検索結果 5724 件
| JaLCDOI | 10.18926/AMO/53335 |
|---|---|
| フルテキストURL | 69_2_71.pdf |
| 著者 | Hiramoto, Hiroki| Dansako, Hiromichi| Takeda, Midori| Satoh, Shinya| Wakita, Takaji| Ikeda, Masanori| Kato, Nobuyuki| |
| 抄録 | Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies. In the present study, we found that the expression level of annexin A1 (ANXA1) in human hepatoma cell line Li23-derived D7 cells was remarkably lower than that in parental Li23 cells, whereas the susceptibility of D7 cells to HCV infection was much higher than that of Li23 cells. Therefore, we hypothesized that ANXA1 negatively regulates persistent HCV infection through the inhibition of viral RNA replication. The results revealed that HCV production was significantly inhibited without a concomitant reduction in the amount of lipid droplets in the D7 cells stably expressing exogenous ANXA1. Further, we demonstrated that ANXA1 negatively regulated the step of viral RNA replication rather than that of viral entry in human hepatocytes. These results suggest that ANXA1 would be a novel target for the development of anti-HCV strategies. |
| キーワード | HCV annexin A1 Li23 cell line Li23-derived D7 cells HCV-JFH-1 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 71 |
| 終了ページ | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899628 |
| Web of Science KeyUT | 000353181700001 |
| タイトル（別表記） | PD-1,CTLA-4 |
|---|---|
| フルテキストURL | 127_63.pdf |
| 著者 | 榮川 伸吾| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-04-01 |
| 巻 | 127巻 |
| 号 | 1号 |
| 開始ページ | 63 |
| 終了ページ | 65 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.63 |
| NAID | 130005068337 |
| タイトル（別表記） | Gene therapy using REIC/Dkk-3-encoding adenoviral vector for the treatment of malignant pleural mesothelioma |
|---|---|
| フルテキストURL | 127_47.pdf |
| 著者 | 豊岡 伸一| |
| キーワード | 悪性胸膜中皮腫 REIC/DKK-3 遺伝子治療 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-04-01 |
| 巻 | 127巻 |
| 号 | 1号 |
| 開始ページ | 47 |
| 終了ページ | 50 |
| ISSN | 0030-1558 |
| 関連URL | http://www.okayama-u.ac.jp/user/oma/ |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.47 |
| NAID | 130005068349 |
| タイトル（別表記） | Cholelithiasis with a cholecystoduodenal fistula complicated with paroxysmal nocturnal hemoglobinuria |
|---|---|
| フルテキストURL | 127_35.pdf |
| 著者 | 加藤 卓也| 松川 啓義| 塩崎 滋弘| 藤 智和| 藤原 康宏| 二宮 基樹| |
| 抄録 | In cases of paroxysmal nocturnal hemoglobinuria (PNH), attention must be paid to potential complications such as thrombosis and hemolysis due to perioperative stress and infection from complement activation. Here we present the case of a 61-year-old Japanese woman with PNH. We made the diagnosis of PNH when she was 28 years old, and we administered repeated steroid medication and erythrocyte transfusion. The patient's cholecystocholedocholithiasis with a cholecystoduodenal fistula was diagnosed based on a survey of the right hypochondriac pain. We performed endoscopic nasobiliary drainage (ENBD) for the prophylaxis of perioperative infection, plus a cholecystectomy and fistulectomy. There were no complications, including hemolysis attack, infection, thrombosis with irrigation erythrocyte transfusion, steroid cover, or the need for heparin administration during the perioperative period. The reduction of the complement activation is necessary in the perioperative management of PNH patients. The prevention of the development of acidosis and hypoxemia, the selection of washed red blood cells, steroid use, appropriate infection measures and thrombosis prophylaxis are all important for the prevention of complications. |
| キーワード | 発作性夜間血色素尿症（PNH）（paroxysmal nocturnal hemoglobinuria (PNH)） 胆嚢十二指腸瘻（cholecystoduodenal fistula） 溶血発作（hemolysis） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-04-01 |
| 巻 | 127巻 |
| 号 | 1号 |
| 開始ページ | 35 |
| 終了ページ | 39 |
| ISSN | 0030-1558 |
| 関連URL | http://www.okayama-u.ac.jp/user/oma/ |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.35 |
| NAID | 130005068351 |
| タイトル（別表記） | The 2013 Incentive Award of the Okayama Medical Association in Neuroscience (2013 Niimi Prize) |
|---|---|
| フルテキストURL | 127_5.pdf |
| 著者 | 表 芳夫| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-04-01 |
| 巻 | 127巻 |
| 号 | 1号 |
| 開始ページ | 5 |
| 終了ページ | 8 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.5 |
| NAID | 130005068350 |
| 著者 | Kobayashi, Junko| Yoshida, Masashi| Tarui, Suguru| Hirata, Masataka| Nagai, Yusuke| Kasahara, Shingo| Naruse, Keiji| Ito, Hiroshi| Sano, Shunji| Oh, Hidemasa| |
|---|---|
| 発行日 | 2014-07-22 |
| 出版物タイトル | PLoS ONE |
