検索結果 - 岡山大学学術成果リポジトリ

Daunorubicin, a topoisomerase II poison, suppresses viral production of hepatitis B virus by inducing cGAS-dependent innate immune response

フルテキストURL	K0005881_abstract_review.pdf K0005881_summary.pdf K0005881_fulltext.pdf
著者	今井大誉\|
発行日	2019-03-25
資料タイプ	学位論文
学位授与番号	甲第5881号
学位授与年月日	2019-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

東アジアと中南米にみられるEBウイルス関連T/NKリンパ増殖異常症：種痘様水疱症と蚊刺過敏症を中心に

タイトル（別表記）	EB virus-associated T/NK lymphoproliferative disorders in East Asia, and South and Central America: Special reference to hydroa vacciniforme and hypersensitivity to mosquito bites
フルテキストURL	130_123.pdf
著者	岩月啓氏\|
キーワード	種痘様水疱症蚊刺過敏症慢性活動性EBウイルス感染症病態予後
出版物タイトル	岡山医学会雑誌
発行日	2018-12-03
巻	130巻
号	3号
開始ページ	123
終了ページ	128
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.130.123
言語	日本語
著作権者	Copyright (c) 2018 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.130.123
NAID	130007542836

Conventional-dose Versus Half-dose Sulfamethoxazole-trimethoprim for the Prophylaxis of Pneumocystis Pneumonia in Patients with Systemic Rheumatic Disease: A Non-blind, Randomized Controlled Trial

JaLCDOI	10.18926/AMO/56464
フルテキストURL	73_1_85.pdf
著者	Abe, Yoshiyuki\| Fujibayashi, Kazutoshi\| Nishizaki, Yuji\| Yanagisawa, Naotake\| Nojiri, Shuko\| Nakano, Soichiro\| Tada, Kurisu\| Yamaji, Ken\| Tamura, Naoto\|
抄録	Pneumocystis pneumonia (PCP) due to Pneumocystis jirovecii infection is the leading cause of fatal opportunistic infections in immunocompromised patients. We will determine whether a daily sulfamethoxazole-trimethoprim (SMX/TMP) dose of 200/40 mg was non-inferior to 400/80 mg for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the rate of PCP prevention at 52 weeks. The secondary outcome is the discontinuation rate of SMX/TMP. The trial will evaluate the optimal dose of SMX/TMP for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy.
キーワード	pneumocystis pneumonia prophylaxis systemic rheumatic disease sulfamethoxazole-trimethoprim conventional-dose versus half-dose
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	85
終了ページ	89
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820060

Predictive Factors for Successful Vaccination Against Hepatitis B Surface Antigen in Patients Who Have Undergone Orthotopic Liver Transplantation

JaLCDOI	10.18926/AMO/56457
フルテキストURL	73_1_43.pdf
著者	Ikeda, Ailee\| Takaki, Akinobu\| Yasunaka, Tetsuya\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Onishi, Hideki\| Ikeda, Fusao\| Shiraha, Hidenori\| Yoshida, Kazuhiro\| Kuise, Takashi\| Nobuoka, Daisuke\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Fujiwara, Toshiyoshi\| Okada, Hiroyuki\|
抄録	Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. A positive anti-hepatitis B surface antibody response was achieved in 29% (8/28) of the LC-B group, 88% (7/8) of the ALF-B group, and 44% (4/9) of the adult non-B ESLD group. All four non-B ESLD infants showed vaccine success. The predictive factors for a good response in LC-B were young age, marital donor, and high donor age. ALF-B and non-B ESLD infants are thus good vaccination candidates. LC-B patients with marital donors are also good candidates, perhaps because the donated liver maintains an efficient immune memory to HBV, as the donors had already been infected in adulthood and showed adequate anti-HBV immune responses.
キーワード	acute liver failure hepatitis B hepatitis B vaccine liver cirrhosis liver transplantation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	41
終了ページ	50
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820053

Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy

JaLCDOI	10.18926/AMO/56178
フルテキストURL	72_4_401.pdf
著者	Wada, Nozomu\| Ikeda, Fusao\| Mori, Chizuru\| Takaguchi, Koichi\| Fujioka, Shin-ichi\| Kobashi, Haruhiko\| Morimoto, Yoichi\| Kariyama, Kazuya\| Sakaguchi, Kosaku\| Hashimoto, Noriaki\| Moriya, Akio\| Kawaguchi, Mitsuhiko\| Miyatake, Hirokazu\| Hagihara, Hiroaki\| Kubota, Junichi\| Takayama, Hiroki\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Takaki, Akinobu\| Iwasaki, Yoshiaki\| Okada, Hiroyuki\|
抄録	Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolled 951 HCV serogroup 1-positive patients who received this combination therapy at our hospital or affiliated hospitals. The presence of RAVs in non-structural (NS) regions 3 and 5A was analyzed by direct sequencing. HCV genotypes were determined by PCR with genotype-specific primers targeting HCV core and NS5B regions. SVR was achieved in 91.1% of patients. Female sex, age > 70 years, and RAVs were significantly associated with non-SVR (p<0.01 for all). Propensity score-matching results among the patients without RAVs regarding sex, age, and fibrosis revealed that mixed HCV infection determined by HCV NS5B genotyping showed significantly lower SVR rates than 1B-mono infection (p=0.02). Female sex and RAVs were significant factors associated with treatment failure of this combination therapy for patients with HCV serogroup 1 infection. Mixed HCV infection other than 1B-mono infection would be useful for predicting treatment failure.
キーワード	mixed genotype daclatasvir asunaprevir HCV serogrouping 1 infection
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	401
終了ページ	406
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140089

