検索結果 47794 件
| JaLCDOI | 10.18926/AMO/63428 |
|---|---|
| フルテキストURL | 76_2_229.pdf |
| 著者 | Kono, Takashi| Monden, Nobuya| Chikuie, Nobuyuki| Taruya, Takayuki| Hamamoto, Takao| Ishino, Takashi| Ueda, Tsutomu| Takeno, Sachio| |
| 抄録 | We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy. |
| キーワード | head and neck osteosarcomas tumor suppressor p16 |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 229 |
| 終了ページ | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503452 |
| Web of Science KeyUT | 000792291900006 |
| JaLCDOI | 10.18926/AMO/63427 |
|---|---|
| フルテキストURL | 76_2_225.pdf |
| 著者 | Mori, Yu| Sano, Yoshifumi| Sugimoto, Ryujiro| Sakao, Nobuhiko| Ryuko, Tsuyoshi| Takeda, Masashi| Kitazawa, Riko| Yukumi, Shungo| Izutani, Hironori| |
| 抄録 | A 75-year-old man presented to our hospital 1 year after partial renal resection for clear cell carcinoma. A right lower lobe lung nodule noted at the time of surgery had increased to 3.0 cm in diameter and was confirmed as squamous cell lung carcinoma by bronchoscopic cytology. Computed tomography had also revealed paratracheal lymph node swelling. He underwent right lower lobectomy with lymph node dissection by video-assisted thoracic surgery. Pathological examination confirmed squamous cell carcinoma of the lung but diagnosed the right hilar and mediastinal lymph node metastases as clear cell carcinoma. |
| キーワード | renal cell carcinoma primary lung cancer double cancer mediastinal lymph node metastasis hilar lymph node metastasis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 225 |
| 終了ページ | 228 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503451 |
| Web of Science KeyUT | 000792291900005 |
| JaLCDOI | 10.18926/AMO/63426 |
|---|---|
| フルテキストURL | 76_2_217.pdf |
| 著者 | Yabuno, Satoru| Sasada, Susumu| Umakoshi, Michiari| Nagase, Takayuki| Sugahara, Chiaki| Kawauchi, Satoshi| Yasuhara, Takao| Date, Isao| |
| 抄録 | A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery. |
| キーワード | cauda equina tumor child dermoid cyst hemilaminectomy spinal tumor |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 217 |
| 終了ページ | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503450 |
| Web of Science KeyUT | 000792291900004 |
| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| フルテキストURL | 76_2_203.pdf |
| 著者 | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| キーワード | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 203 |
| 終了ページ | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hongo, Takashi| Yamamoto, Ryohei| Liu, Keibun| Yaguchi, Takahiko| Dote, Hisashi| Saito, Ryusuke| Masuyama, Tomoyuki| Nakatsuka, Kosuke| Watanabe, Shinichi| Kanaya, Takahiro| Yamaguchi, Tomoya| Yumoto, Tetsuya| Naito, Hiromichi| Nakao, Atsunori| |
| キーワード | Post-extubation dysphagia Speech and language therapy Intensive care Dysphagia Aspiration pneumonia |
| 発行日 | 2022-04-08 |
| 出版物タイトル | Critical Care |
| 巻 | 26巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 98 |
| ISSN | 1364-8535 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 35395802 |
| DOI | 10.1186/s13054-022-03974-6 |
| Web of Science KeyUT | 000779598400004 |
| 関連URL | isVersionOf https://doi.org/10.1186/s13054-022-03974-6 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takatsu, Fumiaki| Yamamoto, Hiromasa| Tomioka, Yasuaki| Tanaka, Shin| Shien, Kazuhiko| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Takahashi, Katsuhito| Toyooka, Shinichi| |
| キーワード | Retroperitoneal sarcoma Lung metastasis Metastasectomy |
| 発行日 | 2022-04-08 |
| 出版物タイトル | World Journal Of Surgical Oncology |
| 巻 | 20巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 114 |
| ISSN | 1477-7819 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 35395855 |
| DOI | 10.1186/s12957-022-02552-y |
| Web of Science KeyUT | 000780301100001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12957-022-02552-y |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fukushima, Kazuhiko| Uchida, Haruhito A.| Fuchimoto, Yasuko| Mifune, Tomoyo| Watanabe, Mayu| Tsuji, Kenji| Tanabe, Katsuyuki| Kinomura, Masaru| Kitamura, Shinji| Miyamoto, Yosuke| Wada, Sae| Koyanagi, Taisaku| Sugiyama, Hitoshi| Kishimoto, Takumi| Wada, Jun| |
