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JaLCDOI 10.18926/AMO/66672
フルテキストURL 78_1_063.pdf
著者 Murakami, Daizo| Nishimoto, Kohei| Takao, Soshi| Miyamaru, Satoru| Kadowaki, Tomoka| Saito, Haruki| Takeda, Hiroki| Ise, Momoko| Suyama, Koichi| Orita, Yorihisa|
抄録 The tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated with a <8 mg/day mean dose of lenvatinib was significantly better than that of the patients treated with 8-24 mg/day (hazard ratio [HR] 0.38 for 1.14-4.54 mg/day, and HR 0.01 for 4.56-7.97 mg/day) adjusted for various factors (e.g., sex, age, drug interruption period). The cumulative dose of lenvatinib administered tended to be higher in the patients treated with low doses (< 8 mg/day) than in the patients treated with relatively high doses (8-24 mg/day). Considering its adverse events, the continuation of lenvatinib treatment with an adequate daily dose and drug interruption may help prolong the survival of patients with unresectable thyroid carcinoma.
キーワード thyroid carcinoma lenvatinib adverse effect survival
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 63
終了ページ 70
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419316
Web of Science KeyUT 001203658200007
JaLCDOI 10.18926/AMO/66671
フルテキストURL 78_1_053.pdf
著者 Ichikawa, Yukiko| Ogino, Tetsuya|
抄録 Ice bags are frequently used in medical care settings for pain relief, comfort, and in some cases, whole-body cooling. This study quantifies heat energy transfer capacity of ice bags and evaluates their cooling effects on body temperature. Forty-eight healthy adults in their 20s were recruited. An ice bag wrapped in two layers of dry towel was applied to the forehead, neck, or palm of each participant for 10 min. The skin surface temperature, heat flow, and core temperature were recorded during the cooling and non-cooling periods, with energy transfer calculated by integrating heat flow over time. Over the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling period, the range increased to 180.0-218.7 kJ·m-2 over 10 min. Skin surface temperature decreased by 3.2-5.7°C, whereas core temperature was unchanged. Ice bag use augmented energy transfer by about 150-180 kJ·m-2 over 10 min, but this was insufficient for rapid whole body cooling due to the small skin-surface area in contact with the ice bag. The measured energy transfer indicated that topical ice bag application absorbs insufficient energy to affect core temperature. Quantitative assessment of energy transfer was shown to inform the safe and appropriate use of thermotherapy.
キーワード cold compress fever hyperthermia thermal conductivity thermoregulation
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 53
終了ページ 61
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419315
Web of Science KeyUT 001203658200009
JaLCDOI 10.18926/AMO/66670
フルテキストURL 78_1_047.pdf
著者 Shimomura, Manabu| Shinozaki, Katsunori| Yano, Takuya| Akabane, Shintaro| Ohdan, Hideki| Hiroshima Surgical study group of Clinical Oncology (HiSCO)|
抄録 Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen.
キーワード metastatic colorectal cancer chemotherapy S-1 prospective phase II study
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 47
終了ページ 52
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419314
Web of Science KeyUT 001203658200005
JaLCDOI 10.18926/AMO/66669
フルテキストURL 78_1_037.pdf
著者 Tanaka, Masato| Meena, Umesh| Taoka, Takuya| Fujiwara, Yoshihiro| Yokomizo, Daiichiro| Bashyal, Santosh Kumar| Sake, Naveen| Arataki, Shinya|
抄録 In adult spinal deformity (ASD) surgery, one of the key factors working to prevent proximal junctional kyphosis is the proximal anchor. The aim of this study was to compare clinical and radiographic outcomes of triangular fixation with conventional fixation as proximal anchoring techniques in ASD surgery. We retrospectively evaluated 54 patients who underwent corrective spinal fusion for ASD. Fourteen patients underwent proximal triangular fixation (Group T; average 74.6 years), and 40 patients underwent the conventional method (Group C; average 70.5 years). Clinical and radiographic outcomes were assessed using visual analogue scale (VAS) values for back pain and the Oswestry disability index (ODI). Radiographic evaluation was also collected preoperatively and postoperatively. Surgical times and intraoperative blood loss of the two groups were not significantly different (493 vs 490 min, 1,260 vs 1,173 mL). Clinical outcomes such as VAS and ODI were comparable in the two groups. Proximal junctional kyphosis in group T was slightly lower than that of group C (28.5% vs 47.5%, p=0.491). However, based on radiology, proximal screw pullout occurred significantly less frequently in the triangular fixation group than the conventional group (0.0% vs 22.5%, p=0.049). Clinical outcomes in the two groups were not significantly different.
