki, Yoshinari| Fujimoto, Shouichi| Atsumi, Tatsuya| Yamagata, Kunihiro| Homma, Sakae| Arimura, Yoshihiro| Makino, Hirofumi| Research Committee of Intractable Vasculitis Syndrome (JPVAS) & Research Committee of Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan| |
| 発行日 | 2021-03-04 |
| 出版物タイトル | Scientific Reports |
| 巻 | 11巻 |
| 号 | 1号 |
| 出版者 | Nature Research |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 33664381 |
| DOI | 10.1038/s41598-021-84627-6 |
| NAID | 120007027577 |
| Web of Science KeyUT | 000626140000051 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-021-84627-6 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Satomi, Takuya| Kawano, Seiji| Inaba, Tomoki| Nakagawa, Masahiro| Mouri, Hirokazu| Yoshioka, Masao| Tanaka, Shoichi| Toyokawa, Tatsuya| Kobayashi, Sayo| Tanaka, Takehiro| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawahara, Yoshiro| Okada, Hiroyuki| |
| キーワード | Endoscopic submucosal dissection Gastric tube Gastric cancer Eso-phagectomy Multicenter study Retrospective study |
| 発行日 | 2021-03-21 |
| 出版物タイトル | World Journal of Gastroenterology |
| 巻 | 27巻 |
| 号 | 11号 |
| 出版者 | Baishideng Publishing Group Inc. |
| 開始ページ | 1043 |
| 終了ページ | 1054 |
| ISSN | 1007-9327 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 33776371 |
| DOI | 10.3748/wjg.v27.i11.1043 |
| NAID | 120007027578 |
| Web of Science KeyUT | 000635258600004 |
| 関連URL | isVersionOf https://doi.org/10.3748/wjg.v27.i11.1043 |