| キーワード | lupus nephritis lupus pneumonitis silicosis SLE |
| 発行日 | 2022-02-18 |
| 出版物タイトル | Medicine |
| 巻 | 101巻 |
| 号 | 7号 |
| 出版者 | Lippincott Williams & Wilkins |
| 開始ページ | e28872 |
| ISSN | 0025-7974 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 35363197 |
| DOI | 10.1097/MD.0000000000028872 |
| Web of Science KeyUT | 000776738500059 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000028872 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nagao, Ryo| Kato, Koji| Kumazawa, Minoru| Ifuku, Kentaro| Yokono, Makio| Suzuki, Takehiro| Dohmae, Naoshi| Akita, Fusamichi| Akimoto, Seiji| Miyazaki, Naoyuki| Shen, Jian-Ren| |
| 発行日 | 2022-04-01 |
| 出版物タイトル | Nature Communications |
| 巻 | 13巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 1764 |
| ISSN | 2041-1723 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 35365610 |
| DOI | 10.1038/s41467-022-29294-5 |
| Web of Science KeyUT | 000777408600010 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41467-022-29294-5 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamamoto, Koichiro| Nakano, Yasuhiro| Tokumasu, Kazuki| Honda, Hiroyuki| Hasegawa, Kou| Sato, Asuka| Ogawa, Hiroko| Obika, Mikako| Hanayama, Yoshihisa| Otsuka, Fumio| |
| キーワード | cinacalcct evocalcet hypercalccmia primary hyperparathyroidism |
| 発行日 | 2022-04-08 |
| 出版物タイトル | Clinical Case Reports |
| 巻 | 10巻 |
| 号 | 4号 |
| 出版者 | Wiley |
| 開始ページ | e05713 |
| ISSN | 2050-0904 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35425612 |
| DOI | 10.1002/ccr3.5713 |
| Web of Science KeyUT | 000781095000001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ccr3.5713 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamamoto, Yukichika| Otsuka, Yuki| Sunada, Naruhiko| Tokumasu, Kazuki| Nakano, Yasuhiro| Honda, Hiroyuki| Sakurada, Yasue| Hagiya, Hideharu| Hanayama, Yoshihisa| Otsuka, Fumio| |
| キーワード | fatigue hypogonadism LOH syndrome long COVID testosterone |
| 発行日 | 2022-03-31 |
| 出版物タイトル | Journal Of Clinical Medicine |
| 巻 | 11巻 |
| 号 | 7号 |
| 出版者 | MDPI |
| 開始ページ | 1955 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35407562 |
| DOI | 10.3390/jcm11071955 |
| Web of Science KeyUT | 000782056600001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm11071955 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Oka, Kosuke| Takagi, Yume| Hagiya, Hideharu| Otsuka, Fumio| |
| キーワード | cat scratch disease lymphadenopathy and subcutaneous abscess |
| 発行日 | 2022-04-14 |
| 出版物タイトル | Clinical Case Reports |
| 巻 | 10巻 |
| 号 | 4号 |
| 出版者 | Wiley |
| 開始ページ | e04816 |
| ISSN | 2050-0904 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35441012 |
| DOI | 10.1002/ccr3.4816 |
| Web of Science KeyUT | 000782511000001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ccr3.4816 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Obata, Nozomi| Tabuchi, Hiroaki| Kurihara, Miyu| Yamamoto, Eiji| Shirasawa, Kenta| Monden, Yuki| |
| キーワード | polyploidy nematode sweetpotato resistant cultivar breeding association study |
| 発行日 | 2022-03-18 |
| 出版物タイトル | Frontiers In Plant Science |
| 巻 | 13巻 |
| 出版者 | Frontiers Media SA |
| 開始ページ | 858747 |
| ISSN | 1664-462X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Obata, Tabuchi, Kurihara, Yamamoto, Shirasawa and Monden. |
| 論文のバージョン | publisher |
| PubMed ID | 35371138 |
| DOI | 10.3389/fpls.2022.858747 |
| Web of Science KeyUT | 000778596100001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fpls.2022.858747 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsui, Teppei| Taki, Masato| Pham, Trung Quang| Chikazoe, Junichi| Jimura, Koji| |
| キーワード | fMRI deep learning explainable AI decoding generative neural network counterfactual explanation |
| 発行日 | 2022-03-16 |
| 出版物タイトル | Frontiers In Neuroinformatics |
| 巻 | 15巻 |
| 出版者 | Frontiers Media |
