検索結果 - 岡山大学学術成果リポジトリ

Statistical Analysis of Prognostic Factors for Survival in Patients with Spinal Metastasis

JaLCDOI	10.18926/AMO/48560
フルテキストURL	66_3_213.pdf
著者	Kataoka, Masaki\| Kunisada, Toshiyuki\| Tanaka, Masato\| Takeda, Ken\| Itani, Satoru\| Sugimoto, Yoshihisa\| Misawa, Haruo\| Senda, Masuo\| Nakahara, Shinnosuke\| Ozaki, Toshifumi\|
抄録	There are a variety of treatment options for patients with spinal metastasis, and predicting prognosis is essential for selecting the proper treatment. The purpose of the present study was to identify the significant prognostic factors for the survival of patients with spinal metastasis. We retrospectively reviewed 143 patients with spinal metastasis. The median age was 61 years. Eleven factors reported previously were analyzed using the Cox proportional hazards model:gender, age, performance status, neurological deficits, pain, type of primary tumor, metastasis to major organs, previous chemotherapy, disease-free interval before spinal metastasis, multiple spinal metastases, and extra-spinal bone metastasis. The average survival of study patients after the first visit to our clinic was 22 months. Multivariate survival analysis demonstrated that type of primary tumor (hazard ratio [HR]＝6.80, p＜0.001), metastasis to major organs (HR＝2.01, p＝0.005), disease-free interval before spinal metastasis (HR＝1.77, p＝0.028), and extra-spinal bone metastasis (HR＝1.75, p＝0.017) were significant prognostic factors. Type of primary tumor was the most powerful prognostic factor. Other prognostic factors may differ among the types of primary tumor and may also be closely associated with primary disease activity. Further analysis of factors predicting prognosis should be conducted with respect to each type of primary tumor to help accurately predict prognosis.
キーワード	spine metastasis survival prognostic factor cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2012-06
巻	66巻
号	3号
出版者	Okayama University Medical School
開始ページ	213
終了ページ	219
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	22729101
Web of Science KeyUT	000305669700004

Visualization of Stent Lumen in MR Imaging: Relationship with Stent Design and RF Direction

JaLCDOI	10.18926/AMO/48559
フルテキストURL	66_3_203.pdf
著者	Ohno, Seiichiro\| Harimoto, Takashi\| Hirosue, Miyuki\| Miyai, Masahiro\| Hattori, Kengo\| Kuroda, Masahiro\| Kanazawa, Susumu\| Inamura, Keiji\| Kato, Hirokazu\|
抄録	Magnetic resonance imaging (MRI) visualization of metallic stent lumens is possible if the stent structure counteracts eddy currents in the lumen induced by the radio frequency magnetic field, B1. To examine the effectiveness of various stent designs in counteracting eddy currents, we anchored eight copper stent models and 2 commercially available nickel-titanium alloy (Nitinol) stents in a gel phantom, perpendicular or parallel to the direction of B1. A mesh stent lumen showed hypointensity irrespective of its alignment relative to B1. A solenoid stent lumen showed hypointensity with the stent axis parallel to B1, but it had the same signal intensity as outside the lumen when perpendicular to B1. A Moebius stent lumen showed no signal reduction, irrespective of alignment relative to B1. Lumens of the commercially available stents showed hypointensity regardless of alignment relative to B1. Computer simulation revealed that the signal intensities of the stents corresponded to magnetic flux densities of B1 in the stents, which are modified by the structure of the stent. While in vivo MRI viewing of a Moebius stent lumen is likely possible regardless of axis alignment, inherent structural weakness may be problematic. As a more practical choice, the solenoid stent is easier to manufacture and generates no hypointensive signal when the axis is parallel to B0.
キーワード	MRI visualization of stent lumen solenoid pattern Moebius pattern direction of B1
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2012-06
巻	66巻
号	3号
出版者	Okayama University Medical School
開始ページ	203
終了ページ	211
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	22729100
Web of Science KeyUT	000305669700003
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/48542

Time Trade-off Utility Analysis for Surgical Intervention in Comitant Strabismus, Glaucoma, and Cataract