Epidemiology of Pediatric Acute Encephalitis/Encephalopathy in Japan

JaLCDOI	10.18926/AMO/56170
フルテキストURL	72_4_351.pdf
著者	Goto, Shinichiro\| Nosaka, Nobuyuki\| Yorifuji, Takashi\| Wada, Tomoaki\| Fujii, Yosuke\| Yashiro, Masato\| Washio, Yosuke\| Hasegawa, Kosei\| Tsukahara, Hirokazu\| Morishima, Tsuneo\|
抄録	We studied the etiology of pediatric acute encephalitis/encephalopathy (pAEE) using epidemiological data obtained from a nationwide survey in Japan. Two-step questionnaires were sent to the pediatric departments of hospitals throughout the country in 2007, querying the number of the cases during 2005-2006 as the first step, and asking for the details of clinical information as the second step. In all, 636 children with pAEE (age ≤ 15 years) were enrolled. For the known etiology of pAEE (63.5% of the total cases), 26 microbes and 2 clinical entities were listed, but the etiology of 36.5% remained unknown. Influenza virus (26.7%), exanthem subitum (12.3%), and rotavirus (4.1%) were the most common, and the incidence of pAEE peaked at the age of 1 year. This trend was common among all etiologies. Among the neurological symptoms observed at the onset of pAEE, seizures were observed more often in patients aged ≤ 3 years, although abnormal speech and behavior were also common in older children. Undesirable outcomes (death and neurological sequelae) occurred at high rates in patients with any known etiology other than mycoplasma. In conclusion, these findings provide comprehensive insight into pAEE in Japan.
キーワード	childhood encephalitis encephalopathy etiology Japan pAEE
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	351
終了ページ	357
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140082

A New Hepatitis Virus Test with Microliter-scale Fingertip Blood Collection in Japan

JaLCDOI	10.18926/AMO/56074
フルテキストURL	72_3_283.pdf
著者	Namba, Shihoko\| Ikeda, Fusao\| Takaguchi, Koichi\| Shimomura, Yasuyuki\| Yasunaka, Tetsuya\| Okada, Hiroyuki\|
抄録	We investigated whether a small amount of blood collected by fingertip blood sampling would be adequate in a mass examination for hepatitis virus infection in Japan. A cross-sectional survey was conducted at health fairs in Kasaoka City and Shodoshima Island, where participants took the hepatitis screening test. A total of 114 consecutive individuals who took the hepatitis screening test were enrolled. Twenty microliters of plasma was successfully obtained from all participants. Among the participants, two had positive results for HBs antigen and two were positive for anti-HCV; all four were > 60 years old and rarely visited the hospital. Thirty-three and 38 patients chronically infected with HBV and HCV, respectively, were examined for confirmatory assays at participating hospitals. All subjects with undetectable serum levels of HBs antigen and anti-HCV had undetectable levels of both markers in fingertip blood, and the levels in serum and fingertip blood were significantly correlated (p<0.01). The lower detection limit of HBs antigen was defined as 0.005 IU/ml, and the cut-off value of anti-HCV was 1.0 by using 10-μl fingertip blood samples. The fingertip blood sampling described herein may be adequate in mass examinations for hepatitis virus testing in Japan.
キーワード	fingertip hepatitis test HBV HCV Japan
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-06
巻	72巻
号	3号
出版者	Okayama University Medical School
開始ページ	283
終了ページ	287
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29926006

Local and Systemic Immune Responses to Influenza A Virus Infection in Pneumonia and Encephalitis Mouse Models

フルテキストURL	O0004482_abstract_review.pdf O0004482_summary.pdf O0004482_fulltext.pdf
著者	長岡義晴\|
発行日	2017-12-27
資料タイプ	学位論文
学位授与番号	乙第4482号
学位授与年月日	2017-12-27
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