| 開始ページ | 802938 |
| ISSN | 1662-5196 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Matsui, Taki, Pham, Chikazoe and Jimura. |
| 論文のバージョン | publisher |
| PubMed ID | 35369003 |
| DOI | 10.3389/fninf.2021.802938 |
| Web of Science KeyUT | 000778735900001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fninf.2021.802938 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Higaki, Fumiyo| Inoue, Satoshi| Oda, Wakako| Matsusue, Eiji| Hiraki, Takao| |
| キーワード | pial blood supply peritumoral brain edema arachnoid plane peritumoral flow void magnetic resonance imaging |
| 発行日 | 2022-04-08 |
| 出版物タイトル | Acta Radiologica Open |
| 巻 | 11巻 |
| 号 | 4号 |
| 出版者 | Sage Publications Ltd. |
| ISSN | 2058-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 35425642 |
| DOI | 10.1177/20584601221091208 |
| Web of Science KeyUT | 000780184200001 |
| 関連URL | isVersionOf https://doi.org/10.1177/20584601221091208 |
| JaLCDOI | 10.18926/AMO/63414 |
|---|---|
| フルテキストURL | 76_2_195.pdf |
| 著者 | Inoue, Shinichiro| Maeda, Isseki| Ogawa, Asao| Yoshiuchi, Kazuhiro| Terada, Seishi| Yamada, Norihito| |
| 抄録 | The clinical benefit of perospirone for treatment of delirium in patients with advanced cancer is not sufficiently clear. The objective of this study was to compare the safety and effectiveness of perospirone to those of risperidone for the treatment of delirium in patients with advanced cancer. This is a secondary analysis of a multicenter prospective observational study in nine psycho-oncology consultation services in Japan. The study used the Delirium Rating Scale (DRS) Revised-98 to measure effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 to assess safety. Data from 16 patients who received perospirone and 53 patients who received risperidone were analyzed. The mean age was 70 years in the perospirone group and 73 years in the risperidone group. Both groups showed a significant decrease in the total score of DRS-R-98 after three days of treatment (perospirone: 11.7 (7.9-15.4) to 7.0 (3.3-10.7), difference −4.7, effect size=0.72, p=0.003; risperidone: 15.5 (13.6-17.4) to 12.2 (10.1-14.2), difference −3.3, effect size=0.55, p=0.00). The risperidone group showed significant improvements in sleep-wake cycle disturbance, orientation, attention, and visuospatial ability. In the perospirone group, there was a significant improvement of sleep-wake cycle disturbance. The median daily dose of perospirone was 4 mg/day. There were fewer episodes of somnolence as an adverse event in the perospirone group. Low-dose perospirone was thus found to be effective for the treatment of delirium in patients with advanced cancer and may be associated with fewer episodes of over-sedation as an adverse event. |
| キーワード | delirium cancer perospirone risperidone |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 195 |
| 終了ページ | 202 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503448 |
| Web of Science KeyUT | 000792291900002 |
| JaLCDOI | 10.18926/AMO/63413 |
|---|---|
| フルテキストURL | 76_2_187.pdf |
| 著者 | Ren, Wanxu| Matsusaki, Takashi| Abugri Osman Bright| Morimatsu, Hiroshi| |
| 抄録 | Remifentanil is an ultra-short-acting opioid that sometimes causes opioid-induced hyperalgesia, which has led to controversy regarding the association between intraoperative remifentanil administration and postoperative pain. This study aimed to assess the effects of the intraoperative remifentanil dose on postoperative pain. Patients undergoing esophageal, gastric/hepatobiliary, or intestinal/colon surgery and using postoperative patient-controlled epidural analgesia were analyzed. The patients were divided into two groups based on the average intraoperative remifentanil dose (high-dose remifentanil [HR] group: ≥0.1 μg/kg/min; low-dose remifentanil [LR] group: <0.1 μg/kg/min). In all, 406 patients met the inclusion criteria. A significant difference in the average dose of remifentanil was seen between the groups during the anesthesia period (0.14±0.05 