| 巻 | 9巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Onoda, Akihisa| Hosoya, Osamu| Sano, Kuniaki| Kiyama, Kazuko| Kimura, Hiroshi| Kawano, Shinji| Furuta, Ryohei| Miyaji, Mary| Tsutsui, Ken| Tsutsui, Kimiko M.| |
|---|---|
| 発行日 | 2014-07-17 |
| 出版物タイトル | Nucleic Acids Research |
| 巻 | 42巻 |
| 号 | 14号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Tada, Kotaro| Hamada, Toshihisa| Asagoe, Kenji| Umemura, Hiroshi| Mizuno-Ikeda, Kazuko| Aoyama, Yumi| Otsuka, Masaki| Yamasaki, Osamu| Iwatsuki, Keiji| |
|---|---|
| 発行日 | 2014-11 |
| 出版物タイトル | European Journal of Dermatology |
| 巻 | 24巻 |
| 号 | 6号 |
| 資料タイプ | 学術雑誌論文 |
| フルテキストURL | K0005072_abstract_review.pdf K0005072_fulltext.pdf |
|---|---|
| 著者 | 小林 純子| |
| 発行日 | 2014-12-31 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5072号 |
| 学位授与年月日 | 2014-12-31 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 英語 |
| フルテキストURL | K0005070_abstract_review.pdf K0005070_fulltext.pdf |
|---|---|
| 著者 | 津崎 龍一郎| |
| 発行日 | 2014-12-31 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5070号 |
| 学位授与年月日 | 2014-12-31 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 英語 |
| フルテキストURL | K0005069_abstract_review.pdf K0005069_fulltext.pdf |
|---|---|
| 著者 | 綿谷 博雪| |
| 発行日 | 2014-12-31 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5069号 |
| 学位授与年月日 | 2014-12-31 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 英語 |
| JaLCDOI | 10.18926/AMO/53122 |
|---|---|
| フルテキストURL | 69_1_51.pdf |
| 著者 | Mu Mu Shwe| Kyi Kyi Nyunt| Okada, Shigeru| Harano, Teruo| Hlaing Myat Thu| Hla Myat Mo Mo| Mo Mo Win| Khin Khin Oo| KhinThet Wai| Khin Saw Aye| Myo Khin| |
| 抄録 | Persistent infection with oncogenic types of human papillomavirus (HPV) is the most important risk factor associated with cervical cancer. This study detected the oncogenic HPV genotypes in cervical neoplasia in relation to clinicopathological findings using a cross-sectional descriptive method in 2011 and 2012. Cervical swabs and colposcopy-directed cervical biopsy tissues were collected from 108 women (median age 45 years;range 20-78) showing cervical cytological changes at Sanpya General Hospital, Yangon, Myanmar. HPV DNA testing and genotyping were performed by polymerase chain reaction and restriction fragment length polymorphism. HPV was identified in women with cervical intraepithelial neoplasia (CIN) 1 (44.4%), CIN2 (63.2%), CIN3 (70.6%), and squamous cell carcinoma (SCC) (74.1%). The association between cervical neoplasia and HPV positivity was highly significant (p＝0.008). Most patients infected with HPV were between 40-49 years of age, and the youngest were in the 20- to 29-year-old age group. The most common genotype was HPV 16 (65.6%) with the following distribution:70% in CIN1, 41.7% in CIN2, 91.7% in CIN3, and 60% in SCC. HPV-31 was the second-most frequent (21.9%):30% in CIN1, 33.3% in CIN2, 8.3% in CIN3, and 15% in SCC. The third-most frequent-genotype was HPV-18 (7.8%):8.3% in CIN1, and 20% in SCC. Another genotype was HPV-58 (4.7%):16.7% in CIN1 and 5% in SCC. The majority of CIN/SCC cases were associated with HPV genotypes 16, 31, 18, and 58. If oncogenic HPV genotypes are positive, the possibility of cervical neoplasia can be predicted. Knowledge of the HPV genotypes distribution can predict the effectiveness of the currently used HPV vaccine. |
| キーワード | human papillomavirus genotyping Myanmar |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-02 |
| 巻 | 69巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 51 |
| 終了ページ | 58 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25703171 |
| Web of Science KeyUT | 000349740300006 |
| JaLCDOI | 10.18926/AMO/53118 |
|---|---|
| フルテキストURL | 69_1_17.pdf |
| 著者 | Suzuki, Norihiro| Takata, Minoru| Shirafuji, Yoshinori| Otsuka, Masaki| Yamasaki, Osamu| Asagoe, Kenji| Hatta, Naohito| Iwatsuki, Keiji| |
| 抄録 | Sentinel lymph node (SLN) biopsies have widely been used for the detection of occult LN metastasis of malignant melanoma (MM). In addition to conventional biomarkers, we assessed the diagnostic and prognostic significance of melanoma-initiating cell (MIC) markers in SLNs of MM. We examined the expressions of gp100, MART-1 and tyrosinase mRNA for routine diagnosis and those of ABCB5, CD133, nestin, KDM5B, NGFR and RANK mRNA as MIC markers. The presence of micrometastasis was confirmed immunohistochemically using antibodies to S-100, HMB-45, MART-1, and tyrosinase. Discordance between immunohistochemical and molecular data was observed in 14 of 70 (20.0%) patients, among whom five (7.1%) were positive for only molecular markers;two of these five patients tested positive for micrometastasis by repeated immunohistochemical stainings. The quantitative expression levels of gp100, MART-1, and tyrosinase mRNA were significantly higher in the metastatic LNs;the cut-off values remain to be elucidated. ABCB5 mRNA expression was detected more frequently in the metastatic SLNs (p＜0.05) and in the group of patients with recurrence. To make a definite diagnosis of metastasis, we still need a combination of immunohistochemical and molecular probes. ABCB5 might be a suitable molecular marker for the detection of melanoma-initiating cells in SLNs. |