キーワード adult spinal deformity proximal junctional kyphosis triangular fixation minimally invasive surgery C arm free
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 37
終了ページ 46
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419313
Web of Science KeyUT 001203658200003
JaLCDOI 10.18926/AMO/66668
フルテキストURL 78_1_029.pdf
著者 Kitayama, Takahiro| Tanaka, Takashi| Kanie, Yuichiro| Marukawa, Yohei| Kojima, Katsuhide| Tanaka, Takehiro| Takao, Soshi| Hiraki, Takao|
抄録 This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD.
キーワード methotrexate lymphoproliferative disorder computed tomography necrosis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 29
終了ページ 36
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419312
Web of Science KeyUT 001203658200001
JaLCDOI 10.18926/AMO/66667
フルテキストURL 78_1_021.pdf
著者 Tamura, Masanori| Furumatsu, Takayuki| Yokoyama, Yusuke| Kintaka, Keisuke| Higashihara, Naohiro| Kawada, Koki| Ozaki, Toshifumi|
抄録 The use of various strategies for arthroscopic meniscal repairs to save the meniscus and prevent the progression of knee osteoarthritis has gradually increased. We investigated the frequency of various arthroscopic treatments and the short-term clinical outcomes of symptomatic isolated medial meniscus (MM) injuries. This retrospective observational study included 193 patients (197 knees) who underwent arthroscopic meniscal treatment for isolated MM injuries between January 2016 and April 2019. Arthroscopic meniscal repairs were divided into two groups: transtibial pullout repairs of MM posterior root tears (MMPRTs) and arthroscopic meniscal repairs for other types of MM injuries. MMPRT pullout repair, other meniscal repairs, and partial meniscectomy were performed in 71.0%, 16.8%, and 12.2% of the knees, respectively. The ratio of women to men and the patient age were higher in the pullout-repair group than the meniscal-repair group. The Preoperative Knee Injury and Osteoarthritis Outcome Score subscale (as an index of daily living activities) was significantly lower in the pullout-repair group than the meniscus-repair group. However, no significant differences were observed in these scores among the two groups postoperatively. Our results suggest that familiarity with the diagnosis and treatment of MMPRTs is necessary for orthopedic surgeons to manage isolated MM injuries.
キーワード knee medial meniscus posterior root tear arthroscopy pullout repair
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 21
終了ページ 27
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419311
Web of Science KeyUT 001203658200002
JaLCDOI 10.18926/AMO/66666
フルテキストURL 78_1_015.pdf
著者 Maeda, Reina| Shien, Tadahiko| Takahashi, Mina| Kawada, Kengo| Kajiwara, Yukiko| Kubo, Shinichiro| Takabatake, Daisuke| Ohtani, Shoichiro| Matsuoka, Kinya| Hikino, Hajime| Ogasawara, Yutaka| Taira, Naruto| Osumi, Shozo| Ikeda, Masahiko| Doihara, Hiroyoshi|
抄録 While local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate the clinical situation and its outcomes. We enrolled patients with fewer than 3 lung nodules suspected of being oligometastases after curative breast cancer surgery. Treatments, including local and systemic therapy, were selected by the physician and patient in consultation. The primary outcome was overall survival (OS); secondary outcomes were the efficacy and the safety of the surgery for lung oligometastases. Between May 2015 and May 2019, 14 patients were enrolled. Resection of lung nodules (metastasectomy) was performed in 11 (78.6%) of 14 patients, and one of these cases was diagnosed as primary lung cancer. Metastasectomies were all performed employing video-assisted thoracic surgery (VATS) without perioperative complications. Systemic therapies were administered to all patients except one. The respective 3-year and 5-year OS rates of patients with lung oligometastases were 91.6% and 81.5%, respectively. Progression occurred in 6 patients: 3 of the 10 with metastasectomy and all 3 without this surgical procedure. Lung metastasectomy was worthwhile as a diagnostic evaluation and may provide long-term benefit in some patients.