vs. 0.07±0.02 μg/kg/min). However, no significant difference was seen in pre- or intraoperative patient characteristics. Numerical rating scale (NRS) scores on postoperative day 1 were similar between the groups (HR: 1.7±2.0; LR: 1.7±2.0; p=0.74). The incidence of poor pain control (NRS > 3/10) was also similar between the groups (HR: 14%; LR: 16%; p=0.57). Older age (> 60 years) and type of surgery (esophageal surgery) were associated with worse postoperative NRS scores. No significant association was seen between the intraoperative remifentanil dose and postoperative NRS scores following thoracoabdominal surgery with postoperative epidural pain management. |
| キーワード | high-dose remifentanil postoperative numerical rating scale type of surgery epidural block |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 187 |
| 終了ページ | 193 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503447 |
| Web of Science KeyUT | 000792291900001 |
| JaLCDOI | 10.18926/AMO/63412 |
|---|---|
| フルテキストURL | 76_2_179.pdf |
| 著者 | Higashi, Tomoko| Murata, Naomichi| Fujimoto, Maki| Miyake, Saki| Egusa, Masahiko| Higuchi, Hitoshi| Maeda, Shigeru| Miyawaki, Takuya| |
| 抄録 | Patients with neurodegenerative diseases are at an increased risk of dysphagia and aspiration pneumonia. In this study, we examined whether ingestion of capsaicin prior to swallowing changes the temporal dynamics of swallowing in such patients. In a crossover, randomized controlled trial, 29 patients with neurodegenerative diseases were given a soluble wafer containing 1.5 μg capsaicin or an identical placebo 20 min prior to testing. For evaluation with video fluoroscopy (VF), patients consumed a barium-containing liquid plus thickening material. The durations of the latency, elevating and recovery periods of the hyoid were assessed from VF. Overall, no significant differences were observed in the duration of each period between capsaicin and placebo treatments. However, reductions in the latency and elevating periods were positively correlated with baseline durations. In subgroup analyses, that correlation was observed in patents with amyotrophic lateral sclerosis (ALS) but not in patients with Parkinson’s disease. The consumption of wafer paper containing capsaicin before the intake of food may be effective in patients with dysphagia related with certain neurodegenerative diseases, particularly ALS patients. Further studies will be needed to validate this finding. |
| キーワード | deglutition disorder fluoroscopy neurodegenerative diseases amyotrophic lateral sclerosis Parkinson disease |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 179 |
| 終了ページ | 186 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503446 |
| Web of Science KeyUT | 000792374900010 |
| JaLCDOI | 10.18926/AMO/63411 |
|---|---|
| フルテキストURL | 76_2_173.pdf |
| 著者 | Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro| |
| 抄録 | To the best of our knowledge, no previous studies have reported a relationship between osteoarthritis (OA) of the lower limbs and OA of the shoulder joints. We evaluated the correlation between shoulder OA and hip OA. We collected contrast-enhanced computed tomography (CECT) images of the shoulder joints of 159 patients with hip OA who underwent primary total hip arthroplasty (THA). The images, taken 1 week after THA to monitor venous thromboembolism (VTE), were used to examine the prevalence of shoulder OA. They were compared with those of 103 controls who underwent CECT during the same period to monitor VTE. Shoulder OA was observed in 15% of the controls and 24% of the THA patients. Although the rate was somewhat higher in the THA group, the difference was not significant. However, in the THA group, significantly more patients with bilateral hip OA (33%) had shoulder OA than those with unilateral hip OA (17%). In summary, the prevalence of shoulder OA was significantly higher in patients with bilateral hip OA. In these patients, pain and instability in the hip joints require them to use arm support to stand up or walk, putting the weight-bearing shoulder at risk of developing OA. |