| キーワード | melanoma cancer-initiating cell sentinel lymph node ABCB5 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-02 |
| 巻 | 69巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 17 |
| 終了ページ | 27 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25703167 |
| Web of Science KeyUT | 000349740300002 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53114 |
| JaLCDOI | 10.18926/AMO/53117 |
|---|---|
| フルテキストURL | 69_1_1.pdf |
| 著者 | Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi| |
| 抄録 | Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells. |
| キーワード | prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-02 |
| 巻 | 69巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25703166 |
| Web of Science KeyUT | 000349740300001 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53128 |
| フルテキストURL | K0005065_abstract_review.pdf K0005065_fulltext.pdf |
|---|---|
| 著者 | 多田 光太郎| |
| 発行日 | 2014-12-31 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5065号 |
| 学位授与年月日 | 2014-12-31 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 英語 |
| フルテキストURL | K0005064_abstract_review.pdf K0005064_fulltext.pdf |
|---|---|
| 著者 | 鈴木 規弘| |
| 発行日 | 2014-12-31 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5064号 |
| 学位授与年月日 | 2014-12-31 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 英語 |
| 著者 | Kikuchi, Satoru| Kishimoto, Hiroyuki| Tazawa, Hiroshi| Hashimoto, Yuuri| Kuroda, Shinji| Nishizaki, Masahiko| Nagasaka, Takeshi| Shirakawa, Yasuhiro| Kagawa, Shunsuke| Urata, Yasuo| Robert M Hoffman| Fujiwara, Toshiyoshi| |
|---|---|
| 発行日 | 2014-12-19 |
| 出版物タイトル | Molecular Therapy |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 上村 一雄| 長田 臨| 菊本 愛生| Sharmin, Sultana| 若井 暁| 金尾 忠芳| |
|---|---|
| 発行日 | 2015-02-01 |
| 出版物タイトル | 岡山大学農学部学術報告 |
| 巻 | 104巻 |
| 資料タイプ | 紀要論文 |
| 著者 | Kondo, Yoshitaka| Nagasaka, Takeshi| Kobayashi, Satoru| Kobayashi, Naoya| Fujiwara, Toshiyoshi| |
|---|---|
| 発行日 | 2014-03 |
| 出版物タイトル | Hepato-Gastroenterology |
| 巻 | 61巻 |
| 号 | 130号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/53028 |
|---|---|
| フルテキストURL | 68_6_379.pdf |
| 著者 | Doi, Shinichiro| Kimura, Shuhei| Morizane, Yuki| Hosogi, Mika| Hosokawa, Mio| Shiode, Yusuke| Kawata, Tetsuhiro| Kondo, Eisei| Shiraga, Fumio| |
| 抄録 | We report a case of POEMS syndrome in a 20-year-old patient diagnosed after visiting an eye clinic with a chief complaint of reduced visual acuity. A male university student aged 20 years was referred to our department complaining of blurred vision in both eyes that had persisted for 1 month. He also noted headache, nausea, and paresthesia in the lower extremities around the same time. The visual acuity of his right and left eye was 20/40 and 20/20, respectively. Optic disc edema and serous retinal detachment were present. Brain magnetic resonance imaging showed no intracranial abnormalities, while elevated cerebrospinal fluid pressure, reduced nerve conduction velocity in both lower extremities, hepatosplenomegaly, M proteinemia, high blood VEGF levels, osteoblastic and osteolytic changes in the spine, and atypical plasma cells in bone lesions were noted. From the above findings, the patient was diagnosed with POEMS syndrome. He received high-dose dexamethasone, thalidomide, and radiotherapy on the sacral mass, followed by high-dose melphalan with autologous stem-cell support, and showed subsequent systemic and ophthalmologic improvement. Here, we report the youngest case ever of POEMS syndrome with ocular manifestation. If patients have optic disc edema in both eyes with no intracranial space-occupying lesion, POEMS syndrome should be considered in differential diagnosis, regardless of age. |
| キーワード | POEMS syndrome serous retinal detachment VEGF |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-12 |
| 巻 | 68巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 379 |
| 終了ページ | 383 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25519033 |
| Web of Science KeyUT | 000346882200009 |