キーワード oligometastasis breast cancer lung metastasectomy
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 15
終了ページ 20
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419310
Web of Science KeyUT 001203658200008
JaLCDOI 10.18926/AMO/66665
フルテキストURL 78_1_009.pdf
著者 Akagi, Naoki| Kanematsu, Akihiro| Shigesaka, Koji| Shimatani, Kimihiro| Yamamoto, Shingo|
抄録 Bacillus Calmette-Guérin (BCG) treatment for non-muscle-invasive bladder cancer frequently causes an intraprostatic BCG granuloma. We investigated the optimal timing for a prostate biopsy after BCG treatment by retrospectively analyzing the cases of 22 patients with non-muscle-invasive bladder cancer who underwent a prostate biopsy after BCG treatment at our institute (2013-2017). Biopsies were indicated for a rising prostate-specific antigen (PSA) level, positive digital rectal examination findings, or the appearance of de novo low apparent diffusion coefficient lesions on MRI. The control group was comprised of 28 age- and PSA-matched patients. The relationships among the cancer detection rate and the patients’ PSA levels and MRI findings were analyzed. Prostate cancer was detected by biopsy in only 13.9% (3/22) of the patients in the BCG group but in 78.5% (22/28) of the control patients (p=0.0001). The three patients in the BCG group in whom prostate cancer was detected had all undergone the biopsy > 1 year after their BCG treatment. The remaining biopsies were performed within 1 year after BCG treatment and resulted in no diagnoses of prostate cancer. We suggest that performing a prostate biopsy early after BCG treatment is not informative or useful.
キーワード bacillus Calmette-Guérin prostate granuloma prostate cancer bladder cancer prostate biopsy
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 9
終了ページ 13
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419309
Web of Science KeyUT 001203658200010
JaLCDOI 10.18926/AMO/66664
フルテキストURL 78_1_001.pdf
著者 Sun, Cuiming| Matsukawa, Akihiro|
抄録 Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis.
キーワード ERK-MAPK SPRED2 fibrosis macrophages
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 8
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419308
Web of Science KeyUT 001203658200006
フルテキストURL fulltext20240221-01.pdf
著者 Iijima, Yuta| Miki, Ryohei| Fujimura, Masatake| Oyadomari, Seiichi| Uehara, Takashi|
キーワード Methylmercury Neuronal cell death Apoptosis CHOP Knockout mouse
発行日 2024
出版物タイトル The Journal of Toxicological Sciences
49巻
2号
出版者 Japanese Society of Toxicology
開始ページ 55
終了ページ 60
ISSN 0388-1350
NCID AN00002808
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 The Japanese Society of Toxicology
論文のバージョン publisher
PubMed ID 38296529
DOI 10.2131/jts.49.55
Web of Science KeyUT 001157348600004
関連URL isVersionOf https://doi.org/10.2131/jts.49.55
フルテキストURL fulltext.pdf
著者 Kanao, Tadayoshi|
キーワード tetrathionate hydrolase reduced inorganic sulfur compounds dissimilatory sulfur metabolism S4-intermediate pathway acidophiles chemoautotroph
発行日 2024-01-29
出版物タイトル Frontiers in Microbiology
15巻
出版者 Frontiers Media
開始ページ 1338669
ISSN 1664-302X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 Kanao.