JaLCDOI	10.18926/AMO/48558
フルテキストURL	66_3_191.pdf
著者	Kishimoto, Fumiko\| Naito, Tomoko\| Hasebe, Satoshi\| Ohtsuki, Hiroshi\|
抄録	The utility value was compared among 3 surgical interventions, and the validity of the time trade-off (TTO) method was evaluated by analyzing the correlations of the utility value with the results of the Visual Function Questionnaire-14 (VF-14) and other variables. The subjects were 127 patients aged 40-85 years who were surgically treated between January 2008 and March 2010, including 26 patients with glaucoma, 50 with cataracts, and 51 with comitant strabismus. The scores on VF-14 and utility values determined using TTO were calculated retrospectively. The mean value (SD) of the utility gain was 0.096 (0.105) for glaucoma, 0.101 (0.105) for comitant strabismus, and 0.167 (0.237) for unilateral and 0.245 (0.167) for bilateral cataracts, indicating significant postoperative improvements in the utility value. A significant correlation was observed between the utility value and the postoperative VF-14 scores of the bilateral cataracts, and the postoperative visual acuity of the better eye of the unilateral cataract. The mean value of the quality-adjusted life years was 2.181 for bilateral and 1.424 for unilateral cataracts, 1.132 for strabismus, and 0.870 for glaucoma with an annual discount rate of 3%. The gain of utility value was highest in bilateral cataracts, and lowest in glaucoma, and thus the TTO analysis was considered to be highly valid for cataract surgery.
キーワード	surgical intervention VF-14 utility analysis time trade-off quality-adjusted life years
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2012-06
巻	66巻
号	3号
出版者	Okayama University Medical School
開始ページ	191
終了ページ	201
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	22729099
Web of Science KeyUT	000305669700002

Dynamin 2 in Charcot-Marie-Tooth Disease

JaLCDOI	10.18926/AMO/48557
フルテキストURL	66_3_183.pdf
著者	Tanabe, Kenji\| Takei, Kohji\|
抄録	Charcot-Marie-Tooth disease (CMT) is an inherited neuronal disorder, and is induced by mutations of various genes associated with intracellular membrane traffic and cytoskeleton. A large GTPase, dynamin, which is known as a fission protein for endocytic vesicles, was identified as a gene responsible for dominant-intermediate CMT type 2B (DI-CMT2B). Of these mutants, the PH domain, which is required for interaction with phosphoinositides, was mutated in several families. Interestingly, the expression of a deletion mutant, 551Δ3, did not impair endocytosis, but induced abnormal accumulation of microtubules. Recent evidence has shown that dynamin 2 regulates the dynamic instability of microtubules, and 551Δ3 lacks this function. We propose a model for the regulation of the dynamic instability of microtubules by dynamin 2 and discuss the relationship between dynamin 2 and CMT.
キーワード	neuropathy Charcot-Marie-Tooth disease membrane traffic dynamin microtubules
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2012-06
巻	66巻
号	3号
出版者	Okayama University Medical School
開始ページ	183
終了ページ	190
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	22729098
Web of Science KeyUT	000305669700001

Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse

著者	Yoshimoto, Masaaki\| Kataoka, Takahiro\| Toyota, Teruaki\| Taguchi, Takehito\| Yamaoka, Kiyonori\|
発行日	2012-02-01
出版物タイトル	Inflammation
巻	35巻
号	1号
資料タイプ	学術雑誌論文

Evaluation of plasma 3-methylhistidine concentration as an index of protein catabolism in horses and dairy cows.

著者	澤田久美子\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

Molecular Genetic Study of Earliness-related Genes in Wheat

著者	吉田哲也\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

球面ステッピングモータを応用した撹拌器とホロノミック移動台車に関する研究

著者	単万里\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

難溶解性薬物シロスタゾールの経口吸収挙動におけるin vitro–in vivo相関に関する研究

著者	鎌田直興\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

ポリフェノール代謝物の抗酸化作用および抗炎症作用

著者	石元秀和\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

現代トルコ語指示詞の研究

著者	Metin, Balpinar\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

現代史における歴史認識の共有－カティンの森事件を事例に－

著者	岡野詩子\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

形容詞性接辞の意味変化に関する史的研究－「－ぽい」と「－らしい」－

著者	岩崎真梨子\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

企業活動に係る個人情報保護－日中の法規制と情報漏えい防止対策－

著者	安井久美\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

「満洲事変」前における東三省地域政権の通貨統一

著者	郭志華\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

Attenuated Sensory Deprivation-induced Changes of Parvalbumin Neuron Density in the Barrel Cortex of FcγRⅡB-deficient Mice

著者	渡邊真紀子\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

High spatial resolution MRA of renal arteries using contrast behavior between fat and water during transient phase before reaching a steady state

著者	木田勝博\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse

著者	吉本雅章\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

Visualization of Stent Lumen in MR Imaging: Relationship with Stent Design and RF Direction

フルテキストURL	K0004591.pdf K004591_honbun.pdf
著者	大野誠一郎\|
発行日	2012-03-23
資料タイプ	学位論文
学位授与番号	甲第4591号
学位授与年月日	2012-03-23
学位・専攻分野	博士（保健学）
授与大学	岡山大学
言語	日本語英語

QT Dispersion Measured by Automatic Computerized 12-lead Electrocardiography Contributes Significantly to Detection of Left Ventricular Hypertrophy in Japanese Patients

著者	泉礼司\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文