| キーワード | shoulder osteoarthritis hip osteoarthritis weight-bearing shoulder total hip arthroplasty |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 173 |
| 終了ページ | 177 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503445 |
| Web of Science KeyUT | 000792374900009 |
| JaLCDOI | 10.18926/AMO/63410 |
|---|---|
| フルテキストURL | 76_2_167.pdf |
| 著者 | Higashionna, Tsukasa| Ushio, Soichiro| Esumi, Satoru| Murakawa, Kiminaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| 抄録 | Febrile neutropenia (FN) is a serious side effect in patients undergoing cancer chemotherapy and frequently proves fatal. Since infection control is crucial in the management of FN, the antimicrobial agent cefozopran (CZOP) has been recommended but not approved for routine use in clinical care of FN in Japan. However, few studies of CZOP in the management of FN have used a thrice daily dose schedule. The aim of this study was to retrospectively compare the efficacy and safety of CZOP at a dose of 1 g three times daily to those of cefepime (CFPM) in the treatment of FN in our lung cancer patients. The response rates of the CZOP and CFPM groups were 89.5% (17/19 cases) and 83.0% (39/47 cases), respectively, with no significant difference between the two groups. The median duration of antimicrobial treatment was 6 days (4-10 days) in the CZOP group and 7 days (3-13 days) in the CFPM group, with no significant difference between groups. The incidence rates of adverse events were 21.1% (4/19 cases) in the CZOP group and 19.1% (9/47 cases) in the CFPM group. No adverse events of Grade 3 or higher were observed in either group. The findings of the present study suggest that CZOP administration at a dose of 1 g three times per day as an antimicrobial treatment alternative against FN. |
| キーワード | febrile neutropenia cefozopran cefepime lung cancer retrospective |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 167 |
| 終了ページ | 172 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503444 |
| Web of Science KeyUT | 000792374900008 |
| JaLCDOI | 10.18926/AMO/63409 |
|---|---|
| フルテキストURL | 76_2_155.pdf |
| 著者 | Kimura, Jiro| Okabayashi, Takehiro| Sui, Kenta| Tabuchi, Motoyasu| Iwata, Jun| Hata, Yasuhiro| Iiyama, Tatsuo| Ono, Noriaki| |
| 抄録 | Small bowel metastasis from renal cell carcinoma (RCC) is rare, and its clinicopathological characteristics are unclear; thus, we revisited the concept of this tumor and reviewed its diagnostic and treatment modalities. We filtered MEDLINE searches of articles published in English between 1950 and 2019, and identified 100 patients who had undergone treatment, including 1 patient from our clinic. We extracted patient characteristics, treatment, and prognostic data, resulting in clinicopathological data on 100 patients (83 men, 17 women). Mean age was 63 years (range, 16-86 years). Tumor sites were duodenum, jejunum, ileum, and multiple sites in 30, 37, 25, and 7 patients, respectively. The 1-, 3-, and 5-year overall survival rates after diagnosis were 53.0%, 36.0%, and 36.0%. Curative resection patients showed 62.1% 5-year survival after surgery, vs. 27.5% in noncurative surgical management cases. Good prognoses can be expected if these tumors are identified early for complete removal. Surgery is the only curative option. To determine the best management strategy and improve prognostic accuracy, we continue to collect and analyze epidemiological and pathological data. Although this condition is rare, surgery should be considered if curative resection is expected. Prognosis after curative resection is not poor, but recurrence is not unlikely. |
| キーワード | renal cell carcinoma small bowel metastasis intestine tumor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 155 |
| 終了ページ | 165 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503443 |
| Web of Science KeyUT | 000792374900007 |