論文のバージョン publisher
PubMed ID 38348185
DOI 10.3389/fmicb.2024.1338669
Web of Science KeyUT 001160607900001
関連URL isVersionOf https://doi.org/10.3389/fmicb.2024.1338669
フルテキストURL fulltext.pdf
著者 Tamura, Masanori| Furumatsu, Takayuki| Yokoyama, Yusuke| Higashihara, Naohiro| Kawada, Koki| Ozaki, Toshifumi|
キーワード Knee injuries Arthroscopy Meniscus Root tear
備考 The version of record of this article, first published in Knee Surgery & Related Research, is available online at Publisher’s website: http://dx.doi.org/10.1186/s43019-023-00206-1|
発行日 2024-02-08
出版物タイトル Knee Surgery & Related Research
36巻
1号
出版者 Springer Nature
開始ページ 8
ISSN 2234-2451
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2024.
論文のバージョン publisher
PubMed ID 38331953
DOI 10.1186/s43019-023-00206-1
Web of Science KeyUT 001160637100001
関連URL isVersionOf https://doi.org/10.1186/s43019-023-00206-1
フルテキストURL fulltext.pdf
著者 Soejima, Yoshiaki| Iwata, Nahoko| Yamamoto, Koichiro| Suyama, Atsuhito| Nakano, Yasuhiro| Otsuka, Fumio|
キーワード bone morphogenetic protein (BMP) orexin catecholamine and adrenal
発行日 2024-01-27
出版物タイトル International Journal of Molecular Sciences
25巻
3号
出版者 MDPI
開始ページ 1585
ISSN 1661-6596
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 by the authors.
論文のバージョン publisher
PubMed ID 38338864
DOI 10.3390/ijms25031585
Web of Science KeyUT 001160350600001
関連URL isVersionOf https://doi.org/10.3390/ijms25031585
フルテキストURL bfsc_042_colophon.pdf
出版物タイトル 岡山大学農学部センター報告
発行日 2020-04-01
42巻
ISSN 0910-8742
言語 日本語
著作権者 岡山大学農学部
論文のバージョン publisher
フルテキストURL bfsc_042_063.pdf
出版物タイトル 岡山大学農学部センター報告
発行日 2020-04-01
42巻
開始ページ 63
終了ページ 63
ISSN 0910-8742
言語 日本語
著作権者 岡山大学農学部
論文のバージョン publisher
フルテキストURL bfsc_042_059.pdf
出版物タイトル 岡山大学農学部センター報告
発行日 2020-04-01
42巻
開始ページ 59
終了ページ 62
ISSN 0910-8742
言語 日本語
著作権者 岡山大学農学部
論文のバージョン publisher
フルテキストURL bfsc_042_015.pdf
出版物タイトル 岡山大学農学部センター報告
発行日 2020-04-01
42巻
開始ページ 15
終了ページ 58
ISSN 0910-8742
言語 日本語
著作権者 岡山大学農学部
論文のバージョン publisher
フルテキストURL bfsc_042_013.pdf
出版物タイトル 岡山大学農学部センター報告
発行日 2020-04-01
42巻
開始ページ 13
終了ページ 14
ISSN 0910-8742
言語 日本語
著作権者 岡山大学農学部
論文のバージョン publisher
フルテキストURL bfsc_042_007.pdf
出版物タイトル 岡山大学農学部センター報告
発行日 2020-04-01
42巻
開始ページ 7
終了ページ 11
ISSN 0910-8742
言語 日本語
著作権者 岡山大学農学部
論文のバージョン publisher
フルテキストURL bfsc_042_001.pdf
出版物タイトル 岡山大学農学部センター報告
発行日 2020-04-01
42巻
開始ページ 1
終了ページ 6
ISSN 0910-8742
言語 日本語
著作権者 岡山大学農学部
論文のバージョン publisher