リンゴ小球形潜在ウイルスベクターを用いたサクラ属果樹のウイルス誘導性ジーンサイレンシングに関する研究

タイトル（別表記）	Virus-induced gene silencing in Prunus fruit tree species with the Apple latent spherical virus vector
フルテキストURL	srfa_107_011_017.pdf
著者	河井崇\|
抄録	Virus-induced gene silencing (VIGS) has been used as a rapid and effective tool for functional analysis of genes in various plants, including woody fruit tree species. In this study, we attempted to develop a VIGS-based gene evaluation system for seven Prunus species, including apricot (P. armeniaca L.), sweet cherry (P. avium L.), almond [P. dulcis (Mill.) D. A. Webb.], peach (P. persica Batsch), Japanese apricot (P. mume Siebold & Zucc.), Japanese plum (P. salicina Lindl.), and European plum (P. domestica L.), with the Apple latent spherical virus (ALSV) vectors. ALSV vectors carrying part of the apricot PHYTOENE DESATURASE (PDS) gene sequence were amplified in Nicotiana benthamiana, and inoculated into the cotyledons of Prunus seedlings by particle bombardment. Typical PDS-silenced phenotypes, characterized by uniform discoloration of the upper leaves, were observed in sweet cherry and some cultivars of apricot and almond several weeks after inoculation. In contrast, attempted ALSV infections of Japanese apricot, Japanese plum, European plum, and the other cultivars of apricot and almond were unsuccessful. Furthermore, although the infection rate of ALSV in peach was high, severe viral infection symptoms were observed in the infected leaves. These results collectively suggested that the efficiency of ALSV infection and VIGS could vary depending on species and/or cultivar in Prunus. The possible use of the ALSV-mediated VIGS system for functional analysis of genes in Prunus is discussed.
キーワード	gene evaluation system post-transcriptional gene silencing virus vector
出版物タイトル	岡山大学農学部学術報告
発行日	2018-02-01
巻	107巻
開始ページ	11
終了ページ	17
ISSN	2186-7755
言語	日本語
論文のバージョン	publisher

Mathematical Formulation and Numerical Simulation of Bird Flu Infection Process within a Poultry Farm

著者	Putri, Arrival Rince\| Nova, Tertia Delia\| Watanabe, Masaji\|
発行日	2016
出版物タイトル	AIP Conference Proceedings
巻	1707巻
資料タイプ	会議発表論文

Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum).

フルテキストURL	viruses-09-00371.pdf
著者	Ogawa, Hirohito\| Kajihara, Masahiro\| Nao, Naganori\| Shigeno, Asako\| Fujikura, Daisuke\| Hang’ombe, Bernard M.\| Mweene, Aaron S.\| Mutemwa, Alisheke\| Squarre, David\| Yamada, Masao\| Higashi, Hideaki\| Sawa, Hirofumi\| Takada, Ayato\|
キーワード	Eidolon helvum Zambia adenovirus bat
発行日	2017-12-04
出版物タイトル	Viruses
巻	9巻
号	12号
出版者	MDPI
開始ページ	371
ISSN	1999-4915
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	publisher
PubMed ID	29207524
DOI	10.3390/v9120371
関連URL	isVersionOf https://doi.org/10.3390/v9120371

Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar

フルテキストURL	K0005596_abstract_review.pdf K0005596_summary.pdf K0005596_fulltext.pdf
著者	Thar Htet San\|
発行日	2017-09-29
資料タイプ	学位論文
学位授与番号	甲第5596号
学位授与年月日	2017-09-29
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Genetic Factors of Low-responsiveness to Hepatitis B Virus Vaccine Confirms the Importance of Human Leukocyte Antigen Class II Types in a Japanese Young Adult Population

JaLCDOI	10.18926/AMO/55442
フルテキストURL	71_5_433.pdf
著者	Yukimasa, Nobuyasu\| Kohama, Shota\| Oboshi, Wataru\| Sato, Shoichi\| Nakamura, Takehiro\|
抄録	We investigated the genetic mechanisms underlying the association between human leukocyte antigen (HLA) types and the immune response to hepatitis B virus (HBV) vaccination in 84 healthy Japanese adults, and found that the HLA-DRB1＊04 and HLA-DQB1＊03 frequencies were higher in the low responders (<10 mIU/ml; n=9, 10.7%) compared to the responders (≥10 mIU/ml, n=75, 89.3%). The combination of DRB1＊04 and DQB1＊03 was associated with a low response to vaccination. The DRB1＊04 and DQB1＊03 haplotypes’ frequencies were significantly higher in the low responders compared to responders. Novel candidate HLA types may be important in Japanese individuals.
キーワード	HBV vaccine antibody response low-responder HLA class II Japanese
Amo Type	Short Communication
出版物タイトル	Acta Medica Okayama
発行日	2017-10
巻	71巻
号	5号
出版者	Okayama University Medical School
開始ページ	433
終了ページ	436
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29042702

Development of hepatitis C virus production reporter-assay systems using two different hepatoma cell lines

フルテキストURL	K0005289_other1.pdf
著者	Takeda, Midori\| Ikeda, Masanori\| Ariumi, Yasuo\| Wakita, Takaji\| Kato, Nobuyuki\|
備考	学位審査副論文\|
発行日	2012-07
出版物タイトル	Journal of General Virology
巻	93巻
号	7号
出版者	Cambridge Univ. Press for the Society for General Microbiology
開始ページ	1422
終了ページ	1431
ISSN	0022-1317
NCID	AA00698722
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	22456614
DOI	10.1099/vir.0.040725-0
Web of Science KeyUT	000306348900003
関連URL	https://doi.org/10.1099/vir.0.040725-0 http://ousar.lib.okayama-u.ac.jp/54272

Identification of host genes showing differential expression profiles with cell-based long-term replication of hepatitis C virus RNA

フルテキストURL	K0005288_other.pdf
著者	Sejima, Hiroe\| Mori, Kyoko\| Ariumi, Yasuo\| Ikeda, Masanori\| Kato, Nobuyuki\|
キーワード	HCV HCV RNA replication system Li23 cells Long-term RNA replication Upregulated host genes Downregulated host genes
備考	学位審査副論文\|
発行日	2012-07
出版物タイトル	Virus Research
巻	167巻
号	1号
出版者	Elsevier Science
開始ページ	74
終了ページ	85
ISSN	0168-1702
NCID	AA10642076
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	22579597
DOI	10.1016/j.virusres.2012.04.008
Web of Science KeyUT	000305496700010
関連URL	https://doi.org/10.1016/j.virusres.2012.04.008 http://ousar.lib.okayama-u.ac.jp/54271

Frequent downregulation of BACH2 expression in Epstein?Barr virus-positive diffuse large B-cell lymphoma

フルテキストURL	K0005572_abstract_review.pdf K0005572_summary.pdf K0005572_fulltext.pdf
著者	能島舞\|
発行日	2017-06-30
資料タイプ	学位論文
学位授与番号	甲第5572号
学位授与年月日	2017-06-30
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja

Efficacy and Safety of Salmeterol/fluticasone Combination Therapy in Infants and Preschool Children with Asthma Insufficiently Controlled by Inhaled Corticosteroids

フルテキストURL	fulltext.pdf
著者	Yoshihara, S.\| Fukuda, H.\| Tamura, M.\| Arisaka, O.\| Ikeda, M.\| Fukuda, N.\| Tsuji, T.\| Hasegawa, S.\| Kanno, N.\| Teraoka, M.\| Wakiguchi, H.\| Aoki, Y.\| Terada, A.\| Hasegawa, M.\| Manki, A.\| Igarashi, H.\|
キーワード	salmeterol/fluticasone combination asthma infant preschool children nighttime sleep disorder score long-acting beta-agonist inhaled corticosteroid
発行日	2016-07
出版物タイトル	Drug Research
巻	66巻
号	7号
出版者	Georg Thieme
開始ページ	371
終了ページ	376
ISSN	2194-9379
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Georg Thieme Verlag
論文のバージョン	publisher
PubMed ID	27273710
DOI	10.1055/s-0042-108852
Web of Science KeyUT	000379389100007
関連URL	isVersionOf https://doi.org/10.1055/s-0042-108852

平成27年度岡山医学会賞胸部・循環研究奨励賞（砂田賞）

著者	野坂宜之\|
発行日	2016-12-01
出版物タイトル	岡山医学会雑誌
巻	128巻
号	3号
資料タイプ	学術雑誌論文

平成27年度岡山医学会賞がん研究奨励賞（林原賞・山田賞）

タイトル（別表記）	The 2015 Incentive Award of the Okayama Medical Association in Cancer Research (2015 Hayashibara Prize and Yamada Prize)
フルテキストURL	128_99.pdf
著者	團迫浩方\|
出版物タイトル	岡山医学会雑誌
発行日	2016-08-01
巻	128巻
号	2号
開始ページ	99
終了ページ	102
ISSN	0030-1558
関連URL	https://doi.org/10.4044/joma.128.99
言語	日本語
著作権者	Copyright (c) 2016 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.128.99
NAID	130005262636

平成27年度岡山医学会賞総合研究奨励賞（結城賞）

タイトル（別表記）	The 2015 Incentive Award of the Okayama Medical Association in General Medical Science (2015 Yuuki Prize)
フルテキストURL	128_91.pdf
著者	梶田藍\|
出版物タイトル	岡山医学会雑誌
発行日	2016-08-01
巻	128巻
号	2号
開始ページ	91
終了ページ	94
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.128.91
言語	日本語
著作権者	Copyright (c) 2016 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.128.91
NAID	130005262638